Gene 88123.m00046 (T.vaginalis)

88123.m00046

Species: T.vaginalis
Alias: 88123.m00046, TvagK0626
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
88123.m00046.AA Protein None 2109 None Fasta, JSON
88123.m00046.kin_dom Protein Kinase Domain None 114 None Fasta, JSON

Protein domain

Protein domains of 88123.m00046.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 88123.m00046.AA HEAT 306-329 29 0.503143 7.41 Pfam 1-24 (31) Show / Hide 
Range on Protein: 306-329
Range on HMM: 1-24/31
Sequence Identity: 29% (7 aa)

VISSLFMLADSPDHVVRECVADAL
... |. . ..||  ||| .. .|
ILPHLLKCLNDPDWEVREAACWCL
HEAT 88123.m00046.AA HEAT 348-368 23 43.520248 0.7 Pfam 4-24 (31) Show / Hide 
Range on Protein: 348-368
Range on HMM: 4-24/31
Sequence Identity: 23% (5 aa)

IFTLALTDPYASVRAKVLQAF
..  .|.|| ..||. .....
HLLKCLNDPDWEVREAACWCL
HEAT 88123.m00046.AA HEAT 381-411 29 0.002986 15.12 Pfam 1-31 (31) Show / Hide 
Range on Protein: 381-411
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

ILSNLSSIVKDEDIDVKINAIKLLGKIAKYN
||. | .  .|.| .|. .|.. ||..... 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 88123.m00046.AA HEAT 726-737 33 63.103838 0.14 Pfam 1-12 (31) Show / Hide 
Range on Protein: 726-737
Range on HMM: 1-12/31
Sequence Identity: 33% (4 aa)

LIPILAARLSDK
..|.|   |.|.
ILPHLLKCLNDP
HEAT 88123.m00046.AA HEAT 785-817 18 1.791671 5.5 Pfam 1-31 (31) Show / Hide 
Range on Protein: 785-817
Range on HMM: 1-31/31
Sequence Identity: 18% (6 aa)

IVPEVISLVNTFSSSTQVCVQMLEALRVFVQYC
|.| .... |  ... .|  . ...| .....|
ILPHLLKCLN--DPDWEVREAACWCLGQLCEHC
HEAT 88123.m00046.AA HEAT 826-856 25 0.220595 8.65 Pfam 1-31 (31) Show / Hide 
Range on Protein: 826-856
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

ILRCSLNALHNDSNEVVHAALQVIYSIVVVL
|| . |..|. .. ||  ||.. . ... ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
FAT 88123.m00046.AA FAT 1237-1294 23 0.000165 15.33 Pfam 99-175 (408) Show / Hide 
Range on Protein: 1237-1294
Range on HMM: 99-175/408
Sequence Identity: 23% (18 aa)

YPLLVKAQQLQEIKEII----NN-----------QENMKFV---WEKRIKLV-REDFDTYYDILSVRLTHIDVNNMI
||..|. |.| |..|||     .           .|..| .   |.|| . .   ...   .||..|  .. ..|..
YPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQR
FAT 88123.m00046.AA FAT 1330-1466 17 5.1e-08 27.07 Pfam 232-408 (408) Show / Hide 
Range on Protein: 1330-1466
Range on HMM: 232-408/408
Sequence Identity: 17% (32 aa)

EVKFLYIKGMWARGNRIDAVKSLNQLLL-EAANY----------------DKTHEPN-----KKLNA-RMYYYCAHWILQLHNLSMFK------NCFNQA
.. . | | |||.|....|   |.. .. . ..                 ..    |     .||.| | |   . |  .|     ..      .... .
QWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLY---EEQYMNWNQEQKDEI

VVALERSLSYESTYYN-SWHRWSWANSVMFRHQP------------TIVQHASNAISGFCRCVQLRQS-KSFSDLIQMIS
  .  .   .  . |   ||.|  .|  .| |..             | ||. .|...| ... | |. .|. |.  ...
LQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
HEAT 88123.m00046.AA HEAT 1496-1526 16 13.341212 2.48 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1496-1526
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

IIPQLFAQFTSKKRFVVMFVSQIVSKLLPDH
|.| |.  ....   | . . . ...|.. .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase 88123.m00046.AA PIKK 1740-2010 31 1.3e-81 277.46 In-house 1-290 (290) Show / Hide 
Range on Protein: 1740-2010
Range on HMM: 1-290/290
Sequence Identity: 31% (93 aa)

LIQQFDASLDIIHSKQRPRNLIIYDQNGLQHLAILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETLFSLIS
 |. .| .. .. .||.|. ..|   .|  .   .|||||||.|||.||.| |.|     |   ..| | | .| ..| | . |||. ||.. ||. .. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NYRTAHNIDPLCENNLFK---------------------EFSSANIDYLRPIQRLEILNEAKNEIPCDDLRESIWLKSISSREWVTRILNFSQSSALMSV
... . .|  . |....                      .  . . . .   ...|...|... .| |....  |.|. .. .| .|  |.  | |.|..
QWCQKKHI--RHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

IGYIIGLGDRHPSNLMLHNASGALIHVDFGDCFEVSKIRIRFPETIPFRLTRMMISALGPSGIEGDFRITAEDTLVLVQNHCDSIMAVLDIF
 |||.|||||||.|.|.   .| ..|.|||.|||. . | ..||..||||||.|. |.|| |.|| || . |... .  .| ...|.|.. |
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 88123.m00046.AA FRAP 1769-2020 42 6.2e-79 268.54 In-house 1-251 (251) Show / Hide 
Range on Protein: 1769-2020
Range on HMM: 1-251/251
Sequence Identity: 42% (107 aa)

QHLAILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETLFSLISNYRTAHNIDPLCENNLFKEFSSANIDYLR
 .  .||||||.| | |.|| | |||. .  .   . . | | || | |.| ..|||  |    ||  || .|| ...|    | |.... .  . | | 
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLP

PIQRLEILNEAKNEIPCDDLRESIWLKSISSREWVTRILNFSQSSALMSVIGYIIGLGDRHPSNLMLHNASGALIHVDFGDCFEVSKIRIRFPETIPFRL
 ... ||   . |    .||.  .|||| .|  |  |  |.  | | ||..|||.|||||||||.||   .| ..|.||||||||   | .||| |||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMMISALGPSGIEGDFRITAEDTLVLVQNHCDSIMAVLDIFLQEPLESDEI
|||.. |.   |||| .|.| |  .  .  | .|.||||. |   ||    .
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 88123.m00046.AA PI3_PI4_kinase 1769-2020 23 4.2e-54 190.84 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1769-2020
Range on HMM: 1-300/300
Sequence Identity: 23% (71 aa)

QHLAILKGHEDLR--LDQRIMQFF-----------------------ELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETLFSLISNYRT
 . .|.||..|||   |.|.||..                       .|.|   . | .|  |.. .  | . | ... |.|..|. ..|.  ....|..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

AHNIDPLCENNLFKEFSSANIDYLRPIQRLEILNEAKNEIPCDDLRESIWLKSISS-REWVTRILNFSQSSALMSVIGYIIGLGDRHPSNLML--HNASG
  .. ..  .. ..  . .. . |  .|..|. .....  | ..|..  | .. .   || ... ||  | | |.|..||.|.||||..|.|.  .  .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

ALIHVDFGDCFE-VSKIRIRFPETIPFRLTR------MMISAL------GPSGIEGDFRITAEDTLVLVQNHCDSIMAVL-------DIFLQEPLESDEI
 |.|.|||.||. .   .  .||..|||.|.      .|..|.      .||| .| || . .... ..  | ...|..|       ..... .| ..  
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase 88123.m00046.AA PI3Kc 1771-2088 22 1.1e-51 178.91 SMART 1-336 (336) Show / Hide 
Range on Protein: 1771-2088
Range on HMM: 1-336/336
Sequence Identity: 22% (78 aa)

LAILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETLFSLISNYRTAHNIDPLCE------------------
  |.|...||| |.|.||.|.|.|   . |     |.|.. .| . |...| |.|..|  .||| .. ..|..  ....  .                  
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--NNLFKEFSSANIDYLRPIQRLEILNEAKNEIPCDDLRESIWLKSISSR-EWVTRILNFSQSSALMSVIGYIIGLGDRHPSNLMLHNASGALIHVDFGD
  .. . ..     . .. ...|.   .| . .. ..|..  | .. ... .|.... || .| | .....|| |.||||..|.||.  .| ..|.|||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVSKIRIRFP----ETIPFRLTRMMISALG----PSGIEGDFRITAEDTLVLVQNHCDSIMAVLDIFLQEPLESDEILDRMNDKLVKNMDTVFSSIEE
.|. .. .. |.    |. |||||..|. . |    ||| .| || ... .. ..  | ..||... ...  |.  .   .   .| .|.    |  .  
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM---EKDIKYLRQRFRLDH-

TWDIEGASDVAYLEIKDATEKIQT----KIVGES-DQQTTSNEAVTKYIDDL
            |  ..|.....     |. ..| . .||    .  ..  .
------------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 88123.m00046.AA ATR 1899-2010 36 9.7e-32 105.11 In-house 157-267 (267) Show / Hide 
Range on Protein: 1899-2010
Range on HMM: 157-267/267
Sequence Identity: 36% (41 aa)

SREWVTRILNFSQSSALMSVIGYIIGLGDRHPSNLMLHNASGALIHVDFGDCFEVSKIRIRFPETIPFRLTRMMISALGPSGIEGDFRITAEDTLVLVQN
...| .   |.  | | ....||||||||||  |...    | ..|||.   |   . ..  ||..|||||. |. ..|| . .| ||   |... ....
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGE-QFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

HCDSIMAVLDIF
| | ||.|.| |
HRDDIMSVWDCF
Kinase 88123.m00046.AA ATM 1902-2015 39 5.8e-28 86.12 In-house 133-245 (304) Show / Hide 
Range on Protein: 1902-2015
Range on HMM: 133-245/304
Sequence Identity: 39% (45 aa)

WVTRILNFSQSSALMSVIGYIIGLGDRHPSNLMLHNASGALIHVDFGDCFEVSKIRIRFPETIPFRLTRMMISALGPSGIEGDFRITAEDTLVLVQNHCD
|  . | .  | |  |..|||.||||||  |...   |  |.|.| |  ||  || .  |||.|||||| ..  .|  |.|| ||   | |.  . |  .
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SIMAVLDIFLQEPL
 .. . .. | .||
TLLTIVEVLLYDPL
Kinase 88123.m00046.AA SMG1 1748-1837 36 1.4e-15 47.93 In-house 1-90 (242) Show / Hide 
Range on Protein: 1748-1837
Range on HMM: 1-90/242
Sequence Identity: 36% (33 aa)

LDIIHSKQRPRNLIIYDQNGLQHLAILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETLFSL
. |.  | .|. |.     |     . || ||| || |||||  ..|         |        | .||.  ..|||| ||||  || |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGL
Kinase 88123.m00046.AA SMG1 1901-1962 41 1.7e-14 44.25 In-house 182-242 (242) Show / Hide 
Range on Protein: 1901-1962
Range on HMM: 182-242/242
Sequence Identity: 41% (26 aa)

EWVTRILNFSQSSALMSVIGYIIGLGDRHPSNLMLHNASGALIHVDFGDCFEVSKIRIRFPE
||      .  | | ||..||||||||||  | ..    |  .|.|.  |||  |  .. ||
EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase 88123.m00046.AA ATR 1739-1834 29 4.6e-13 40.43 In-house 1-96 (267) Show / Hide 
Range on Protein: 1739-1834
Range on HMM: 1-96/267
Sequence Identity: 29% (28 aa)

SLIQQFDASLDIIHSKQRPRNLIIYDQNGLQHLAILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETL
. |  ||  ..|. | |.|. . .   .|  .. . | ..||| | | |.| ||||.    |  .  | . .  | . |.  ....|  |.   ||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL
Kinase 88123.m00046.AA DNAPK 1741-1834 36 6e-12 39.6 In-house 4-97 (301) Show / Hide 
Range on Protein: 1741-1834
Range on HMM: 4-97/301
Sequence Identity: 36% (34 aa)

IQQFDASLDIIHSKQRPRNLIIYDQNGLQHLAILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLIQCVDGAETL
|  ||    .. |  ||. .||       |  . || ||||.|||| | |   |  .  |    .| |    | | |     |||  ||   .|
IAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase 88123.m00046.AA FATC 2081-2109 48 7.2e-11 37.85 Pfam 5-33 (33) Show / Hide 
Range on Protein: 2081-2109
Range on HMM: 5-33/33
Sequence Identity: 48% (14 aa)

VTKYIDDLINQATDMYNLSYLYHGWTPLW
|.  .|.||..||| .||. .|.|| | |
VEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 88123.m00046.AA DNAPK 1909-1986 35 1e-10 35.01 In-house 190-267 (301) Show / Hide 
Range on Protein: 1909-1986
Range on HMM: 190-267/301
Sequence Identity: 35% (28 aa)

FSQSSALMSVIGYIIGLGDRHPSNLMLHNASGALIHVDFGDCFEVSKIRIRFPETIPFRLTRMMISALGPSGIEGDFR
|  . |.  . ..| | ||||  | |     |  | .|||  |         ||  ||||||  |  . | .| | ..
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMY
Kinase 88123.m00046.AA ATM 1772-1825 29 9e-05 10.73 In-house 2-55 (304) Show / Hide 
Range on Protein: 1772-1825
Range on HMM: 2-55/304
Sequence Identity: 29% (16 aa)

AILKGHEDLRLDQRIMQFFELINQHISHDFLDESRSLRIIRYQITPISKKAGLI
 . || .||| |  . | | . |  .        | | |  |.. |.|...| .
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL