Gene 83007.m00246 (T.vaginalis)
83007.m00246
Species: T.vaginalis
Alias: TvagK0844, 83007.m00246
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 83007.m00246.AA | Protein | None | 1156 | None | Fasta, JSON |
| 83007.m00246.kin_dom | Protein Kinase Domain | None | 307 | None | Fasta, JSON |
Protein domains of 83007.m00246.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_rbd | 83007.m00246.AA | PI3K_rbd | 338-416 | 24 | 1.6e-05 | 23.01 | Pfam | 35-115 (115) | Show / Hide |
Range on Protein: 338-416 Range on HMM: 35-115/115 Sequence Identity: 24% (20 aa) SIQCRYDISADKAIVQLIAK---IEKHQKINIGRDPSEFVLLLQGTDEVIAGDTPLVQFMCVRQFLVSNQPVMNVMLAEKSQ ..|| . .... . |...| . . ...| .| .|| . | ||...||.|| || ..|... .. . ...| |.. TFQCNPNDTPFQVMHQAFCKMAMKHSVHDQNDVQNPGDYVLKVCGRDEYLHGDHPLCQFEYIRNCI-MWGRCPHLTLMECCS |
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| PI3K_rbd | 83007.m00246.AA | PI3K_rbd | 301-416 | 19 | 0.00014 | 10.75 | SMART | 1-116 (116) | Show / Hide |
Range on Protein: 301-416 Range on HMM: 1-116/116 Sequence Identity: 19% (23 aa) RMRISSTDPP-LYTCTKTQIALKCELRAGITDVVVTGASIQCRYDISADKAIVQLIAK---IEKHQKINIGRDPSEFVLLLQGTDEVIAGDTPLVQFMCV |....... . | |. . | | ... ...| . ..|. . |...| . . ..| . |. ...| . | ||....|.|| || .. MSRKCPEHIWMKTINNKIIIVVHWEKR---VCNWQQTKTMDCNPNCTPDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYI RQFLVSNQPVMNVMLAEKSQ | .. .. . .. | |.. RNCI-MWGRCPHFVLMECCK |
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| PI3K_C2 | 83007.m00246.AA | PI3K_C2 | 475-579 | 22 | 9.1e-08 | 30.16 | Pfam | 1-114 (168) | Show / Hide |
Range on Protein: 475-579 Range on HMM: 1-114/168 Sequence Identity: 22% (26 aa) KVENVGITVAII--NGTQTICDPITLPVQKGGA----KYILVNQPITFQ-ISPRVLPHSARLSISVFDYDQRTNY---MKKPKKKKDNGNIASLNFPMFT . ... ..... .|.. .|.|. . | .. . . |. ||| | . || .|||.|..... . | . .|. |. |.|.| PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNM--NEQNKK-CPIGWCNLPLFD H-DGWLNMGTTSRKM-W | .. |..| . .| | HEKCMLRCGMHKLHMTW |
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| PI3Ka | 83007.m00246.AA | PI3Ka | 624-811 | 30 | 9.3e-49 | 169.22 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 624-811 Range on HMM: 1-232/232 Sequence Identity: 30% (72 aa) NRMSMH-LSTEEIARLETFENLDALGVLSPEDKTLIWNNR-AKFKQNERMLP-----LVLQSLDYTSPVQVAEIPYILNEW--AEISPTDALTLLDPKFA .. . .. || .|| ... . .|. |.| ||| | ... . || .|.. . . . .|.. .... | ..|.| ||| ||||||. DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP D---RDVRKYAVEHLEAFNDNEIMLYMLQLVQALKFE--------------------------LYDDSPLAHFLLRRGLAEPKFLGHQLFWQLMSEA--- | . ||.|||. ||...|.|. .| ||||||||.| | ||||..|||.| |. | .||...|.| || DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH ---HISQIRQRFSAVLVNFIYGI-GSYWKELKT | ... ||| .| ...|. | . ..|. CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Ka | 83007.m00246.AA | PI3Ka | 650-811 | 34 | 4.3e-44 | 153.26 | Pfam | 26-211 (211) | Show / Hide |
Range on Protein: 650-811 Range on HMM: 26-211/211 Sequence Identity: 34% (65 aa) LSPEDKTLIWNNR-AKFKQNERMLP------LVLQ-SLDYTSPVQVAEIPYILNE--WAEISPTDALTLLDPKFAD--RDVRKYAVEHLEA-FNDNEIML |. |.| ||| | . | . || || . ... |||. ... |..|.| ||| |||..|.| . || |||. || . |.|. . LTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLC YMLQLVQALKFE----LYDDSPLAHFLLRRGLAEPKFLGHQLFWQLMSEA------HISQI-RQRFSAVLVNFIYGIGSYWKELKT |.||||||||.| ..||.|..|||.|.. . .||..|| . || |.. . |||. .| . ...| . ..| . YLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK |
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| PI3Kc | 83007.m00246.AA | PI3Kc | 895-1156 | 27 | 8.3e-85 | 288.97 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 895-1156
Range on HMM: 1-336/336
Sequence Identity: 27% (92 aa)
KTMFKVGDDLRQDQLTLQIMKVMEHLWRQN----QLDLRMNCYGVLPTGFNQGFIEVVPNSITEQVLQQEEGRWTG------------------------
.||.|||||||....|. ..| ..|... ..||.|. |...||| . |.||.|||. | .| . |..
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-------------------------------VFKPNIMNDFLAKNNSTA-VTLNIAKENFLLSSAGYAVSSCVIGLADRHPGNIMVQ-RDGHFFHIDFGH
.|||....|.. ... .. . |..|| .| ||| . . . |. |||..|||. .|| |||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKKKLGYQ---REDAPFHFSPACAEALG--GVGSEQYKRFEDTSANAYNILRRNANLLMSMMLLMLGTGI-PELQKP-EDIIYMKNMLNLG-VSEE
..|...||.|.. || .|| . . .. | |. |.....| .. ||...|...||.|... .|....| |.... .||.| .. ..| .|.|
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EAATIFKK-----YIQMSLDSTKTTVNNWIHNLVVS
|||. |.. .|. |..| |.... .||.
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | 83007.m00246.AA | PI3_PI4_kinase | 893-1107 | 25 | 7.8e-60 | 209.9 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 893-1107 Range on HMM: 1-300/300 Sequence Identity: 25% (76 aa) PVKTMFKVGDDLR--QDQLTLQIM-----------------------KVMEHLWRQNQLDLR----MNCYGVLPTGFNQGFIEVVPNSITEQVLQQEEGR .. .||.||||| ||....|. ..| .|... .|.| |. | ..||| . |.||.|||. | . .. . . WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV WTGVFK-----------------------------------PNIMNDFLAKNNSTA-VTLNIAKENFLLSSAGYAVSSCVIGLADRHPGNIMV---QRDG . . .... ... |.| .| .. |..|| .| ||..| . ..|..|||..|||| .| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HFFHIDFGHFLGNFKKKLGYQREDAPFHFSP------ACAEALGG----VGSEQYKRFEDTSANAYNILRRNANLLMSMM-------LLMLGTGIPELQK | |||||||.....| | . .|. ||.. . .|.|| |. | .|.|. ||..|||..||.|... ..|. .|.|.. . HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 83007.m00246.AA | FRAP | 1007-1032 | 62 | 5e-06 | 18.44 | In-house | 153-179 (251) | Show / Hide |
Range on Protein: 1007-1032 Range on HMM: 153-179/251 Sequence Identity: 62% (17 aa) VIGLADRHPGNIMVQRD-GHFFHIDFG ..|| |||| ||| || | ||||| ILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 83007.m00246.AA | ATR | 969-1097 | 20 | 9e-06 | 15.11 | In-house | 142-267 (267) | Show / Hide |
Range on Protein: 969-1097 Range on HMM: 142-267/267 Sequence Identity: 20% (27 aa) KPNIMNDFLAKNNSTAVTLNIAKENFLLSSAGYAVSSCVIGLADRHPGNIMVQR-DGHFFHIDFGHFLGNFKK-KLGYQREDAPFHFSPACAEALGGVGS .| | .|. . . ..||.. | | ... .||| ||| ||.... | |.|. | . . | || ..| ... HPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCI---FNSGEQFEVPEIVPFRLTHNMVFGMGPMKT EQYKRFEDTSANAYNILRRNANLLMSMMLLM . | ..| . . .||.. YGL--FRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 83007.m00246.AA | PIKK | 990-1033 | 42 | 3.1e-05 | 15.44 | In-house | 185-229 (290) | Show / Hide |
Range on Protein: 990-1033 Range on HMM: 185-229/290 Sequence Identity: 42% (19 aa) AKENFLLSSAGYAVSSCVIGLADRHPGNIMVQRD-GHFFHIDFGH ..||.. | | .. ..|| |||| |||.... | |||||. RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | 83007.m00246.AA | PIKK | 897-953 | 31 | 0.007438 | 6.67 | In-house | 34-94 (290) | Show / Hide |
Range on Protein: 897-953 Range on HMM: 34-94/290 Sequence Identity: 31% (19 aa) MFKVGDDLRQDQLTLQIMKVMEHLWRQN----QLDLRMNCYGVLPTGFNQGFIEVVPNSIT ..| ..|||||| ..| .| . ... . .| . | | | . . | || |.|. | LCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT |
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