Gene 89704.m00120 (T.vaginalis)

89704.m00120

Species: T.vaginalis
Alias: TvagK0846, 89704.m00120
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI3K

Sequence

Name Sequence Type Origin Length Description Download
89704.m00120.AA Protein None 1040 None Fasta, JSON
89704.m00120.kin_dom Protein Kinase Domain None 308 None Fasta, JSON

Protein domain

Protein domains of 89704.m00120.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_C2 89704.m00120.AA PI3K_C2 365-466 23 7.6e-16 59.28 Pfam 1-121 (168) Show / Hide 
Range on Protein: 365-466
Range on HMM: 1-121/168
Sequence Identity: 23% (28 aa)

EANNYIVRVVIL--HGSNEISAPM-MTRPSLGC----SSVAWNEALNIS-IQIMQLPRAARVAITLFNYDKIGTNK---------APIATCNVPVFNF-D
. ....|.. .   || . .. |.  |..  ..    ... ||| ..   ||. .|||.||  ||....     ..          ||. ||.| |.. .
PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEK

GWFNSGVKFWSM-WNGKDTDP
. ...| .  .| | .|...|
CMLRCGMHKLHMTWPSKPPCP
PI3K_C2 89704.m00120.AA PI3K_C2 345-443 19 2.9e-05 23.38 SMART 8-133 (133) Show / Hide 
Range on Protein: 345-443
Range on HMM: 8-133/133
Sequence Identity: 19% (25 aa)

YAKENFS-----IIIGGCFNIPSDLEAN------NYIVRVVILHG-SNEISAPMMTRP---SLGCS-S-----VAWNEALNI-SIQIMQLPRAARVAITL
. ...|      | | .  .|.     .      ...|.. . ||  . ...|. |..   .. .. .     . ||| |.. .||. .|||.|| .||.
CCNRPFVFLPHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLPRMARLCITI

FNYDKIGTNKAPI-----ATCNVPVF
. . . .  ..|.     ...|.  |
WDVYDDSKKSEPFFSRCVGWSNFDWF
PI3Ka 89704.m00120.AA PI3Ka 512-694 29 4e-45 157.15 SMART 1-232 (232) Show / Hide 
Range on Protein: 512-694
Range on HMM: 1-232/232
Sequence Identity: 29% (69 aa)

SSQTKI-IVEEMRKKNFDLL-----KKPTDEARANLYRYRYDFI-DIPSMLP-----LVLSSIDYTVTTQVNEIPALLQRW--QRPPPTIALSLLDSQYA
. . |.   ||.|..  |..     .. |.| .  ....|...  . |  ||      .|.... .  ..|..  .|...|     .|  || |||. ..
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP

D---HRVREFAVRCLESLSDDEIMLYMLQLIQALKYE--------------------------MYDDSPLCRFLFRRGLNEPKFLGHQLFWQLISEA---
|     ||..||.|||..||||. .| |||.||||||                           | ||||||||..| |  |  .||...|.| ||    
DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH

---HISHIRRRFSSFVVNFLYGS-GIYRDELLK
   | .|. .|| .    ...|. | .  .|.|
CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
PI3Ka 89704.m00120.AA PI3Ka 541-694 32 5.2e-42 146.09 Pfam 34-211 (211) Show / Hide 
Range on Protein: 541-694
Range on HMM: 34-211/211
Sequence Identity: 32% (58 aa)

LYRYR-YDFI-DIPSMLP------LVLS-SIDYTVTTQVNEIPALLQR--WQRPPPTIALSLLDSQYAD--HRVREFAVRCLES-LSDDEIMLYMLQLIQ
....| | ..  .|  ||        |. ..  .  .||..  .|...  |   .|  ||.|||. ..|    ||..||.|||| .||||. .|.||| |
IWKFRHY-CCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQ

ALKYE----MYDDSPLCRFLFRRGLNEPKFLGHQLFWQLISEA------HISHI-RRRFSSFVVNFLYGSGIYRDELLK
|||||     ..||.| |||..|..  .  .||..|| . ||       |....   ||..    .... | .. .|.|
ALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK
PI3Kc 89704.m00120.AA PI3Kc 778-1039 29 2.3e-84 287.47 SMART 1-336 (336) Show / Hide 
Range on Protein: 778-1039
Range on HMM: 1-336/336
Sequence Identity: 29% (99 aa)

RVLFKVGDDLRQDQLTLQIMRVMEHLWRKE----GIDLHMRCYAVLPTGFNQGFIEVVPNTITEQALQQ-------------------------------
.|.||.|||||||....|. |.| ..|.|.    . ||||| |...||| . |.||.|||. |   .|                                
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

---------------------ERGTFSGIWD---SSTISDYLCKVNQTEQ-NQQVARSNFMYSSAGYAVATCVLGIADRHPGNILLQ-NDGHFLHIDFGH
                     .   | |  .     .. |.. . . ..  . . ||.|| .| ||| ..| .||| |||..||.|  ..|| .||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLGNFKTKLGYQ---RENAPFHFSPACANVLG--DVDGEMFKQFRVLCGQAFNILRHNSKLLVTLLMLMLGTGI-PELQKA-EDIRYMTDMLMLN-KTDS
..|....|.|..   || .|| . .   .| |  ... ..|..|| .| .|....|..| |...|. .|....| |....  .||.|  . ..|. ..| 
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

EAKIEFDK-----LTNKSLESTRTKLNNLFHNIAVS
||   |..     | ..|.||  |.....|||.|  
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
PI3_PI4_kinase 89704.m00120.AA PI3_PI4_kinase 776-990 23 3.7e-56 197.69 Pfam 1-300 (300) Show / Hide 
Range on Protein: 776-990
Range on HMM: 1-300/300
Sequence Identity: 23% (71 aa)

PIRVLFKVGDDLR--QDQLTLQIM-----------------------RVMEHLWRKEGIDLH----MRCYAVLPTGFNQGFIEVVPNTITEQALQQERGT
 ....||.|||||  ||....|.                        |.|  .|.|.| |.     |. | ..||| . |.||.|||. | . .. . ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

FSGIWD-----------------------------------SSTISDYLCKVNQTE-QNQQVARSNFMYSSAGYAVATCVLGIADRHPGNILL---QNDG
  .. .                                      . ... | | ..  . . ||.|| .| ||..|.. .||..|||..||..     .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HFLHIDFGHFLGNFKTKLGYQRENAPFHFSP------ACANVLGD----VDGEMFKQFRVLCGQAFNILRHNSKLLVTLL-------MLMLGTGIPELQK
|  ||||||.....|.| .  .|  ||.. .         ...|.     . ...  || .| .|...||... |...||        .|. .|.|.. .
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase 89704.m00120.AA FRAP 874-915 48 4.1e-07 22.32 In-house 137-179 (251) Show / Hide 
Range on Protein: 874-915
Range on HMM: 137-179/251
Sequence Identity: 48% (21 aa)

RSNFMYSSAGYAVATCVLGIADRHPGNILLQ-NDGHFLHIDFG
| |.  | |   .|  .||. |||| ||.||   |  .|||||
RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG
Kinase 89704.m00120.AA PIKK 780-836 37 2.3e-05 15.92 In-house 34-94 (290) Show / Hide 
Range on Protein: 780-836
Range on HMM: 34-94/290
Sequence Identity: 37% (23 aa)

LFKVGDDLRQDQLTLQIMRVMEHLWRKE----GIDLHMRCYAVLPTGFNQGFIEVVPNTIT
|.| ..|||||| ..|  ..|  . .|.      .||.| |.| | . . | || |.|. |
LCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT
Kinase 89704.m00120.AA ATR 873-980 20 4.8e-05 12.65 In-house 163-267 (267) Show / Hide 
Range on Protein: 873-980
Range on HMM: 163-267/267
Sequence Identity: 20% (22 aa)

ARSNFMYSSAGYAVATCVLGIADRHPGNILLQN-DGHFLHIDFGHFLGNFKTKLGYQRENAPFHFSPACANVLGDVDGEMFKQFRVLCGQAFNILRHNSK
.|.|.. | | ...   ..|. |||  |||..   |   |.|.    .  ..      |  ||       . .| .  .    ||  |     ..|..  
SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQF--EVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRD

LLVTLLMLM
 .. ..   
DIMSVWDCF
Kinase 89704.m00120.AA PIKK 873-916 40 6.4e-05 14.28 In-house 185-229 (290) Show / Hide 
Range on Protein: 873-916
Range on HMM: 185-229/290
Sequence Identity: 40% (18 aa)

ARSNFMYSSAGYAVATCVLGIADRHPGNILLQND-GHFLHIDFGH
.|.|.  | |   ..  .||. |||| ||... . |  .|||||.
RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC
Kinase 89704.m00120.AA ATR 779-836 33 0.076398 1.57 In-house 34-95 (267) Show / Hide 
Range on Protein: 779-836
Range on HMM: 34-95/267
Sequence Identity: 33% (21 aa)

VLFKVGDDLRQDQLTLQIMRVMEHLWRKEGID----LHMRCYAVLPTGFNQGFIEVVPNTIT
.. |  ||||.|    ..  ... . ||.  .    .||| |||.|   . . || | ||.|
MMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTAT
Kinase 89704.m00120.AA FRAP 778-840 25 0.158384 1.56 In-house 3-69 (251) Show / Hide 
Range on Protein: 778-840
Range on HMM: 3-69/251
Sequence Identity: 25% (17 aa)

RVLFKVGDDLRQDQLTLQIMRVMEHLWRKEGI----DLHMRCYAVLPTGFNQGFIEVVPNTITEQAL
  | |  .|.|||   .|.   .  | . .      .| .. |...|   | | |  |..  | ..|
HFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHIL