Gene 85165.m00039 (T.vaginalis)

85165.m00039

Species: T.vaginalis
Alias: TvagK0840, 85165.m00039
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MOK

Sequence

Name Sequence Type Origin Length Description Download
85165.m00039.AA Protein None 394 None Fasta, JSON
85165.m00039.kin_dom Protein Kinase Domain None 240 None Fasta, JSON

Protein domain

Protein domains of 85165.m00039.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85165.m00039.AA RCK 1-255 41 1.5e-85 271.41 In-house 32-298 (298) Show / Hide 
Range on Protein: 1-255
Range on HMM: 32-298/298
Sequence Identity: 41% (110 aa)

MKNPYQTLEEVKQLPEITTLIELRDCPFIVKLHEVLFDFKQKSLALVFEKLDMNLYEYTCM---VGSGLPTKE--ASLIIYQILQGLSAMHAKYLFHRDM
||. . ..||...|.||. |  |   | |.||.||..| .  .|..||| .|||||...      .  || ..     |.|||||||. || .  ||||.
MKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDL

KPENCMINRE--------TLEVKIVDLGSTRKSFERGPYTEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLFPGKHELDQINRIHALCG
|||| |.. .        .  .|| | |. |    . |||.|||||||||||.||....|   .|.|||||  |||   ||||||  |.|||. |.   |
KPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG

TPTKDILKVFLQNPNTQLNYNFPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
||.|...  . ..  .|.|.|||.   . .    .  |    .|.|..| ..|  |||   || || |
TPNKKDWPDG-YKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 85165.m00039.AA MOK 1-255 41 1e-80 252.6 In-house 32-283 (283) Show / Hide 
Range on Protein: 1-255
Range on HMM: 32-283/283
Sequence Identity: 41% (106 aa)

MKNPYQTLEEVKQLPEITTLIELRDCPFIVKLHEVLFDFKQKSLALVFEKLDMNLYEYTCMVGSGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENC
||  ....|.| .| ||  .  |   | |..||||.|| |  .|||. | .|||.||        || |   . .||... |  ||   .||||.|||| 
MKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENI

MINRETLEVKIVDLGSTRKSFERGPYTEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLFPGKHELDQINRIHALCGTPTKDILKVFLQN
.|  . |  |. | || |  . . |||||.||||||||| ||| | |   .|.|.|||. ||..  .|||||  |.||| .||   ||| . ||  | .|
LIKQDHL--KLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFPGVNEVDQISKIHDVMGTPCQKILNKF-KN

PNTQLNYNFPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
    .||.||...   |   ..  .    .... .  | | .|||   .. || |
QSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 85165.m00039.AA CMGC 16-255 20 6.6e-80 262.08 In-house 71-513 (513) Show / Hide 
Range on Protein: 16-255
Range on HMM: 71-513/513
Sequence Identity: 20% (92 aa)

EITTLIELR----------------DCPFIVKLHEVLFDFK---------------QKSLALVFEKLDMNLYEYTCMVGS--------GLPTKE------
||  | .|.                . . ||||.... . .                ..| |||| .|..||.|  .           .|.  .      
EIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPH

------ASLII------YQILQGLS--AMHAKY--LFHRDMKPENCMINRETLE-------------------VKIVDLGSTRKSFER------------
         ..      ||||.||    .| .    .|||.|||| .|| ..                     .|| | |. |.  ..            
RRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSF

----------GPYTEYVSTRWYRAPEILLTS---------GQYGPSVDVWAVGCMLYELLEN--------RPLFP-----------GKHELDQINRIHAL
           |||.||.||||||||||| .         ..|....|.|.|||...|.. .        .||||           ||...||...|  .
KNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKV

CGTPT---------------KDILKVFLQNPNTQL------------------------NYNFPYRRRQHIADFMSPTSF--------------------
.||||               ...   ....|. ..                        | .|| ...... ... . ..                    
LGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFK

---------------LVTDLIEDLLIYNPLDRITVDGALAHPVF
               .  ||.. .|.|.| .|||.. ||.|| |
SHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 85165.m00039.AA CDK 16-255 32 8.6e-67 212.67 In-house 58-284 (284) Show / Hide 
Range on Protein: 16-255
Range on HMM: 58-284/284
Sequence Identity: 32% (85 aa)

EITTLIELRDCPFIVKLHEVLFDFK---------QKSLALVFEKLDMNLYEYTCMVGSGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRET
||..| ||  .| |||||.|  . .         ...| .||| .|. |..|               ...|.|.||. .| .   |||.|| | .||.  
EISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNG

L----EVKIVDLGSTRKSF-------ERGPYTEYVSTRWYRAPEILLTSGQYG--PSVDVWAVGCMLYELLE---NRPLFPGKHELDQINRIHALCGTPT
      .|| | |  |.         .. .||  | |.||||||.|| | .|.  ...|.|.||| ..|..    ..|||||. |.||. .|  .|||||
EVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPT

KDILKVFLQNPNTQLNYNFPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
 |.   . . |.                           ||.. .| |.|  ||. . || || |
EDNWPGVTKLPDY--------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 85165.m00039.AA MAK 1-192 43 3e-60 190.33 In-house 62-270 (352) Show / Hide 
Range on Protein: 1-192
Range on HMM: 62-270/352
Sequence Identity: 43% (91 aa)

MKNPYQTLEEVKQLPEITTLIELRDCPFIVKLHEVLFDFKQKSLALVFEKLDMNLYEYTCMVGS-GLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPEN
||  . ..||  .| |.  |  |   | |||| ||. |     | .||| .  |||.         .|  .   |.|||||||  ||    |||||||||
MKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDSENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPEN

CMINRE----------------TLEVKIVDLGSTRKSFERGPYTEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLFPGKHELDQINRIH
 |..                     .|| | |  |    . ||| |||||||||||.|| |..|.  .|.|||||   ||   ||||||  | |||  | 
IMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKIC

ALCGTPTKD
   |||.||
QVLGTPKKD
Kinase 85165.m00039.AA CDC2 16-255 34 4.6e-59 179.92 In-house 50-301 (301) Show / Hide 
Range on Protein: 16-255
Range on HMM: 50-301/301
Sequence Identity: 34% (90 aa)

EITTLIELRDCPFIVKLHEVLFDFKQKSLALVFEKLDMNLYEYTC-MVG--SGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRETLEVKIV
|| .| ||.| | |||||.|..    ..| .||| |||.| .|.    .  . .|      ..||||||..  |..  .||| || |  |...   .|| 
EISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIA

DLGSTRK-SFERGPYT--EYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYEL---LENRPLFPGKHELDQINRIHALCGTPTKDILKVFLQNPNTQLN
| |  |  ..   .||    | |.||||||||| . .|  .||.|..|| ..|.    ...|||.|. | ||. .|    |||. ...    |.|    .
DFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPD--YK

YNFPYRRRQHIADFMSP---------TSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
  ||  ..| . . .           .     ||.. .|.|.| .||... ||.|| |
NTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 85165.m00039.AA ERK1 75-255 42 7e-52 178.68 In-house 106-289 (289) Show / Hide 
Range on Protein: 75-255
Range on HMM: 106-289/289
Sequence Identity: 42% (79 aa)

IYQILQGLSAMHAKYLFHRDMKPENCMINRETLEVKIVDLGSTR----KSFERGPYTEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLF
.|||| ||  .|.    |||.|| | ..|. | ..|| | |  |    .    |  |||| |||||||||.| |  |  |.|.|.|||.| |.| |||.|
LYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF

PGKHELDQINRIHALCGTPTKDILKVFLQNPNTQLNYNFPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
|||| |||.| | .. | | .| |.  . .   .     |.. ..  |     .     ||.. .| .||  ||||. |||||  
PGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 85165.m00039.AA S_TKc 5-255 24 9.2e-51 175.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-255
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

YQTLEE-----------VKQLP----------------EITTLIELRDCPFIVKLHEVLFDFKQKSLALVFEKLDM---NLYEYTCMVGSG-----LPTK
|. |..           ..                   ||  | .  ..|.||||..|  |   ..| .|.| .|    .|..| .  |..     .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRETLEVKIVDLGSTRKSFERGPYTEYVSTRWYRAPEILLTSGQYGP-SVDVWAVGCMLYELLENRP
.|  ..|||...|  .| .   ||| |||| ....   ..|| | |. |.       | .. |.||.|||.|    .||. ..|.|..||.|||.|  .|
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYP

LFPGKHELDQINRIHALCGTPTKDILKVFLQNPNTQLNYNFPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALA-------HPVF
.||      |....  ..|                                     |  . |.|. .| ..| .|.|.  ||.       || |
PFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85165.m00039.AA Pkinase 22-255 27 3e-50 178.05 Pfam 56-293 (293) Show / Hide 
Range on Protein: 22-255
Range on HMM: 56-293/293
Sequence Identity: 27% (71 aa)

ELRDCPFIVKLHEVLFDFKQKSLALVFEKLDM-----NLY------EYTCMVGSGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRETLEV-
.| ..|.||.|...  |   ... .|.| ...      |.      ...|.  . .. .|.  ..||||.||  .|..   |||.||||..|. .. .. 
RL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF--Y-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHID

---KIVDLGSTRK--SFERGPYTEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLFPGK----HELDQINRIHALCGTPTKDILKVFLQN
   || | |. ..      . .| .. |.||.|||.....  |||.||.|..||.|||.|  ||.|||.    . .||. .|    |.|..        .
ACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSI

PNTQLNYNFPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
..    .  . .  .    |   .|    |.|...| ..| .|.| . .| || |
SYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 85165.m00039.AA MAPK 74-255 33 2.3e-48 165.27 In-house 120-328 (328) Show / Hide 
Range on Protein: 74-255
Range on HMM: 120-328/328
Sequence Identity: 33% (71 aa)

IIYQILQG--LSAMHAKYLFHRDMKPENCMINRETLEVKIVDLGSTR----KSFERG-----------PYTEYVSTRWYRAPEILLT--SGQYGPSVDVW
..|||| |  |  .|     ||| ||.|  .| |  ..|| | |  |    ......             ||||.|||||||||.|   .  |  .||.|
FMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMW

AVGCMLYELLE-NRPLFPGKHELDQINRIHALCGTPTKDILKVFL--QNPNTQLNYN--FPYRRRQHIADFMSP----TSFLVTDLIEDLLIYNPLDRIT
.||| . |.|  ..||||||. .||.|.| ...|||... ..     ... . .  .  .|.. ... ..  .     .. .  ||.| .|  .| .|||
SVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRIT

VDGALAHPVF
|. ||.|| |
VEEALQHPYF
Kinase 85165.m00039.AA ERK7 16-255 32 4.9e-48 162.21 In-house 48-292 (292) Show / Hide 
Range on Protein: 16-255
Range on HMM: 48-292/292
Sequence Identity: 32% (80 aa)

EITTLIELRDCPFIVKLHEVLFDFKQKSLALVFEKLDMNLYEYTCMVGSGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRETLEVKIVDLG
||. | |... | |..| .|.     . . |||| ..  |       |. |       |.||.|. .  ||   . |||.|| | ... | . ||. | |
EIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHA-VIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECM-VKVCDFG

-----STRK--SFERGPYTEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLFPGKHELDQINRIHALCGTPTKDILKVFLQNPNTQLNYN
     . ..  . . .  |||| ||||||||||| | .| . || | .|| | |.| ..|.|||   ..||..|  . . ||.  ..    .   ..  .
LARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQ

FPYRRRQHIADFMSPTSFLVTDLIEDLLIYNPLDRITVDGALAHPVF
 . ..|. . ..|  ..    ||.  ||..||  |.|.. ||.||  
MNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 85165.m00039.AA CDKL 29-201 37 3.3e-43 145.56 In-house 60-231 (286) Show / Hide 
Range on Protein: 29-201
Range on HMM: 60-231/286
Sequence Identity: 37% (66 aa)

IVKLHEVLFDFKQKS-LALVFEKLDMNLYEYTCMVGSGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRETLEVKIVDLGSTRKSFERG-PY
|| | ||   |..|  | ||||  | .. ..     .|.. .    ...|||....  |     ||| ||||  |.    .||. | |  |   . |  |
IVNLIEV---FRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIY

TEYVSTRWYRAPEILLTSGQYGPSVDVWAVGCMLYELLENRPLFPGKHELDQINRIHALCGTPTKDILKVFLQNP
|.|| |||||||| |.   |||..||.||.||.. |..   ||.||. ..||  .|    |. . .  ..|..||
TDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNP
Kinase 85165.m00039.AA TyrKc 5-262 16 7.2e-07 -111.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 5-262
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

YQTLEE-------------------VKQLP---------EITTLIEL-RDCPFIVKLHEVLFDFKQ-----KSLALVFE------------KLDMNLYEY
 . ...                   || |          |.  . .|  . | ||.|. |  . .      . | .|.|            |   .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----

TCMVGSGLPTKEASLIIYQILQGLSAMHAKYLFHRDMKPENCMINRETLEVKIVDLGSTRKSFER------GPYT-------EY--VSTRWYRAPEILLT
       |..|.   . .|| .| .  | | . |||    ||.....   ||| | | .|.  .       . |        .   .  ||. ||| .  
-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-N

SGQYGPSVDVWAVGCMLYELLEN-RPLFPG-----------KHELDQINRIHALCG----TPTKDILKVFLQNPNTQLNYNFPYRRRQHIADFMSPTSFL
 | . .  |||. | ...|.. .  .  ||            . ..| .|                                          |   .. .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------FVCCPDEM

VTDLIEDLLIYNPLDRITVDGALAHPVFAELNELY
 . ....   ..| ||         | |.|. |. 
YQ-IMKQCWHEDPEDR---------PTFSEIHECF
Kinase 85165.m00039.AA MAK 230-255 30 3.4e-05 12.02 In-house 327-352 (352) Show / Hide 
Range on Protein: 230-255
Range on HMM: 327-352/352
Sequence Identity: 30% (8 aa)

DLIEDLLIYNPLDRITVDGALAHPVF
.|..|.| ..|  | |   .. .| |
ELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 85165.m00039.AA CDKL 230-255 30 0.000136 11.62 In-house 261-286 (286) Show / Hide 
Range on Protein: 230-255
Range on HMM: 261-286/286
Sequence Identity: 30% (8 aa)

DLIEDLLIYNPLDRITVDGALAHPVF
|... .|  .| .|.|.. .. || |
DFMKKCLHMDPDERMTCEQLMHHPYF