Gene 88808.m00123 (T.vaginalis)
88808.m00123
Species: T.vaginalis
Alias: 88808.m00123, TvagK1006
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88808.m00123.AA | Protein | None | 354 | None | Fasta, JSON |
| 88808.m00123.kin_dom | Protein Kinase Domain | None | 156 | None | Fasta, JSON |
Protein domains of 88808.m00123.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 88808.m00123.AA | CAMKL | 168-261 | 34 | 3.2e-32 | 100.0 | In-house | 195-297 (297) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 195-297/297 Sequence Identity: 34% (36 aa) GSVNYAAPEVFKG---PFDPFAADIWSLGMTLYALLLGDCPINGQSV------EEIQEKIKEMKEVKLP-SYFSP-TVTSLLRHMLQLNPKDRMTIEDVM || .|.|||.|.| |.| ...||||.| .|||.. | | ..... .. |.|. . | .... . .|.|.||| ||..|.||...| GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIM EHPFV .||.. NHPWM |
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| Kinase | 88808.m00123.AA | CAMK | 106-261 | 22 | 1e-31 | 98.94 | In-house | 178-425 (425) | Show / Hide |
Range on Protein: 106-261
Range on HMM: 178-425/425
Sequence Identity: 22% (55 aa)
ETQVRQIFAEMAIIVHHLHKKHVAILDIQPNSFFLTQT-----------------GILKIGVLTSAGLYEP------------------------NELTK
| ..|..| .. ||..|..... .|. | |.. . .|| | ..| ... |
EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK
ELPGSVNYAA-PEVFKG--------------PFDPFAADIWSLGMTLYALLLGDCPINGQ-------------SVEEIQEKIKEMKEVKLPSYFSP----
. |. |.| |||..| | .....|.||.| ||..| | | .| . .|. |||.. | |.||||
TFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN
-------------------TVTSLLRHMLQLNPKDRMTIEDVMEHPFV
. .|.|.||| .|..|||||....||..
YGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 88808.m00123.AA | PLK1 | 18-261 | 27 | 6.5e-28 | 88.62 | In-house | 9-253 (253) | Show / Hide |
Range on Protein: 18-261 Range on HMM: 9-253/253 Sequence Identity: 27% (68 aa) EGDFYVSYLLEDIRTKMKYTGFLIHRKKLLYSPYIQKLHKILDIQASFGFPMMQNVIEVITDEELQLIVFDY-KYKSLMQLFTNGETLFETQVRQIFAEM .| | | ..| || . | .. .. |. . .|. . ..| . . . .. . |.. || . . .||| | ... | | . KGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQI AIIVHHLHKKHVAILDIQPNSFFLTQTGILKIGVLTSAGLYEPN-ELTKELPGSVNYAAPEVFKGPFDPFAADIWSLGMTLYALLLGDCPINGQSVEEIQ . ...||.... |.. || . .||| | | . | | | | || |||| . | ||||.| .| ||.| | ....| VEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETY EKIKEMKEVKLPSYFSPTVTSLLRHMLQLNPKDRMTIEDVMEHPFV .||. | ..||. |.. .|.|.||. .|. | ||| |.. |. SRIKKN-EYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 88808.m00123.AA | Ciliate-E2-Unclassified | 74-261 | 20 | 2.2e-27 | 92.08 | In-house | 87-352 (352) | Show / Hide |
Range on Protein: 74-261
Range on HMM: 87-352/352
Sequence Identity: 20% (55 aa)
IEVITDEELQLIVFDY-KYKSLMQLFTNGET-----------------LFETQVR-----QIFAEMAIIVHHLHKKH-VAILDIQPNSFFLTQTG---IL
... .|.. || .| ....|.| .. .. . | |.. ..||. .||.|. . ||.|. .... | .
FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYI
KIGVLTSAGLYEPN----------------ELTKELPGSVNYA----APEVFKG-PFDP---FAADIWSLGMTLYALLLGDCPINGQSVEE---------
|| . .. |. | .... |. || ||||..| | ...||||||. ||..| | .| .... |.
KIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI
------IQEKIKEMKEVKLPS--------YFSPTVTSLLR----HMLQLNPKDRMTIEDVMEHPFV
...... |... |. ||.. ... ||. ||. |.|.|....||.
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 88808.m00123.AA | AMPK | 168-261 | 40 | 9.6e-27 | 76.48 | In-house | 161-254 (254) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 161-254/254 Sequence Identity: 40% (38 aa) GSVNYAAPEVFKG-PFDPFAADIWSLGMTLYALLLGDCPINGQSVEEIQEKIKEMKEVKLPSYFSPTVTSLLRHMLQLNPKDRMTIEDVMEHPFV || .|||||. | . |||| | |||.| | | ... . |||. |...|...|| . .|..|||| .| |.||.|...||. GSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNG-EYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | 88808.m00123.AA | MARK | 168-261 | 37 | 3.3e-25 | 79.51 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 167-262/262 Sequence Identity: 37% (36 aa) GSVNYAAPEVFKG-PFDPFAADIWSLGMTLYALLLGDCPINGQS--VEEIQEKIKEMKEVKLPSYFSPTVTSLLRHMLQLNPKDRMTIEDVMEHPFV |. |.|||.|.. | | ...|||||| ||... | | |.. .|...|| | . |.. |. .|.. .|..||..|.|||..|.||.. GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGK-YDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 88808.m00123.AA | ULK | 168-261 | 29 | 1.4e-24 | 82.81 | In-house | 213-329 (329) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 213-329/329 Sequence Identity: 29% (35 aa) GSVNYAAPEVFKGP-----FDPFAADIWSLGMTLYALLLGDCP----INGQSVEEIQEKIKE-------MKEVKLPSY-------FSPTVTSLLRHMLQL |. | ||....| .. . .||||||. .| .| | .| .| | ||. |. .| .| . .|| . .|.| ||| GTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQY NPKDRMTIEDVMEHPFV ..|||...|.. .||.. DEKDRISWEELFNHPWF |
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| Kinase | 88808.m00123.AA | ULK | 168-261 | 29 | 1.6e-24 | 83.94 | In-house | 209-324 (324) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 209-324/324 Sequence Identity: 29% (35 aa) GSVNYAAPEVFK--G---PFDPFAADIWSLGMTLYALLLGDCP----INGQSVEEIQEKIKE-------MKEVKLPSY-------FSPTVTSLLRHMLQL |. | ||.... | |.. . .||||||. .| .| | .| .| | ||. |. .| ... . .|| . .|.| ||| GTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQY NPKDRMTIEDVMEHPFV ..|||...|.. .||.. DEKDRISWEEIFNHPWF |
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| Kinase | 88808.m00123.AA | Pkinase | 153-261 | 21 | 1.7e-23 | 84.2 | Pfam | 158-293 (293) | Show / Hide |
Range on Protein: 153-261
Range on HMM: 158-293/293
Sequence Identity: 21% (30 aa)
SAGL--YEPNELTKELPGSVNYAAPEVFK-GPFDPFAADIWSLGMTLYALLLGDCPINGQ----SVEEIQEKIKEMKEVKLPSYFS--------------
.| . | .|. .. . |. .|.|||| . |. .. ..|.||.| .|| .|.| | |. . . ...|.. .. .|.. ..
LAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH
---------PTVTSLLRHMLQLNPKDRMTIEDVMEHPFV
.. .... .|...||.| |.|....||..
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 88808.m00123.AA | RSK | 168-261 | 30 | 8.1e-22 | 76.76 | In-house | 170-278 (278) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 170-278/278 Sequence Identity: 30% (33 aa) GSVNYAAPEVFK----GP-FDPFAADIWSLGMTLYALLLGDCPING---QSVEEIQEKIKEMK-EVKLP--SYFSPTVTSLLRHMLQLNPKDRMT----- ....|.|||. | . | |.|.|||| .| .| | | | .. .|| ..|.. | ...| .| |.. .|.|.||. .|..| . YTIEYMAPEMLKRANQQGGHDK-ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD IEDVMEHPFV .|.. .||. AEEIKQHPWF |
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| Kinase | 88808.m00123.AA | QIK | 101-261 | 29 | 6.3e-21 | 75.84 | In-house | 112-272 (272) | Show / Hide |
Range on Protein: 101-261 Range on HMM: 112-272/272 Sequence Identity: 29% (47 aa) GETLFETQVRQIFAEMAIIVHHLHKKHVAILDIQPNSFFLTQTGILKIGVLTSAGLYEPNELTKELPGSVNYAAPEVFKGP-FDPFAADIWSLGMTLYAL | . | . |..| ... ||..||.... |. | . || .... .| . || |||||.|.| .| .||||.| ||.| GVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVL LLGDCPINGQSVEEIQEKIKEMKEVKLPSYFSPTVTSLLRHMLQLNPKDRMTIEDVMEHPFV | | |..... .... . | ...| . | .| |||| ..|. |.||. ...|. VCGALPFDGKTLQNLRQRVLSGK-FRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| S_TKc | 88808.m00123.AA | S_TKc | 9-261 | 18 | 5e-16 | 58.18 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-261
Range on HMM: 1-231/231
Sequence Identity: 18% (51 aa)
YHLLETSAEEGDFYVSYLLEDIRTKMKYTGFLIHRKKLLYSPYIQKLHKILDIQASFGFPMMQNVIEVITDEELQLIVFDYKYK---SLMQLFTNGET--
|..|.. .| | . |. ... || . |.. ... . ..| . . | . ..|. | . .|..| .|... . .
YEILRK-IGKGAFGKVYKCRHKK-----TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LFETQVRQIFAEMAIIVHHLHKKHVAILDIQPNSFFLTQTGILKIGVLTSAGLYEPNELTKELPGSVNYAAPEVFKGPFDPFAADIWSLGMTLYAL
. | ..| ...... . ..|.... |. | .|.. .||. .| .. . . |. .| ||||. .......|.||.| .|| .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEM
LLGDCPINGQSVEEIQEKIKEMKEVKLPSYFSPTVTSLLRHMLQLNPKDRMTIEDVME-------HPFV
| | | .... .||. || . ...|..|| .|..|.|. .... ||..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 88808.m00123.AA | RSK | 106-128 | 30 | 0.291984 | 0.82 | In-house | 103-125 (278) | Show / Hide |
Range on Protein: 106-128 Range on HMM: 103-125/278 Sequence Identity: 30% (7 aa) ETQVRQIFAEMAIIVHHLHKKHV |. .....|| . | |||.... EDEACFYMAEIVLAVEHLHQQGI |
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