Gene 97241.m00123 (T.vaginalis)
97241.m00123
Species: T.vaginalis
Alias: 97241.m00123, TvagK1031
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 97241.m00123.AA | Protein | None | 395 | None | Fasta, JSON |
| 97241.m00123.kin_dom | Protein Kinase Domain | None | 179 | None | Fasta, JSON |
Protein domains of 97241.m00123.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 97241.m00123.AA | TKL | 88-266 | 18 | 3.2e-27 | 95.09 | In-house | 118-364 (364) | Show / Hide |
Range on Protein: 88-266 Range on HMM: 118-364/364 Sequence Identity: 18% (47 aa) EYPRLGTLNDAISSRDPMLEDPTNKMKIIHGIASALLYLHSNK--------ITLTNLNSSTIWIDENCE--------------PIIGDLSYSCIDGPDFM || |.| . . . .......||... ||||.. | .|.|. | .||| . . |.|. | ... EYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN SNFEFDEKA--------------FV----YYSPECLANGT--------------KKVTNKADIFAFGMVLYHLLSGEPPSQ-LSSREEL---------YE .| . . .||.| . . .. . |.|...||.||. .|....| . . ..... . MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMM ERYYGGRPQFG------------PNFPPMFEELISMCWESEIDQRPTAQEIIDVL . | || |..|| . .|. .||... ..||..|||.. | VCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 97241.m00123.AA | LRRK | 175-268 | 26 | 3.8e-24 | 82.33 | In-house | 243-351 (351) | Show / Hide |
Range on Protein: 175-268 Range on HMM: 243-351/351 Sequence Identity: 26% (29 aa) FVYYSPECLAN-GTKKVTNKADIFAFGMVLYHLLSGE-PPSQLSS-------REELYEERYYGGRPQFGPN-FPP-----MFEELISMCWESEIDQRPTA ... .||.. . |.. | |.|...|||.|..||... .| . . .|.. .. | || . .. || |...|| ||. . ..||.. PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHF QEIIDVLSS ..|...||. SQIVKRLSQ |
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| Kinase | 97241.m00123.AA | TKL-Unique | 175-266 | 28 | 1.3e-16 | 55.2 | In-house | 190-290 (290) | Show / Hide |
Range on Protein: 175-266 Range on HMM: 190-290/290 Sequence Identity: 28% (29 aa) FVYYSPECLANGTKKVTNKADIFAFGMVLYHLLSGEP------PSQLSSREELYEERYY---GGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDV | . .|| | . .. ..|.|...||.||. ..... | | ..|...| | . || ... |. . .|| .|| .. .|||. .||| FRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHR L | L |
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| Kinase | 97241.m00123.AA | TK | 177-266 | 19 | 2.1e-13 | 40.52 | In-house | 351-486 (486) | Show / Hide |
Range on Protein: 177-266
Range on HMM: 351-486/486
Sequence Identity: 19% (26 aa)
YYSPECLANG-------TKKVTNKADIFAFGMVLYHLLS-G-EPPSQLSSR---------EELYE-----------------ERYYGGRPQFGPNFP---
...||||. . ..| | | |...|| ... ... | ||. | .|..| .|. .|. | ..
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR
--------PMFEELISMCWESEIDQRPTAQEIIDVL
.....|. .||. . ..||| ... . |
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | 97241.m00123.AA | MLK | 189-266 | 26 | 1.5e-12 | 39.99 | In-house | 212-291 (291) | Show / Hide |
Range on Protein: 189-266 Range on HMM: 212-291/291 Sequence Identity: 26% (21 aa) KVTNKADIFAFGMVLYHLLSGEPPSQ--LSSREELYEERYYGGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDVL |.. |.|.. .|.||. .|..| | . ... . ... | | || ....|. ...|...||... .||. ..|. | KYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 97241.m00123.AA | TKL-ciliate1 | 175-266 | 28 | 1.6e-12 | 39.22 | In-house | 178-279 (279) | Show / Hide |
Range on Protein: 175-266 Range on HMM: 178-279/279 Sequence Identity: 28% (29 aa) FVYYSPECLA---NGTKKVTNKADIFAFGMVLYHLLSGEPPS--QLSSREELYEERYYGGRPQFGP-----NFPPMFEELISMCWESEIDQRPTAQEIID | . || . . .. |.||.|.| |.| | . ..| ..| . ||| || |. | .|. ||. .|| ..|||. FHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQ VL .| IL |
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| Kinase | 97241.m00123.AA | TKL-ciliate2 | 191-267 | 33 | 3.9e-11 | 32.83 | In-house | 196-273 (273) | Show / Hide |
Range on Protein: 191-267 Range on HMM: 196-273/273 Sequence Identity: 33% (26 aa) TNKADIFAFGMVLYHLLSGEPPSQLSSREELYEERYYGG-RPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDVLS | |||.|.....|. . | ||| . . |. || | || | .|. ||. . . ||. .||| | TEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE |
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| Kinase | 97241.m00123.AA | HH498 | 179-266 | 24 | 4.8e-11 | 30.84 | In-house | 193-284 (284) | Show / Hide |
Range on Protein: 179-266 Range on HMM: 193-284/284 Sequence Identity: 24% (23 aa) SPECLANGTKKVTNKADIFAFGMVLYHLLSGEPP-SQLSSREELYEERYYGGRPQFGPN----FPPMFEELISMCWESEIDQRPTAQEIIDVL .|| .. | . |.|.| ..|... ....| | . . | | .|| . .| || |||. . . ||. .|. .| APEVFSQCQ-KYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL |
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| Kinase | 97241.m00123.AA | ARK | 230-265 | 36 | 6.4e-10 | 32.51 | In-house | 245-280 (280) | Show / Hide |
Range on Protein: 230-265 Range on HMM: 245-280/280 Sequence Identity: 36% (13 aa) RPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDV || .| |. .. ||. ||... | ||...||. RPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE |
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| Kinase | 97241.m00123.AA | CZAK | 235-266 | 38 | 3.1e-09 | 29.85 | In-house | 244-279 (279) | Show / Hide |
Range on Protein: 235-266 Range on HMM: 244-279/279 Sequence Identity: 38% (14 aa) PN-FPPMFE---ELISMCWESEIDQRPTAQEIIDVL | ..|| . |||.|||.. | ||. .|.. | PQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL |
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| S_TKc | 97241.m00123.AA | S_TKc | 15-272 | 18 | 4.6e-09 | -43.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-272 Range on HMM: 1-231/231 Sequence Identity: 18% (50 aa) QEKISVQSDGKYSHTKQVATGLDCFTKYYKQCDIITLKKLINDVQISTKMTHKVFGPIIGYAISPNNGLLVSREYPRL--GTLNDAISSRDP----MLED |.. . | .. ... . |. . ..... .|| | |. .... . . | . || |.| | | .| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP PTNKMKIIHGIASALLYLHSNKITLTNLNSSTIWIDENCEPIIGDLSYSCIDGPDFMSNFEFDEKAFV----YYSPECLANGTKKVTN-KADIFAFGMVL . .... |..|| |.||..| | . | .|| . |.| ... . |. | .|| | . . |.|. ..| .| E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCIL YHLLSGEPPSQLSSREELYEERYYGGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIID---VLSSSDLI | .|.|.|| . ..... .| . ..|. |.. . ..|||| |. . . . YEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 97241.m00123.AA | TKL-Unique | 51-146 | 23 | 5.8e-08 | 24.35 | In-house | 39-148 (290) | Show / Hide |
Range on Protein: 51-146 Range on HMM: 39-148/290 Sequence Identity: 23% (26 aa) LKKLINDVQISTKMT-HKVFGPIIGYAI----SPNNGLLVSREYPRLGTLNDAISS--------RDPMLEDPTNKMKIIHGIASALLYLHSNK--ITLTN .....| | .. | |. ..|| . .|.| .|. || .|.|.| .. .. . .. ...|... ||... |||... |. .. MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVM-EYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRD LNSSTIWIDEN | || . .|.| LKSSNFLVDNN |
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| TyrKc | 97241.m00123.AA | TyrKc | 12-266 | 18 | 2.4e-07 | -103.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 12-266 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) FVEQEKISVQS-----DGKYSHTKQVATGLDCFTKYYKQCDIITLKKLINDVQISTKM--THKVFGPIIGYAISPN------NGLLVSREYPRLGTLNDA . .|. |... ... | | . .. ... .| .| |. ..|..... |.. || .| |.| ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY ISSRDPMLEDPTNKMKIIHGIASALLYLHSNKITLTNLNSSTIWIDENCEPIIGDLSYSCIDGPD---------FMSNFEFDEKAFV---YYSPECLANG . .. | . . .. . ||. ||||... | . ..|| |.| | . | .. . ..|. . ..|||. LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--N TKKVTNKADIFAFGMVLYHLLS-GEPPSQL-----SSREELYEERYYGGRPQFGPN--------FPPMFEELISMCWESEIDQRPTAQEIIDVL ..| | | |...|| ... ... |..| | .|..| |.|. || |. .....||. . ..||| .||.. . YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 97241.m00123.AA | Pkinase_Tyr | 178-266 | 32 | 2.6e-07 | 25.4 | Pfam | 181-270 (270) | Show / Hide |
Range on Protein: 178-266 Range on HMM: 181-270/270 Sequence Identity: 32% (30 aa) YSPECLANGTKKVTNKADIFAFGMVLYHLLS-GEPP--SQLSSREELYEER-YYGGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDVL ..|||...| | | |. .|| ... ... || | . | ||.|| |.| .| |. .|. .||. . ..||| .||. | MAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 97241.m00123.AA | Pkinase | 177-266 | 18 | 6.2e-07 | 25.59 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 177-266 Range on HMM: 177-293/293 Sequence Identity: 18% (22 aa) YYSPECLANGTKKVTNKADIFAFGMVLYHLLSGEPPSQLS----SREELYEERYYGGRPQFGPNFP-----------------------PMFEELISMCW | .|| . | .. . |.|....| .|| .|.|.|| . . . . .. . ..|.. ..| . . ..|. |. YMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL ESEIDQRPTAQEIIDV--L . .||||..| . CKDPKKRPTAEQILQHPWF |
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| Kinase | 97241.m00123.AA | CZAK | 191-214 | 37 | 0.001714 | 8.73 | In-house | 200-223 (279) | Show / Hide |
Range on Protein: 191-214 Range on HMM: 200-223/279 Sequence Identity: 37% (9 aa) TNKADIFAFGMVLYHLLSGEPPSQ | |.|.. |||.|. .. .. | | TEKVDVYSFGMILWCIITCDQPYQ |
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| Kinase | 97241.m00123.AA | LRRK | 88-136 | 27 | 0.004763 | 6.61 | In-house | 135-192 (351) | Show / Hide |
Range on Protein: 88-136 Range on HMM: 135-192/351 Sequence Identity: 27% (16 aa) EYPRLGTLNDAIS--SRDPM----LE-DPTNKMKIIHGIASALLYLHSNK--ITLTNL ||...|.|.. .. ..|.. . ... | || ||... ||||.. | ..| EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDL |
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| Kinase | 97241.m00123.AA | Pkinase | 114-131 | 33 | 3.560533 | 1.7 | Pfam | 112-129 (293) | Show / Hide |
Range on Protein: 114-131 Range on HMM: 112-129/293 Sequence Identity: 33% (6 aa) KIIHGIASALLYLHSNKI ... |...| |.||..| FYMYQILRGLEYCHSMGI |
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