Gene 93242.m00183 (T.vaginalis)

93242.m00183

Species: T.vaginalis
Alias: TvagK0229, 93242.m00183
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
93242.m00183.AA Protein None 293 None Fasta, JSON
93242.m00183.kin_dom Protein Kinase Domain None 218 None Fasta, JSON

Protein domain

Protein domains of 93242.m00183.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 93242.m00183.AA Pkinase 3-224 26 1.7e-48 172.19 Pfam 23-293 (293) Show / Hide 
Range on Protein: 3-224
Range on HMM: 23-293/293
Sequence Identity: 26% (71 aa)

YGSNFALKKIPEEFFNQ---------SEIDCLIAIDHPKIVSLYRYYRFDGCVYMLMEYCPN-----DLNKLMK--SRRQI--ESSELYSYVSAVLEAVK
.|  .|.|.|. .  .          |||  .  ..|| || ||.... .. .|| ||||..     ||  ...  ... .  .  |. .|.  .|....
TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

ACHDRCIAHSYIKPSNFFIDKYNRI----KIGDFGLSKM--YKDKPLSSLLEGTELFMAPEIFTENQYNPMKSDIWAVGVTIYFMATHLYPFYSK-----
 ||.. | |  .||.|..||. . |    ||.||||.|   |  ..  . . ||  .||||.  ..|| . |.|.|..|...| |..   ||...     
YCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN

-DPEILFEKIQSGVYSDDCIDD---------------------KNLCKVISSCLKINPYERLTINQLLELPYF
 |.  ....| .. .. |.  .                     ......|..||. .|..|.|. |.|. |.|
HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 93242.m00183.AA CAMK 19-224 19 1.7e-47 150.66 In-house 79-425 (425) Show / Hide 
Range on Protein: 19-224
Range on HMM: 79-425/425
Sequence Identity: 19% (68 aa)

QSEIDCLIA-------IDHPKIVSLYRYYR------------FDGC--------VYMLM---EYCPND------LNKLMKS--------------RRQIE
..||...         .||| |..|| .|             .  .        .|| |   |||..       .... .               |. ..
RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFT

SSELYSYVSAVLEAVKACHDRCIAHSYIKPSNFFIDKY-----------------NRIKIGDFGLSKMYKD------------------------KPLSS
 .|   |.  ...||. ||.. |.|  .|| |  .|.                  | ||| |||.......                         .. .
EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK

LLEGTELFMA-PEIFTE-------------NQYNPMKSDIWAVGVTIYFMATHLYPFYSK-------------DPEILFEKIQSGVYS-DDCIDDK----
   ||  .|| ||..               ..| . |.|.|..||  |.| .  .|||..             ... |||||..| |. ..   ..    
TFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN

-------------------NLCKVISSCLKINPYERLTINQLLELPYF
                        |...|. .| .|.|| | |. | .
YGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
S_TKc 93242.m00183.AA S_TKc 3-224 26 4.8e-47 163.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 3-224
Range on HMM: 1-231/231
Sequence Identity: 26% (68 aa)

Y----------------------GSNFALKKIPEEFFNQSEIDCLIAIDHPKIVSLYRYYRFDGCVYMLMEYCPN---DLNKLMKSRRQ------IESSE
|                      |  .|.|.|.     ..||..|   .|| || || ...  ...|| ||||..   || ...|.|.       .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

LYSYVSAVLEAVKACHDRCIAHSYIKPSNFFIDKYNRIKIGDFGLSKMYKDKPLSSLLEGTELFMAPEIFTENQYNPMKSDIWAVGVTIYFMATHLYPFY
  .|.  ...|.. ||.. | |  .||.| ..|.  .|||.||||.. .      . . ||  .||||..   .|.. |.|.|..|...| |..   ||.
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

SKDPEILFEKIQSGVYSDDCIDDKNLCKVISSCLKINPYERLTINQLLE-------LPYF
  ... .|.||           .. ..  |. ||. .| .|.|. ..|.        |.|
--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93242.m00183.AA CAMKL 19-224 27 7.6e-38 118.25 In-house 60-297 (297) Show / Hide 
Range on Protein: 19-224
Range on HMM: 60-297/297
Sequence Identity: 27% (67 aa)

QSEIDCLIAID---HPKIVSLYRYYRFDGC------VYMLMEYCPND---LNKLMKSR----RQIESSELYSYVSAVLEAVKACHDRCIAHSYIKPSNFF
. || ..  ..   || |..||  .  . .      .|. ||||..    |    ...    . .. .|   |   ...||. ||...|.|  ||| |  
RREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL

IDKYN--RIKIGDFGLSKMYKD-----KPLSSLLEGTELFMAPEIFTE--NQYNPMKSDIWAVGVTIYFMATHLYPFYSKDPE-------ILFEKIQSGV
.|. .   ||| |||.| ||..       . .   |.  .||||||     .|.  | |||. ||. |.| .  .||   . .        |..|| .| 
LDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-

YSDD--CIDDKNLCKVISSCLKINPYERLTINQLLELPYF
| ..  .  .  .   |.. |. || .| || |... | .
YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 93242.m00183.AA Ciliate-E2-Unclassified 25-224 24 2.9e-36 123.28 In-house 75-352 (352) Show / Hide 
Range on Protein: 25-224
Range on HMM: 75-352/352
Sequence Identity: 24% (68 aa)

LIAIDHPKIVSLYRYYRFDGCVYMLMEYC------------------PNDLNKLMKSRRQIESSELY-----SYVSAVLEAVKACHDRC-IAHSYIKPSN
|. ..|| || .. . . . ..|. ||||                   ||| . ||.|....  .        |   .|.. . .|    | |  |||.|
LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPEN

FFIDKYN---RIKIGDFGLSK-----------------MYKDKPLSSLLEGTELFM----APEIFTENQYNPM---KSDIWAVGVTIYFMATHLYPFYSK
 ..|. .   .||| |||.||                 ..|.. ...   ||  .|    |||.. ...|. .   |.|||..|| .|.| .  ||||..
ILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFC-GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN

DPEI----------------LFEKIQSGVYSDDCIDD-----------KNLCK-VISSCLKINPYERLTINQLLELPYF
. |.                |...|. . .. .. .            |....  ....|| || .|.|..|.|. |.|
NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 93242.m00183.AA Ciliate-E2 28-224 21 2.3e-34 115.37 In-house 89-365 (365) Show / Hide 
Range on Protein: 28-224
Range on HMM: 89-365/365
Sequence Identity: 21% (63 aa)

IDHPKIVSLYRYYR--FDGCVYMLMEYCPN-DLNKLMKSR----------------RQIE--SSELYS--------YVSAVLEAVKACHDRC-IAHSYIK
..|| |. .| ..    | ..|. ||||   || ...|..                ..|   . .. .        |.  ...|.. .| .  | |  ||
LNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PSNFFIDKYNRIKIGDFGLSKMYKDKPLSSL--------------------------------LEGTELFMAPEIFTENQY--------NPMKSDIWAVG
|.| ..     ||| |||||| |.|.    .                                . ||  .|||||.   .|           |.|||..|
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

VTIYFMATHLYPFYSKDPEILFEKIQSGVYSDDCI------------------DDKNLCKVISS----CLKINPYERLT-INQLLELPYF
|..|.| .  .||        ...|. . .. .|                    ...    |.     .|. .| .|.| ..|.|. |.|
VILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 93242.m00183.AA NEK 19-224 30 4.2e-31 106.99 In-house 51-286 (286) Show / Hide 
Range on Protein: 19-224
Range on HMM: 51-286/286
Sequence Identity: 30% (74 aa)

Q-SEIDCLIAIDHPKIVSLYRYYRFDG--CVYMLMEYCP--NDLNKL---MKSRR----QIESSELYSYVSAVLEAVKACHDR-----CIAHSYIKPSNF
| .|.  |  ..|| ||. |  .  ..  | .  ||||    || ..    | ..     .| ..   .    . |.| .|||      | |  |||.| 
QNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNI

FIDKYNR----IKIGDFGLSKMYKDK--PLSS-LLEGTELFMAPEIFTENQYNPMKSDIWAVGVTIYFMATH--LYPFYSK--DPEILFEKIQSG-VYSD
|..| |.    .||||||.||. ...   ... .  ||  .|.||.. .  ||  |||||..|. .| |.|     ||...  . . |. ||. |  |. 
FLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQV-GTPYYMSPEVCQNKPYN-NKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPP

DCIDDK-----NLCKVISSCLKINPYERLTINQLLELPYF
  | ..      | ..||..|. .| .| ..||.||.|. 
--IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 93242.m00183.AA MARK 19-224 32 3.3e-30 96.06 In-house 47-262 (262) Show / Hide 
Range on Protein: 19-224
Range on HMM: 47-262/262
Sequence Identity: 32% (70 aa)

QSEIDCLIAIDHPKIVSLYRYYR--FDGC-VYMLMEYCPN-DLNKLMKSR--RQIESSELYSYVSAVLEAVKACHDRCIAHSYIKPSNFFIDKYN--RIK
..||. .  .||| |..|. .      .. .|. |||... .|   .|..  . .. .| . . . ...||. ||.. |.|  ||| |  ||. .   ||
MREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIK

IGDFGLSKMYKDKPLSSLLEGTELFMAPEIFTENQYNPMKSDIWAVGVTIYFMATHLYPFY--SKDPEILFEKIQSGVYSDDCIDDKNLCKVISSCLKIN
| |||.|   .   . .   ||  .||||||    |.  | |||. ||  ||| .  .||   ..| . |..||..|.|.  |   | . . |.. |..|
IIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVN

PYERLTINQLLELPYF
| || || .... | .
PEERPTIEEIMKHPWM
Kinase 93242.m00183.AA ULK 7-224 20 2e-28 96.38 In-house 31-329 (329) Show / Hide 
Range on Protein: 7-224
Range on HMM: 31-329/329
Sequence Identity: 20% (62 aa)

FALKKIP---EEFFN------------QSEIDCLIAID--------HPKIVSLYRYYRFD--GCVYMLMEYCPN-DLNKLMKSRRQ----------IESS
.| |.|.   .  .|            ..||. .  ..        || || || ... .   ..|. ||||.  || ...| ..           .. .
VACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQ

ELYSYVSAVLEAVKACHDRCIAHSYIKPSNFFIDKYN------------RIKIGDFGLSKM---Y-KDKPLSSLLE------GTELFMAPEIFT----EN
|  ..    |.. |. |.. | |  |||.|  |.. .            ..||.|||..|.     ... .           || |.|||.|.     . 
EAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQK

QYNPMKSDIWAVGVTIYFMATHLYPFYSKDPEILF-----EKIQSG------VYSDDCIDD---------KNLCKVISSCLKINPYERLTINQLLELPYF
.|.  |.||| .|. .| | .  .|||.  .. ..     . |. .      . .     .         ...   |. .|.... .| .. .|.. | |
PYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 93242.m00183.AA STE 4-224 18 1.5e-27 94.45 In-house 30-359 (359) Show / Hide 
Range on Protein: 4-224
Range on HMM: 30-359/359
Sequence Identity: 18% (62 aa)

GSN---------FALKKIP----------------------EEFFNQSEIDCLIAID--HPKIVSLYRYYRFDG-------CVYMLMEYCP-NDLNKLMK
| .         .| |...                      |.   . ||. .   .  || ||  | .|  .|        ... |||..   | ...|
GEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIK

---SRRQ-----------IESSELYSYVSAVLEA-VKACHDRCIAHSYIKPSNFFIDKYNRIKIGDFGLSKMYKD-----------------KPLSSLLE
   .. .           .. |..  .. ..|..  .  |.  | |  |||.| ..     .|. |||...   |                 .  .  . 
HKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFV

GTELFMAPEIFTE------NQYNPMKSDIWAVGVTIYFMATHLYPFYS-KDPEILFEKIQS-GVYS---------DDC--IDD-----------------
||  .||||. .       ..|.  |.||| .| ||  |||  .|.   .... .|..... ....         ...  . |                 
GTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY

-----KNLCKVISSCLKINPYERLTINQLLE--LPYF
     ....  |. ||...| .| | .|||.   | .
PHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 93242.m00183.AA ULK 7-224 21 1.7e-26 91.1 In-house 31-324 (324) Show / Hide 
Range on Protein: 7-224
Range on HMM: 31-324/324
Sequence Identity: 21% (62 aa)

FALKKIP-----EEFFN----------QSEIDCLIAID---HPK--IVSLYRYYRFD--GCVYMLMEYCPN-DLNKLMKSRRQ---------IESSELYS
.| |.|.     .   .          ..||  .  ..   ||   || || ... .    .|. ||||.  || ...| ..          .. .|  .
VACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQ

YVSAVLEAVKACHDRCIAHSYIKPSNFFIDKYN------------RIKIGDFGLSKM--Y--KDKPLSSLLE------GTELFMAPEIFT----ENQYNP
.    ... |. |.. | |  |||.|  | . .            ..||.|||..|.  .  ... .   .       || |.|||.|.     . .|. 
FFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYD

MKSDIWAVGVTIYFMATHLYPFYSKDPEILF----EKIQSG-----VYSDDCIDDK----------NLCKVISSCLKINPYERLTINQLLELPYF
 |.||| .|. .| | .  |||.|  .. ..    . |. |        .  |. .          ..   |. .|.... .| .. .... | |
YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 93242.m00183.AA MELK 19-224 26 3.5e-26 86.24 In-house 45-254 (254) Show / Hide 
Range on Protein: 19-224
Range on HMM: 45-254/254
Sequence Identity: 26% (55 aa)

QSEIDCLIAIDHPKIVSLYRYYRFDGCVYMLMEYCP-NDLNKLMKSRRQIESSELYSYVSAVLEAVKACHDRCIAHSYIKPSNFFIDKYNRIKIGDFGLS
. |.| | .. | .|  || |   .  ..|.|||||  ..   . .. ..| .|   .   .. |.   | .  ||  .|| |...| . ..|. |||| 
KTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLC

KMYKDKPLSSLLE---GTELFMAPEIFTENQYNPMKSDIWAVGVTIYFMATHLYPFYSKDPEILFEKIQSGVYSDDCIDDKNLCKVISSCLKINPYERLT
   | .     |.   |   . |||.    ||     |.|..|. .| .     ||     .|.. ||.||.|        .  ...   |...|  |. 
AKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRIS

INQLLELPYF
. .||. |. 
MKNLLNHPWV
TyrKc 93242.m00183.AA TyrKc 1-222 19 9.1e-11 -48.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-222
Range on HMM: 1-280/280
Sequence Identity: 19% (55 aa)

MQYGSNF-----------------ALKKIP----EEFFNQSEIDCLIAI--DHPKIVSLYRYYRFD-------GCVYMLMEYCPN-DLNKLMKSRRQ-IE
 . |                    | |..     |.|   .|.  .  .  .|| || || . . .       . ....|||.|. ||..  ...|  . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFM--REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

SSELYSYVSAVLEAVKACHDRCIAHSYIKPSNFFIDKYNRIKIGDFGLSKMYKDK-------PLSSLLE--GTE--L---FMAPEIFTENQYNPMKSDIW
 ..| |.   . .     |.... |  .   |  ... ...||.|||||.  .|.          .  |  |.   |    |||| . .. ... |||.|
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVW

AVGVTIYFMATHLYPFYS------KDPEILFEKIQSGVYSDDCIDD----------KNLCKVISSCLKINPYERLTINQLLELP
. ||... . |   . |.      .... ..|....| |  .. ..          . . .....| . .| .| | ... |. 
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF