Gene 87875.m00064 (T.vaginalis)

87875.m00064

Species: T.vaginalis
Alias: 87875.m00064, TvagK0300
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
87875.m00064.AA Protein None 855 None Fasta, JSON
87875.m00064.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 87875.m00064.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87875.m00064.AA TKL 31-277 23 6.2e-74 251.93 In-house 1-364 (364) Show / Hide 
Range on Protein: 31-277
Range on HMM: 1-364/364
Sequence Identity: 23% (89 aa)

IGKGGFGEVNRAIQKS--------TGRDVAIKQIFAERLEGNRL-------------------------RRYIGEIKTMAKCDNMFLVPFVGFTAEPP--
||.|||||| ... .         ||.|||.|..  .    . .                          . . ||. | ...   .|.|.|.  .||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YAIVSEYMPNSA-LDNYIRHRNNDMLSGTQLTAIAIGIAHGMIHIHS--------KNIIHRDLKAANILLDSKLF-------------
            ..|| ||.|.   |....           |.  .|..|| || . ||        ..||||||| .|||.|...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PRIADFGIAR-FEDSTDAGMTA------------------KIGTPNYMAPELITSK----------------DYTNKVDVYAYAMILYEMSENQRPFKG
 . |.|||..| .. |..  .|.                  ..|||..||||..  .                .|. |.|||.....|.|.   .||...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LKVN---------DIFQQVVQRDERPNFT------------RMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEF
.. .         ..| .|... .||                 .| .. ||...||| ||| ||||.|| ...
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 87875.m00064.AA TKL-Unique 27-277 28 1.3e-67 230.9 In-house 1-290 (290) Show / Hide 
Range on Protein: 27-277
Range on HMM: 1-290/290
Sequence Identity: 28% (82 aa)

FGDVIGKGGFGEVNRAIQKSTGRDVAIKQIFAERLEGNRLRR-YIGEIKTMAKCD-NMFLVPFVGFTA----EPP-YAIVSEYMPNSALDNYIRH-----
|. .|| ||.|.| ... ...  .|||||.. . .  |....  . |...| | .   ..| ..|...     || . ||.||.| . |....       
FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---RNNDMLSGTQLTAIAIGIAHGMIHIHSKN--IIHRDLKAANILLDSK-----LFPRIADFGIARFEDSTDAGMTA---------KIGTPNYMAPELI
   .||  |.  |   .|| || ||...|...  |||||||  |.|.|..     .  .|.|||...| .. ... .          ..|....||||..
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

TS--KDYTNKVDVYAYAMILYEMSENQR------PFKGLKVNDIFQQVVQ--RDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEF
..  ..|..|.|||.....|.|. ....      |..|.  . ... | .  .  ||      |  ...||..||..||. ||||.|| .. 
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Pkinase 87875.m00064.AA Pkinase 25-277 26 1.3e-58 205.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

FDFGDVIGKGGFGEVNRAIQKSTGRDVAIKQIFAERLEGNRLRRYIG--EIKTMAKCDNMFLVPFVGFTA-EPPYAIVSEYMPNS----ALDNYIR-HRN
. .| .||.|.||.| ... |.||. ||.|.|  .. . . ... .   ||. |....  . | . ..   .. . .| ||...      |  ||. .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NDM-LSGTQLTAIAIGIAHGMIHIHSKNIIHRDLKAANILLDSKLFP----RIADFGIARFE-DSTDAGMTAKIGTPNYMAPELIT-SKDYTNKVDVYAY
. . .|  ..  ..  |. |. ..||..||||||| .|||.|..  .    .|.|||.|..     .  ||   |||.|||||.|  ...|. |||....
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

AMILYEMSENQRPFKGL------KVNDIFQQVVQRDERPNFTRMTP-------------------APLQKLIKRCWDRDPEMRPSFEEIFEE--F
  |||||   . ||.|         . ..... ... . ..    .                    .....||.|...||. ||..|.|..   |
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 87875.m00064.AA S_TKc 25-284 28 1.1e-57 198.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-284
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

FDFGDVIGKGGFGEVNRAIQKSTGRDVAIKQIFAERLEGNRLRRYIGEIKTMAKCDNMFLVPFVGFTAEPPYAIVSEYMPN--SALDNYIRHRNN----D
......||||.||.| ... |.||| ||||.|          .. . ||. . | .  ..| . ..  .  . .| ||...    |  ||..|.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

MLSGTQLTAIAIGIAHGMIHIHSKNIIHRDLKAANILLDSKLFPRIADFGIARFEDSTDAGMTAKIGTPNYMAPELITSKDYTN-KVDVYAYAMILYEMS
 ..  .   ..  |. .. ..||..||||||| .|||||.     |.|||.||.        |  .|||.|||||..    |.  |.|...   ||||| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

ENQRPFKGLKVNDIFQQVVQRDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEFRSG--RVYF
  . ||    .. .|....            . ..  .|..|...||| ||.  |.... .      .|
CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 87875.m00064.AA MLK 25-277 27 3e-57 196.49 In-house 1-291 (291) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-291/291
Sequence Identity: 27% (79 aa)

FDFGDVIGKGGFGEVNRAIQKSTG---RDVAIKQIFA-------ERLEGNRLRRYIGEIKTMAKCD-NMFLVPFVGFTAEP-P-YAIVSEYMPNSALDNY
..|  .||.|.||.| ..  . .    . ||.|...|       .  |   ... . . . . .   .   ..|.|  ..| . ..||.||.... | |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRH-RNNDM-----------LSGTQLTAIAIGIAHGMIHIHSKN---IIHRDLKAANILLDS------KLFPRIADFGIARFEDSTDAGMTAKIGTPNYM
..  |.. |            .  ..  .|  .|.||   ||.    |||||||  |||.|       ..  .|.|||..|.  .... |. ..||. .|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APELI---TSKDYTNKVDVYAYAMILYEMSENQRPFK-GLKVNDIFQQVVQRDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEF
||| |    .  |. |.||. ....|.||   . |.| ...   |. .|..  .||      |... ||.|.||. ||. |||| .| ...
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 87875.m00064.AA Dicty5 98-281 38 4.8e-52 177.41 In-house 76-260 (260) Show / Hide 
Range on Protein: 98-281
Range on HMM: 76-260/260
Sequence Identity: 38% (72 aa)

IVSEYMPNSALDNYIRHRNN----DMLSGTQLTAIAIGIAHGMIHIHSKNIIHRDLKAANILLDSKLFPRIADFGIARFEDSTDAGMTAKIGTPNYMAPE
.|.||  |  | || . . .     .. ..||  .||.|| .| |.||.||||||||  |.|.   .   | |||. || |    .||  .||...||.|
HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQL-HMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACE

LITSKDYTNKVDVYAYAMILYEMSENQRPFKGLKVNDIFQQV-VQRDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEFRSGR
| ... |..|.|||... .|.||     |.. .  | . . | |.  |||      |    .||| ||   |  |||| || . |.|  
LFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNI--NNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 87875.m00064.AA TyrKc 25-277 28 2.6e-49 171.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

FDFGDVIGKGGFGEVNRAIQKSTGRDVAIKQIFAERLEGNRLRRYIGEIKTMAKC--DNMFLVPFVGFTAE--------PPYAIVSEYMPNSALDNYI-R
  .|...| | |||| ... |   ..||.| . ..      ..  . |.. | |   ..  .| ..|   .        .|. || ||||. .|..|. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HRNNDMLSGTQLTAIAIGIAHGMIHIHSKNIIHRDLKAANILLDSKLFPRIADFGIARFEDST-------DAGMTAK-IGTP-----NYMAPELITSKDY
||..  |.  .|  ... || || ..||||.||||| | |.|.....  .|.||| .|. ..        |  ....  |.        |||| |  . .
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TNKVDVYAYAMILYEMSEN-QRPFKG-----LKVNDIFQQVVQRDERPNFTR---M----TPAPLQKLIKRCWDRDPEMRPSFEEIFEEF
| | ||...   ..|.  . | |  |     ..  .....| |.. .|       |     |. . ...|.||..|||.||.|.|| |.|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 87875.m00064.AA Dicty4 98-279 32 6e-49 161.46 In-house 79-277 (277) Show / Hide 
Range on Protein: 98-279
Range on HMM: 79-277/277
Sequence Identity: 32% (64 aa)

IVSEYMPNSALDNYIRH-----RNNDMLSGTQLTA---IAIGIAHGMIHIHSKN--IIHRDLKAANILLDSKLFPRIADFGIAR----FEDSTDAGMTAK
||.||||   | . ..        .. |. .  ..   .|. .| ||.. |. |  |||||||..|.| |  .   ..|||...     || .| .... 
IVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKD-NQMTA

IGTPNYMAPELITSKDYTNKVDVYAYAMILYEMSENQRPFK--GLKVNDIFQQVVQRDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEE--FRS
.||| .||||   .. |. |.||| ....|.|.   | |.   .     ..  |..  .||     .|... .||..||| ||. ||||||| ..    .
CGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 87875.m00064.AA Pkinase_Tyr 25-277 29 3.4e-48 163.87 Pfam 1-270 (270) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-270/270
Sequence Identity: 29% (80 aa)

FDFGDVIGKGGFGEVNRAIQK----STGRDVAIKQIFAERLEGNR--LRRYIGEIKTMAKC-DNMFLVPFVGFTA--EPP--YAIVSEYMPNSALDNYIR
  || ..|.| |||| ... |    .|. .||.| .  |        ..  . |.|.| .  ..  .| ..|     . |  . || ||||.  |..| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HR--NNDMLSGTQLTAIAIGIAHGMIHIHSKNIIHRDLKAANILLDSKLFPRIADFGIARFEDSTDAG---MTAKIGTPNYMAPELITSKDYTNKVDVYA
 .  ... |.  .|  ... || || . .|||.||||| | |.|...... .|.||| ||   ..|      .        |||| |  . .| | ||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YAMILYEMSE-NQRP-FKGLKVNDIFQQVVQRDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEF
.   ..|.    . | ..|.. ....... .. .|    . .|... .|.|.||. |||.||.|.|| |..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 87875.m00064.AA TK 25-277 16 5.7e-47 155.05 In-house 1-486 (486) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)

FDFGDVIGKGGFG---EVNRAIQKSTG-------------------------RDVAIKQIFAERLEGNRLRRY---------------IGEIKTMA--KC
  .|...|.| ||   || ... .. .                          .||.|.. ..  .  . ..                  |.| |   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNMFLVPFVG-FTAE------------PPYAIVSEYMPNSA----LDNYIRHR-----------------------------------------------
.   .| ..|  | .            .|. || ||||.      |..| | .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------NNDMLSGTQLTAIAIGIAHGMIHIHSK------NIIHRDLKAANILLDSKLF-----------PRIADFGIA-
                           ... |.  ||  ..  || || ..|||      |..|||| | |.|.....             .||||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RFEDSTDAGMTAKIGTPNY--------------------------MAPELITSKD---------YTNKVDVYAYAMILYEMSE-NQRPFKGLK
       |  .| |   ... .. .                           |||| ....          .| | ||...   ..|.    | |. |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VN---------DIFQQVVQRDER---------------PNFTRMTP-------------APLQKLIKRCWDRDPEMRPSFEEIFEEF
 |         . . . ..|  |               |    ...             . .. |...||..||| ||.|... |..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 87875.m00064.AA Dicty4-Unclassified 25-277 31 1.7e-46 157.21 In-house 1-263 (263) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-263/263
Sequence Identity: 31% (84 aa)

FDFGDVIGKGGFGEVNRAIQKSTGRDVAIKQIFAERLEGNR---LRRYIGEIKTMAKCDNMFLVPFVGFTAEP-----PYAIVSEYMPNSALDNYIR---
      |||| | .| . . |  |.|||.| .| |     |   .  .  |.  .       ||   |    |      . || | |.   |   |    
IQIDQFIGKGHFSKVHKGNWK--GKDVAVK-KFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKP

HRNNDMLSGTQ--LTAIAIGIAHGMIHIHSKNIIHRDLKAANILLDSKLFPRIADFGIARFEDSTDAGMTAKIGTPNYMAPELITSKDYTNKVDVYAYAM
   .  ..       ..|. || || | |..|.||||.|..|||.|     .||||||.|  | .   ||.  |||   .||      |. | ||| |||
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN-MTTIAGTPKWESPECLMHESYNQKSDVYSYAM

ILYEMSENQRPFKGLK-VNDIFQQVVQRDERPNFTRMTPAPLQKLIKRCWDRDPEMRPSFEEIFEEF
.|||.     |. .   . ..   |  .  ||      .  ..|||| ||  ||  ||....| .  
MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 87875.m00064.AA LRRK 95-279 31 3.5e-46 159.76 In-house 129-351 (351) Show / Hide 
Range on Protein: 95-279
Range on HMM: 129-351/351
Sequence Identity: 31% (70 aa)

PYAIVSEYMPNSALDNYIRHRNNDML-----S---GTQLTAIAIGIAHGMIHIHSKN--IIHRDLKAANILL-DSK-----------LFPRIADFGIAR-
|...| ||.|. .|. ..... .| .     .   ...|  ||. || || . ||.|  |||||||  ||||  |.               |||||| | 
PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLK-IALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRM

FEDSTDAG-MTAKIGTPNYMAPELIT---SKDYTNKVDVYAYAMILYE-MSENQRPFKGLK-V-----NDIFQQVVQRDERPNFTRM-TPA-----PLQK
|  ..  |    . |.| .|||| .     . || |||.|...|||.| ..   .|| ... .     . .... ...  || .     |       .|.
F-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQD

LIKRCWDRDPEMRPSFEEIFEEFRS
||. ||. ||. ||.|..|..   .
LIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 87875.m00064.AA STE 25-278 21 8.9e-45 155.07 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

FDFGDVIGKGGFGEVNRAIQKS---------------TGRDVAIKQIFAERLE---------------GNRLRRYIGEIKTMAKCD--NMFLVPFVGFTA
... ..||||.||.| .|. .                ||. .||||.  |. .                . . ... |||.| ||.    . | . |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

--------EPPYAIVSEYMPNSALDNYIRHRNNDMLS------------GTQLTAIAIGIAHG-MIHIHSKNIIHRDLKAANILLDSKLFPRIADFGIAR
        .    |. |||..  ||  |.|.     .             .|. .|.  | .| . ..||..|||||.|.|||||       ..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-FEDS--------------TDAGMT-AKIGTPNYMAPELITS------KDYTNKVDVYAYAMILYEMSENQRPF---KGLKV--NDIFQQVVQR------
 ..||              | ....   .||| .|||| |.       |.|. |.|..     . || . . |.   . ...  . .| ...|.      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---DERPNFTRMTP-------------------APLQKLIKRCWDRDPEMRPSFEEIFE---EFR
   .. | .   .                     ...  |..| ..||. ||. ..  .   .| 
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 87875.m00064.AA RIPK 132-277 32 1.9e-37 125.13 In-house 116-290 (290) Show / Hide 
Range on Protein: 132-277
Range on HMM: 116-290/290
Sequence Identity: 32% (57 aa)

IAHGMIHIHSKN--IIHRDLKAANILLDSKLFPRIADFGIARF-EDS--TD--------AGMTAKI--GTPNYMAPELIT--SKDY----TNKVDVYAYA
|. ||   ||.|  ||||||| .|||.|. .   ||||| | . . |  ..         .|. |   ||  ||.||..    |.     | | ||| .|
ISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFA

MILYEMSENQRPFKGLKVNDIFQQVVQRDERPNFT---RMTPAP-----LQKLIKRCWDRDPEMRPSFEEIFEEF
....|   .  |. . |   ..  ..... ||. .   . .| |     . .|..|||. ||. ||.| |. |..
IVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase 87875.m00064.AA RIPK 31-105 31 4.9e-10 30.37 In-house 1-86 (290) Show / Hide 
Range on Protein: 31-105
Range on HMM: 1-86/290
Sequence Identity: 31% (27 aa)

IGKGGFGEVNRAIQKSTGRDVAIKQ----IFAERLEGNRLRRYIGEIKTMAKCDNMFLVPFVGFTAEP------P-YAIVSEYMPN
.|.|||||| .|  .. | .||.|       .. ..       . | | |.| .. . ||  ||. ..        |.|| |||.|
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMEN
Kinase 87875.m00064.AA Dicty4 25-54 40 0.000288 10.33 In-house 1-28 (277) Show / Hide 
Range on Protein: 25-54
Range on HMM: 1-28/277
Sequence Identity: 40% (12 aa)

FDFGDVIGKGGFGEVNRAIQKSTGRDVAIK
 .... ||||.|||| ... .  | .||.|
INIEQRIGKGSFGEVYKGTWR--GKEVAVK
Kinase 87875.m00064.AA LRRK 25-56 22 0.000424 10.38 In-house 1-59 (351) Show / Hide 
Range on Protein: 25-56
Range on HMM: 1-59/351
Sequence Identity: 22% (13 aa)

FDFGDVIGKGGFG-EVNRAIQKS--------------------------TGRDVAIKQI
. ..  ||.|||| .| ||. ..                           . .||||..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase 87875.m00064.AA Dicty5 27-54 50 0.008291 5.49 In-house 3-28 (260) Show / Hide 
Range on Protein: 27-54
Range on HMM: 3-28/260
Sequence Identity: 50% (14 aa)

FGDVIGKGGFGEVNRAIQKSTGRDVAIK
|.|.|  |  | |   | |  |.|||||
FHDWIASGASGRVYNGIYK--GMDVAIK