Gene 93494.m00049 (T.vaginalis)

93494.m00049

Species: T.vaginalis
Alias: 93494.m00049, TvagK0606
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
93494.m00049.AA Protein None 207 None Fasta, JSON
93494.m00049.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of 93494.m00049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93494.m00049.AA RCK 4-205 48 3.5e-108 344.39 In-house 1-219 (298) Show / Hide 
Range on Protein: 4-205
Range on HMM: 1-219/298
Sequence Identity: 48% (106 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKIK-HDNVVRLMQVFRENE--YLYLVFECLGESLLKTLQN---RTGPF
   || .||| .| |.| .. .||.|||||||||||.. ||| .|.|.|||||.. |.|.. |  |.|.|.   ||.|||.. . | . ...   |. ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

TDAE--VRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAE---------NGKLKIADFGLAREIKSKPPYTEYVGTRWYRAPEIIIHHPFYNSSVDIWSV
.  .  ..  |  .| |||  | .||||||.|| |..  .         .. .|||||||.||| ||||||.||.||||||||.. .  .||| .|||.|
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIAAELYMLKPLFQGTSE
|||..|||||.||| |.||
GCIMYELYMLRPLFPGSSE
Kinase 93494.m00049.AA MAK 4-207 41 1.6e-100 320.74 In-house 1-255 (352) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-255/352
Sequence Identity: 41% (107 aa)

FEEIKVIGDGGFGIVTKCRD------------------------------NDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKIK-HDNVVRLMQVFR--
.  || .||| .| |.. ..                              .||| .||||.||.|| ..|||..| |||||.|.. |.|.|.|  |.|  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENEYLYLVFECLGESLLKTLQNRTG-PFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAEN-----------------GKLKIADFGLAREIKS
||. ||.|||.. | |   .  |.   |   ..| .|  .| ||| .|  |||||| || |..                       .|||||||||||.|
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KPPYTEYVGTRWYRAPEIIIHHPFYNSSVDIWSVGCIAAELYMLKPLFQGTSEND
||||| || ||||||||.  .   |.| .|.| ||||.||||...||| |.|| |
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEID
Kinase 93494.m00049.AA CMGC 4-207 26 2.1e-87 287.17 In-house 1-361 (513) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-361/513
Sequence Identity: 26% (98 aa)

FEEIKVIGDGGFGIVTKCRD--------------NDTGQIVAIKKMKQKFATFEECL-----------QLKEVKSLRKIK-----------------HDN
.| ||.|| | .|.| ||||              ..|..||||||.|..|   |...            | |.| |....                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVRLMQVFRENE-----------------YLYLVFECLGESLLKTLQNRTG--------PFTDAE------------VRYVM------HEVLSGLA--IV
.|.|  .|. ..                 .||||||... .|.. ..|  .        |... .            ..| |      . .| ||.    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HGQG--FFHRDVKPDNLLWAEN--------------------GKLKIADFGLAR--EIKSKP--------------------PYTEYVGTRWYRAPEIII
| ..  ..||| || |.|  .|                    |.|||.||||||  .. |..                    |||.|| |||||||||..
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

HHPFYN---------SSVDIWSVGCIAAELYM--------LKPLFQGTSE-----------ND
  . |.         ...|.|||||| ||.|.        .||||.| ||            |
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHID
Kinase 93494.m00049.AA Pkinase 4-207 32 5.2e-70 243.69 Pfam 1-222 (293) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-222/293
Sequence Identity: 32% (74 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLK---EVKSLRKIKHDNVVRLMQVFRENEYLYLVFECLGE-----SLLKTLQ-NRT
.. ...|| |.|| | ||.. .||.|||.|..| . .  ... ..    |.. .....|.|.|||  .|... ..|.|.|...      .|   ..  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPF--TDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKL----KIADFGLARE--IKSKPPYTEYVGTRWYRAPEIIIHHPFYNSSVDIWSV
|.|  .. |.. .| ..|.||.  | .|. |||.||.|.|  .|| .    ||.|||||.   . ... .| ..||.||.|||.| ... | ..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIAAELYMLKPLFQGT----SEND
||| .|..  .|.|.|     . .|
GCILYEMLCGRPPFPGHCWHDN-HD
Kinase 93494.m00049.AA CDC2 4-205 38 6.9e-69 210.68 In-house 1-214 (301) Show / Hide 
Range on Protein: 4-205
Range on HMM: 1-214/301
Sequence Identity: 38% (84 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEEC-----LQLKEVKSLRKIK-HDNVVRLMQVFRENEYLYLVFECLGESLLKTLQNRTG--
.. |. || | .|.|.||.|..|.||||.|| . .  ...|        ..|   | ..| |.|.|.|  |. .   ||.|||.|   | | . .  .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLE--QEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKN

-PFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAREIKS-KPPYT--EYVGTRWYRAPEIIIHHPFYNSSVDIWSVGCIAA
 ... . |.  |.  |.|..  | .. .||| ||.|.|  ..|..||||||||| .   . .||    | |.|||||||     .|. .||.||.||| |
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

ELYML---KPLFQGTSE
|..|    ||||.| ||
EMFMDVTKKPLFHGDSE
Kinase 93494.m00049.AA CDK 4-207 34 3.8e-65 207.3 In-house 1-232 (284) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-232/284
Sequence Identity: 34% (84 aa)

FEEIKVIGDGGFGIVTKCRDNDTG-----QIVAIKKMKQKF---ATFEECLQ---LKEVKSLRKIKHDNVVRLMQVFREN-----------EYLYLVFEC
.| .. || | .|.| |.|| .||     ||||.|| .         .| .    . |.. |... |.|.|.|. |.  .             ||.||| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LGESLLKTLQNRTGPFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGK-----LKIADFGLAREIKS-------KPPYTEYVGTRWYRAPE
.   | | .           ..  |.  |.||.  | ... ||| || |.|  .||.     ||||||||||.  .         .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

IIIHHPFYN--SSVDIWSVGCIAAELYM---LKPLFQGTSEND
.      |.   ..|.|||||| ||...    ||||.|.|| |
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEID
Kinase 93494.m00049.AA CDKL 4-205 40 5.5e-61 207.24 In-house 1-205 (286) Show / Hide 
Range on Protein: 4-205
Range on HMM: 1-205/286
Sequence Identity: 40% (83 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQ-KFATFEECLQLKEVKSLRKIKHDNVVRLMQVFRENEYLYLVFECLGESLLKTLQNRTGPFTDAEV
.| . ..| |  | | |||. .||||||||| |  .    .    . |.| |.  || | | |  ||| .  |.||||    ..| .|. .     .  |
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWA-ENGKLKIADFGLAREIKSKPP--YTEYVGTRWYRAPEIIIHHPFYNSSVDIWSVGCIAAELYMLKPL
| .|  .|....  | .   |||.|| |.|    || .|. |||.|| . .||   ||.|| ||||||||  .  . | ..||||..||. ||. .  ||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FQGTSE
. | |.
WPGQSD
Kinase 93494.m00049.AA MAPK 4-207 34 1.5e-56 194.04 In-house 1-242 (328) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-242/328
Sequence Identity: 34% (85 aa)

FEEIKVIGDGGFGIVTKCRDND------TGQIVAIKKMKQKFATFEECLQ-LKEVKSLRKI-KHDNVVRLMQVFRE------NEY-----LYLVFECLGE
.. .| || | .|.| ...|.       .|..|||||. . | .   |   . |.| || . .|.|...|  .|.       |.      .|.|.|  . 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

SLLKTLQNRTGPFTDAEVRYVMHEVLSG--LAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAREIKSKPPY---------------TEYVGTRWYRA
 | . .. .  | .|  ..| |  .| |  |   |  .  ||| || |.|  ||. |||.|||||| | ..  .               |||| ||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEIIIH--HPFYNSSVDIWSVGCIAAELYM-LKPLFQGTSEND
|||.       |. .||.|||||| ||..   ||||.|..  |
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYID
Kinase 93494.m00049.AA S_TKc 4-206 29 2.5e-56 194.39 SMART 1-220 (231) Show / Hide 
Range on Protein: 4-206
Range on HMM: 1-220/231
Sequence Identity: 29% (73 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKIKHDNVVRLMQVFRENEYLYLVFECLGE---SLLKTLQNRTGP----
.| ...|| |.|| | |||...||.|||||..|        .  ..|.. |.| .|.|.|.|  ||.. ..||.|.|...    .|.. ...| ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAREIKSKPPYTEYVGTRWYRAPEIIIHHPFYNS-SVDIWSVGCIAAELY
 |.  ..|..|......|.  | .|. |||.||.|.|  |   .||.||||||..      | ..||.||.|||..     |.  ..|.||.||| .|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

MLKPLFQGTSE--------------------------------N
  .|.|. . .                                .
CGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase 93494.m00049.AA CDK5 4-207 37 2.2e-55 173.25 In-house 1-207 (287) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-207/287
Sequence Identity: 37% (79 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEE-----CLQLKEVKSLRKIKHDNVVRLMQVFRENEYLYLVFECLGESLLKTLQNRTGPFT
.| .  ||.| .|.| | |. .|. |||.|. .      .|     .  . |.  |. .|| |.|||  |   .  | |||| . . | | . ...|   
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLD----SEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMD

DAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLARE--IKSKPPYTEYVGTRWYRAPEIIIHHPFYNSSVDIWSVGCIAAELY-M
 . ... |   | |||. | .   ||| || |||   ||.|| |||||||   |  .  |.  | | |||.| . .    |. |.|.||.||| ||.   
MHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVR-CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

LKPLFQGTSEND
..||| |....|
GRPLFPGNDVED
Kinase 93494.m00049.AA p38 4-207 35 5.5e-52 175.87 In-house 1-211 (289) Show / Hide 
Range on Protein: 4-207
Range on HMM: 1-211/289
Sequence Identity: 35% (77 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQI---VAIKKMKQKFATFEECLQL-KEVKSLRKIKHDNVVRLMQVFRE-NEYL------YLVFECLGESLLKTLQN
..... .| | .| | | .| .|||    |||||.   | . .       |.. |. ..|.||. |. ||   .. .      |.| .  | .| . .  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

RTGPFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAREIKSKPPYTEYVGTRWYRAPEIIIHHPFYNSSVDIWSVGCIAAE
 .  ..| ....    .| ||  .|  |  ||| || |.   |.  |.| ||||||.  ..   |.||.|||||||||.     |.  |||||||||.||
QR--LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE--MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LYMLKPLFQGTSEND
|   ..|| |.  .|
LITGRTLFPGDDHID
Kinase 93494.m00049.AA ERK 4-204 37 8.8e-52 178.34 In-house 1-221 (307) Show / Hide 
Range on Protein: 4-204
Range on HMM: 1-221/307
Sequence Identity: 37% (84 aa)

FEEIKVIGDGGFGIVTKCRDND-----TGQIVAIKKMKQKFATFEECLQ-LKEVKSLRKIK-HDNVVRLMQVFREN-----EYLYLVFECLGESLLKTLQ
.. || ||.|..|.| ...|.      |||.||||| .. | .  .| . | | | ||  | |.|.. |  ....|     . .|.|.|     | .. .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

NRTGPFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAR----EIKS-----KPPYTEYVGTRWYRAPEIIIHHPFYNSSVD
..  . .|. . | |   |.||  .| .. .||| || |.|  .|. |||.||||||    .. .     .. .|||| |||||||||.   . |....|
SQQ-ELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIAAELYMLKPLFQGTS
|||.||| ||... ||||.| .
IWSCGCIFAEMLGRKPLFPGKD
Kinase 93494.m00049.AA Pkinase_Tyr 4-185 28 1.8e-14 49.64 Pfam 1-199 (270) Show / Hide 
Range on Protein: 4-185
Range on HMM: 1-199/270
Sequence Identity: 28% (58 aa)

FEEIKVIGDGGFGIVTKCRDN----DTGQIVAIKKMKQKFATFEE---CLQLKEVKSLRKI-KHDNVVRLMQVFR-ENEY--LYLVFE--CLGESLLKTL
 . .|..| | || | |.. .    .|.. ||.|..|.  |. |.      ..|.| .... .|.|.|||. |   . |   .|.|.|  ..| .||. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDYL

QNR---TGPFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAREIKSKPPYTEYVGT------RWYRAPEIIIHHPFYNSSV
...    .|.|  .     ... .|..  . ... |||.   | | .||.. ||.|||||| | ..  |  ....      .|. ||| | .   ...  
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKS

DIWS
|.||
DVWS
Kinase 93494.m00049.AA TyrKc 4-200 18 6.7e-11 -46.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-200
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKI--KHDNVVRLMQVFREN-------EYLYLVFE-CLGESLLKTLQNR
 . .|..| | ||.| |.. .   . ||.|..|       .   ..| . ..|.  .|.|.|||  | ..        | |..|.| . . .|.. |...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

TGPFTDAEVRYVMHEVLSGLAIVHGQGFFHRDVKPDNLLWAENGKLKIADFGLAREIKSK-------PPYT------EY--VGTRWYRAPEIIIHH----
 . .. ..  . .. . .| .  | ... |||    | | .||.  ||.||||.|.|...         |.      .   .  ||. ||| | ..    
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFTT

--------------------PFYN------SSVDIWSV------------GC------IAAELYM------------------LKPLF
                    | ..      |  ..               ..        .|.|.                  .. .|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF