Gene 134846.m00005 (T.vaginalis)

134846.m00005

Species: T.vaginalis
Alias: TvagK0575, 134846.m00005
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
134846.m00005.AA Protein None 400 None Fasta, JSON
134846.m00005.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of 134846.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 134846.m00005.AA RCK 4-284 50 2.8e-166 531.85 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 50% (151 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMKAKYNSFEECLQEKEVKSLRKIK-HENVEKLLQVFREND--HLYLVFELLDESLLKTMSK---RTQPF
   || ||||..|.|.| .|... ..||||||| |..| ||| . .|.|||||.. |.|. ||. |.|.||  .||.|||..|. | . |     |....
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

SNEK--VRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQ---------DGVLKIADFGLAREIRSRPPYTEYISTRWYRAPEIILRHPFYNSPVDIWAA
. ..  .. || ||. ||. .||.||||||.|| |.. .          ....|||||||.|||||.||||.|.|||||||||..||  .||||.|||| 
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GAIMAELYMLKPIFPGSSETDQMYKICSVLGNPTMETWPDGVKLAAKTGFKMGNGYHTSLQQLMPNASPEAIDLMIQLLQFDPSKRPSASQALTHPFF
|.||.|||||.| |||||| || .|||.|.| |. ..||||.||| ...|. ..   ..|.|| ||.|...|.||  .|| ||.||..|.||| ||.|
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 134846.m00005.AA MAK 4-284 42 4.7e-147 471.44 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 42% (150 aa)

FEEIKVLGDGAFGVVTKCRN------------------------------LDNDQFVAIKKMKAKYNSFEECLQEKEVKSLRKIK-HENVEKLLQVFR--
.  || ||||..| |.. .                                |.   ||||.|| |. |.|||..  |||||.|.. | |. ||. |.|  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENDHLYLVFELLDESLLKTMSKRTQ-PFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQD-----------------GVLKIADFGLAREIRS
||||||.||| . | |   |  |.   |.   .| || ||  ||  .|| ||||||||| |.. .                    ..|||||||||||||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

RPPYTEYISTRWYRAPEIILRHPFYNSPVDIWAAGAIMAELYMLKPIFPGSSETDQMYKICSVLGNPTMET----------------WPDGVKLAAKTGF
.|||| |.|||||||||. ||   |.||.|.|| |.||||||...|.|||||| ||..|||.||| |. ..                |||| .|| . .|
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

KMGNGYH---TSLQQLMPNASP-EAIDLMIQLLQFDPSKRPSASQALTHPFF
.  .      ..|..|.||.|. .||.||  .||.|| ||| |.|.. .|.|
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 134846.m00005.AA CMGC 4-284 24 1.8e-117 387.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

FEEIKVLGDGAFGVVTKCRN--------------LDNDQFVAIKKMKAKYNSFEECL-----------QEKEVKSLRKIK-----------------HEN
.| ||..| |..||| |||.               .....|||||.| .    |...              |.| |....                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VEKLLQVFREND-----------------HLYLVFELLDESLLKTMSK--------RTQPFSNEK------------VRYIM------GQIFPGLN--II
. ||. .|. ..                 |||||||..| .|.. . .        | .|.|  .            ..|.|       ||. ||.   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKQG--FFHRDMKPDNLLWSQD--------------------GVLKIADFGLAR--EIRSRP--------------------PYTEYISTRWYRAPEIIL
|...  ..|||.|| |.| ...                    |.|||.||||||  ...|..                    |||.|..|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

RHPFYN---------SPVDIWAAGAIMAELYM--------LKPIFPGSSE-----------TDQMYKICSVLGNPT---------------ME-------
. . |.         .|.|.|..| |.||.|.        .||.|||.||            ||..||. |||.||                |       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------TWPDGVKLAAKTGFKMGNGYHTSLQQLMPN-----------------------------------ASPEAIDLMIQLLQFDP
                  .|....... . ... .. .  ....|.|.                                   ..|.||||. ..||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SKRPSASQALTHPFF
.||..|.||| ||.|
DKRITAEQALQHPYF
Kinase 134846.m00005.AA CDK 4-284 32 1.4e-97 312.82 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 32% (104 aa)

FEEIKVLGDGAFGVVTKCRNLDND-----QFVAIKKMKAKY---NSFEECLQE---KEVKSLRKIKHENVEKLLQVFREN-----------DHLYLVFEL
.| .. .| |..||| |.|.....     |.||.|| .      .  .| .      |.. |... |.|. ||. |.  .             ||.||| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDESLLKTMSKRTQPFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGV-----LKIADFGLAREIRS-------RPPYTEYISTRWYRAPE
.|  | | |.          .. .| |.  ||. .|.... |||.|| |.| . .|.     ||||||||||.  .       . .||  . |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

IILRHPFYN--SPVDIWAAGAIMAELYM---LKPIFPGSSETDQMYKICSVLGNPTMETWPDGVKLAAKTGFKMGNGYHTSLQQLMPNASPEAIDLMIQL
. |    |.   |.|.|..| |.||...    ||.|||.||.||. ||. ..| || ..||. .||                            ||. ..
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LQFDPSKRPSASQALTHPFF
|..||.|| ||.||| ||.|
LCYDPKKRISAEQALQHPYF
Kinase 134846.m00005.AA CDK7 4-284 35 1.9e-95 254.63 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 35% (103 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMK--AKYNSFEECLQE---KEVKSLRKIKHENVEKLLQVFRENDHLYLVFELLDESLLKTMSKRTQPFS
.| || .| | |..| | . .  .| ||||| |     . ..  .      |.| |. ..|.||  |. .|   . ..|||...|  |          . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

NEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAREIRS-RPPYTEYISTRWYRAPEIILRHPFYNSPVDIWAAGAIMAELYMLK
   .  .| ..  ||   |.    |||.|| ||| ...|.|||||||||| . |    ||  . ||||||||       | . ||.|. | |.|||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PIFPGSSETDQMYKICSVLGNPTMETWPDGVKLAAKTGFKMGNGY-HTSLQQLMPNASPEAIDLMIQLLQFDPSKRPSASQALTHPFF
|..|| |. ||. .|.. || || |.||.  ...    ||   ||  | |...   || ...|||  .. ..|.|| ...|.| .|.|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 134846.m00005.AA CDC2 4-284 37 2.9e-90 277.56 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 37% (115 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMKAKYNSFE-----ECLQEKEVKSLRKIK-HENVEKLLQVFRENDHLYLVFELLDESLLKTMS---KRT
.. |. .| | .|||.||.... .| ||.|| . .... .      ..  .|   | ..| |.|. ||  |. .   ||.||| ||  | | |    .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAI--REISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKN

QPFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAREIRS-RPPYT--EYISTRWYRAPEIILRHPFYNSPVDIWAAGAIMA
.... ..|. .| ||  |..  | .. .||| ||.|.| . .|..||||||||| .     .||    . |.||||||| |.  .|. |||.|. | |.|
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

ELYML---KPIFPGSSETDQMYKICSVLGNPTMETWPDGVKLAAKTGFKMGNGYHTS--LQQLMPN---------ASPEAIDLMIQLLQFDPSKRPSASQ
|..|    ||.|.| || || .||  .|| |. .|||.  .|   . .|.  .  .   |....||         . ||.|||  |.|| ||.|| || .
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQL---PDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

ALTHPFF
|| ||.|
ALQHPYF
Kinase 134846.m00005.AA S_TKc 4-284 31 6.2e-89 302.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMKAKYNSFEECLQEKEVKSLRKIKHENVEKLLQVFRENDHLYLVFELLDE---SLLKTMSKRTQP----
.| ....| ||||.| |||. . .. ||||..|        .  ..|.. |.| .|.|. ||. ||.. ||||.|.|..|    .|.. . ||  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAREIRSRPPYTEYISTRWYRAPEIILRHPFYNS-PVDIWAAGAIMAELY
 |.   .|..| ||. .|. .|..|. ||| ||.|.| ..  ..||.||||||..      | .. |.||.|||..     |.  ..|.|. | |..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

MLKPIFPGSSETDQMYKICSVLGNPTMETWPDGVKLAAKTGFKMGNGYHTSLQQLMPNASPEAIDLMIQLLQFDPSKRPSASQALT-------HPFF
  .| ||   . ..|.|..                                        ||||.|.. ..||.||.|||.| .||.       ||.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 134846.m00005.AA Pkinase 4-284 31 8.2e-89 306.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMKAKYNSFEECLQEK---EVKSLRKIKHENVEKLLQVFRENDHLYLVFELLDE-----SLLKTMS-KRT
.. ....| |.||.| ||.. .. . ||.|..| . .. ... .     |.. .....|.|. .|. .|...||.|.|.|...      .|   .| .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QPF--SNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVL----KIADFGLARE--IRSRPPYTEYISTRWYRAPEIILRHPFYNSPVDIWAA
 .|  | . .. .| ||. ||. .|..|. |||.||.|.| ...|..    ||.|||||.   . . . .| .  |.||.|||.|. .. | ..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GAIMAELYMLKPIFPGS----SETDQMYKICSVLGNPTMETWPDGVKLAAKTGFKMGNGYHTSLQQLMPNASPEAIDLMIQLLQFDPSKRPSASQALTHP
| |..|..  .|.|||.    .  |||..|| ..| |... ||        . |.     |. .. . .|.|.|..|..  .|..||.|||.| |.| ||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH--W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase 134846.m00005.AA MAPK 50-284 36 7.1e-73 248.42 In-house 54-328 (328) Show / Hide 
Range on Protein: 50-284
Range on HMM: 54-328/328
Sequence Identity: 36% (100 aa)

EVKSLRKI-KHENVEKLLQVFRE------NDH-----LYLVFELLDESLLKTMSKRTQPFSNEKVRYIMGQIFPG--LNIIHKQGFFHRDMKPDNLLWSQ
|.| || . .|||. ||| .|.       |..     .|.|.|| .  | . .  .  | |.. ..|.| ||  |  |  ||  .  ||| || |.|  .
EIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNE

DGVLKIADFGLAREIRSRPPY---------------TEYISTRWYRAPEIILR--HPFYNSPVDIWAAGAIMAELYM-LKPIFPGSSETDQMYKICSVLG
.. |||.|||||| | .   .               |||..|||||||||.|      |.  ||.|..| |.||..   ||.|||..  ||. .| .|||
NCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG

NPTMETWPDGV--KLAAKTGFKMGN-GYHTS--LQQLMPN----ASPEAIDLMIQLLQFDPSKRPSASQALTHPFF
.|..| .      . |..    .||  ...   .... ||    |.|.||||. ..|.|||.|| .. .|| ||.|
TPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 134846.m00005.AA CDKL 4-218 41 1.1e-72 247.78 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-218/286
Sequence Identity: 41% (90 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMKA-KYNSFEECLQEKEVKSLRKIKHENVEKLLQVFRENDHLYLVFELLDESLLKTMSKRTQPFSNEKV
.| . ..| |. ||| |||| .. | ||||| |  ...  .    . |.| |.  ||||   |. ||| .  |.||||  | ..| .  .. .    ..|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWS-QDGVLKIADFGLAREIRSRPP--YTEYISTRWYRAPEIILRHPFYNSPVDIWAAGAIMAELYMLKPI
| .| ||  ..|  ||.   ||| || |.| . ..|..|. |||.|| . . |   ||.|  ||||||||  .  . | .||||||.| .|||. .  |.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGSSETDQMYKICSVLGN
.||.|. ||.|.|  .||.
WPGQSDIDQLYHIQKCLGP
Kinase 134846.m00005.AA ERK 4-284 35 8.5e-70 238.2 In-house 1-307 (307) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-307/307
Sequence Identity: 35% (108 aa)

FEEIKVLGDGAFGVVTKCRNLD-----NDQFVAIKKMKAKYNSFEECLQE-KEVKSLRKIK-HENVEKLLQVFREN-----DHLYLVFELLDESLLKTMS
.. || .|.||.||| ....       ..|.||||| .  ..   .| .   | | ||  | |||. .|. ....|     . .|.|.|| .  | ..  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

KRTQPFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAR----EIRSR-----PPYTEYISTRWYRAPEIILRHPFYNSPVD
 . |. | . . | | ||  ||  || .. .||| || |.|   ...|||.||||||    .. ..     . .|||..|||||||||.|  . |....|
SQ-QELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWAAGAIMAELYMLKPIFPGSSETDQMYKICSVLGNP-TMETWPDG-VKLAAKTGFKMGN--GYHTSLQQLMPNAS--PEAIDLMIQLLQFDPSKRPSAS
||..| |.||... ||.||| .  .|.  | ...| | . |.  .   . | |  ....|      ... . |||.  |.||||  ..|.|||.|| .. 
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

QALTHPFF
..| ||.|
ECLEHPYF
Kinase 134846.m00005.AA p38 4-284 34 3.5e-68 232.1 In-house 1-289 (289) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-289/289
Sequence Identity: 34% (102 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQF---VAIKKMKAKYNSFEECLQE-KEVKSLRKIKHENVEKLLQVFRE-NDHL------YLVFELLDESLLKTMSK
..... .| ||.| | | .  . .|    |||||.   . | .       |.. |. ..|||| .|| ||   .. .      |.| .. . .| . |  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIM--

RTQPFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAREIRSRPPYTEYISTRWYRAPEIILRHPFYNSPVDIWAAGAIMAE
..| .| ......  ||  ||  ||  |  ||| || |.    |  |.| ||||||.  .    |.|. |||||||||.|    |.  ||||  | ||||
KCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE--MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LYMLKPIFPGSSETDQMYKICSVLGNPTMETWPDGVKLAAKTGFK-MGNGYHTSLQQLMPNASPEAIDLMIQLLQFDPSKRPSASQALTHPFF
|   .. |||.   ||. .| .|.| |. | |    . .|..  . .       .... ..|.| ||||.  .|. || || .|..|..||.|
LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 134846.m00005.AA TyrKc 4-284 20 1.9e-14 11.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

FEEIKVLGDGAFGVVTKCRNLDNDQFVAIKKMKAKYNSFEECLQE--KEVKSLRKI--KHENVEKLLQVFREN-------DHLYLVFELLDE-SLLKTMS
 . .|.|| ||||.| |..     . ||.|..|.        ...  .| . ..|.  .|.|. .|. | ..        . |..|.|. .  .|..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRTQPFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAREIRSR-------PPYT------EY--ISTRWYRAPEIILRHPF
|.   .....  ... ||  | . .|.... |||    | | . ... ||.||||.|.| .          |.      .   .  ||. ||| | ..  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YNSPVDIWAAGAIMAELYMLKPIFPGSSET--DQMYKICSVLGNPTMETWPDG----VKLAAKTGFKMGNGYHTSLQQLMPNASPEAIDLMIQLLQFDPS
...  |.|. |  | |.. .    .   .      . .   . .  .   |.                            . ...|  ..| |  ..||.
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------FVCCPDEMYQIMKQCWHEDPE

KRPSASQALTHPFF
.||. |.   | .|
DRPTFSEI--HECF
Kinase 134846.m00005.AA Pkinase_Tyr 4-150 28 2.2e-13 45.98 Pfam 1-161 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-161/270
Sequence Identity: 28% (46 aa)

FEEIKVLGDGAFGVVTKCRNL----DNDQFVAIKKMKAKYNSFE---ECLQEKEVKSLRKI-KHENVEKLLQVFR-ENDH--LYLVFELLDE-SLLKTMS
 . .|.|| ||||.| |..      .... ||.|..| .. . .   | . . |.| .... .|.|. .|. |   . ..  .|.|.|.    .||.   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KR---TQPFSNEKVRYIMGQIFPGLNIIHKQGFFHRDMKPDNLLWSQDGVLKIADFGLAREI
|.    ||.. .    .  ||  |..  . ... |||    | | . ..| ||.|||||| |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 134846.m00005.AA CDKL 245-284 36 8.2e-13 40.14 In-house 246-286 (286) Show / Hide 
Range on Protein: 245-284
Range on HMM: 246-286/286
Sequence Identity: 36% (15 aa)

SLQQLMPNAS-PEAIDLMIQLLQFDPSKRPSASQALTHPFF
.| . .||.| ..|.|.| ..|. ||..|....|.. ||.|
PLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 134846.m00005.AA MAPK 4-35 31 4.1e-09 27.44 In-house 1-38 (328) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-38/328
Sequence Identity: 31% (12 aa)

FEEIKVLGDGAFGVVTKCRNLD------NDQFVAIKKM
.. .| .| ||.||| ...         ....|||||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKI