Gene 99240.m00005 (T.vaginalis)

99240.m00005

Species: T.vaginalis
Alias: TvagK0444, 99240.m00005
External Links:
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
99240.m00005.AA Protein None 710 None Fasta, JSON
99240.m00005.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of 99240.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 99240.m00005.AA AGC 338-603 28 5e-145 377.75 In-house 1-395 (395) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-395/395
Sequence Identity: 28% (116 aa)

FEFVKRISSGAFATVFIAKKK------LTGDIYAIKAIPKTV-FQQKN--QTSRILKE------------RDILLEIS----------NPYVVT-FYYSI
|||.| |. |.| .|. ..||       ||..||.| . | .  ..|.  .  ... |            |.|| ...          .|..|   .|| 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ISDKN--LYLVTEFVP--------GGDLYSVLQMFG-----AFDEESAKIYLYQ-------ILQALKYIHG-NGIIHRD-LKPDNILVTAEGTLKLTDFG
 ....  ||.| |..|        ||.. . |...|      |||| |..|. .       |. || |.|  .|||||| |||.||| ...| .||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSSQGCVNRQVNQEIEE-------------------------------------------ADTCEIVG--TLDYMAPEVLLNQPHTFAVDFWS--LGCML
|. .|  .. ..|.  .                                           . |  ..|  | .|||||.|    ...|.| ||  |||..
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

FEFLTGVPPFHAET----------EEETTQNIL------TSKVEFY--------EEDEITNEARDLIIRLLEPNPEKRLGSKS-------IDEIFNHPWL
.|.||| |||....          ..|. |.|.      . ||.|         |......||.||| .||...||||||..        ..|| |||| 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 99240.m00005.AA MAST 338-603 35 8.20000000001e-112 361.79 In-house 1-334 (334) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-334/334
Sequence Identity: 35% (119 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIPKTVFQQKNQTSRILKERDILLEISNPYVVTFYYSIISDKNLYLVTEFVPGGDLYSVLQMFGAFDEES
|||.| || ||.  |. .|.| |.|..|.| | |     ||...    ||.|| ...||.|| ..||  ....|..| |.. |||. | |.|.|.|||. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTLKLTDFGLSSQGCVNRQVNQEIE-----------------EADTCE-----------------
||.|. ..  .| |.|  ||.||||||||.| ...|  ||||||||  | .... . ..                  . |. .                 
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

-----------------------IVGTLDYMAPEVLLNQP-HTFAVDFWSLGCMLFEFLTGVPPFHAETEEETTQNILTSK---VEFYEE------DEIT
                       ..||.||.||||.|.|. |  .|| ||.| ...|||.|.|||  .| ||. ||||  .   .|..|.      ....
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

NEARDLIIRLLEPNPEKRLGSK-SIDEIFNHPWL
 ||.|||..||.|.|.||||..   ||. .|| .
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 99240.m00005.AA MAST 338-603 35 9.80000000001e-111 339.62 In-house 1-337 (337) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-337/337
Sequence Identity: 35% (120 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIPKTVFQQKNQTSRILKERDILLEISNPYVVTFYYSIIS--DKNLYLVTEFVPGGDLYSVLQMFG-AFD
|||.| || ||.  |. .|.| |.|..|.| | .     |||   .  ||.|| ...||.|| ..||  .  .| |..| |.. |||  | |.|.| ...
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTLKLTDFGLSSQGCVNRQVNQEIE-------------------EADTCE------------
|. ||.|. ..  .| |.|  ||.||||||||.| .. | .||||||||  | .... | ..                    .. .              
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

---------------------------IVGTLDYMAPEVLLNQP-HTFAVDFWSLGCMLFEFLTGVPPFHAETEEE-TTQNILT--SKVEFYEE------
                           ..|| ||.||||.| |. .  .|| ||.| ...|||.|.||| ..| || . |||.    ..|. ||      
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

DEITNEARDLIIRLLEPNPEKRLGSKSIDEIFNHPWL
|... ||.|||..||.||| ||||..  ||| .||  
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 99240.m00005.AA S_TKc 338-603 33 1.2e-101 344.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-231/231
Sequence Identity: 33% (94 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIPKTVFQQKNQTSRILKERDILLEISNPYVVTFYYSIISDKNLYLVTEFVPG--GDLYSVLQMFGA---
.|... | .|||..|. ...| || |.||| |.           .|..|..|| .   |..|..|... . ..||.|.|...|  |||.....  |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTLKLTDFGLSSQGCVNRQVNQEIEEADTCEIVGTLDYMAPEVLLNQPHTF-AVDFW
   |.|  |. |.|||..||.|.| .|||||||||.|||..   ..|..||||. |                  ..||..|||||||   .... ..| |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGCMLFEFLTGVPPFHAETEEETTQNILTSKVEFYEEDEITNEARDLIIRLLEPNPEKRLGSKSIDE----IFNHPWL
|.||.|.|.|.| |||.  ..... ..|.            . ||.|.| ..|. .||||..   . .    | .|||.
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 99240.m00005.AA Pkinase 338-603 29 6.4e-95 326.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIPKTVFQQKNQTSRIL-KERDILLEISNPYVVTFYYSIISDKNLYLVTEFVPGG----DLYSVLQ--MF
......| ||.|..|.....| ||.|.|.| |.|     . . ....  |  |..... |..|..|..  .....|.|.|...||    ||.....  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GAF--DEESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTL----KLTDFGLSSQGCVNRQVNQEIEEADTCEIVGTLDYMAPEVLL-NQPHTF
|.|  .|. .| |.||||..|.|.| .|||||||||.|||.  .|..    |..||||. |         .     .  ..||..||||||.. .|... 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

AVDFWSLGCMLFEFLTGVPPFHAE------TEEETTQNILTSKVEFYEEDEIT-------------------NEARDLIIRLLEPNPEKRLGSKSIDEIF
.|| ||.||.|.|.|.| |||  .      .. .  ..|.  ...| .. ...                    |..|.| ..|...|.||..   ...|.
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQIL

NHPWL
.|||.
QHPWF
Kinase 99240.m00005.AA Akt 338-603 37 2.3e-91 292.31 In-house 1-264 (264) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-264/264
Sequence Identity: 37% (102 aa)

FEFVKRISSGAFATVFIAKKKLTGDIY-AIKAIPKTVFQQKNQTSRILKERDILLEISNPYVVTFYYSIISDKNLYLVTEFVPGGDLYSVLQMFGAFDEE
|.|.| . .|.|. || .||| |...| |.|.. | . .||||   .. || ||  . .|..|  .||  . ..||.|.....||.|.. ||  . |.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

SAKIYLYQILQALKYIHGNGIIHRD-LKPDNILVTAEGTLKLTDFGLSSQGCVNRQVNQEIEEADTCEIVGTLDYMAPEVLLNQPHTFAVDFWS-LGCML
 |. |  .|  |. . | ..|| || ||| |||. ..| ..||||||. ..     . .. ....|  . ||  |.|||.|... || |||.|. ||| .
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKEN-----IIKDHDKTKT--FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVM

FEFLTGVPPFHAETEEETTQNILTSKVEFYEEDEITNEARDLIIRLLEPNPEKRLG--SKSIDEIFNHPWL
.|...| |||...  ..  ..|....|.| . | | .|..|||..||. .|.||||  .. ..|| .|||.
YEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 99240.m00005.AA RSK 341-603 36 3.4e-89 302.64 In-house 1-278 (278) Show / Hide 
Range on Protein: 341-603
Range on HMM: 1-278/278
Sequence Identity: 36% (103 aa)

VKRISSGAFATVFIAKKK---LTGDIYAIKAIPKTVFQQKNQ-TSRILKERDILLEIS-NPYVVTFYYSIISDKNLYLVTEFVPGGDLYSVLQ---MFGA
.|    |..  ||. .|.    || ||| | . | .. |..  | . ..||.||...   | .|| .|.   .. |||..|...||.|.  ||   .|| 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTA---EGTLKLTDFGLSSQGCVNRQVNQEIEEADTCEIVGTLDYMAPEVLL---NQP-HTFAV
|.|. |..|...|  |....|  |||||||||.||| .    ||..||||||.. |.     .... . ..|   ..|..|||||.|     |  |. |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----RCDHNQWTMT--FCYTIEYMAPEMLKRANQQGGHDKAC

DFWSLGCMLFEFLTGVPPFHA---ETEEETTQNILTSK--VEFYEEDEITNEARDLIIRLLEPNPEKRLG--SKSIDEIFNHPWL
| ||||. ..| ||| |||..   .. .|. ..|.. |  ... . .....||.||| ..|. .|.||||   . ..|| .|||.
DWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 99240.m00005.AA Ciliate-E2 338-603 25 3.6e-89 302.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

FEFVKRISSGAFATVFIAKKKLTGD-----------------------IYAIKAIPKTVFQQKNQTSRIL----------KERDILLEISNPYVVTFYYS
..|.| | .|.|..|. .|.....                        |||.| . |   .|..|  .|.          .|. || ....|... .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

II--SDKNLYLVTEFVPGGDLYSVLQ------------MFGAFDEESAKIYLYQILQ---------------ALKYIHGNG-IIHRDLKPDNILVTAEGT
 .  .|.|.|||.|.. ||||.. ..              . |.|. .| . .||||               ||.|.| .. |||||.||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKLTDFGLSS----QGCVNRQVNQEIEEADTCE---------------------IVGTLDYMAPEVLLNQP---------HTFAVDFWSLGCMLFEFLTG
.|..|||||     . . ... .|. ..                          |.||. |||||.| ...         .....|.||||..|.|.|.|
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

VPPFHAETEEETTQNILTSKVEFYEE----------------DEITNEARDLIIR----LLEPNPEKRLGSKSIDEIFNHPWL
 |||         |.|.  |..| ..                .....|. ||| .    .|. .||||..  ....|.||||.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 99240.m00005.AA AktR 338-603 35 4e-87 295.77 In-house 1-268 (268) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-268/268
Sequence Identity: 35% (98 aa)

FEFVKRISSGAFATVFIAKKK-LTGDIYAIKAIPKTVFQQKNQTSRILKERDILL-EISNPYVVTFYYSIISDKNLYLVTEFVPGGDLYSVLQMFGAFDE
|.. | . .|||..|. ..||  ....||.| | |. ....|| .... ||.|.  ....|  | ..|.. ....|... |..|||.|...|.  . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ESAKIYLYQILQALKYIHGN-GIIHRDLKPDNILVTAEGTLKLTDFGLSS-QGCVNRQVNQEIEEADTCEIVGTLDYMAPEVLLN-QPHTFAVDFWSLGC
| |..|  ||| || | | .  || |||||.|||   .| .|.||||||  |.     .. . |.|..  ..||  |||||.... ..|...||.|..|.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQF-----MMHYDEKAYS--FCGTPEYMAPEMITKKKGHNKSVDWWAFGI

MLFEFLTGVPPFHAETEEETTQNILTSK-VEFYEEDEITNEARDLII-RLLEPNPEKRLG--SKSIDEIFNHPWL
 ..| .|| ||| ..  ..  |.|...  ..| .  .......|||  .||  ||.||||  .....|| .||| 
FIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 99240.m00005.AA CAMK 343-603 21 3e-84 271.26 In-house 1-425 (425) Show / Hide 
Range on Protein: 343-603
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

RISSGAFATVFIAKKKLTG------------DIYAIKAIPKTVFQQKN-------------------------QTSRILKERDILLE-------ISNPYV
 . .|.|..|. .. |.|.              .||| |.|.  . |.                            ....| .|.         .. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTFYYSIIS-------------------DKNLYLVT---EFVPGG----DLYSVLQMF---------------GAFDEESAKIYLYQILQALKYIHGNGI
. .|  . .                   ||..|.|.   |...||    ||.. ..                 | |.|. |. |  ||..|..|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPDNILVTAE-----------------GTLKLTDFGLSSQ---GCVNR------------QVNQEIEEADTCEIVGTLDYMA-PEVLLN------
.||||||.|||..                   ...|..|||.. .   |  |.            |.....|     . .||. ||| ||||.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QPHTFAVDFWSLGCMLFEFLTGVPPFHAE-------------TEEETTQNILTSKVEFYE--------------EDEITNE--------ARD
        .......| ||.|..|.  |.| ||| ..             ...|. ..|.. | .|..               |.|..|        ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIIRLLEPNPEKRLGSKSIDEIFNHPWL
|| ..|...||||.   .|... ||||.
LIRKMLQVDPEKRM---TIEQCLNHPWM
Kinase 99240.m00005.AA Ciliate-E2-Unclassified 338-603 26 6.1e-83 281.86 In-house 1-352 (352) Show / Hide 
Range on Protein: 338-603
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIP-KTVFQQKNQTSR--------ILKERD-------------ILLEISNPYVVTFYYSIISDKNLYLVT
....| | .|.|..|. ...| .. .||.| .  . .. ||.. .         .....              ||| . .|..| ..|   ...|.|.|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFVPGGDLYSVLQMFGA-----------------FDEESAK-----IYLYQILQALKYIHGNG-IIHRDLKPDNILVTAEG---TLKLTDFGLSS-----
|...||||   .. ..                  |.|. ||      |..||||.|.|.| .. |||||.||.|||.. .|    .|..|||.|.     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

-------QGCVNRQVNQEIEEADTCEIVGTLDYM----APEVLLNQPHT----FAVDFWSLGCMLFEFLTGVPPFHAETEEE----------------TT
       |  ...|.... .   .. ..||. ||    ||||| .| .     ...|.||||. |.|.|.| .|| ....|.                  
NNCDTNQQ--QKMQIWKQQM---MWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

QNILTSKVEFYEEDE------ITNEARDLIIRLLEPNPEKRLGSK-SIDEIFNHPWL
|||.  ...| ....      . .|| |.| .||  ...|..... ....|.||||.
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 99240.m00005.AA NDR 338-486 43 6.1e-62 189.55 In-house 1-154 (350) Show / Hide 
Range on Protein: 338-486
Range on HMM: 1-154/350
Sequence Identity: 43% (67 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIPKTVFQQKNQTSRILKERDILLEIS--NPYVVTFYYSIISDKNLYLVTEFVPGGDLYS---VLQMFGA
||..| |..|||  |....|| ||.|||.| . |.   .|||.  ...||||. | .  ||.||  ||| . ...|||| |..||||. .   .|.... 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FDEESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTLKLTDFGLSSQG
|.|. |. |   .  |. ..| .|.||||.||||.|. . | .|||||||. .|
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGG
Kinase 99240.m00005.AA NDR 504-603 40 3.5e-47 143.17 In-house 241-350 (350) Show / Hide 
Range on Protein: 504-603
Range on HMM: 241-350/350
Sequence Identity: 40% (45 aa)

IVGTLDYMAPEVLLN-QPHTFAVDFWSLGCMLFEFLTGVPPFHAETEEETTQNILTSKVEF------YEEDE-ITNEARDLIIRLLEPNPEKRLGSKS--
.||| |||||||... . .....|.|||||...|.|.|.|||...| .|| ..|.  |  .      ..... .. || ||| ||. |.|..||||.   
TVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKG

IDEIFNHPWL
.||| .||. 
VDEIKSHPFF
Kinase 99240.m00005.AA Pkinase_Tyr 338-483 25 4.9e-18 61.71 Pfam 1-158 (270) Show / Hide 
Range on Protein: 338-483
Range on HMM: 1-158/270
Sequence Identity: 25% (41 aa)

FEFVKRISSGAFATVFIAKKK----LTGDIYAIKAIPKTVFQQKN-QTSRILKERDILLEI-SNPYVVTFYYSII-SDKN--LYLVTEFVPGGDLYSVLQ
 .| | . .||| .|. .. |     |.   |.| . |    ...      ..|  |. .. ..| .| .|  ..  ..   .|.|.|..|.|||.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

M----FGAFDEESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTLKLTDFGLS
      .... .    . .|| ... | . ...|||||   |.||| ... | .||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 99240.m00005.AA TyrKc 338-598 21 5.8e-17 51.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 338-598
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FEFVKRISSGAFATVFIAKKKLTGDIYAIKAIPKTVFQQKNQTSRILKERDILLEI--SNPYVVTFYYSIISD-------KNLYLVTEFVPGGDLYSVLQ
 .. | . .||| .|. .. |      |.| . .           ...|  |. ..  ..| .| .|  ....       . |..|.|..|.||| . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

MFGA-FDEESAKIYLYQILQALKYIHGNGIIHRDLKPDNILVTAEGTLKLTDFGLSSQGCVN-----RQVNQEIEEADTCEIVGTLDYMAPEVLLNQPHT
  .  .  .    . .|| .   |.| ...|||||   |.||....| | .|||||  .        ..      | . .  .  .  ||||..     |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FAVDFWSLGCMLFEFLT-GVPPFHA-----ETEEETTQNILTSKVEFYEED-------EITNEARDLIIRLLEPNPEKRLGSKSIDEIF
.. | || | ...| .| | .|         . .|  ... . .     ..       . . |  ... .  . .||.|   . | |.|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 99240.m00005.AA Pkinase_Tyr 511-544 36 0.936672 3.18 Pfam 181-216 (270) Show / Hide 
Range on Protein: 511-544
Range on HMM: 181-216/270
Sequence Identity: 36% (13 aa)

MAPEVLLNQPHTFAVDFWSLGCMLFEFLT-GVPP-F
||||.. .   | . | || |  ..| .| |  | .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY