Gene 80364.m00037 (T.vaginalis)

80364.m00037

Species: T.vaginalis
Alias: 80364.m00037, TvagK0646
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
80364.m00037.AA Protein None 483 None Fasta, JSON
80364.m00037.kin_dom Protein Kinase Domain None 296 None Fasta, JSON

Protein domain

Protein domains of 80364.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 80364.m00037.AA DYRK2 155-450 43 7.50000000001e-139 454.37 In-house 1-318 (318) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-318/318
Sequence Identity: 43% (139 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPDKNSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPMS
.||  . ||| ||||..|||||||| ||||.. |    |.|  .|. | .|. . ..| ....|. .| |. | |. . || |.|||||| .   ||  |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTMKCRVIDFGSSCFDGH-QKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMMIGRP
|| .   |. .|..| | ||.|..|||.||||.||         |||||||||.   . | |||||.|||||||||.||| . |.||| ||..|. .| |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGDNEHEQLEMIMEVFGVPPVSVINQ-----CKRKAEFFT---------------PDNKPLLRNRRKKLRMPGQSNLRAATK-FSDPVFLDFLQKCFE
||||.|| .|. ..|||.| || .....     |.|.  ||.               .. ...  ||..| |.|| ... .. |   |. |.||...|||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WDQDKRITAEQALNHQWF
|| ..|.|..|||.| |.
WDPSERMTPSQALKHPWI
Kinase 80364.m00037.AA DYRK 155-450 42 1.1e-127 430.48 In-house 1-320 (320) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-320/320
Sequence Identity: 42% (137 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPDKNSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPM-
.||  . ||| |||| .|.||||.. ||||.. | . .| |..||. | ..||. .|| ....|. .| |..|.|  . || | |||||. .  .||.  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLQQIHSIAKHMLNGLAFCHKH-NVVHCDMKPENVLLLPN-STMKCRVIDFGSSCFDGHQKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMMIG
||. . ..|. .|..| | ||. | .|||.||||..|    .     ||||||||| ... | |||||.|||||||||..|. . |.||. ||..|. .|
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

RPLFPGDNEHEQLEMIMEVFGVPPVSVINQ--CKRKAEFFTP-------------------DNKPLLRNRRKKLRMPGQSNLRAATKFSDPVFLDFLQKC
 |||||.|| .|| .||||.| ||  .|..  |.|| .||.                    .. .. ...|.. |.||..|. .. .  |  |.||..||
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKC

FEWDQDKRITAEQALNHQWF
..|| .||||..|||.| ||
LQWDPHKRITPSQALQHPWF
Kinase 80364.m00037.AA CMGC 155-450 22 1.8e-107 354.34 In-house 1-513 (513) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-513/513
Sequence Identity: 22% (114 aa)

FEIRAIFGKGAFGQVLRCYD--------------HKTKQQVAIKLVINTEQMHEQGK-------------IEVMIVQHLNKY---------NPDKNSD--
.||    |.|..|.| .|.|              |.|...|||| . | . ..||.|              |..| .||||.         .||.. .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRTFDAFIWRQ-----------------HIAVSFEILGMNLYEYSRSIRF-------QPMSLQQ------------IHSIA------KHMLNGLA--FC
||. .| |  ..                 |.   || ....||.| .. .|       .|.|  .            | ..       . .|.||.  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKHN--VVHCDMKPENVLLLPN------------------STMKCRVIDFGSSCFDGHQ------------------------KYEYIQSRYYRAPEVIL
|.|.  ..|.|.||||.|. .|                  . .. ...|||.... ..                          ..|...|.|||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GIK----------YGPPMDIWSFACIVVEMMIG--------RPLFPGDNE-----------HEQLEMIMEVFGVPPVSVINQ-------CKRKAEFF---
| |          |..|.|.||..||  ||. |        .|||||..|            .||..|..|.| |. ..|..       ||.. |..   
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMI

---------------------TPDNKPLLRN--RRKKLRMPGQSNLRAATKF--------------------------------SDPVFLDFLQKCFEWD
                     ... .  ...  | .. . .  .||    ..                                 || ..|.|.|....|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

QDKRITAEQALNHQWF
 ||||||||||.| .|
PDKRITAEQALQHPYF
Kinase 80364.m00037.AA DYRK1 155-403 39 4.2e-78 265.8 In-house 1-251 (321) Show / Hide 
Range on Protein: 155-403
Range on HMM: 1-251/321
Sequence Identity: 39% (99 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPDKNSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPMS
.|| .  |||.|||| . |||.....||||.. |     .| .||. ..  .||  ...   ||.    |..| |. . ||.|  |||.  |   |. .|
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LQQIHSIAKHMLNGLAF--CHKHNVVHCDMKPENVLLLPNSTMKCRVIDFGSSCFDGHQKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMMIGR
|  .. .|. |.  | |      ...|||.||||.||      . ..|||||||  |.  |.|||||.||.|||.|||.|   .|.||  ||.||| .| 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGDNEHEQLEMIMEVFGVPPVSVINQCKRKAEFFTPDNKPLLRNRRKK
||| | || .|.. |.|| |.||  .|.|  .   .|. |..     ....
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTR
Kinase 80364.m00037.AA S_TKc 155-450 25 4.7e-75 256.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-231/231
Sequence Identity: 25% (78 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPDKNSDIVRTFDAFIWRQHIAVSFEILGM---NLYEYSRSIRFQ
.||  . ||||||.| .|...||...|||| .       |. . |. | ..       .   ||. .|.|   .|. . .| ..    .|..| .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----MSLQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTMKCRVIDFGSSCFDGHQKYEYIQSRYYRAPEVILGIKYGP-PMDIWSFACIVV
.    ..  .. .... ....|..||.|...|.| ||||.||         ..|||....     . .. ...|.||||.   .||. . |.||. ||. 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMIGRPLFPGDNEHEQLEMIMEVFGVPPVSVINQCKRKAEFFTPDNKPLLRNRRKKLRMPGQSNLRAATKFSDPVFLDFLQKCFEWDQDKRITAEQALN
||. |.|.||      |..|.... |                                               .| ..||..||...| .||.|| .||.
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------HQWF
       |.||
DEWDIKCHPWF
Kinase 80364.m00037.AA YAK 155-389 35 5.2e-65 219.69 In-house 1-239 (347) Show / Hide 
Range on Protein: 155-389
Range on HMM: 1-239/347
Sequence Identity: 35% (86 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPDKNSD----IVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRF
. .  . |.| ||||  |    |.  .|.| . |      |.| |. | . ||.     |      |.|  | |... |  . ||.| .|||||    .|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QPMSLQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTMKCRVIDFGSSCFDGHQKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMMI
  .| | |    |  | |.      ...||| ||||..|        ..|||||||      | |||.|.||.||.|... |    | ||  |||.|   
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GRPLFPGDNEHEQLEMIMEVFGVPPVSVINQCKRKAEFF
| |.|||  | .|.  | .. | ||  .|.| . |  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase 80364.m00037.AA Pkinase 155-450 25 3.1e-63 221.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-293/293
Sequence Identity: 25% (86 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKI-----EVMIVQHLNKYNPDKNSDIVRTFDAFIWRQHIAVSFEILGM-----NLYEY
..|  . |.|.||.| .|....| ..||.| .   .. ... ..     |. | ..||     .|  |||..|.|  ..|| . .| ...      |..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPN--IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

SR---SIRFQPMSLQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTMKC----RVIDFGSSCF---DGHQKYEYIQSRYYRAPEVIL-GIKYG
 .   . .|  .| ... .... .| ||..||.....|.|.||||.|.   ... .    ...|||....    ..  . .  ...|.|||||. | .||
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

PPMDIWSFACIVVEMMIGRPLFPGD----NEHEQLEMIMEVFG------------VPPVSVINQCKRKAEFFTPDNKPLLRNRRKKLRMPGQSNLRAATK
|. |.||. ||. ||. |||.|||.    | |.|..|| .. |            ... . ... . .                          ..   .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------F-HWTF-H

FSDPVFLDFLQKCFEWDQDKRITAEQALNHQWF
  .. ..||. .|...|  ||.||||.|.| ||
NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 80364.m00037.AA HIPK 155-389 35 2.9e-60 188.27 In-house 1-237 (329) Show / Hide 
Range on Protein: 155-389
Range on HMM: 1-237/329
Sequence Identity: 35% (84 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPDKNSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPMS
.|.  . |.| |||| .|  . |.  ||||.  |      ||.||| | . | . |.| . ..|| .. |  ..|.   ||.|  |||.. .  .| |. 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTM--KCRVIDFGS-SCFDGHQKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMMIG
|. |  | .  |  |.   .  ..| |.||||..|   .    . .|||||| | .    .  |.|||||||||.|||...   .|.||  |.. | . |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

RPLFPGDNEHEQLEMIMEVFGVPPVSVINQCKRKAEFF
.||.|| .| .|   | .  . |  . ...  .|  ||
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFF
Kinase 80364.m00037.AA DyrkP 155-359 34 1.2e-43 141.16 In-house 1-209 (323) Show / Hide 
Range on Protein: 155-359
Range on HMM: 1-209/323
Sequence Identity: 34% (73 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHLNKYNPD-KNSDIVRTFDAFIWRQHIAVSFEILGMNLYE---YSRSIRF
. |    |  || . . | | .| | . .|.. |     .|   |. ... .| || |     ..| .| |  . |. .  |.|  ||||   . |    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYIN-YNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

QP-MSLQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTMKCRVIDFGSSCFDGHQKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMM
|.   .  .  | . .| .| . |   ..|||.||||.|.   .  . ..||||||||       |.||| |||||||.| ||   .|.||  ||. |. 
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELW

IGRPLFPGDN
 |  ||  ||
TGNVLFQNDN
Kinase 80364.m00037.AA Ciliate-E2 155-450 18 1.9e-42 143.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-365/365
Sequence Identity: 18% (76 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIK-----------------LVINTEQMHEQGKIEVMIVQHLNK-----YNPDK------------NSDIVRT
...  . |.|.||.| .| . |...|.|||                   .. ..|......... ..|...     |   |            .  |.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFY---KKINEKNILEQLNHPNIIKM

FDAFI--WRQHIAVSFEIL-GMNLYEYSRSIRFQ---------PMSLQQIHSIAKHMLN---------------GLAFCHKHN-VVHCDMKPENVLLLPN
...|.   ...|   .| . |..|..| .. . .         ......|  | |. |.               .| ..|. | ..| | ||||.|.   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

STMKCRVIDFGSSCFDG-----------HQKYEYIQ------------------------SRYYRAPEVILGIK---------YGPPMDIWSFACIVVEM
    . .|||| | .             ...| . .                        . .| |||.. | |         |.   ||||. .|  ||
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

MIGRPLFPGDNEHEQLEMIMEVFGVPPVSVINQCKRKAEFFTPDNKPLLRNRRKKLRMPGQSNLRAATKFSDPVFL-------------DFLQK----CF
. |.| |                                        .  .  .|.. | . .    |.  . . .             |...|    ..
LFGKPPF----------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRML

EWDQDKRIT-AEQALNHQWF
. |..|||| .||.|||.||
QKDPEKRITGWEQILNHPWF
Kinase 80364.m00037.AA CDK 319-450 29 6e-37 115.64 In-house 183-284 (284) Show / Hide 
Range on Protein: 319-450
Range on HMM: 183-284/284
Sequence Identity: 29% (41 aa)

RYYRAPEVIL-GIKYG--PPMDIWSFACIVVEMMI---GRPLFPGDNEHEQLEMIMEVFGVPPVSVINQCKRKAEFFTPDNKPLLRNRRKKLRMPGQSNL
. |||||. |   .|.  .| |.||. || .||.    ..||||||.|..||..| ...| |  ..   ..   ..                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

RAATKFSDPVFLDFLQKCFEWDQDKRITAEQALNHQWF
            |.|.|..  | .|||.|||||.|..|
------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 80364.m00037.AA CLK 155-289 28 5.8e-36 104.78 In-house 1-147 (350) Show / Hide 
Range on Protein: 155-289
Range on HMM: 1-147/350
Sequence Identity: 28% (42 aa)

FEIRAIFGKGAFGQVLRCYDHKT-KQQVAIKLVINTEQMHEQGKIEVM-IVQHLNKY-NPDKNSD--IVRTFDAFIW-RQHIAVSFEILGMNLYEYSRSI
.|| .  | |.|| |..| |||  |..||.| . | |.  |. ..|.  | ...|.  .|.. .   ... .| |     ||. .||..| ..|.  .| 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R------FQPMSLQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLL
.      ..|  ...| ..|.  .. . | |.   .| | |||| ..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase 80364.m00037.AA CLK 298-374 41 1.9e-28 81.8 In-house 187-266 (350) Show / Hide 
Range on Protein: 298-374
Range on HMM: 187-266/350
Sequence Identity: 41% (33 aa)

RVIDFGSSC---FDGHQKYEYIQSRYYRAPEVILGIKYGPPMDIWSFACIVVEMMIGRPLFPGDNEHEQLEMIMEVFGVP
.||||||     ||   ... ...| |||||||||  .  | |.||..|| .|  .|  ||.. ...| |.|. .. |.|
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase 80364.m00037.AA DyrkP 407-450 45 6.1e-12 34.92 In-house 280-323 (323) Show / Hide 
Range on Protein: 407-450
Range on HMM: 280-323/323
Sequence Identity: 45% (20 aa)

PGQSNLRAATKFSDPVFLDFLQKCFEWDQDKRITAEQALNHQWF
| .|||||  .  | .|.|| ..|   |  .| ||  ||.| ||
PKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 80364.m00037.AA CDK 260-289 36 5.2e-10 28.05 In-house 112-141 (284) Show / Hide 
Range on Protein: 260-289
Range on HMM: 112-141/284
Sequence Identity: 36% (11 aa)

SIAKHMLNGLAFCHKHNVVHCDMKPENVLL
.. . .|.||..||.....| |.|| | |.
CYMWQLLRGLHYCHSNWIMHRDLKPQNILI
Kinase 80364.m00037.AA CLK 423-450 42 9.9e-10 24.6 In-house 323-350 (350) Show / Hide 
Range on Protein: 423-450
Range on HMM: 323-350/350
Sequence Identity: 42% (12 aa)

FLDFLQKCFEWDQDKRITAEQALNHQWF
. | ..|..| |  ||||. .|| | .|
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 80364.m00037.AA TyrKc 155-450 17 6e-07 -110.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 155-450
Range on HMM: 1-280/280
Sequence Identity: 17% (59 aa)

FEIRAIFGKGAFGQVLRCYDHKTKQQVAIKLVINTEQMHEQGKIEVMIVQHL--NKYNPDKNSDIVRTFDAFIWR-------QHIAVSFEILGM-NLYEY
 .   . | ||||.| ..      .|||.| . .    .|    |  |  .|  .      .  ||| . . .         . . . .|     .| .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGH------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

SRSIRFQPMSLQQIHSIAKHMLNGLAFCHKHNVVHCDMKPENVLLLPNSTMKCRVIDFGSSCFDGHQ-------KYEYI----QSR-----YYRAPEVIL
 |. | .  .... .|..    .| .. |..|..| |    |.|.  |    ... ||| | . ..        .|       ...        |||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GIKYGPPMDIWSFACIVVEMM-IGRPLFPG-----DNEHEQLEMIMEVFGVPPVSV---INQCKRKAEFFTPDNKPLLRNRRKKLRMPGQSNLRAATKFS
  |. .  |.|||     |..  | .  ||      .  | .| ... .  |.      .                              .        .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------F-----VCCP

DPVFLDFLQKCFEWDQDKRITAEQALNHQWF
| ..    ..| . | ..| | ..   |. |
DEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 80364.m00037.AA CDK 155-184 31 5e-06 15.0 In-house 1-35 (284) Show / Hide 
Range on Protein: 155-184
Range on HMM: 1-35/284
Sequence Identity: 31% (11 aa)

FEIRAIFGKGAFGQVLRCYDHKTK-----QQVAIK
.|. .  | |..|.| .. |..|.     | ||.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK
Kinase 80364.m00037.AA HIPK 423-450 46 7e-05 10.77 In-house 302-329 (329) Show / Hide 
Range on Protein: 423-450
Range on HMM: 302-329/329
Sequence Identity: 46% (13 aa)

FLDFLQKCFEWDQDKRITAEQALNHQWF
| . | |   ||..||||  .||||.. 
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 80364.m00037.AA DYRK1 423-450 35 0.000419 9.75 In-house 294-321 (321) Show / Hide 
Range on Protein: 423-450
Range on HMM: 294-321/321
Sequence Identity: 35% (10 aa)

FLDFLQKCFEWDQDKRITAEQALNHQWF
| | ...  ..|  .|||  .|| |..|
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 80364.m00037.AA YAK 422-450 24 0.048422 2.28 In-house 319-347 (347) Show / Hide 
Range on Protein: 422-450
Range on HMM: 319-347/347
Sequence Identity: 24% (7 aa)

VFLDFLQKCFEWDQDKRITAEQALNHQWF
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CFIDFINQLLQLNPRERWKPMQAMQHPFI