Gene 86480.m00094 (T.vaginalis)

86480.m00094

Species: T.vaginalis
Alias: 86480.m00094, TvagK0291
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
86480.m00094.AA Protein None 1053 None Fasta, JSON
86480.m00094.kin_dom Protein Kinase Domain None 120 None Fasta, JSON

Protein domain

Protein domains of 86480.m00094.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86480.m00094.AA STE 208-327 21 6e-16 52.91 In-house 1-175 (359) Show / Hide 
Range on Protein: 208-327
Range on HMM: 1-175/359
Sequence Identity: 21% (37 aa)

FEVHKKIGSNEYCEVFCASQK------STGRI--------VAMMKFLSTKFSN----------------LTFSILKSEIRTLSILN--HPSLLGFYGFGT
.|  .|||.  . .|..|  .      .||..        .  .| .. . .|                  .  .. ||.... .|  ||    .||   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

--------DNYYAIYREHMPNGNLSELLRNN----SNLN----------TTQLTIIILGISFG-LQYLHNNHIIH
        |..  |. |.|..| |.......     .||           .|. .|.  |  | |.|||..||||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH
Kinase 86480.m00094.AA TK 208-330 12 1.4e-14 44.51 In-house 1-266 (486) Show / Hide 
Range on Protein: 208-330
Range on HMM: 1-266/486
Sequence Identity: 12% (34 aa)

FEVHKKIGSNEYC---EVFCA---------------------------SQKSTGRIVAMMKFLSTKFSNLTFS-ILK------------SEIRTLS--IL
 .. ||.|. ...   ||. .                           ... |   |.|.|  ..  ..  |  ...            .|.  ..  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPSLLGFYGFGTDN-------------YYAIYREHMPNGN----LSELLRNNSN---------------------------------------------
.|| .. .||  |..              . |  |.||.|.    | . ||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNTTQLTIIILGISFGLQYLHNN------HIIHQNL
                               |.. ||  . . |. |..||| .      ...| .|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase 86480.m00094.AA Ciliate-E2-Unclassified 208-346 16 3.1e-14 45.79 In-house 1-189 (352) Show / Hide 
Range on Protein: 208-346
Range on HMM: 1-189/352
Sequence Identity: 16% (31 aa)

FEVHKKIGSNEYCEVFCASQKSTGRIVAMMKFLSTKFSNLTFSILKSEIRTLSILNHPS--------------------------LLGFYGFGTDNYYAI
....|.||.  ...|. . .|...  .. || .. . ..   .|.... . . ....                            .  || | ....  |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

YREHMPNGNLSELLRNNSN----------------LNTTQLTI------IILGISFGLQYLHNNH-IIHQNLSSETIYLDSD---FYPHIA
  | ...|.|.. ......                  | | ..      ..  |  ||.||| .. ||| ..  | | .|..   .|. |.
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII
Kinase 86480.m00094.AA TKL-Unique 210-340 25 1.6e-13 44.25 In-house 1-148 (290) Show / Hide 
Range on Protein: 210-340
Range on HMM: 1-148/290
Sequence Identity: 25% (38 aa)

VHKKIGSNEYCEVFCASQKSTGRIVAMMKFL-STKFSNLTFSILKSEIRTLSILN-HPSLLGFYGFGTD-----NYYAIYREHMPNGNLSELLR------
. .|||...|..|. .  ...  .||. .|    ..||     ...|..... |. || .. ..|. .|     ... |  | .| |.| ..|       
FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

----NNSNLNTTQLTIIILGISFGLQYLHNNH--IIHQNLSSETIYLDSD
    ||..||  |   ... |. |. |||..   ||| .| |  ...|..
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN
Kinase 86480.m00094.AA Ciliate-E2 208-327 16 3.6e-13 41.54 In-house 1-184 (365) Show / Hide 
Range on Protein: 208-327
Range on HMM: 1-184/365
Sequence Identity: 16% (31 aa)

FEVHKKIGSNEYCEVFCASQKSTGRI------------------VAMMKFLSTKFSNLTFSILKSEIRTL----------------SILNHPSLLGFY-G
....||||.  .  |. ........                   |.....    ...    ..|.||. .                ..|||| .. .|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FG--TDNYYAIYREHMPNGNLSELLRNN-----------SNLNTTQLTIIILGISF---------------GLQYLHNNH-IIH
|   .||.. .  |    |.| ....||            ...  .   |.  |                 .|.|||... |||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH
Kinase 86480.m00094.AA TKL 214-341 22 4.1e-13 43.58 In-house 1-177 (364) Show / Hide 
Range on Protein: 214-341
Range on HMM: 1-177/364
Sequence Identity: 22% (41 aa)

IGSNEYCEVFCASQKS--------TGRIVAMMKFLSTK-------------------------FSNLTFSILKSEIRTLSILNHPSLLGFYG------F-
|||  ..||. .  .         ||. ||. || |.                          ..   .  .. ||. .| |.|| .. |.|      . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GTDNYYAIYREHMPNGN-LSELLRNNSNLNTTQLTIIILGISFGLQYLHNNH--------IIHQNLSSETIYLDSDF
       |......|  | .|.|. |. |.         |.  ..|.|. |..|||...        ||| .| |. | .|...
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENW
Kinase 86480.m00094.AA Ciliate-E2a 208-327 25 5.3e-13 34.64 In-house 1-125 (275) Show / Hide 
Range on Protein: 208-327
Range on HMM: 1-125/275
Sequence Identity: 25% (33 aa)

FEVHKKIGSNEYCEVFCASQKSTGRIVAMMKFLSTKFSNLT--FSILKSEIRTLSILNHPSLLGFYGF--GTDNYYAIYREHMPNGNLSELLRNNSNLNT
....||||.  .  |. | .| ||   ||.||   |... .     .. ||  .. |.|| .. .|..  . .||| .. |    | | . .... ....
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVM-EYCEGGELYDKIKQCKRFFE

T--QLTIIILGISF-GLQYLHNNHIIH
   .   |.  .   ||.|.|...|.|
EIQEICDIMQQLLWQGLHYMHQRNIMH
Kinase 86480.m00094.AA TyrKc 208-428 18 6.8e-12 -30.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-428
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

FEVHKKIGSNEYCEVFCASQKSTGRIVAMMKFLSTKFSNLTFSILKSEIRTLSIL--NHPSLLGFYGFGTD--------NYYAIYREHMPNGNLSELLRN
 .  ||.|. ...||. .  |   . ||  .  . .        . .|.| .. |  .|| .. .||  |.          . |  |.||.|.| . ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NSN-LNTTQLTIIILGISFGLQYLHNNHIIHQNLSSETIYLDSDFYPHIAEIG------SGDSN-------DSIFV----SEKD------------NIS-
. . |.. .|  . . |. | .||| ...||  |    . .....   .. |.       ...        | . .    ..|.            | . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

--------AYGRILWEIITYGSGPEHR----------------EKSSLVIPSI--------ATIKLCKIIRSCQESNPNLRPSLNDILKNRKEL
        ..|  .||| |||  |                   .   . .|          .. .. .|...| . .|. ||. ..|   ....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase 86480.m00094.AA MLK 208-327 21 2.6e-11 35.64 In-house 1-150 (291) Show / Hide 
Range on Protein: 208-327
Range on HMM: 1-150/291
Sequence Identity: 21% (32 aa)

FEVHKKIGSNEYCEVFCASQKSTG---RIVAMMKFLSTKFSNLTFS-----ILKSEIRTLSILNHPS----LLGFYGFGTDN-Y-YAIYREHMPNGNLSE
...|..|||  ...|. .  . .    .|||  .. ...|     .      .. |.| |.||.||        |||  ... . ..|  | ...| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLRNNSN--------------LNTTQLTIIILGISFGLQYLHNNH---IIH
.|.....                  ..  . | .. |..|||..    |||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIH
Kinase 86480.m00094.AA S_TKc 208-430 18 4.6e-11 -14.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-430
Range on HMM: 1-231/231
Sequence Identity: 18% (50 aa)

FEVHKKIGSNEYCEVFCASQKSTGRIVAMMKFLSTKFSNLTFSILKSEIRTLSILNHPSLLGFYGFGTDNYYAIYREHMPN--GNLSELLRNNSN-----
.|...|||.  . .|...  |.|||||| .| ..          ...||. |.  .|| .  .|..  |... .  |....  |.| ......       
YEILRKIGKGAFGKVYKCRHKKTGRIVA-IKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LNTTQLTIIILGISFGLQYLHNNHIIHQNLSSETIYLDSDFYPHIA----------------------EIGSGDSNDSIFVSEKDNISAYGR-------
 ..  .   ..  |  .|.|.|...|||  |  | | ||.    ||                       |.                   ||.       
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQLTTFCGTPWYMAPEVL-----------------GYGKCKCDWWS

---ILWEIIT----YGSGPEHREKSSLVIPSIATIKLCKIIRSCQESNPNLRPSLNDILK----NRKELYL
   ||.| ..    .    .. .   ..     .  .. .|| | . .|. ||.  ..|.     ..  ..
CGCILYEMLCGYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86480.m00094.AA Pkinase 208-327 22 4.8e-11 40.12 Pfam 1-131 (293) Show / Hide 
Range on Protein: 208-327
Range on HMM: 1-131/293
Sequence Identity: 22% (29 aa)

FEVHKKIGSNEYCEVFCASQKSTGRIVAMMKFLSTKFSNLTFSILKS--EIRTLSILNHPSLLGFYGFG-TDNYYAIYREHMPNG----NLSELLR--NN
.....||||  . .|. .  |.||.|||. ..   . .     ..    ||. .  ||||  . .|..  ..... .  |....|     |.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SNL--NTTQLTIIILGISFGLQYLHNNHIIH
 ..     ..  ... |  ||.|.|.. |||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase 86480.m00094.AA Abl 208-330 26 7.2e-09 25.19 In-house 1-123 (252) Show / Hide 
Range on Protein: 208-330
Range on HMM: 1-123/252
Sequence Identity: 26% (33 aa)

FEVHKKIGSNEYCEVFCASQKSTGRIVAMMKFLSTKFSNLTFSILKSEIRTLSILNHPSLLGFYGFGT-DNYYAIYREHMPNGNLSELLRNNSNLNTTQL
  ...|.|   | ||. .  |  . .|| .| |  |  ..       |   .  . || |    |  | .  . |  |.|..||| . ||...  . . .
IMMKHKLGGGQYGEVYEGVWKRHDCTVA-VKTL--KEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAV

TIIILG--ISFGLQYLHNNHIIHQNL
... .   |..|..|| ..| ||  |
VLLYMATQIASGMSYLEKRHFIHRDL
Kinase 86480.m00094.AA TK-Unique 208-332 18 2.8e-08 24.78 In-house 1-161 (294) Show / Hide 
Range on Protein: 208-332
Range on HMM: 1-161/294
Sequence Identity: 18% (30 aa)

FEVHKKIGSNEYCEVFCASQKSTG-----RIVAMMKFLSTKFSNLTFSILKSEIRTLSILN-HPSLLGFYGFGT---DNYYAIYREHMPNGNLSELLRNN
.|| ..||. .. .|. .  ...      ....  | |  ... .. . ...||. .. |  || .. ..|  |   .. . |. |..|.|||  .||..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIM-EYCPCGNLQHYLRTC

S-N-------------------------LNTTQLTIIILGISFGLQYLHN--NHIIHQNLSS
  .                         ..  .|  .. .|  |..||.    .|.| .|..
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCA
Kinase 86480.m00094.AA Pkinase_Tyr 252-327 26 8.1e-08 27.11 Pfam 50-134 (270) Show / Hide 
Range on Protein: 252-327
Range on HMM: 50-134/270
Sequence Identity: 26% (23 aa)

LKSEIRTLSIL-NHPSLLGFYGFGT---DN--YYAIYREHMPNGNLSELLRN----NSNLNTTQLTIIILGISFGLQYLHNNHIIH
. .|..... | .|| .. .||  |   .   .| .  |.||.|.| . ||.    . .|.. .|  . . |. |..||.....||
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVM-EYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase 86480.m00094.AA TKL-Unique 402-425 29 0.000662 9.87 In-house 267-290 (290) Show / Hide 
Range on Protein: 402-425
Range on HMM: 267-290/290
Sequence Identity: 29% (7 aa)

KIIRSCQESNPNLRPSLNDILKNR
..|. |  ..|  |||...|..  
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase 86480.m00094.AA Abl 360-382 52 0.001366 7.29 In-house 176-198 (252) Show / Hide 
Range on Protein: 360-382
Range on HMM: 176-198/252
Sequence Identity: 52% (12 aa)

SEKDNISAYGRILWEIITYGSGP
| |  . |.| .|||| |||  |
SSKSDVWAFGVLLWEIATYGMSP
Kinase 86480.m00094.AA TKL 367-425 21 0.005452 6.62 In-house 274-364 (364) Show / Hide 
Range on Protein: 367-425
Range on HMM: 274-364/364
Sequence Identity: 21% (20 aa)

AYGRILWEIIT----YGSGPEH----------------REKSSLVIPSI----------ATI--KLCKIIRSCQESNPNLRPSLNDILKNR
..| .||||.|    |   |.                  ..  . ||.|           ..   ..|..  | ...|. ||| ..|||  
SFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 86480.m00094.AA TK 367-425 12 0.006062 4.85 In-house 379-486 (486) Show / Hide 
Range on Protein: 367-425
Range on HMM: 379-486/486
Sequence Identity: 12% (14 aa)

AYGRILWEIITYGSGPEHREKSS---------------------------------LVIP--SIAT--------------IKLCKIIRSCQESNPNLRPS
..|  .||| ||| .| . . |.                                 .  |    ..                .  ....| . .|. ||.
SFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPT

LNDILKNR
  ....  
FSQLHEQL
Kinase 86480.m00094.AA TK-Unique 360-382 34 0.008958 5.54 In-house 217-239 (294) Show / Hide 
Range on Protein: 360-382
Range on HMM: 217-239/294
Sequence Identity: 34% (8 aa)

SEKDNISAYGRILWEIITYGSGP
..| .. ..| ..||| |.|. |
TTKSDVWSFGVLMWEIFTLGACP
Kinase 86480.m00094.AA Ciliate-E2-Unclassified 394-423 22 0.152242 1.15 In-house 318-348 (352) Show / Hide 
Range on Protein: 394-423
Range on HMM: 318-348/352
Sequence Identity: 22% (7 aa)

SIATIKLCK-IIRSCQESNPNLRPSLNDILK
|   . ... ..... . ||| |.....||.
SPEAKDFINDLLQKMLKKNPNKRITFEQILN