Gene 83695.m00113 (T.vaginalis)

83695.m00113

Species: T.vaginalis
Alias: 83695.m00113, TvagK0455
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
83695.m00113.AA Protein None 294 None Fasta, JSON
83695.m00113.kin_dom Protein Kinase Domain None 207 None Fasta, JSON

Protein domain

Protein domains of 83695.m00113.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83695.m00113.AA CK1 9-262 25 3.8e-80 272.57 In-house 1-339 (339) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-339/339
Sequence Identity: 25% (85 aa)

FEVIKKLGQGSFG-EIFLG-----KNKNDG-----TSVAIKIEPKKSPKKV--LNNDITFLTKAKDQ--------------------KYIPKFYASGSDD
..|.||.|.|.|| .|...     |.....     . .|.|.||||| ...  |  .. .. | ...                    ....... .| .|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

DYT-WLAMEYLGPSLEHIIN--KLPNKKLSKKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLLRH--------------SREAPIALIDYGLSK-VYY
||  .. |. |||.|| . .  ...|.|.|.|..|  |  .|.|.| .|.  .|||||||.|...                ...  . .||.|...  | 
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DE-----------RAKMHLPPKP---HCGFFG-SLLYASPNTHMRRDLARRDDMFSWFYVLADLLTDN--LPWRDNKNPQE-----VLNIKAKYDVAPLI
|            . ..| ||..   ..|| |  . |.|.|.| .... ||||. ||||.|...|  .  |||.. | . .     |   | ..   .. 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

EMVP-------------QIEEIYKQIINMQYVSKPDYEGF
 . .             .  .|.| | ...| ..|||| .
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 83695.m00113.AA TTBKL 9-266 24 3.1e-64 215.76 In-house 1-288 (288) Show / Hide 
Range on Protein: 9-266
Range on HMM: 1-288/288
Sequence Identity: 24% (72 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKS-PK--KVLNNDITFLTKAK--DQKYIPKFYASGSDDDYTWLAMEYLGPSLEHIINKLPNKK-LS
....|..|.| ||.........| ...|...|.|..  .  ...   .  |.|    .....||...||  .||....|. .||.|  . ...|||| .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

KKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLLRHS-----REAPIALIDYGLSKVYYDERA----------KMHLPPKP---HCGFFGSLLYASPNT
.  .. ..  .|||.  .|.  .||||.||.|. .  .     |.  . |||.|... | .. .          .|. .|..   ...| |.. |.||| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HMRRDLARRDDMFSWFYVLADLLTDNLPWRDNKNPQEVLNIKAKYDVAPLIE-------MVPQIEEIYKQIINMQYVSKPDYEGFRKLL
|.|... | ||..||.|... |.   |||.. ... |.   | .     |         . .. ....| . ...| . |||| .....
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 83695.m00113.AA CK1-Unclassified 9-203 36 2.4e-53 155.83 In-house 1-206 (244) Show / Hide 
Range on Protein: 9-203
Range on HMM: 1-206/244
Sequence Identity: 36% (76 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLNNDITFLTKAKDQK-------YIPKFYASGSDDD--YTWLAMEYLGPSLEHIINKLPNK
..||.|.||||||||....|..... ||||.| |.|  . |   . ...  .. .       .||| | .| ...  |  . |..|||||| . |.  |.
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR

KLSKKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLL--RHSREAPIALIDYGLSKVYYDE-RAKMHLPPKPHCGFFGSLLYASPNTHMRRDLARRDDM
|.| |  |  |  ..  || .|. ..||||||| | |   .  .   . .||.|||| |.|  . . | | .   .. |   ||| |.|      ||||.
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

FSWFYVL
 |  |||
ESLGYVL
Kinase 83695.m00113.AA TTBK 9-262 32 4.5e-48 166.02 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-257/257
Sequence Identity: 32% (83 aa)

FEVIKKLGQGSFGEIFLGKNKNDG-TSVAIKIEPKKSPKKVLNNDITFLTKAKDQKYIPKFYASGSDDDYTWLAMEYLGPSLEHIINKLPNKKLSKKCAL
  |.|| |.| ||||. .|.       ||||.|  . || ||   .  | |   .... .|.  | .|.. .. |. .| .|     | |  . |   .|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

TMAKYILYAIEAVHELSYIHRDIKPGN--VLLRHSREAPIALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHMRRDLARRDDMFSWFYVLAD
 . . || .||..|.. . |||||| |  . .  |.   . ..|.||   |         || .  || |   ||| | |  |.. |.||. | ||.|  
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVR-PPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LLTDNLPWRDNKNPQEVLNIKAKYDVAPLIEMVP-QIEEIYKQIINMQYVSKPDYEGF
 .   ||||  |   .| ..| |||   |.. .| ...   . |  ..|  .|||  .
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 83695.m00113.AA CK1 9-196 38 5.5e-46 156.32 In-house 1-199 (271) Show / Hide 
Range on Protein: 9-196
Range on HMM: 1-199/271
Sequence Identity: 38% (76 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTS--VAIKIEPKKSPKKVLNNDITFLTKAKD------QKYIPKFYASGSD--DDYTWLAMEYLGPSLEHIINKLPN
..|..|.||||||.|.||.| ..|    ||||.|..||    |.  . ...  ..       ..||. | .| .   ||  . |..||||||   |.  |
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC-N

KKLSKKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLL-R-HSREAPIALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHMRRDLARRDDM
.|.| |  |  |  ..  || ||. ..||||||| | |  |   ..  . .||.||.| |.| . . | | . . .. |   ||| |||. .   |||||
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM
Kinase 83695.m00113.AA CK1-A 9-213 37 2.4e-42 147.0 In-house 1-205 (261) Show / Hide 
Range on Protein: 9-213
Range on HMM: 1-205/261
Sequence Identity: 37% (77 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLNNDITFLTKAKDQKYIPKFYASGSDDDYTWLAMEYLGPSLEHIINKLPNKKLSKKCALT
. ...|.| ||||.|.|| | ..|  ||||.| .|     |. .    .  .    ||.    |.. ||  . |. |||||| . | . ... . |  | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

MAKYILYAIEAVHELSYIHRDIKPGNVLLRHSREA-PIALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHMRRDLARRDDMFSWFYVLADLL
.|  ..  || ||| ..||||||| | |.   |    . |||.||.| | |.|.. |.| .      |   ||| | |.  . .||||| |  ||.    
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

TDNLPW
   |||
RGKLPW
Kinase 83695.m00113.AA CK1-D 9-213 36 6.7e-40 138.41 In-house 1-205 (261) Show / Hide 
Range on Protein: 9-213
Range on HMM: 1-205/261
Sequence Identity: 36% (75 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLNNDITFLTKAKDQKYIPKFYASGSDDDYTWLAMEYLGPSLEHIINKLPNKKLSKKCALT
. . .|.| ||||.|..|.| . .  ||||.|. |.    |. .  |    .    ||.    |.. ||  . |. |||||| . |   ..| | |  | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFN-YCHRKFSLKTVLM

MAKYILYAIEAVHELSYIHRDIKPGNVLLRHSREAP-IALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHMRRDLARRDDMFSWFYVLADLL
.|  ..  || .|  ..||||||| | |.   .    . .||.||.| | | |.. |.| . .    |   ||| |||.  . .||||. |  |||    
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

TDNLPW
   |||
RGSLPW
Kinase 83695.m00113.AA CK1-G 9-196 38 1.6e-35 117.83 In-house 1-191 (266) Show / Hide 
Range on Protein: 9-196
Range on HMM: 1-191/266
Sequence Identity: 38% (73 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLNNDITFLTKAKDQK-YIPKFYASGSDDDYTWLAMEYLGPSLEHIINKLPNKKLSKKCAL
. | || | |.|||.|.|||   .  ||||.|| ||    |     |      .   ||. |  |    |  . |. ||||||   . . . | | |  .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

TMAKYILYAIEAVHELSYIHRDIKPGNVLL-RHSREAP--IALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHMRRDLARRDDM
 .|. ..  .|.||. . | ||.|| | |  | | . .  | .||.|. | | | . | | |   |    |   | | |||. |   |||||
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM
Kinase 83695.m00113.AA Worm6 9-134 29 8.9e-29 100.48 In-house 1-134 (279) Show / Hide 
Range on Protein: 9-134
Range on HMM: 1-134/279
Sequence Identity: 29% (40 aa)

FEVIKKLGQGSFGEIFLGKNKNDGT--SVAIKIEP--KKSPKKVLNNDITFLTKAKDQK--YIPKFYASGSDDD--YTWLAMEYLGPSLEHIINKLPNKK
..| ||.|.|.|| ... ..| |..   .|.| |   .......|  ..  |...| .|  . .|.   |  |   . .. |. .|..|. ..  .|..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSKKCALTMAKYILYAIEAVHELSYIHRDIKPGN
.|  ..|  |   | ||| .|   .||||.||||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGN
Kinase 83695.m00113.AA Ciliate-E2 9-154 24 1.7e-27 91.45 In-house 1-204 (365) Show / Hide 
Range on Protein: 9-154
Range on HMM: 1-204/365
Sequence Identity: 24% (51 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIK--------------IEPKKSPKKVLNNDITFLTKAKDQKY-----------------------IPKFYAS
...|||.|||.|| ....|.....  .|||                 |.  .|.....  . .| ... .                       | |.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GS--DDDYTWLAMEYL-GPSLEHIINKLPNKKLSK---------KCALTMAKYILY---------------AIEAVHELS-YIHRDIKPGNVLLRHSREA
    ||..  | |||. | .|...|.. . |....         | .... |.||.               |.|  |.    ||||||| |.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PIALIDYGLSK
 | .|| ||||
-IKIIDFGLSK
Kinase 83695.m00113.AA Pkinase 9-224 21 2.7e-26 94.06 Pfam 1-228 (293) Show / Hide 
Range on Protein: 9-224
Range on HMM: 1-228/293
Sequence Identity: 21% (51 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLN------NDITFLTKAKDQKYIPKFYASGSDDDYTWLAMEYLGP-----SLEHIINKLP
.....|.|.||||. .....|..|  ||.|| .|.. |.  .      . |  . .  . ..| ..| .  |.|. .. |||..      .| ..|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NKKL--SKKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLLRHSREAP---IALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHM-RRDLA
....  | . .  ... || ..|  |. . ||||.|| |.|.  ..  .   . ..| ||.|...      . .     .| |.. |..|  .. ...  
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RRDDMFSWFYVLADLLTDNLPWRDNK------NPQEVLN
.. ||.|   .|. .|. ..|.. ..      .......
PKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMIC
Kinase 83695.m00113.AA S_TKc 9-254 21 3.7e-26 94.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-254
Range on HMM: 1-231/231
Sequence Identity: 21% (57 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLNNDITFLTKAKDQKYIPKFYASGSDDDYTWLAMEYLGP---SLEHIINKLPNKK----L
.|...|.|.|.||. .....|..|  ||||| .     . . . |  | |  . ..| |.| .  | |. .. |||..    .| ..| | . ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SKKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLLRHSREAPIALIDYGLSKVYYDERAKMHLPPKPHCGFFGSLLYASPNTHMRRDLAR-RDDMFSWF
.   |  ... |. |.|  |..  ||||.|| |.|| .     | ..| ||....                | |.. | .|         . . |. |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

YVLADLLTDNLPWRDNKNPQEVLNIKAKYDVAPLIEMVPQIEEI----YKQIIN-------MQYV
 .|. .|.   |..   ..|.....    ..  .|.   | .        .. .       ....
CILYEMLCGYPPFP---QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83695.m00113.AA Worm6 147-262 25 2e-20 70.2 In-house 153-279 (279) Show / Hide 
Range on Protein: 147-262
Range on HMM: 153-279/279
Sequence Identity: 25% (32 aa)

LIDYGLSK-VYYDERAKMHLPPK-PHCGFFGSLLYASPNTHMRRDLARRDDMFSWFYVLADLLTDNLPWRDNKNPQEVL-NIKAKYDVAP------LIEM
..|.|...  .|... .   .|. ..||| | . ||. . | .... |.||. ||||....... .||||  | ...|  . |....         . . 
MLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGP

VP--QIEEIYKQIINMQYVSKPDYEGF
.|  . ..| . | ...| ..|||.  
CPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 83695.m00113.AA TyrKc 9-207 16 5.9e-08 -93.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-207
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

FEVIKKLGQGSFGEIFLGKNKNDGTSVAIKIEPKKSPKKVLNNDITFLTKA-KDQKYIPKFYASGSDD-------DYTWLAMEYLGP-SLEHIINKLPNK
 . .|||| | |||...|. |   . ||.|   . . .. . . .  ..|  .. . | ..|.  ...       .  .. |||    .| . . |  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KLSKKCALTMAKYILYAIEAVHELSYIHRDIKPGNVLLRHSREAPIALIDYGLSKVYYDE----------------RAK---------------------
 |. |  | ..  |    |  |.  .||||.   |.|. . . . |.  | |||.  ||.                 .|                     
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS--DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

-------------MHLPPKPHCG-----FFGSLLYASPNTHMRRDLARR----------DDMFS--------------WFYVLADLL
             . .  .|. |        . ...   . .|..              |.|..               |  . ...
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 83695.m00113.AA Pkinase_Tyr 9-39 40 7.5e-07 23.82 Pfam 1-35 (270) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-35/270
Sequence Identity: 40% (14 aa)

FEVIKKLGQGSFGEIFLGKNK----NDGTSVAIKI
 . .||||.|.|||...|. |    |... ||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKM