Gene 93293.m00055 (T.vaginalis)

93293.m00055

Species: T.vaginalis
Alias: 93293.m00055, TvagK0326
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
93293.m00055.AA Protein None 820 None Fasta, JSON
93293.m00055.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of 93293.m00055.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93293.m00055.AA TKL 28-280 23 4e-80 272.49 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-280
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGAGAFGEVFLATHINTQ--------KKRAIKKLYTKELKGQDL-------------------------KLFVREAEILAVCKNKFLLPFFGCTLKYP--
|| |.||||. ... ..         |  |.||. ... .  ..                         . ...|. ..  ..   ...| |. .  |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FSIITEYIPCGTLFNAINHKEGSPDLSATNKSIIAYGIARGLQYLHEHN--------IIHRDIKSRNILLRDNLY-------------
            . |..||.|.|.|.. ..            .  .|..||||..||| .|        |||||.||.|||. .|.              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PVICDFGLSRRVYEIEQPNPNSTMTR--------------DVGTPHYMSPELIFNR----------------PYTNKIDVYAYAIILWEMLKETTPYK-
 . ||||||||.. . .. | ..|...               .||| .|.||.. .                 .|. |.|||...|.|||.|   .||. 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

-GMSDIQIA-------YAVTQKDERPEFP------------KIIQPGLKSLISRCWDKDPDKRPTFKEIVREF
 ........       . | .| .||. |            . . |..|.|. .||| ||.|||.|.||. ..
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 93293.m00055.AA MLK 22-280 28 8.6e-69 234.86 In-house 1-291 (291) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-291/291
Sequence Identity: 28% (85 aa)

FKIGDSIGAGAFGEVFLATHINTQ---KKRAIKKLY----TKELKGQDLKLFVREAEILAVCKNKF----LLPFFGCTLKY-P-FSIITEYIPCGTLFNA
...   ||.|.||.|....  |.    |  |.|.       |  ..   . | .|...|.. . .       .| |. |.. . | |..||...| |.| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

INHKEGSPD-----------LSATNKSIIAYGIARGLQYLHEHN---IIHRDIKSRNILLRD------NLYPVICDFGLSRRVYEIEQPNPNSTMTRDVG
.. ... ..            .   .  .|. .|||..|||..    |||||.||.|||. .      ..  .|||||.|| ......     .|.   |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCT-----NMMSNAG

TPHYMSPELI---FNRPYTNKIDVYAYAIILWEMLKETTPYK-GMSDIQIAYAVTQKDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVREF
|. .|.|| |    . .|. | ||. ....|||||   .||| ... ..||. |... .||  |. . ...|.|...||. || |||.|..|| ..
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 93293.m00055.AA Pkinase 22-280 28 1.4e-66 232.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

FKIGDSIGAGAFGEVFLATHINTQKKRAIKKLYTKELKGQDLKLFVR--EAEILAVCKNKFLLPFFGCTL-KYPFSIITEYIPCG----TLFNAIN---H
..||  ||.|.||.|....|..|.|. |.|..  .. | . ..  .|  |..|.. .. .. . ....   |    ...|| ..|     ||  |    |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KEG--SPDLSATNKSIIAYGIARGLQYLHEHNIIHRDIKSRNILLRDNLYP----VICDFGLSRRVYEIEQPNPNSTMTRDVGTPHYMSPELIF-NRPYT
.    |..        ..| |.|||.|.|...|||||.|. |||. .| ..     ||||||.. ..      .|| ||  .|||.||.||.|  ...|.
GCFYFSEWECKF----YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

NKIDVYAYAIILWEMLKETTPYKGM------SDIQIAYAVTQKDERPEFPKIIQ-------------------PGLKSLISRCWDKDPDKRPTFKEIVRE
 |.|.... .||.|||   .|..|       ...|. . . ... . ..|. .                    . .|..|..|..||| ||||...|.  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
  |
PWF
Kinase 93293.m00055.AA S_TKc 22-281 27 1.4e-65 225.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

FKIGDSIGAGAFGEVFLATHINTQKKRAIKKLYTKELKGQDLKLFVREAEILAVCKNKFLLPFFGCTLKYPFSIITEYIPC--GTLFNAINHKEGSPD--
..|.. || ||||.|....|..|... |||..          . . || .||   . ...  ....     . ...||..   |.||  | .. . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSATNKSIIAYGIARGLQYLHEHNIIHRDIKSRNILLRDNLYPVICDFGLSRRVYEIEQPNPNSTMTRDVGTPHYMSPELIFNRPYTN-KIDVYAYAII
 ..      ..| |...|.|.|.|.|||||.|  |||| .     ||||||.|..            |  .|||.||.||..   .|.  |.|...  .|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LWEMLKETTPYKGMSDIQIAYAVTQKDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVR--------EFK
|.|||   .|.    ..|  . .              | .|..|..|..|||.||||  |. .        .. 
LYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93293.m00055.AA Dicty4 22-282 34 1.9e-61 203.73 In-house 1-277 (277) Show / Hide 
Range on Protein: 22-282
Range on HMM: 1-277/277
Sequence Identity: 34% (96 aa)

FKIGDSIGAGAFGEVFLATHINTQKKRAIKKL-YTKE-LKGQDLKLFVREAEILAVCKNKFLLPFFG-CT----LKYPFSIITEYIPCGTLFNAINH---
 .|.. || |.||||...|    .|. |.|||  ... .    |. | .|..|..   .  .. | | ||     .  ..| ||| | |.|.. ..    
INIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---KEGSPDLSATNK-SIIAYGIARGLQYLHEHN--IIHRDIKSRNILLRDNLYPVICDFGLSRRVYEIEQPNP-NSTMTRDVGTPHYMSPELIFNRPYT
   .. ..|..   .   .|  .|||...||. |  |||||.|| |.|  .|.   .||||||..  ..|. .   .|.   .||| .|.||   ..||.
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA---CGTPCWMAPEVMMHQPYN

NKIDVYAYAIILWEMLKETTPYK--GMSDIQIAYAVTQKDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVRE--FKD
 | ||| ..|.|||.|    ||   .|.  |.. || .| .||. |.   | .|.|| .|||.|| .||.|.||. .     
EKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 93293.m00055.AA TKL-Unique 24-280 27 9.6e-60 204.8 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-280
Range on HMM: 1-290/290
Sequence Identity: 27% (80 aa)

IGDSIGAGAFGEVFLATHINTQKKRAIKKLYTKELKGQDLKL-FVREAEILAVCK-NKFLLPFFGCTLK---YPF--SIITEYIPCGTLFNAINH-----
.. .||.|..|.|. ...  ...  |||..  .|..  ...  | .|  .. . .  .... ..| . .   ||   .|..||.| |.| . ..      
FWNKIGEGGYGQVYKGKWRGYPV--AIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KEGSPDLSATNKSIIAYGIARGLQYLHEHN--IIHRDIKSRNILLRDNL----YPV-ICDFGLSRRVYEI-EQPNPNST---MTRDVGTPHYMSPEL
   .. .. |.  ..  .|  ||.|. |||  .  |||||.||.|.|.  |.    . . |||||||.    | . .| ...    .  .|.. .|.||.
NNNNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

IFN--RPYTNKIDVYAYAIILWEMLKETT------PYKGMSDIQIAYAVTQ--KDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVREF
. .    |..|.|||...|.|||..  .       ||.||...|.. .|..  .  ||. |  . . .. || .||. ||..||.| ||. . 
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 93293.m00055.AA Dicty5 90-284 38 2.4e-59 202.9 In-house 72-260 (260) Show / Hide 
Range on Protein: 90-284
Range on HMM: 72-260/260
Sequence Identity: 38% (76 aa)

KYPFSIITEYIPCGTLFNAINHKEG--SPDLSATNKSIIAYGIARGLQYLHEHNIIHRDIKSRNILLRDNLYPVICDFGLSRRVYEIEQPNPNSTMTRDV
|||| ..|||.  |.|||. | ..      ..   .  .| .||.....||  ||||||.|| |.|.  |.   | ||| || |    .      || .|
KYPF-HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYH------MTMHV

GTPHYMSPELIFNRPYTNKIDVYAYAIILWEMLKETTPYKGMSDIQIAYAVTQKDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVREFKDGK
||. .|..||   .||..| |||...|.||||.   .||. .  . |.  | .| |||. || ..     ||  ||   | .||.||||.  |.   
GTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMV-MKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 93293.m00055.AA STE 22-281 21 7.3e-59 201.87 In-house 1-359 (359) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

FKIGDSIGAGAFGEVFLATHIN---------------TQKKRAIKKLYTKELK---------------GQDLKLFVREAEILAVCK--NKFLLPFFGCTL
... . || ||||.|..| ...               |..  |||..  .. .                .... . .| .|.  |.   ..   ..|| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KYP--------FSIITEYIPCGTLFNAINHKEGSPD-----------LSATNKSIIAYGIARG-LQYLHEHNIIHRDIKSRNILLRDNLYPVICDFGLSR
|            |. ||.. |.|   |.|| | ..           .. .  ..|.. | .| |.|||.|.|||||||. ||||       .||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RVYEI--EQPNPN-----------STMTRDVGTPHYMSPELIFN------RPYTNKIDVYAYAIILWEMLKETTPYKGMSDIQIAYAVTQK---------
.. ..  .. . .           .  . .|||| .|.|| | .       .|. | |..   . ..||.    |.  |.. .  .. ...         
QLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----DERPEFPKIIQ-------------------PGLKSLISRCWDKDPDKRPTFKEIVR---EFK
     .. | .|  ..                   | .|  |..| .|||.|||| ..  .   .| 
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 93293.m00055.AA TK 22-280 15 1.3e-52 174.34 In-house 1-486 (486) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-486/486
Sequence Identity: 15% (74 aa)

FKIGDSIGAGAFG---EVFLATHINTQK-------------------------KRAIKKLYTK-ELKGQDLKL-----------FVREAEILAVCK----
 ..|. .|.|.||   ||.... ..  .                         . |.| |  . .   .. ..           | .|||.... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NKFLLPFFG-CTLK------------YPFSIITEYIPCGT----LFNAINHKEG---------------------------------------------
  . .. ..| || .             |. |..|| |.|     | .    . .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------SPDLSATNKSI-------------------IAYGIARGLQYLHEH------NIIHRDIKSRNILLRDNLY-----------PVICDFGLSRR
        .|.|. .                       ... ||.|..|||..      |..|||.  ||.|. .|.              |.|||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----VYEIEQPNPNSTMTRDVGTPH-------------------------YMSPELIF---------NRPYTNKIDVYAYAIILWEMLK--ETTPYKGMS
         ... . . ... ||.                          .|.|| ..         .. .| | ||... . .||..   ....| |||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

D--------IQIAYAVTQKD--------------ERPEFPKIIQ--------------PGLKSLISRCWDKDPDKRPTFKEIVREF
.         |  .   ..                |.. |.                 . .  |. .||..||..||||.......
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 93293.m00055.AA HH498 22-280 27 2.9e-52 163.78 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-284/284
Sequence Identity: 27% (81 aa)

FKIGDSIGAGAFGEVFLATHINTQKKRAIKKLYTKE-LKGQD-----LKLFVREAEILAVCKNKFLLPFFGCTLKYP--FSIITEYIPCGTLFNAI----
..   .||.|.||.|.. .  |  |  |.|    .  .   |        |.||. |.    .     | . ..  |  | |.|.|.  | ||       
IEFHEKIGSGSFGKVYKGEWRN--KIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

---------NHKEG--SPDLSATNKSIIAYGIARGLQYLHE---HNIIHRDIKSRNILLRDNLYPVICDFGLSRRVYEIEQPNPNSTMTRDVGTPHYMSP
         || .      ..   | .|.  .|.| .|||.   | |||||  | |||.  .   |. ||| || | ...      .||   | . .|.|
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMH----DDNMTKQPGNLRWMAP

ELIF-NRPYTNKIDVYAYAIILWEMLKETTPYKGMSDIQIAYAVTQKDERPEFPKI----IQPGLKSLISRCWDKDPDKRPTFKEIVREF
|    .  |. |.||. ||...|||.    |.     .  |  .. .  ||  |      |     .|| .||.  |. ||.| .||.  
EVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 93293.m00055.AA Pkinase_Tyr 22-280 29 6.7e-52 176.39 Pfam 1-270 (270) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-270/270
Sequence Identity: 29% (81 aa)

FKIGDSIGAGAFGEVFLATHI----NTQKKRAIKKLYTKELKGQD---LKLFVREAEILAVC-KNKFLLPFFGCTL--KYP--FSIITEYIPCGTLFNAI
 ..|  .|.||||||...|      ||. . |.|.|  ||   ..   .. | |||.|.    ... .. . |. .  . |    |..|| |.| | .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

NHK-EGSPDLSATNKSIIAYGIARGLQYLHEHNIIHRDIKSRNILLRDNLYPVICDFGLSRRVYEIEQPNPNSTMTRDVGTPHYMSPELIFNRPYTNKID
  . |. . |.   .  ... ||.|..||...|.||||.  ||.|. .|.   ||||||.| .|. ..    ..   .      |.|| |... .| | |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGKFTTKSD

VYAYAIILWEMLK-ETTP-YKGMSDIQIAYAVTQKDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVREF
|... . .||..    .| |.|||. ..  ..... .| . |.   . . .|. .||..||..||||.||....
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 93293.m00055.AA Dicty4-Unclassified 22-280 33 3e-50 170.27 In-house 1-263 (263) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-263/263
Sequence Identity: 33% (90 aa)

FKIGDSIGAGAFGEVFLATHINTQKKRAIKKLYTKELKGQ--DLKLFVREAEILAVCKNKFLLPFFGCTLKYP------FSIITEYIPCGTLFNAIN---
 .|   || |.| .|     .   |  |.||.     |     .. | .| |||       |.   |  .  |      . |..| .. |.||  |.   
IQIDQFIGKGHFSKVHKG--NWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN-PRSHKSTMCIVMEFMHKGNLFEVIHSKP

-HKEGSPDLSATNKSIIAYGIARGLQYLHEHNIIHRDIKSRNILLRDNLYPVICDFGLSRRVYEIEQPNPNSTMTRDVGTPHYMSPELIFNRPYTNKIDV
  .. .  |  |    .|  ||.|.|.||  |.||||||| |||.  .    | |||.||   .|.    | .||   |||   |||      |. | ||
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISR---VIDF---NFNMTTIAGTPKWESPECLMHESYNQKSDV

YAYAIILWEMLKETTPYKGMS-DIQIAYAVTQKDERPEFPKIIQPGLKSLISRCWDKDPDKRPTFKEIVREF
| ||..|.|..    || .    . .|  |  |  ||. |  . . .|.||  ||  || ||||. .|.   
YSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 93293.m00055.AA TyrKc 22-280 27 1.3e-49 172.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-280/280
Sequence Identity: 27% (79 aa)

FKIGDSIGAGAFGEVFLATHINTQKKRAIKKLYTKELKGQDLKLFVREAEILAVC--KNKFLLPFFGCTLK--------YPFSIITEYIPCGTLFNAI-N
 . |. .| ||||||...| .    . |.|.|         .. | |||.|.     ... .. ..|. ..         |  |..|| | | | . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HKEGSPDLSATNKSIIAYGIARGLQYLHEHNIIHRDIKSRNILLRDNLYPVICDFGLSRRVYEI------EQPNPNST--MTRDVGTPHYMSPELIFNRP
|..    |.   .  ... ||.| .|||..|.||||.  ||.|. .|.   |.|||||| .|.       ..    ..   ....     |.|| |. . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTNKIDVYAYAIILWEML-KETTPYKG-----MSDIQIAYAVTQKDERPEFPKI--------IQPGLKSLISRCWDKDPDKRPTFKEIVREF
.| | ||... . .||..    .|| |     ||....   | .. .|.. |.           . . .....||. ||..||||.||...|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 93293.m00055.AA LRRK 92-282 31 2.8e-43 150.1 In-house 129-351 (351) Show / Hide 
Range on Protein: 92-282
Range on HMM: 129-351/351
Sequence Identity: 31% (72 aa)

PFSIITEYIPCGTLFNAINHKEGSP------DLSATNKSIIAYGIARGLQYLHEHN--IIHRDIKSRNILL-RD----------NLYPV-ICDFGLSRRV
|. ...||.|.|.|   . .|. ..      ..| . |  ||. ||.|..||| ||  ||||| || |||| .           . . . |.|||.|| .
PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-M

YEIEQPNPNSTMTRDVGTPHYMSPELIFNR---PYTNKIDVYAYAIILWEMLKET-TPYKGMS-------DIQIAYAVTQKDERPEFPKI-IQP-----G
.   |. ...   . ||.| .|.|| . .     || |.|.|....|||| |  .  |. ...        .||  ... .  || .|     |      
F---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKII-EGLRPTIPQHYCPPCQPWHM

LKSLISRCWDKDPDKRPTFKEIVREFKD
...||  ||. ||.|||.| .||   ..
YQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 93293.m00055.AA LRRK 22-53 22 0.000292 10.96 In-house 1-59 (351) Show / Hide 
Range on Protein: 22-53
Range on HMM: 1-59/351
Sequence Identity: 22% (13 aa)

FKIGDSIGAGAFG-EVFLATHIN-----------------------TQKKR---AIKKL
.||. .|| |.|| .|. |. ..                       .  ..   ||||.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW