Gene 87414.m00283 (T.vaginalis)

87414.m00283

Species: T.vaginalis
Alias: 87414.m00283, TvagK0298
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
87414.m00283.AA Protein None 1030 None Fasta, JSON
87414.m00283.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 87414.m00283.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87414.m00283.AA TKL 28-275 25 2.5e-82 279.82 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-275
Range on HMM: 1-364/364
Sequence Identity: 25% (97 aa)

VGKGATCEVYQAHHLA--------TGAVCAVKKFLSET-------------------------FTAAEIHNFYREIKILSRARNYFLIPFYGISFSSP--
.|.|. .|||....          || . ||||| |.                          ..  .   . .||...|| |   ...|.|.....|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YIIAMKYIKRGS-LHSAIFHKEGAPQLTPTNKTIIAFCIASGMQYLHEHD--------VIHRDLKSLNVLLDGKLY------------
            . | | |...|| ||  .          .  .  .|  ||.||.||| ..        .||||||| |.|.| ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PHICDFGISRVKSDSDQ-------------------LMTKMIGTPHWMAPEVFSSN----------------DYTNKVDIYSFAILLWELISEERPYK
  . |||||.||..| | .                      . .||| ||||||.  .                .|. |.|.|||.|.|||... .|||.
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

GYSAPQLI---------AAVCTKNERPPIP------------KKCTTKLKNLLTQCWHKNPKLRPTFADIMDTI
.|  .. |         . || |..|||||            . | . .|.|...||. .|. ||.| .|....
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 87414.m00283.AA MLK 22-275 28 4e-73 249.23 In-house 1-291 (291) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-291/291
Sequence Identity: 28% (82 aa)

FKILSTVGKGATCEVYQAHHLATG---AVCAVKKFLSETFTAAEI-----HNFYREIKILSRARNYF----LIPFYGISFSS-P-YIIAMKYIKRGSLHS
....  .|.|. ..|. .   ..     . |||.. ...| .. .      .| .|...|.. .        |.|||.. .. . . | | |.  |||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

AIFHKEGAPQ-----------LTPTNKTIIAFCIASGMQYLHEHD---VIHRDLKSLNVLLD------GKLYPHICDFGISRVKSDSDQLMTKMIGTPHW
 .  ... .             ..  .  .|. .|.||.|||...   .||||||| |.|.|      ...   |||||.|| ...... |....||. |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

MAPEVF---SSNDYTNKVDIYSFAILLWELISEERPYK-GYSAPQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDTI
|||||.    .. |. |.|..|....|||... | ||| .|.. . .. |  ...|||||. |   .|.|..|||. .|. ||.|. |.   
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 87414.m00283.AA TKL-Unique 24-275 28 4.1e-70 239.23 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-275
Range on HMM: 1-290/290
Sequence Identity: 28% (84 aa)

ILSTVGKGATCEVYQAHHLATGAVCAVKKFL-SETFTAAEIHNFYREIKILSRAR-NYFLIPFYGISF----SSP-YIIAMKYIKRGSLHSAIFH-----
.....| |. ..||.. .   |   |.|.|   | .   .. .|..|...... .   ..  ..|...    . | ..| | |. .|||.. .       
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KEGAPQLTPTNKTIIAFCIASGMQYLHEHD--VIHRDLKSLNVLLDGK-----LYPHICDFGISRVKSDSDQLMTKMI---------GTPHWMAPEV
   ..  . |.. ..  .| .||.|| |||  .  .|||||||.|.|.| .     .   |||||.|...| ...  ....         |.. ||||||
NNNNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

FSS--NDYTNKVDIYSFAILLWELISEER------PYKGYSAPQLIAAVCT--KNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDTI
...  ..|..|.|.|||.| |||... ..      ||.|..  |....| .  .| |||||  |   ...|..|||| .|  ||.| .|   .
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 87414.m00283.AA Dicty4 22-278 33 2.9e-63 209.91 In-house 1-277 (277) Show / Hide 
Range on Protein: 22-278
Range on HMM: 1-277/277
Sequence Identity: 33% (93 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKF--LSETFTAAEIHNFYREIKILSRARNYFLIPFYGISF---SSP--YIIAMKYIKRGSLHSAIFH---
 .| .  |||.  ||| .     |   ||||.  . ..| ....  | .|..|..  |.  .. |.| .    | |    | . |  .|.|.| .     
INIEQRIGKGSFGEVYKGT--WRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---KEGAPQLTPTNK-TIIAFCIASGMQYLHE--HDVIHRDLKSLNVLLDGKLYPHICDFGISR----VKSDSDQLMTKMIGTPHWMAPEVFSSNDYTNK
   ..  ....   .   .|| .| ||..||.   ..||||||| | | |  .   .||||.|.    ... .| .|| ..||| ||||||  .. |. |
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQPYNEK

VDIYSFAILLWELISEERPYK--GYSAPQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDT-IRNG
.| |||.|.|||.   . ||   . . .|...||| | .|||||. | ...| |.. ||...|. ||.|. |    | . 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 87414.m00283.AA Pkinase_Tyr 22-275 29 1.5e-58 198.88 Pfam 1-270 (270) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-270/270
Sequence Identity: 29% (80 aa)

FKILSTVGKGATCEVYQAHHL----ATGAVCAVKKFLSETFTAAE--IHNFYREIKILSRA-RNYFLIPFYGISF--SSP--YIIAMKYIKRGSLHSAIF
 ... . |.||  |||...       |.  .|||.   |. .  .  .  | ||.||..   ..  .. .||.    . |  ..| | | . |.|..   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HK-EGAPQLTPTNKTIIAFCIASGMQYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISRVK--SDSD-QLMTKMIGTPHWMAPEVFSSNDYTNKVDIYS
 . |. ..||.  .  ... ||.||.||...  |||||   |.|.. ..   ||||| .|     |   .  ..      |||||... . .| | |..|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FAILLWELIS-EERP-YKGYSAPQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDTI
| .|.||...  | | |.| |  ......  ...| |.|..|. .. .|..||||..|. ||||..|   .
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 87414.m00283.AA LRRK 22-277 24 2.9e-57 196.56 In-house 1-351 (351) Show / Hide 
Range on Protein: 22-277
Range on HMM: 1-351/351
Sequence Identity: 24% (85 aa)

FKILSTVGKGATC-EVYQAHHL--------------------------ATGAVCAVKKFLS--------------------------------ETFTAAE
.|| . .|.|..  .||.|                             . ..  |.||..                                 .....  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IHNFYREIKILSRARNYFLIPFYGISFSSPYIIAMKYIKRGSLHSAIFHKEGAPQ------LTPTNKTIIAFCIASGMQYLHEHD--VIHRDLKSLNVLL
 . | .|. |.|. .   ... .|... .|....| |.  |.|.. ...|.  ..      .... |  ||  ||.||.||| |.  .||||||| |.||
FREFRHEVWIMSHLNHPNIVSLKGFCI-HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

---D---------GKLYPHICDFGISR-VKSDSDQLMTKMIGTPHWMAPEVFSSN---DYTNKVDIYSFAILLWELISEE-RPYKGYSAP------QLIA
   .              .|.||||||  ...   .  .. |.| |||||.   |    || |||.|||...||||.. . .|. ... .       .| 
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

AVCTKNERPPIPKK-CTT-----KLKNLLTQCWHKNPKLRPTFADIMDTIRN
   ..  ||.||   |.       ...|...||. .|| ||.| .| ...  
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 87414.m00283.AA STE 22-270 22 7.7e-56 191.83 In-house 1-350 (359) Show / Hide 
Range on Protein: 22-270
Range on HMM: 1-350/359
Sequence Identity: 22% (81 aa)

FKILSTVGKGATCEVYQAHHL------ATGAV---------CAVKKFLSETFTA---------------AEIHNFYREIKILSRAR--NYFLIPFYGISF
..... .||||. .||.| .        || |         .|.|.   |. ..                |. .. .||||... .    . . .||  |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SSP--------YIIAMKYIKRGSLHSAIFHKEGAPQLTP---------TNKTI--IAFCIASG-MQYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISR
             |.| |.  ||| . | || | ..  .           . |  |.. |  | ..|||.| .||||.|. |.||       .||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VKSDS----------------DQLMTKMIGTPHWMAPEVFSS------NDYTNKVDIYSFAILLWELISEERPYKGYSAPQLIAAVCTK-----------
  .||                .|  . ..||| |||||| .       ..|. |.||.|. ....|..  . |.  .. .. . .  ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NERPPIPK-------------------KCTTKLKNLLTQCWHKNPKLRPTFAD
   .. ||.|                    |.. ..|. . .|  |.|. |||  .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 87414.m00283.AA HH498 22-275 30 1.2e-54 171.53 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-284/284
Sequence Identity: 30% (87 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTA-AE-----IHNFYREIKILSRARNYFLIPFYGISFSSP--YIIAMKYIKRGSLHSAI----
.. . ..| |.  .||       . . ||| . ...| .  .        | ||. |..|  .   . | . .   |    |   |.  ||| |      
IEFHEKIGSGSFGKVYKGEW--RNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

---------FHKEG--APQLTPTNKTIIAFCIASGMQYLHE---HDVIHRDLKSLNVLLDGKLYPHICDFGISR-VKSDSDQLMTKMIGTPHWMAPEVFS
          | .      . .  | .|.  .| ||.|||.   | .||||| | |.|..      . |||.|| |..  |  ||| .| . ||||||||
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFS

-SNDYTNKVDIYSFAILLWELISEERPYKGYSAPQLIAAVCTKNE-RPPIPKK----CTTKLKNLLTQCWHKNPKLRPTFADIMDTI
 .  |. |||..|.|. .||. . | |.  |  |   ||  .  . |||||         .  ||. .||| .|  ||.|..|.  .
QCQKYSIKVDVFSYAMCIWEMHTREVPFHHY-KPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 87414.m00283.AA S_TKc 22-282 25 2.3e-54 187.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-282
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTAAEIHNFYREIKILSRARNYFLIPFYGISFSSPYIIAMKYIKR--GSLHSAIFHKEGAPQ--
..|| ..||||  .||...|  || ..|.|.            ...|||.||.. .  ... .|..  .. . . | |.    |.|.. | .. . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTPTNKTIIAFCIASGMQYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISRVKSDSDQLMTKMIGTPHWMAPEVFSSNDYTN-KVDIYSFAILLWELI
 ...     ..  |.....|.|.| .||||||  |.|||      |||||..|.        | ..|||..|||||.    |.  |.|..|. ..|.|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SEERPYKGYSAPQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMD---TIRNGKAYF
. . |.     .|..  ..            .  .|... .|..|.|. |||  ...     |..   .|
CGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC-HPWF
Kinase 87414.m00283.AA Dicty5 99-279 36 3.2e-52 178.05 In-house 80-260 (260) Show / Hide 
Range on Protein: 99-279
Range on HMM: 80-260/260
Sequence Identity: 36% (68 aa)

YIKRGSLHSAIFHKEG---APQLTPTNKTIIAFCIASGMQYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISR-VKSDSDQLMTKMIGTPHWMAPEVFS
|...||| ..   ..     | . .. .  .|  || .|..||   .|||||||.|.|.   .   | |||.|| |  |    ||  .||. |||.|.| 
YCHNGSLFNYLNDQRKTTGQPIAYFQ-QLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFV--DNRYHMTMHVGTQCWMACELFN

SNDYTNKVDIYSFAILLWELISEERPYKGYSAPQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDTIRNGK
.. |..|.|.|||.| |||..    ||.   .   |.    | ||| ||| | |   ||   ||   |..||.|  |.....   
GQPYHQKCDVYSFGIVLWEMFTRKEPYDNI-NNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 87414.m00283.AA Dicty4-Unclassified 22-275 34 2.7e-50 170.44 In-house 1-263 (263) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-263/263
Sequence Identity: 34% (92 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTAA--EIHNFYREIKILSRARNYFLIPFYGISFSSP------YIIAMKYIKRGSLHSAIF---
 .|.  .|||.  .|.       |   ||||| .  | .    | .| .|. ||       |.  || .   |      ..| |  . .| |   |    
IQIDQFIGKGHFSKVHKGNW--KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKP

-HKEGAPQLTPTNKTIIAFCIASGMQYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISRVKSDSDQLMTKMIGTPHWMAPEVFSSNDYTNKVDIYSFAI
  ..   .|  |    .|| || |||.||  ..||||.|| |.|.|      | |||||||  |  . ||   ||| | .||.     |. | |.||.|.
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRV-IDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAM

LLWELISEERPYKGYS-APQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDTI
.|.||.  . || .      .   || |  || ||  |   .| |   |||  |. |||. .| .  
MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 87414.m00283.AA TyrKc 22-275 25 6e-50 173.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTAAEIHNFYREIKILSRA--RNYFLIPFYGISFS--------SPYIIAMKYIKRGSLHSAI-F
 . . . | || .|||...       .|||.  ...     .  |.||..|...   ..  .. .||.  .         |. | | | . |.|.. .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HKEGAPQLTPTNKTIIAFCIASGMQYLHEHDVIHRDLKSLNVLLDGKLYPHICDFGISRVKSDS------DQLMTKM--IGTP-----HWMAPEVFSSND
|..    |..  .  ... ||.||.|||.. .|||||   |.|.. ..   |.||| ||   |       ..  .|.   |.       |||||..  . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTNKVDIYSFAILLWELISEERPYKGY-----SAPQLIAAVCTKNERPPIPKK--------CTTKLKNLLTQCWHKNPKLRPTFADIMDTI
.| | |..|| ...||. .   .           .| . .   . .|.|.|.         |.... .. .|||| .|. ||||..| . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 87414.m00283.AA TKL-ciliate2 22-276 34 2.5e-49 162.55 In-house 1-273 (273) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-273/273
Sequence Identity: 34% (95 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTAAEIHNFYREIKILSRARNYFLIPFYGISFSSP-YIIAMKYIKRGSLHSAIFHKEGAPQLTP
 .|   .  |    .|.|    .  | |||||  .     .| .|  | . .   |   .. | |    .| . | | | .|||| | .  ..   .|| 
LEIQNKITEGGYGIIYKAKWREI--VVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDV--RLTW

TNKTIIAFCIASGMQYLHEHD--VIHRDLK--------------------SLNVLLDGKLYPHICDFGISRVKSDSDQLMTKMIGTPHWMAPEVFSSNDY
  .  ||  || |. |||  .  .||||||                    |||||.|  .   . |||  ||| . |  ||  |||  |||||| ... |
EDRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQ-DNYMTNKIGTYQWMAPEVIKAFYY

TNKVDIYSFAILLWELISEERPYKGYSAPQLIAAVCTKNERPPIPKKCTTKLKNLLTQCWHKNPKLRPTFADIMDTIR
| | |..|..|.|||. | | ||.. .       |  .| || ||| |  .. .|. .||  |  |||.| .|.  . 
TEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase 87414.m00283.AA Pkinase 22-275 25 4.5e-49 174.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

FKILSTVGKGATCEVYQAHHLATGAVCAVKKFLSETFTAAEIHNFYR--EIKILSRARNYFLIPFYGIS--FSSPYIIAMKYIKRG----SLHSAIF-HK
..|....|.|.  .||..||  || . |||..  ..    .  .  |  ||.|. | .  . . .|..    ...| . | |   |    .|.. |  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWR

EGAPQL--TPTNKTIIAFCIASGMQYLHEHDVIHRDLKSLNVLLDGKLYP----HICDFGISRVK-SDSDQLMTKMIGTPHWMAPEVFS-SNDYTNKVDI
.|.  .  ..     ..  |..|..|.|.. .||||||. |.|.| . ..    .|||||.....   ... ||   |||..|||||   ...|. |||.
HGC--FYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFAILLWELISEERPYKGY------SAPQLIAAVCTKNERPPIPKKCT-------------------TKLKNLLTQCWHKNPKLRPTFADIMDT--I
.|. ..|.|... . |..|       .  |.|. .  .  . ..|..|.                     .| ... |..|.|| |||...|.    .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF