Gene 92880.m00170 (T.vaginalis)

92880.m00170

Species: T.vaginalis
Alias: 92880.m00170, TvagK0493
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
92880.m00170.AA Protein None 320 None Fasta, JSON
92880.m00170.kin_dom Protein Kinase Domain None 172 None Fasta, JSON

Protein domain

Protein domains of 92880.m00170.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92880.m00170.AA CK1 10-263 24 5.8e-64 218.82 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-339/339
Sequence Identity: 24% (83 aa)

FKLISKIGDGGFG-NIWLC-----QSTEDD-----LLYALKLEPTSSQ--RQTLRFEAQVLKKLKGTE--------------------IAPLFKIDGTDQ
.|.. |||.||||  |...      .....       ||.|.|| .|     .|  |.|..|||.| .                    . ... . | ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NNF-YCAMELCGANLFDIAQ--HLPEKKFAMEYIPRLAYNLFCLVEVLHSKGYVHRDIKPQNFVVRPKGN--------------RPICLIDFGISK-VYL
... |  |.|.| || |. .   .. .|| |  . ..|. .   .|..|..|..||||||.||..  ...              | . .||||...  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DNNGN------------HLEARE---NAAAMG-SMLYASSNAYDHMDLSRRDDLISLIYSILDLAGIE--LPWCG-------------KSNDIDFNTIKK
|..|.            | ..||   ..  .|    |.| |. ......||||| |..| ....   .  ||| .             |     ... |.
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QHTLESLVAP-----LGEGFVQIARHIQGLQYADAPNYDAI
. ... |  |     . . | .|. .| .|.| |.|.|..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 92880.m00170.AA TTBKL 10-267 26 4.7e-48 160.35 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-288/288
Sequence Identity: 26% (76 aa)

FKLISKIGDGGFGNIWLCQSTEDDLL-YALKLEPTS-SQ-RQTLRFEAQVLKKLK--GTEIAPLFKIDGTDQNNFYCAMELCGANLFDIAQHLPEKK-FA
.. . .|| |||| . .  ...|    .|.| |... .   ... .|..||.||   |   .| ..  |  ..  . .|.||| || |.   .| || | 
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

MEYIPRLAYNLFCLVEVLHSKGYVHRDIKPQNFVVRPKGN-----RPICLIDFGISKVYLDNNGNH-----------LEARE---NAAAMGSMLYASSNA
 . . |... ..  .  .|..|..|||.||.|...  ...     | . |||||... |....|.             ..|.    |  .|.. |.| |.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

YDHMDLSRRDDLISLIYSILDLAGIELPWCGKSNDIDFNTIKKQHTLESLVAP------LGEGFVQIARHIQGLQYADAPNYDAIRKTL
 |.....| ||| |..|.|  |..  ||| . ..  .    ||....| |         .   |  ...|.  |.|.| |.|. |.. .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 92880.m00170.AA Worm6 10-263 26 3.4e-40 139.86 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-279/279
Sequence Identity: 26% (74 aa)

FKLISKIGDGGFGNIWLCQSTEDDL--LYALKLEP--TSSQRQTLRFEAQVLKKLKGTE--IAPLFKIDGTDQN--NFYCAMELCGANLFDIAQHLPEKK
.|.  |||.|||| . ... ..|     .|.|.|    ...|| |..|. |||..|       . .   |. .|   .|. |.|.| || |. ...|..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FAMEYIPRLAYNLFCLVEVLHSKGYVHRDIKPQNFVVRP------KGNRPICLIDFGISK--VYLDNNGNHLEAR-ENAAAMGSMLYASSNAYDHMDLSR
| |    ..|      .|.||. |..|||.||.|| .        .  . |...|||...  .|.....     | .... .|   ||. .........|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLISLIYSILDLAGIELPWCGKSNDIDFNTIKKQ---HT----LESLVAPLGE-GFVQIARHIQGLQYADAPNYDAI
.||. |  | ....   .||| . . . . . .||.   .|     . . .|    .|. |   | ...| |.|.|. |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 92880.m00170.AA TTBK 10-263 33 2.3e-38 133.17 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-257/257
Sequence Identity: 33% (87 aa)

FKLISKIGDGGFGNIWLCQSTEDD-LLYALKLEPTSSQRQTLRFEAQVLKKLKGTEIAPLFKIDGTDQNNFYCAMELCGANLFDIAQHLPEKKFAMEYIP
 | . ||| |||| |.  .    .    |.|.|    ..| |. |  ||||| | . .  |   | . .  |  |.| | || |   . |. .| .    
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RLAYNLFCLVEVLHSKGYVHRDIKPQNFVV--RPKGNRPICLIDFGISKVYLDNNGNHLEARENAAAMGSMLYASSNAYDHMDLSRRDDLISLIYSILDL
||   .   .|  || |. |||||| || .   |.  | . ..|||    |.   |.   .|| |   |   ||| ||    .. |.||| || |     
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF

AGIELPWCGKSNDID-FNTIKKQHTLESLVAPLGEGFVQIARHIQGLQYADAPNYDAI
.   |||  |  | |    .|..  .  |.  . . | |   ||. |.|.| |.|  |
VQGQLPWR-KIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 92880.m00170.AA CK1-D 10-263 30 9.6e-36 123.52 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-261/261
Sequence Identity: 30% (79 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALKLEPTSSQRQTLRFEAQVLKKLKGTEIAPLFKIDGTDQNNFYCAMELCGANLFDIAQHLPEKKFAMEYIPR
...  ||| | ||.|.. .  . .   |.|||.  ..   | .|... | ..|    |  .  | . .     |.| |  | |.  .  ..||..  .  
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLM

LAYNLFCLVEVLHSKGYVHRDIKPQNFV--VRPKGNRPICLIDFGISKVYLDNN-GNHLEARENAAAMGSMLYASSNAYDHMDLSRRDDLISLIYSILDL
||  ..| .| .|.. ..|||||| ||.  .  .||  . .||||..| | | .   |.  |||    |   ||| |    .. |||||| || | ..  
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM-VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

AGIELPWCG-----KSNDIDFNTIKKQHT-LESLVAPLGEGFVQIARHIQGLQYADAPNYDAI
.   ||| |     | .  .  . || .| .. | . . . |.|   . . |.. | |.|  .
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 92880.m00170.AA CK1-A 10-215 33 6.7e-35 120.69 In-house 1-207 (261) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-207/261
Sequence Identity: 33% (69 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALKLEPTSSQRQTLRFEAQVLKKLKGTEIAPLFKIDGTDQNNFYCAMELCGANLFDIAQHLPEKKFAMEYIPR
..|. ||| | || |.|  ....    |.|.|    .   | .||.| . |.|    |  .  |.....    |.| |  | |.   . ...|.|  .  
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

LAYNLFCLVEVLHSKGYVHRDIKPQNFV--VRPKGNRPICLIDFGISKVYLDNNG-NHLEARENAAAMGSMLYASSNAYDHMDLSRRDDLISLIYSILDL
||  .   .| .| |...|||||| ||.  .    |. . |||||..| | |..   |.. ||    .|   ||| ||   .. |||||. |. | ..  
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNK-LFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF

AGIELPWCG
   .||| |
NRGKLPWQG
Kinase 92880.m00170.AA CK1-Unclassified 118-201 46 4.3e-22 62.02 In-house 117-204 (244) Show / Hide 
Range on Protein: 118-201
Range on HMM: 117-204/244
Sequence Identity: 46% (41 aa)

VEVLHSKGYVHRDIKPQNFVV--RPKGNRPICLIDFGISKVYL--DNNGNHLEARENAAAMGSMLYASSNAYDHMDLSRRDDLISLIY
.|.||.|...|||||| ||..  . |    . .||||.|| |.  |..|.| . |||    |   ||| ||   .  |||||| || |
IEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGY
Kinase 92880.m00170.AA CMGC 10-157 15 4.6e-22 68.47 In-house 1-254 (513) Show / Hide 
Range on Protein: 10-157
Range on HMM: 1-254/513
Sequence Identity: 15% (39 aa)

FKLISKIGDGGFGNIWLCQS--------------TEDDLLYALK--LEPTSSQRQ------------TLRFEAQVLKKLK----------------GTE-
.. |.||| | .|. . |.               .|.. ..|.|   .|   ..|            .   | . ||.|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IAPLFKIDGTDQ----------------NNFYCAMELCGANLFDIAQHLP--------------------------EKKFAMEYIPRLAYNLFCLVE--V
|  |. |  ...                |..|  .|... .|... .. .                           |.| . .|   .| ... ..   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHSKG--YVHRDIKPQNFVVRPKGNRP------------------ICLIDFGISKVY
.||..   .|||.||.|  . ...  .                  . ..||| .. |
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY
Kinase 92880.m00170.AA Pkinase 10-164 25 5.8e-21 75.2 Pfam 1-168 (293) Show / Hide 
Range on Protein: 10-164
Range on HMM: 1-168/293
Sequence Identity: 25% (43 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALK----LEPTSSQRQTLRF--EAQVLKKLKGTEIAPLFKIDGTDQNNFYCAMELCGAN--LFDIAQHLP---
.....||| |.||  ..|.   .  ..|.|     .  |...||.|   |.|..|.|.   |  |. .  .  .. |  ||.|.    ..| . ..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

EKKF--AMEYIPRLAYNLFCLVEVLHSKGYVHRDIKPQNFVVRPKGNR--PICLIDFGISKVY-LDNNGNH
...|   .. . . .| ... .| .||.| .|||.||.|. .  .|.   .....|||..|.. . ||.  
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-M
Kinase 92880.m00170.AA CK1-Unclassified 10-62 33 1.6e-18 51.3 In-house 1-53 (244) Show / Hide 
Range on Protein: 10-62
Range on HMM: 1-53/244
Sequence Identity: 33% (18 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALKLEPTSSQRQTLRFEAQVLKKLKG
...| ||| | ||.| .|  .... ..|.||| . |   .| .||.... |..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQN
Kinase 92880.m00170.AA Ciliate-E2 10-166 23 2.2e-18 59.71 In-house 1-215 (365) Show / Hide 
Range on Protein: 10-166
Range on HMM: 1-215/365
Sequence Identity: 23% (53 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALK-----------------------------LEPTSSQRQTLR---------FEAQVLKKLKGTEIAPLFKI
.|.| ||| |.|| ...|.  ... ..|.|                             .| ...  . .|          | ..|..|.   |  ..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

DGT-DQNNFYCAMELCGA-NLFDIAQHLPEK---------KFAMEYIPRLAYNLFC---------------LVEVLHSKG-YVHRDIKPQNFVVRPKGNR
  . |.||.|  ||.|   .|||. .. . |         .| .. | .. . ..                 .| ||||.  .||||||.| ..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PICLIDFGISKVYLDNNGNHLE
 |..||||.|| | |.| |...
-IKIIDFGLSKKYDDDNQNRTH
Kinase 92880.m00170.AA CK1 118-199 42 1.9e-16 53.27 In-house 118-202 (271) Show / Hide 
Range on Protein: 118-199
Range on HMM: 118-202/271
Sequence Identity: 42% (36 aa)

VEVLHSKGYVHRDIKPQNFVV-R-PKGNRPICLIDFGISKVYLD-NNGNHLEARENAAAMGSMLYASSNAYDHMDLSRRDDLISL
.|..|.|...|||||| ||.. |  |    . .||||..| |.| ....| . |||    |   ||| |.   .  |||||. ||
IEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESL
Kinase 92880.m00170.AA CK1 10-62 33 1.2e-15 50.49 In-house 1-55 (271) Show / Hide 
Range on Protein: 10-62
Range on HMM: 1-55/271
Sequence Identity: 33% (19 aa)

FKLISKIGDGGFGNIWLCQSTEDDLL---YALKLEPTSSQRQTLRFEAQVLKKLKG
.... ||| | || | |.  . ..     .| |||.  |  . | .||...| |.|
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQG
Kinase 92880.m00170.AA S_TKc 10-271 18 2.5e-13 18.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-271
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALKLEPTSSQRQTLRFEAQVLKKLKGTEIAPLFKIDGTDQNNFYCAMELCGA---NLFDIAQHLPEKK----F
.... ||| |.||  ..|. .... ..|.|  .     ...| | |.||| .   |  |. .  .  ...|  ||.|.    .|||. .. . ..    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

AMEYIPRLAYNLFCLVEVLHSKGYVHRDIKPQNFVVRPKGNRPICLIDFGISKVYLDNNGNHLEARENAAAMGSMLYASSNAYDHMDLSR-RDDLISLIY
    . ...| ..| .| .||.| .|||.||.|  .       | ..|||.....                 |.  | .         .. . |  |.  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

SILDLAGIELPWCGKSNDIDFNTIKKQHTLESLVAPLGEGFVQIARHIQGLQYADAPNYDAIRK-----TLEPMF
 .  ..  . |..      .. ..||            . . .. |..     .. |    . .      . | |
ILYEMLCGYPPFP-----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92880.m00170.AA TyrKc 10-231 15 3.9e-05 -139.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-231
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

FKLISKIGDGGFGNIWLCQSTEDDLLYALKLEPTSSQRQTLRFEAQVLKKL--KGTEIAPLFKIDGTDQ------NNFYCAMELCGANLFDIAQHLPEKK
 .|. |.| | || ..... .   .  | |    .. |. .. ||....||  .   |  |. .  ...         .  ||..   . |  ..| ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM--PHGDLKDYLRKHR

--FAMEYIPRLAYNLFCLVEVLHSKGYVHRDIKPQNFVVRPKGNRPICLIDFGISKVYLDN----------------NGNH--------LEARENA----
  . |.     ..   |  | ||||...|||.   |  |  ..   |.  ||| |.   |                 .|.         .|.        
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS--DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

--------------AAMGSMLYAS--------SNAYDHMDLSRRDDLISL-------IYSILDLAGIELPWCGKSND-IDFNTIKKQHTL
                 | . |          . .. . .  .| .           . .      ..  |  . .|   |..|   . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 92880.m00170.AA CK1 247-261 20 0.127724 1.59 In-house 257-271 (271) Show / Hide 
Range on Protein: 247-261
Range on HMM: 257-271/271
Sequence Identity: 20% (3 aa)

RHIQGLQYADAPNYD
... .|.....|.|.
NYCRQLHFEEKPDYM