Gene 89123.m00090 (T.vaginalis)

89123.m00090

Species: T.vaginalis
Alias: 89123.m00090, TvagK0597
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CRK7-like

Sequence

Name Sequence Type Origin Length Description Download
89123.m00090.AA Protein None 353 None Fasta, JSON
89123.m00090.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of 89123.m00090.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89123.m00090.AA CDK 18-305 37 4.5e-128 411.91 In-house 1-284 (284) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-284/284
Sequence Identity: 37% (122 aa)

FKVIENIGDGTYGSVQKCKDERTN-----EIVALKKIKIINQ-----NDGFPQNTIREVKLLKQLRHDNIVLLKSVVHSKS---------DQSIYLVFEY
.. .| || |||| | |..| .|.     .|||||||.. |.      .|||. .|||..|||.| |.||| |. |.|.|.         . ..|.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CYYDLDALIHMQDIPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNI-----LKLGDFGLARELT-------NKGRYSDSVITLWYRPPELF
. .||  ...        ||..|.||.  | |.  ....||||||.|  |..| .     ||..||||||.         .   |.  |.|||||.||| 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LGCHEYG--PEVDIWSAACILYEMIA---KQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTSAAKLPNRLKEHLKKHLPPEQHDIIDL
||. .|.  ...|.||. ||..||.    ..|||  .  | |.. ||.|||||..|.||.....                                  ||
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------------DL

LLKMLRMNPKKRISAETAMNHPYF
| ||| ..|||||||| |..||||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 89123.m00090.AA CMGC 18-305 24 1.9e-116 384.37 In-house 1-513 (513) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

FKVIENIGDGTYGSVQKCKD--------------ERTNEIVALKKIK---IINQ------NDGFPQNTIREVKLLKQLR-----------------HDNI
...|. || |||| | ||.|               .||||||.||||     .|       ||||. ..||.|.||.|.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VLLKSVVHSKS---------------DQSIYLVFEYCYYDLDALIHMQD----------IPEAT------------IKTIM------RQLITVLC--YLA
| |. ....|                ....||||||. .||  .|...            .|              || .|      .|... |   |. 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

VKN--VVHRDLKPANMFITKNNIL--------------------KLGDFGLARELTNKGR----------------------YSDSVITLWYRPPELFLG
 ..  ..||||||.|  |..|. |                    |..|||||| . .  .                      |.. | |.|||.||. ||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

C---------HEYGPEVDIWSAACILYEMIAK--------QPLFAAREN-----------ISQIHEIFKICGTPD---------------DDDWPEWKQ-
.         ..|....|.||..||..||. .        .|||  . .           | |...|||..|||.               ...||.... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

------------------YDSNKAMLFTSAAKLPNRLKEHLKKHLPP-----------------------------------EQHDIIDLLLKMLRMNPK
                  ...     . |  ..|.. . ..|.  |.                                   . .. |||| |||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISAETAMNHPYF
|||.|| |..||||
KRITAEQALQHPYF
Kinase 89123.m00090.AA CDC2 18-305 39 4.3e-110 339.64 In-house 1-301 (301) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-301/301
Sequence Identity: 39% (122 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDG--FPQNTIREVKLLKQLR-HDNIVLLKSVVHSKSDQSIYLVFEYCYYDLDALIH-----M
.. || || |||| | |||| .||.|||||||.. ....|  .|. .|||  .|| |. |.||| |. |.|.   ...|.||||...||  .       .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QDIPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLAREL-TNKGRYS--DSVITLWYRPPELFLGCHEYGPEVDIWSAACILY
. .|....| .| |..  ....  . ..|||||| | .| |.  .|..||||||   ...  |     |.|||||.||. |||  |  .||.||  ||..
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EM---IAKQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTSAAKLPNRLKEHLKKHLPP---------EQHDIIDLLLKMLRMNPKKRI
||   . | |||..   | |.  ||.| |||....||. .|.   |       .. |.  .  |.|..|            .. |||| .||. .| |||
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYK-------NTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRI

SAETAMNHPYF
||..|..||||
SAKEALQHPYF
Kinase 89123.m00090.AA CRK7 18-305 35 6.1e-95 321.73 In-house 1-343 (343) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-343/343
Sequence Identity: 35% (122 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQ---NDGFPQNTIREVKLLKQLRHDNIVLLKSVVHSK-------SDQ-SIYLVFEYCYYDLDAL
.. |. || |||| | | |. .|.|.|||||..  |     .|||   |||.|.|.|| |.||| || .| .|       ..  |.|.||||   ||  |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

IH---MQDIPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTN---KGRYSDSVITLWYRPPELFLGCHEY--------
     |... .  .| .|.||   . |.  ||. |||.| .|  .  . ..|. |||||| .     .  |   ||||||||||| ||  .|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------GPEVDIWSAACILYEMIAKQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTS--AAKLP
                              |||.|.||  ||| |   |.|.| ..  . |.  |.||||.|  . |||  .    ..|        .| 
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

NRLKEHLKKHLPPEQHDIIDLLLKMLRMNPKKRISAETAMNHPYF
.   .| |  ..|..    ||| ||| ..||||..|| . .|..|
EEFYHHKKPVFMPKE--CLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 89123.m00090.AA S_TKc 18-305 28 1.4e-92 314.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDGFPQNTIREVKLLKQLRHDNIVLLKSVVHSKSDQSIYLVFEYCYY---DLDALIHMQD---
..... || |..|.| ||.. .|..|||.|.||         ....||...||. .|.||| |. | ..   ...|.|.|||     ||  .|. .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNKGRYSDSVITLWYRPPELFLGCHEYGP-EVDIWSAACILY
    .|| ... .|.|..  | |.  ....||||||.| ....   .|..||||||.|      .  . |.||..||..     ||. ..|.||  ||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

EMIAKQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTSAAKLPNRLKEHLKKHLPPEQHDIIDLLLKMLRMNPKKRISAETAMN-----
||.. .|.|       |....||..|                                           .. .|.. |.|...|.||..|  |..     
EMLCGYPPFP------QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYF
  ||.|
KCHPWF
Kinase 89123.m00090.AA CDK5 18-305 41 5.3e-91 287.76 In-house 1-287 (287) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-287/287
Sequence Identity: 41% (122 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDGFPQNTIREVKLLKQLRHDNIVLLKSVVHSKSDQSIYLVFEYCYYDL----DALIHMQDIP
.. .| ||.|||| | | ..  | ||||||.... .   | |   |||. ||| |.| ||| |  |.|  |.. . ||||.|  ||    | .    .. 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIH--SEKKLTLVFEFCDQDLKKYMDSCNG--EMD

EATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNKGR-YSDSVITLWYRPPELFLGCHEYGPEVDIWSAACILYEMI-AK
 ..|| .| ||   | .   ..| |||||| |. | || .|||.||||||      | ||  |.|||||||   .|   |   .|.||. ||. ||. | 
MHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

QPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTSAAKLPNRLKEH-LKKHLPPEQHDIIDLLLKMLRMNPKKRISAETAMNHPYF
.|||   .   |   |||| |||  | ||   .    |.     . ..| .  .  .... |       ||| |||..||..||||. |..||||
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPN----HQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 89123.m00090.AA PITSLRE 18-305 39 5.3e-88 298.66 In-house 1-295 (295) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-295/295
Sequence Identity: 39% (119 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKII--NQNDGFPQNTIREVK-LLKQLRHDNIVLLKSVVHSKSDQSIYLVFEYCYYDLDALI--HM---
|. .  |. |||| | . || ||.||||||..|.      .|||   .||.. .|. |.|.||| .| .|  .   .||.|.||   ||  |.  .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QDIPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNK-GRYSDSVITLWYRPPELFLGCHEYGPEVDIWSAACILYEM
|   .  ||. | ||     ..  . . ||||| .|. .. . |||..|||||||       |.  |.||||| ||| ||| .| . ||.||  ||. |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

IAKQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAML-FTSAAKLPNRLKEHLK--KHLPPEQHDIIDLLLKMLRMNPKKRISAETAMNHPYF
| ..|||  .  | ||. |||  |||    || |.  .  |.|  |.     .| |... .  .|.        ||| .||  |||.||.|. |. ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP--YNNLRKRFPAENHI---SDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 89123.m00090.AA Pkinase 18-305 30 1.6e-85 295.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDGFPQNTIR--EVKLLKQLRHDNIVLLKSVVHSKSDQSIYLVFEYCYY-----DLDALIH--
..... || |..|.| ||..  |..|||.|.||  .......|. .|  |....| |.|.||| |. ....  ...||.|.|||       || ..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-MQDI--PEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNIL----KLGDFGLARE--LTNKGRYSDSVITLWYRPPELFLGCHEYGPEVDIW
    .  .| ..| .|.|..  | |.  ....||||||.| .| .|. .    |..|||||.   . |.. ... . |.||..||. .|. .|||.||.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SAACILYEMIAKQPLFAAR----ENISQIHEIFKICGTPDDDDWPEWKQ-YDSNKAMLFTSAAKLPNRLKEHLKKHLPPEQHDIIDLLLKMLRMNPKKRI
|. ||||||. ..|.|  .    . ..|.. |..| |.| . |||.|   ....  .  . .        . ...  .    . .|.. ..|...||||.
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

SAETAMNHPYF
.|| ...||.|
TAEQILQHPWF
Kinase 89123.m00090.AA MAPK 18-305 31 2.9e-81 276.27 In-house 1-328 (328) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-328/328
Sequence Identity: 31% (105 aa)

FKVIENIGDGTYGSVQKCKDER------TNEIVALKKIKIINQNDGFPQNTIREVKLLKQL-RHDNIVLLKSVVHSK-----SD----QSIYLVFEYCYY
.. ...|| | || | ...| |      ....||.|||    ||  . . |.||.|||. . .|.||. |. . . .     ..    . ||.|.|..  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLDALIHMQD-IPEATIKTIMRQLITV--LCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNK---------------GRYSDSVITLWYRPP
|| ..|..|.   .  |. .| |..    | |.   ||.||||||.|  ...|  ||..|||||| . ..               .  .. | | ||| |
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELFLG--CHEYGPEVDIWSAACILYEMIA-KQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTSAAKLPNRLKEHLKKHLPP----EQH
|. |.   ..|   ||.||. ||. ||.   .|||  .  | |.  |....|||.....   .. ... . .. |   ||.. | ...| .|      ..
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICM-SEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

DIIDLLLKMLRMNPKKRISAETAMNHPYF
. |||| ||| ..|.|||..| |..||||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 89123.m00090.AA ERK7 18-305 36 3.4e-71 242.69 In-house 1-292 (292) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-292/292
Sequence Identity: 36% (107 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDGFPQNTIREVKLLKQLR-HDNIVLLKSVVHSKSDQSIYLVFEYCYYDLDALIH-MQDIPEA
..... .| | || | |  | || ..||||||    .|.   | | ||. .|.... |.||. |  |.. . |. ||||||.   || | |   . . . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

TIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNKGRYSDS-------VITLWYRPPELFLGCHEYGPEVDIWSAACILYEM
  . || ||.  . |.   ||.||||||.|. .  .  .|. |||||| ....  |...       | | ||| ||  || |.| . || ||  ||| ||
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

IAKQPLFAARENISQIHEIFKICGTPDDDDWPEWKQYDSNKAMLFTSAAKLPNRLKEHLKKHLPPEQHDIIDLLLKMLRMNPKKRISAETAMNHPYF
. ..|.|.    . ||  | .. . |   |    .  .|. |.   .. .   . .. |.. .|  ..| |||| ..| .|||||..|| |..||| 
LRGKPMFPGTSTMNQIEKILETIPKPTQED---IEAIGSHYAWNMLEQMN--QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 89123.m00090.AA CDK-DD1 18-240 38 1.4e-69 213.85 In-house 1-225 (379) Show / Hide 
Range on Protein: 18-240
Range on HMM: 1-225/379
Sequence Identity: 38% (88 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDGFPQNTIREVKLLKQLRH-DNIVLLKSVVHSKSDQSIYLVFEYCYYDLDALIHMQD--IPE
. .|. .|.|.|||| |     | ..||||..| .|| || |.    |.|.|.||||  ||| |     .  .    .||||  .||  ..  .   .  
YQIISKCGQGIYGSVFKAIHKITHCMVALKNFKDWNQEDGEPK---VECKYLMQLRHCKNIVHLIDHFYNFKNSKYVMVFEYFEHDLWKFMSNHQCYMSL

ATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNK--GRYSDSVITLWYRPPELFLGCHEYGPEVDIWSAACILYEMIAKQ
  ||  ..||   .  . .  . ||| ||||  |. .  ||..|||..   |.      |  |..|||||||| .|   ||||.|.||  ||| |||   
PCIKCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTYYTKRSEKHFSHQVVSLWYRPPELLMGSCQYGPEIDMWSVGCILMEMITNF

PLFAARENISQIHEIFKICGTPDDDDWP
 .||  .   |   |.| ||.| .  ||
YMFAGSNEQQQLELICKLCGCPTEKNWP
Kinase 89123.m00090.AA CDK4 18-240 38 6e-65 221.72 In-house 1-234 (290) Show / Hide 
Range on Protein: 18-240
Range on HMM: 1-234/290
Sequence Identity: 38% (90 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQND--GFPQNTIREVKLLKQLR---HDNIVLLKSVVH-SKSDQ---SIYLVFEYCYYDLDALIH
.. .  || | || | .  |  |  .||||...| ....  | |. ||||. ....|    | ||| |..| | .  |     | .||| |  ||  .. 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

MQDI---PEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNKGRYSDSVITLWYRPPELFLGCHEYGPEVDIWSAACIL
       |. ||| .|.||.. . .|    ..|||||| |. .| .  .|| ||||||.  ..      |.||||| ||  |    |   ||.||..|| 
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCIF

YEMIAKQPLFAARENISQIHEIFKICGTPDDDDWP
 ||   .|||       | | ||.. |.|  ||||
AEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWP
Kinase 89123.m00090.AA Pkinase_Tyr 18-171 30 8.9e-17 57.45 Pfam 1-167 (270) Show / Hide 
Range on Protein: 18-171
Range on HMM: 1-167/270
Sequence Identity: 30% (52 aa)

FKVIENIGDGTYGSVQKCKDE----RTNEIVALKKIKIINQNDGFPQNT------IREVKLLKQL-RHDNIVLLKSVVHSKSDQ-SIYLVFEYCYY-DLD
 . .. .| | .|.| |..       |.  || |..|     .|  .        .||.|..||| .|.||| |  |. ..... .||.|.||. . ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

ALIHMQ-----DIPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNKGRY
   . .      ..  ..  . .|    . ||. || .||||   |  .|.||. | .|||||| ..|.. |
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY
Kinase 89123.m00090.AA CDK-DD1 277-305 44 2.3e-15 43.33 In-house 351-379 (379) Show / Hide 
Range on Protein: 277-305
Range on HMM: 351-379/379
Sequence Identity: 44% (13 aa)

DIIDLLLKMLRMNPKKRISAETAMNHPYF
...||...||  .|||||... | .||.|
SFLDLIERMLTLCPKKRINTKEALQHPWF
Kinase 89123.m00090.AA TyrKc 18-305 17 2.8e-13 -7.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

FKVIENIGDGTYGSVQKCKDERTNEIVALKKIKIINQNDGFPQNTIREVKLLKQL--RHDNIVLLKSVVHSK-----SDQSIYLVFEYCYY-DLDALIHM
 . .. .| | .| | |..     . || |..|         .  .|| .....|  .|.||| |  |. ..     ... ...|.||. . ||.  .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QD--IPEATIKTIMRQLITVLCYLAVKNVVHRDLKPANMFITKNNILKLGDFGLARELTNK-------GRYS-----DSV--ITLWYRPPELFLGCHEYG
    .. ..   .. |      ||. ||..||||   |  ...|.. | .||||.|.....         |.     ..   . .   .|| .   ... 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

PEVDIWSAACILYEMI--AKQPL-------FAARENISQIHEIFKICGTPD----DDDWPEWKQYDSNKAMLFTSAAKLPNRLKEHLKKHLPPEQHDIID
.. |.||    ..|.    .||          ..| | .. . .     |.                                        .    .. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------FVCCPDEMYQ

LLLKMLRMNPKKRISAETAMNHPYF
. ..  . .|..| . ..   | .|
IMKQCWHEDPEDRPTFSEI--HECF
Kinase 89123.m00090.AA CDK4 279-305 55 3e-12 38.12 In-house 264-290 (290) Show / Hide 
Range on Protein: 279-305
Range on HMM: 264-290/290
Sequence Identity: 55% (15 aa)

IDLLLKMLRMNPKKRISAETAMNHPYF
.|||.|||. |..||.||. . .||||
DDLLQKMLCYNHHKRMSAYQCLQHPYF