85746.m00199

Species: T.vaginalis
Alias: TvagK0654, 85746.m00199
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
85746.m00199.AA Protein None 415 None Fasta, JSON
85746.m00199.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of 85746.m00199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85746.m00199.AA CMGC 136-374 16 6.2e-51 165.1 In-house 158-513 (513) Show / Hide
Range on Protein: 136-374
Range on HMM: 158-513/513
Sequence Identity: 16% (63 aa)

HGLSMRK------------NKGFPLSAVRTILIQILKGLA--EMENKG--LVHGDIKPENIIFSLR----------KAGNLTSFEAYKNAISNLSFSIMR
..||  .             | |.. ..| .  |||.||.   .  ..   .| |.||||| .. .          .                       
MPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS-----------------------

DEFENQDVLN----------ISLIDWSSSS-MGYN-----------------------QNAQYMQSRYYRAPEILMRSS----------YGPGVDIWSTA
         .          . ..|. ..   . .                       .. .| ..|.|||||||....          |....|.|| .
---------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVG

CVAVELFIG--------KPLFPGADE-----------LDMIRIIQQRLGIFPHSVIRKMG--------SDSIAASTD------------------EWMID
|.  |.. |        |||||| .|           .|..  | . || .. ..|.|          .. .   ..                  .|...
CIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEF

PKNYL-----PGNFEAFICEESRRQDN---------------------------------EVLLFINLMRLMLQLNPDARASASSALSHPFI
 .||.      ...     ..    ..                                 .  ..|.|.  |||..|| | .|. ||.||..
ARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

S_TKc 85746.m00199.AA S_TKc 40-374 19 3e-39 137.64 SMART 1-231 (231) Show / Hide
Range on Protein: 40-374
Range on HMM: 1-231/231
Sequence Identity: 19% (68 aa)

VKILAPLGRGISGSVFAVQVVECEKQPTIVSTMLCLKIFKTNSVAISQAENEILILPLTHRNFNTGRFSVFPSYLTSFKIDGHLGFLMELGGP---SLFH
 .|| ..|.|  |.|. .. ..             .|| |       ....|| ||   |  .    . || .        .|| . ||. .    .||.
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFD

GLSMRKNKG----FPLSAVRTILIQILKGLAEMENKGLVHGDIKPENIIFSLRKAGNLTSFEAYKNAISNLSFSIMRDEFENQDVLNISLIDWSSSSMGY
 .  |. .|    ||   .| .. ||...|. . ..| .| |.||||| ..                                   .| ..|  ..    
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------------------------HIKICDFGLARQL-

NQNAQYMQSRYYRAPEILMRSSYGP-GVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRKMGSDSIAASTDEWMIDPKNYLPGNFEA
     .  ...|.|||.|   .||.  .|.||  |.  |.. |.|.||  ..  |...|                                         
---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------------------

FICEESRRQDNEVLLFINLMRLMLQLNPDARASASSALS-------HPFI
               .....| .|| .|. | .|  ||        ||..
------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 85746.m00199.AA DYRK 237-304 45 1.6e-28 101.06 In-house 163-230 (320) Show / Hide
Range on Protein: 237-304
Range on HMM: 163-230/320
Sequence Identity: 45% (31 aa)

QYMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK
.| |||.|||||.. .  |.  .|.||  |. .|||.|.|||||..| |... |.. ||..|. .|.|
TYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDK

Kinase 85746.m00199.AA Pkinase 241-374 23 2.7e-22 79.93 Pfam 174-293 (293) Show / Hide
Range on Protein: 241-374
Range on HMM: 174-293/293
Sequence Identity: 23% (33 aa)

SRYYRAPEILM-RSSYGPGVDIWSTACVAVELFIGKPLFPGA----DELDMIRIIQQRLGIFPHSVIRKMGSDS-IAASTDEWMIDPKNYLPGNFEAFIC
...|.|||... .. ||| ||.||  |.  |.. |.|.|||.    . .|.. .|....|  .|. . .  | |     .. |                 
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F

EESRRQDNEVLLFINLMRLMLQLNPDARASASSALSHPFI
 .... .|    .. ... .|...|  | .|  .| ||..
-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 85746.m00199.AA RCK 142-285 29 3e-22 67.14 In-house 96-221 (298) Show / Hide
Range on Protein: 142-285
Range on HMM: 96-221/298
Sequence Identity: 29% (45 aa)

KNKGFPLSA--VRTILIQILKGLAEMENKGLVHGDIKPENIIFSL-----RKAGNLTSFEAYKNAISNLSFSIMRDEFENQDVLNISLIDWSSSSMGYNQ
..| .| .   .. |. |||.||| | ..|  | |.|||||  .       .                            ||  .| ..| ...   ...
RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFED----------------------------QDQDHIKIADFGLCREIRSK

N--AQYMQSRYYRAPEILMRS-SYGPGVDIWSTACVAVELFIGKPLFPGADELD
.    |  .|.|||||.| |.  |   .|||.  |...|| . .|||||..|.|
PPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEID

Kinase 85746.m00199.AA DYRK2 238-304 41 7.4e-22 67.57 In-house 162-228 (318) Show / Hide
Range on Protein: 238-304
Range on HMM: 162-228/318
Sequence Identity: 41% (28 aa)

YMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK
| |||.|||||.  .  ||  .|.||  |...||..|.||||| .| | .  ..  ||. | ... .
YIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDT

Kinase 85746.m00199.AA HIPK 238-292 58 6.6e-19 55.73 In-house 163-217 (329) Show / Hide
Range on Protein: 238-292
Range on HMM: 163-217/329
Sequence Identity: 58% (32 aa)

YMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQ
|.||||||||||..   .   .|.||  ||  ||| | ||.||||| | || |.|
YLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQ

Kinase 85746.m00199.AA YAK 238-304 41 2.2e-18 58.69 In-house 165-231 (347) Show / Hide
Range on Protein: 238-304
Range on HMM: 165-231/347
Sequence Identity: 41% (28 aa)

YMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK
| |.|.||.|||..   |   .| ||  |. .||| | |.|||. | . |  |   ||..|  .| .
YIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQ

Kinase 85746.m00199.AA CDKL 242-295 47 2e-17 56.14 In-house 163-217 (286) Show / Hide
Range on Protein: 242-295
Range on HMM: 163-217/286
Sequence Identity: 47% (26 aa)

RYYRAPEILMR-SSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLG
| ||||| |    .||. ||||. .||  |.. | ||.||  ..|    ||. ||
RWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLG

Kinase 85746.m00199.AA CDK 242-285 42 2.2e-17 52.03 In-house 183-232 (284) Show / Hide
Range on Protein: 242-285
Range on HMM: 183-232/284
Sequence Identity: 42% (21 aa)

RYYRAPEILM-RSSYG--PGVDIWSTACVAVELFI---GKPLFPGADELD
. |||||.|.  . |.  ...|.||  |. .|.|    .||||||  |.|
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEID

Kinase 85746.m00199.AA MAK 238-287 47 3.2e-17 50.94 In-house 207-257 (352) Show / Hide
Range on Protein: 238-287
Range on HMM: 207-257/352
Sequence Identity: 47% (24 aa)

YMQSRYYRAPEILMRSS-YGPGVDIWSTACVAVELFIGKPLFPGADELDMI
|   | |||||.| ||. |.  .|.|   |...||.. .|||||. | | |
YVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQI

Kinase 85746.m00199.AA PRP4 236-304 39 1.5e-16 57.12 In-house 163-231 (320) Show / Hide
Range on Protein: 236-304
Range on HMM: 163-231/320
Sequence Identity: 39% (27 aa)

AQYMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK
. | .||.||||||..  .|  ..|.||..|   ||. || .|||    .|.. .    | .|.  |||
TPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRK

Kinase 85746.m00199.AA HIPK 41-181 31 8.8e-13 36.09 In-house 2-133 (329) Show / Hide
Range on Protein: 41-181
Range on HMM: 2-133/329
Sequence Identity: 31% (44 aa)

KILAPLGRGISGSVFAVQVVECEKQPTIVSTMLCLKIFKTNSVAISQAENEILILPLTHRNFNTGRFSVFPSYLTSFKIDGHLGFLMELGGPSLFHGLSM
 .|  ||||  |     ||| | |. |  . |  .|| | .     | ..|. ||    .. |   . .  .|   |.   |     |.    |.  .  
EVLEFLGRGTFG-----QVVKCWKRGT--NEMVAIKILKNHPYYARQGQIEVSIL-HCLSQENADEYHFVRAYEC-FHHKNHTCLVFEMLEQNLYDFQKQ

RKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII
 |    || ..|.|| |.|. |. . . ||.| |.|||||.
NKFMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIM

Kinase 85746.m00199.AA DYRK 141-180 36 1.8e-10 35.65 In-house 95-135 (320) Show / Hide
Range on Protein: 141-180
Range on HMM: 95-135/320
Sequence Identity: 36% (15 aa)

RKNKGFPLSAVRTILIQILKGLAEMENK-GLVHGDIKPENI
.....|.|..||... |||..|  ....  ..|.|.|||||
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENI

Kinase 85746.m00199.AA DYRK 336-374 30 3.3e-09 30.82 In-house 283-320 (320) Show / Hide
Range on Protein: 336-374
Range on HMM: 283-320/320
Sequence Identity: 30% (12 aa)

ESRRQDNEVLLFINLMRLMLQLNPDARASASSALSHPFI
..| |  ....|... . .||..|. | ..| || ||..
DPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF

Kinase 85746.m00199.AA MAK 143-181 47 9.3e-09 23.54 In-house 124-163 (352) Show / Hide
Range on Protein: 143-181
Range on HMM: 124-163/352
Sequence Identity: 47% (19 aa)

NK-GFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII
..  || ...| |. ||| ||| |   |  | |.|||||.
DRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIM

Kinase 85746.m00199.AA RCK 348-374 48 1.1e-08 23.41 In-house 272-298 (298) Show / Hide
Range on Protein: 348-374
Range on HMM: 272-298/298
Sequence Identity: 48% (13 aa)

INLMRLMLQLNPDARASASSALSHPFI
|.||. ||| .|. |..|. || ||..
IELMEKMLQWDPQKRITAQQALQHPYF

Kinase 85746.m00199.AA CDK 349-374 42 1.3e-08 23.47 In-house 259-284 (284) Show / Hide
Range on Protein: 349-374
Range on HMM: 259-284/284
Sequence Identity: 42% (11 aa)

NLMRLMLQLNPDARASASSALSHPFI
.|.  ||...|. | ||. ||.||. 
DLLNKMLCYDPKKRISAEQALQHPYF

Kinase 85746.m00199.AA DYRK2 141-180 37 1.5e-08 23.54 In-house 94-133 (318) Show / Hide
Range on Protein: 141-180
Range on HMM: 94-133/318
Sequence Identity: 37% (15 aa)

RKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENI
.. .|| |. ||    .||..|       ..|.| |||||
NHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENI

Kinase 85746.m00199.AA YAK 346-374 44 5.4e-08 22.84 In-house 319-347 (347) Show / Hide
Range on Protein: 346-374
Range on HMM: 319-347/347
Sequence Identity: 44% (13 aa)

LFINLMRLMLQLNPDARASASSALSHPFI
.|| ..  .|||||  | ... |  ||||
CFIDFINQLLQLNPRERWKPMQAMQHPFI

Kinase 85746.m00199.AA CDKL 348-374 25 3e-07 20.82 In-house 260-286 (286) Show / Hide
Range on Protein: 348-374
Range on HMM: 260-286/286
Sequence Identity: 25% (7 aa)

INLMRLMLQLNPDARASASSALSHPFI
...|. .|...|| | ... ...||. 
LDFMKKCLHMDPDERMTCEQLMHHPYF

Kinase 85746.m00199.AA YAK 144-181 44 4.5e-07 19.67 In-house 101-138 (347) Show / Hide
Range on Protein: 144-181
Range on HMM: 101-138/347
Sequence Identity: 44% (17 aa)

KGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII
.||  . .|. ..||| |.   ||| ..| | |||||.
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIM

Kinase 85746.m00199.AA MAK 348-374 37 7e-06 14.3 In-house 326-352 (352) Show / Hide
Range on Protein: 348-374
Range on HMM: 326-352/352
Sequence Identity: 37% (10 aa)

INLMRLMLQLNPDARASASSALSHPFI
| ||. ||| .|. |. |. .. .|. 
IELMKDMLQWDPNKRPTAQQCCKYPYF

Kinase 85746.m00199.AA CDKL 141-180 37 9e-06 15.73 In-house 90-129 (286) Show / Hide
Range on Protein: 141-180
Range on HMM: 90-129/286
Sequence Identity: 37% (15 aa)

RKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENI
.. .| . . || .. ||||...   .   .| |||||||
EYPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENI

Kinase 85746.m00199.AA HIPK 347-374 28 1.3e-05 13.16 In-house 302-329 (329) Show / Hide
Range on Protein: 347-374
Range on HMM: 302-329/329
Sequence Identity: 28% (8 aa)

FINLMRLMLQLNPDARASASSALSHPFI
|..... |. .... | . . || |||.
FVHVLKKMCTWDAHKRITPCEALNHPFV

Kinase 85746.m00199.AA CDK 126-180 20 6.1e-05 11.57 In-house 107-139 (284) Show / Hide
Range on Protein: 126-180
Range on HMM: 107-139/284
Sequence Identity: 20% (11 aa)

LMELGGPSLFHGLSMRKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENI
.|.                      ..... |.|.||. .  .. .| |.|| ||
YMD----------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNI

Kinase 85746.m00199.AA PRP4 354-374 47 6.2e-05 14.08 In-house 300-320 (320) Show / Hide
Range on Protein: 354-374
Range on HMM: 300-320/320
Sequence Identity: 47% (10 aa)

MLQLNPDARASASSALSHPFI
.|.| |  | .   || ||||
CLMLDPKKRITCNEALKHPFI

Kinase 85746.m00199.AA PRP4 142-181 37 0.000195 12.25 In-house 99-138 (320) Show / Hide
Range on Protein: 142-181
Range on HMM: 99-138/320
Sequence Identity: 37% (15 aa)

KNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII
|..|. | |||    |..  |  . . . .| |||| ||.
KDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL

Kinase 85746.m00199.AA Pkinase 120-183 28 0.000201 16.72 Pfam 72-142 (293) Show / Hide
Range on Protein: 120-183
Range on HMM: 72-142/293
Sequence Identity: 28% (20 aa)

DGHLGFLMELGGP-----SLFHGLSMRKNKGF--PLSAVRTILIQILKGLAEMENKGLVHGDIKPENIIFS
..|. . ||. .      .||. .| .....|  .   .. .. |||.||. . ..| .| |.||||| ..
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

Kinase 85746.m00199.AA DYRK2 346-374 34 0.000922 7.74 In-house 290-318 (318) Show / Hide
Range on Protein: 346-374
Range on HMM: 290-318/318
Sequence Identity: 34% (10 aa)

LFINLMRLMLQLNPDARASASSALSHPFI
.||.  .  ..  |. | ..| || ||.|
NFIDFIKRCFEWDPSERMTPSQALKHPWI