Gene 88289.m00180 (T.vaginalis)

88289.m00180

Species: T.vaginalis
Alias: 88289.m00180, TvagK0396
External Links:
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
88289.m00180.AA Protein None 430 None Fasta, JSON
88289.m00180.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of 88289.m00180.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88289.m00180.AA AGC 35-297 26 2.6e-131 341.46 In-house 1-395 (395) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-395/395
Sequence Identity: 26% (104 aa)

FNIGRVLGRGAFGEVLKVQDI------ETGKYYAMKVLSKSR---IAREKKLSYVLLE------------RDAMTTLK----------HPNIIR-LYLTF
|.. .|.|.|.||.|  |..        ||||||||||.|..   | ..... ... |            |. .....          ||.|.. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDPSN--LYYVVELAE---------NG-DLQHVLN---QYKSIDLPIAKQLLGQ-------TLLALAHMHQ-HRIIHRD-IKPENILLDHYNRVKITDFG
||...  || | |...          | .| . |    .... | . |.  . .       ..||| ..|. . ||||| .||||||||.   .|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TVKI--------------------------------------YKENEPFY----------SQRGSFVG--SPEYVSPETLNETTISAATDLWA--FGCLI
  |.                                       ..|  ..           .  .|.|  .|||..|| |     . | | |.  .|||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNN-MSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

FQFITGYSPFHTGS----------NYDTFQKIE------SGNYVIP----------DYVPEDAKDIIQKLLKVKPEERLGYGDCDTN---YQTIRSHPFF
....|||.||.  .           ...||||.      . .  .|          ... ..|||.|.|||.. ||.|||.|. | .   .. |..||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 88289.m00180.AA PDK1 35-297 37 9.80000000001e-118 362.37 In-house 1-307 (307) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-307/307
Sequence Identity: 37% (117 aa)

FNIGRVLGRGAFGEVLKVQDIET----GKYYAMKVLSKSRIAREKKLSYVLLERDAMTTLK-----HPNIIRLYLTFQDPSNLYYVVELAENGDLQHVLN
| .|...|.|....| .. ..||    .| || |...|. |.||||  ||  |...|. |      ||.|..|| |||| ..||.| |...|||| | ..
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

Q--YKSIDLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDHYNRVKITDFGTV---KIYKEN-----------------------EPFYSQRGSFV
   ..| |   ..    . ..|| |.| . |||||.||||||||  ....||||||    ||  |.                       |. .. ..|||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GSPEYVSPETLNETTISAATDLWAFGCLIFQFITGYSPFHTG-----SNYDTFQKIESGNYVIPDY--VPEDAKDIIQKLLKVKPEERLG-YGDCDTNYQ
|  |||||| |..  .. ..|.||.||.|.|...|  ||        . | |||||    |..||   .|..|||...|||...| .||.    |.  ||
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECG-GYQ

TIRSHPFF
.|. ||||
QIKAHPFF
Kinase 88289.m00180.AA S_TKc 35-297 31 3.2e-95 323.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYYAMKVLSKSRIAREKKLSYVLLERDAMTTLKHPNIIRLYLTFQDPSNLYYVVELAEN--GDLQHVLNQYKS---
. |.|..|.||||.| |.....||...|.|...            .. |.. .   .||||..|| .||| ..|| | |....  ||| ... ....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IDLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDHYNRVKITDFGTVKIYKENEPFYSQRGSFVGSPEYVSPETLNETTISA-ATDLWAFGCL
   ..   |. .. |...||...|.|.|||||.||||||||.  ..||.|||  ...           .|.|.|.|..|| |     .  . | |..||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IFQFITGYSPFHTGSNYDTFQKIESGNYVIPDYVPEDAKDIIQKLLKVKPEERLGYGDCDTNYQTIRSHPFF
.. ...|| ||.    . .|.||           ...|||.|.|.|.. ||.|..  .. .. . |..||.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88289.m00180.AA Ciliate-E2 35-297 23 1e-80 274.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

FNIGRVLGRGAFG-----EVLKVQDIE------------------TGKYYAMKVLSKSRIAREKKLSYVL----------LERDAMTTLKHPNIIRLYLT
... ...|.|.||     .| |||  .                  ..|.||||...|. |   |.  ...           |.  . .|.|||||..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DPSNLYYVVELAENGDLQHVLN------------QYKSIDLPIAKQLLGQTLL---------------ALAHMHQHR-IIHRDIKPENILLDHYNR
||  | .|.|.| |... |||.. ..            . |....  .|..  | |                || ..|.   ||||||||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKITDFGTVKIYKENEP---------FYSQRGS--------------------FVGSPEYVSPETLNETT---------ISAATDLWAFGCLIFQFITGY
.||.|||. |.|....           | . ..                    ..|.|.|..|| ||             . . |.|..|........|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

SPFHTGSNYDTFQKIESGNYVIP------------------DYVPEDAKDIIQK----LLKVKPEERLGYGDCDTNYQTIRSHPFF
 ||        .|.|. ... .|                  .......||.|.|    .|...||.|..      ... |  ||.|
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------GWEQILNHPWF
Kinase 88289.m00180.AA Pkinase 35-297 27 3.8e-79 274.05 Pfam 1-293 (293) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYYAMKVLSKSRIAREKKLSYVLL--ERDAMTTLKHPNIIRLYLTFQDPSNLYYVVELAENG----DLQHVLN--Q
. |||..|.|.||.| | ... ||| .|.|...|.  ....|. . ..  |   |  |.||||.||| .|.|....| | |..|.|    || ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

YKSI--DLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDHYNRV----KITDFGTVKIYKENEPFYSQRGSFVGSPEYVSPETLN-ETTISAATDL
....  .   .|  . |.| .|...|...|||||.||||||.|. . .    ||.|||  | ..  .  .|   .|.|.|.|..|| ..  . .. . | 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGCLIFQFITGYSPFHTG------SNYDTFQKIESGNYVIPDYVP---------------------EDAKDIIQKLLKVKPEERLGYGDCDTNYQTIR
|..||.......|. ||         . .  ...| .. .  . . .                     |..||.| ..|...|..|..        . | 
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------AEQIL

SHPFF
 ||.|
QHPWF
Kinase 88289.m00180.AA RSK 38-297 32 2.1e-78 266.8 In-house 1-278 (278) Show / Hide 
Range on Protein: 38-297
Range on HMM: 1-278/278
Sequence Identity: 32% (92 aa)

GRVLGRGAFGEVLKVQDI---ETGKYYAMKVLSKSRIAREKK-LSYVLLERDAMTTLK-HPNIIRLYLTFQDPSNLYYVVELAENGDLQHVLNQYKS---
 .|||.|..|.|  .. .    ||..||||||.|. |.. .| . ... ||. . . . ||.|..|. .||... || . |. . |.|   | . |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

IDLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDH---YNRVKITDFGTVKI--YKENEPFYSQRGSFVGSPEYVSPETLN----ETTISAATDLW
..   |.. . .  ||. |.||. |||||.||||||.|.     ..|.||||  |.   ..|.. ..    |... ||. || |.    . . ..| |.|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT----FCYTIEYMAPEMLKRANQQGGHDKACDWW

AFGCLIFQFITGYSPFHT---GSNYDTFQKIESGN--YVIP--DYVPEDAKDIIQKLLKVKPEERLGYGDCDTNYQTIRSHPFF
 .|.|..   ||..||.     .  .....|..|.    .|  .|. ..|||.|.|.|.. |. |||.|  |.  . |..||.|
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDA--EEIKQHPWF
Kinase 88289.m00180.AA CAMK 40-297 21 2.7e-78 251.72 In-house 1-425 (425) Show / Hide 
Range on Protein: 40-297
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

VLGRGAFGEVLKVQDIETG------------KYYAMKVLSKSRIA-------------------------REKKLSYVLLERDAMTT-------LKHPNI
.||||.||.| ......|.            . .|.|...|...                          |.|..  |. | . | .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYLTFQD-------------------PSNLYYVV---ELAENG----DLQHVLNQYKS---------------IDLPIAKQLLGQTLLALAHMHQHRI
|.|| ...|                   ....| |    |....|    ||   . . ..               ..   |...  | . |....|.| |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENILLDHY-----------------NRVKITDFGTVKI------------YKENEPFYSQ----------RGSFVGSPEYVS-PETLN-----
.|||.||||||||.                  | .||.|||  ..            ||..| . ..             |.|.|||.. || ||     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------ETTISAATDLWAFGCLIFQFITGYSPFHTG-------------SNYDTFQKIESGNYV-IPDY-----------------------VPEDA
         .. .. ..| |. |.. .   .||.||                . |..|.|| .|.|  .|.|                       | ...
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDIIQKLLKVKPEERLGYGDCDTNYQTIRSHPFF
|| |.|.|.| ||.|.       . . . .||..
KDLIRKMLQVDPEKRM-------TIEQCLNHPWM
Kinase 88289.m00180.AA Ciliate-E2-Unclassified 35-297 25 7.7e-70 238.33 In-house 1-352 (352) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-352/352
Sequence Identity: 25% (93 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYYAMKVLSKSRIAREKKLSYV---LLERDAMTTLK-------------------HPNIIRLYLTFQDPSNLYYVV
..|....|.|.||.| |.|......||||| ..|..|   |.  ..   ..| ..|  .|                   ||.|.... .|||  |.| | 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELAENGDLQHVLNQYKS-----------------IDLPIAK-----QLLGQTLLALAHMHQH-RIIHRDIKPENILLDHYN---RVKITDFGTVKIYKEN
|..|.|||.  ....|.                 ..   ||     ... | |..| ..|.   ||||||||||||.|  .   ..||.|||  | |..|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

EPFYSQRG-------------SFVGSPEYV----SPETLNETTIS----AATDLWAFGCLIFQFITGYSPFHTGSNYD----------------TFQKIE
. ..  ..             .|.|.|.|     .|| | .   .     . | |..|........|| ||   . ..                 .|.| 
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SGNYV--------IPDYVPEDAKDIIQ----KLLKVKPEERLGYGDCDTNYQTIRSHPFF
 .|.         ||. ... |||.|.    |.||..|..|.       ... |  ||.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-------TFEQILNHPWF
Kinase 88289.m00180.AA CAMKL 35-297 27 1.6e-67 214.47 In-house 1-297 (297) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-297/297
Sequence Identity: 27% (85 aa)

FNIGRVLGRGAFGEVLKVQD-IETGKYYAMKVLSKSRIAR-------------EKKLSYVLLERDAMTTLK---HPNIIRLYLTFQDPSN------LYYV
..||..||.|.||.|   .. . ||. .|.|.. |..|               |...  .  |   |  |.   |||||.|| ....|..      .| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

VELAENGD--LQHVL--NQYKS--IDLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDHYN--RVKITDFGTVKIYKEN-EPFYSQRGSFVGSPEY
 |....|.  |.. .  . ..   .. . |...  | . |....|.|.|.||||||||||||. .   .||.|||   .|...  .       | |||.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

VSPETLNE--T-TISAATDLWAFGCLIFQFITGYSPFH-------TGSNYDTFQKIESG-NYV-IPDYVPEDAKDIIQKLLKVKPEERLGYGDCDTNYQT
 .|| ..   .  .  ..| |. | . .  ..|| ||          .|. .. ... .  |  |. .|. |..|.|.|.|.|.||.|        . . 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRP-------TIHQ

IRSHPFF
|..||..
IMNHPWM
Kinase 88289.m00180.AA AktR 35-297 37 6.3e-65 222.01 In-house 1-268 (268) Show / Hide 
Range on Protein: 35-297
Range on HMM: 1-268/268
Sequence Identity: 37% (103 aa)

FNIGRVLGRGAFGEVLKVQDI-ETGKYYAMKVLSKSRIAREKKLSYVLLERDAMT-TLKHPNIIRLYLTFQDPSNLYYVVELAENGDLQHVLNQYKSIDL
| . ..||.||||.|  ||.  ...|.||||...|. | .... .....||. |    .|| |..|. .||. ..|... |  ..|.| ..|.. | .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PIAKQLLGQTLLALAHMHQH-RIIHRDIKPENILLDHYNRVKITDFGTVK--IYK-ENEPFYSQRGSFVGSPEYVSPETLNE-TTISAATDLWAFGCLIF
  |.    | |||| . |||  || ||.||||||||    |||||||  |  . . ..|. |    ||.|.|||..||....      . |.||||..|.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAY----SFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIY

QFITGYSPFHTGSNYDTFQKIESGN-YVIPDY--VPEDAKDIIQ-KLLKVKPEERLGYGDCDTNYQTIRSHPFF
  .||. ||  ... . |||| . .   .|..  . . .||.|| |||.  |..||||.. ..  . |.|||.|
EMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGW--EEIKSHPWF
Kinase 88289.m00180.AA Aur 35-178 38 2.5e-55 144.11 In-house 1-147 (257) Show / Hide 
Range on Protein: 35-178
Range on HMM: 1-147/257
Sequence Identity: 38% (56 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYYAMKVLSKSRIAREKKLSYVLLERDAMTTLKHPNIIRLYLTFQDPSNLYYVVELAENGDLQHVLNQY--KSIDL
| ||. ||.|.||.|  ... .|.. .|.||..|. |  ..   ..  |   .. |.||||...|  |.|  . | . | |..|.| ..| .   |..| 
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

PIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLD-HYNRVKITDFG
..|     |. .|| ..|   |||||||||||||| ... .|| |||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFG
Kinase 88289.m00180.AA PKA 35-181 41 8.5e-41 141.86 In-house 1-149 (263) Show / Hide 
Range on Protein: 35-181
Range on HMM: 1-149/263
Sequence Identity: 41% (62 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYYAMKVLSKSRIAREKKLSYVLLERDAMTTLKHPNIIR-LYLTFQDPSNLYYVVELAENGDLQHVLNQYKSIDLP
|.| ..||.| || |  ... ..|.|||||.|.|..| |.|    |. |.  .. .|||.|.. .| ||||...||.| |... |.... |   .. . |
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

IAKQLLG-QTLLALAHMHQHRIIHRDIKPENILLDHYNRVKITDFGTVK
.||     |  |||  .|.. ||.|| ||||||.| .  .|||||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase 88289.m00180.AA Aur 201-279 25 2.2e-26 66.17 In-house 166-246 (257) Show / Hide 
Range on Protein: 201-279
Range on HMM: 166-246/257
Sequence Identity: 25% (21 aa)

EYVSPETLNETTISAATDLWAFGCLIFQFITGYSPFHT-GSNYDTFQKIE-SGNYVIPDYVPEDAKDIIQKLLKVKPEERL
.|..||  .. .     |.|..| |.. ...|..||    .   |...|   .....|......||| |.|.|.. |..|.
DYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRM
Kinase 88289.m00180.AA TyrKc 35-291 23 3.1e-16 39.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-291
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYY---AMKVLSKSRIAREKKLSYVLLERDAMTTL--KHPNIIRLYLTFQDP-------SNLYYVVELAENGDLQH
   |..||.|||||| |      |...   | |.| ..       .   . |   |. |  .||||.|||    ..         |. |.|....|||..
ITLGKKLGEGAFGEVYK------GTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLNQYKS-IDLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDHYNRVKITDFG-TVKIYKE-----NEPFYSQ----RGSFVGSPEYVSPETLNET
 |  ..  . ..   .   |     .. |....||||.   |.|... ..|||.||| . .|| .     ..  |..     | ..      .||..|. 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

TISAATDLWAFGCLIFQFIT-GYSPFHT-----GSNYDTFQKIESGNYV-IPDY--------VPEDAKDIIQKLLKVKPEERLGYGDCDTNYQTI
. . ..| |.|| ...   | | .|         ||.. ......|..  .|..         |..  .|...  . .||.|    ..   .. .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase 88289.m00180.AA Pkinase_Tyr 35-252 28 1e-15 53.87 Pfam 1-233 (270) Show / Hide 
Range on Protein: 35-252
Range on HMM: 1-233/270
Sequence Identity: 28% (69 aa)

FNIGRVLGRGAFGEVLKVQDIETGKYY----------AMKVLSKSRIAREKK--LSYVLLERDAMTTL-KHPNIIRLYLTFQ---DPSNLYYVVELAENG
  .|..||.|||||| |      |...          | |.| |   | ..   .   . |   |..| .||||.|||       .|...| |.|....|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

DLQHVLNQY----KSIDLPIAKQLLGQTLLALAHMHQHRIIHRDIKPENILLDHYNRVKITDFGTVKIYKENEPFY-SQRGSFVGSPEYVSPETLNETTI
|| . | .     ......   |   |   .... .....||||.   |.|... | |||.|||  .   .|.  |  .||.        .|| .|.   
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKF

SAATDLWAFGCLIFQFIT-GYSP-FHTGSNYDTFQKI-ESGN
. ..| |.|| |..  .| | .| .   ||.. ...| |.|.
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY
Kinase 88289.m00180.AA PKA 218-297 33 2.6e-15 57.21 In-house 181-263 (263) Show / Hide 
Range on Protein: 218-297
Range on HMM: 181-263/263
Sequence Identity: 33% (29 aa)

DLWAFGCLIFQFITGYSPFHTG--SNYDTFQKIESGNYVIPDYVPEDA---KDIIQKLLKVKPEERLGYGDCDTN-YQTIRSHPFF
| ||.|.||. . .||.||     .  ....|| .| .  | ..  ||   || | ||| | ...|.|   .  |  . |. |..|
DWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYG---NMKNGVNDIKNHKWF