Gene 81529.m00430 (T.vaginalis)

81529.m00430

Species: T.vaginalis
Alias: TvagK0365, 81529.m00430
External Links:
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
81529.m00430.AA Protein None 472 None Fasta, JSON
81529.m00430.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of 81529.m00430.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81529.m00430.AA AGC 59-321 26 2.9e-122 317.51 In-house 1-395 (395) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-395/395
Sequence Identity: 26% (104 aa)

FNLGQVIGQGAFGQVLEVEDK------ETLKHYAMKVLLKSH---IMREKKMNYVTIE------------RDAMTKLN----------HPNIVK-LYLTF
|..  |||.|.||.|  |..|       | | |||||| |.|   |...... .. .|            |. ..|.|          ||.||| |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDPGN--LFYVVELAP--------NGDLQKVIAEYH-----TLCIPAAKVLLGQ-------VLLAIAHMHK-KRIMHRD-LKPENILLDSENRVKITDFG
||. .  |. | |..|         |..   .  ..     ..  ..|.  . .       ..||. ..|. . | ||| |||||||||..  .|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKIFGPDQEFRSERG------------------------------------------------SFVG--SADYVSPETLKETPITPSSDLWS--YGCIV
 .|..  |.| ... .                                                .|.|  ...|..|| |     ... | ||  .||. 
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YALLTGEGPFHTES----------SYATFQRIE------SNDFKVP----------DFVPEDAKDLIEKLLKLDPTERLGHETYDED---YKPIRDHPFF
| .|||  ||. ..           . .||.|.      ... | |          ... ..|||||.|||. ||..|||    |.    .. |..||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 81529.m00430.AA PDK1 59-321 38 4.2e-122 375.99 In-house 1-307 (307) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-307/307
Sequence Identity: 38% (118 aa)

FNLGQVIGQGAFGQVLEVEDKET----LKHYAMKVLLKSHIMREKKMNYVTIERDAMTKLN-----HPNIVKLYLTFQDPGNLFYVVELAPNGDLQKVIA
|  | .|| |... |  . .|||     | || |.. |..| ||||. ||..|...|..||     ||.||||| ||||  .| .| |..||||| . . 
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

E--YHTLCIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSENRVKITDFGTA---KIFGPD-------------QEFR----------SERGSFV
   . .. .  ..    . ..|. |.|.. | ||||||||||||......|||||||   ||. ..             |. .          . ..|||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GSADYVSPETLKETPITPSSDLWSYGCIVYALLTGEGPFHTE-----SSYATFQRIESNDFKVPDF--VPEDAKDLIEKLLKLDPTERLG-HETYDEDYK
| | ||||| | . ..|||.|.|..|||.| ...|  ||  .     . | |||.|   ..  ||   .|..||||..|||..||..||.  ..  ..|.
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDEC-GGYQ

PIRDHPFF
.|. ||||
QIKAHPFF
Kinase 81529.m00430.AA S_TKc 59-321 31 3.2e-89 303.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

FNLGQVIGQGAFGQVLEVEDKETLKHYAMKVLLKSHIMREKKMNYVTIERDAMTKLNHPNIVKLYLTFQDPGNLFYVVELAPN--GDLQKVIAEYHT---
. ....||.||||.|  . .|.| ...|.|..           . .  |.. . | .|||||||| .||| ..|. | |....  ||| ..| .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LCIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSENRVKITDFGTAKIFGPDQEFRSERGSFVGSADYVSPETLKETPITP-SSDLWSYGCI
   .    |. .. |...|....|...|.||||||||||||.  ..||.||| |...           .|.|. .|..|| |   . .. ..| || |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VYALLTGEGPFHTESSYATFQRIESNDFKVPDFVPEDAKDLIEKLLKLDPTERLGHETYDEDYKPIRDHPFF
.| .|.|. ||.    ...|..|           ...|||.|.|.|. ||..|..     .|   |. ||.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81529.m00430.AA Pkinase 59-321 29 6e-81 280.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FNLGQVIGQGAFGQVLEVEDKETLKHYAMKVLLKSHIMREKKMNYVT-IERDAMTKLNHPNIVKLYLTFQDPGNLFYVVELAPNG----DLQKVIA--EY
. .|..||.|.||.| .  .| | | .|.|.. |.|.  .|... .   |   | .|||||||.|| .|.|....  | |....|    ||  .|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HTL--CIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSENRV----KITDFGTAKIFGPDQEFRSERGSFVGSADYVSPETLK-ETPITPSSDLW
 ..      .|  . |.| .....|...|.||||||||||.|... .    ||.||| || |       |   .|.|. .|..|| ..  ....|..| |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SYGCIVYALLTGEGPFHTE------SSYATFQRIESNDFKVPDFVP---------------------EDAKDLIEKLLKLDPTERLGHETYDEDYKPIRD
|.|||.| .|.|. ||  .      . .. ..|| . ... . . .                     |..||.|...|..||..|..        . |  
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------AEQILQ

HPFF
||.|
HPWF
Kinase 81529.m00430.AA CAMK 64-303 21 1.4e-77 249.36 In-house 1-414 (425) Show / Hide 
Range on Protein: 64-303
Range on HMM: 1-414/425
Sequence Identity: 21% (91 aa)

VIGQGAFGQVLEVEDKETL------------KHYAMKVLLKSHIM-------------------------REKKMNYVTIERDAMTK-------LNHPNI
..|.|.||.| ....|.|             ...|.|.. |. .                          |.|..  |  | . | |       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYLTFQDPGN------------------LFYVV----ELAPNG----DLQKVIAEY---------------HTLCIPAAKVLLGQVLLAIAHMHKKRI
.||| ...|| .                   .| |    |....|    ||   | |                . ..   |. .  |.. |....|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDLKPENILLDSE-----------------NRVKITDFGTAKIFGPDQEFR--------------------SERGSFVGSADYVS-PETLK-------
.||||||||||||.                  | .||.||| |..| |... .                         |.|.  |.. || |.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------ETPITPSSDLWSYGCIVYALLTGEGPFHTE-------------SSYATFQRIESNDFK-VPDF-----------------------VPEDAKD
       .....|..| || |.| |..|.|. ||  .             . | .|..| . ..   |..                       | ...||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIEKLLKLDPTERL
|| |.|. ||..|.
LIRKMLQVDPEKRM
Kinase 81529.m00430.AA RSK 61-321 31 3.9e-75 255.93 In-house 1-278 (278) Show / Hide 
Range on Protein: 61-321
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

LGQV--IGQGAFGQVLEVEDKETLKHYAMKVLLKSHIMREKK-MNYVTIERDAMTKLN-HPNIVKLYLTFQDPGNLFYVVELAPNGDLQKVIAEYHT---
| .   .|.|.. .. ..... | ..|||||| |. |.. .|   ..  ||. .   . ||.||.|. .||..| |. . |. . |.| . . .  .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LCIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDS---ENRVKITDFGTAKIFGPDQEFRSERGSFVGSADYVSPETLK----ETPITPSSDLWSY
..   |.. . .. ||. |.|.. | ||||||||||.|.   | ..|.|||| .|.| .|....    .|.....|. || ||    .   . . |.|| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTM--TFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GCIVYALLTGEGPFHT---ESSYATFQRIESND--FKVP--DFVPEDAKDLIEKLLKLDPTERLG--HETYDEDYKPIRDHPFF
|.. | .|||  ||.    ...  ...||....  .. |  ... ..||||| |.|. ||  |||  .    .| . |..||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGP----QDAEEIKQHPWF
Kinase 81529.m00430.AA Ciliate-E2 59-321 22 1.5e-73 250.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-365/365
Sequence Identity: 22% (88 aa)

FNLGQVIGQGAFGQVLEVEDKET-----------------------LKHYAMKVLLKSHIMREKKMNYVT----------IERDAMTKLNHPNIVKLYLT
... ..||||.||.| .......                        | ||||.. |. |   |.....           .|.  . .||||||.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DPGNLFYVVELAPNGDLQKVIAEYHTLC-----------IPAAKVLLGQVLL---------------AIAHMHKKR-IMHRDLKPENILLDSENRV
||  |  |...| |..  |||.. | .  . .           .  .| .  |.|                |. ..|.|  |.|||.||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGTAKIFGPD---------QEFRSERGS--------------------FVGSADYVSPETLKETP---------ITPSSDLWSYGCIVYALLTGEG
||.|||..|.. .|         ..   . ..                    ..|.. |..|| |.  .          . ..|.|| |.| | .|.|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFHTESSYATFQRIESNDFKVPDF------------------VPEDAKDLIEK----LLKLDPTERLGHETYDEDYKPIRDHPFF
||        .| |. .... | .                  .....|||| |    .|. || .|..      ... | .||.|
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------GWEQILNHPWF
Kinase 81529.m00430.AA CAMKL 59-302 27 2.8e-66 210.48 In-house 1-285 (297) Show / Hide 
Range on Protein: 59-302
Range on HMM: 1-285/297
Sequence Identity: 27% (79 aa)

FNLGQVIGQGAFGQVLEVED-KETLKHYAMKVLLKSHIM-REKKMNY-----------VTIERDAMTKLN---HPNIVKLYLTFQDPGN------LFYVV
...|...|.|.||.|   .. . | ...|.|.. |. |  ......            .. |   | .||   ||||.||| ....| .      .. | 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELAPNGD--LQKVI--AEYHT--LCIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSEN--RVKITDFGTAKIFGP-----DQEFRSERGSFVGS
|....|.  |.  |   ...   .  . |. .  |.. |....|...| |||.||||||||. .   .||.||| . .. |     .| ..     | ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLK----TFCGS

ADYVSPETLKE--TPIT-PSSDLWSYGCIVYALLTGEGPFHTES-------SYATFQRIESNDFKVPD---FVPEDAKDLIEKLLKLDPTER
  | .|| ..   .|   |  | || | | ||...|. ||  ..        . .. ...  . . |.   .|. |..||| |.|. .|..|
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKR
Kinase 81529.m00430.AA AktR 59-321 35 1.2e-65 224.4 In-house 1-268 (268) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-268/268
Sequence Identity: 35% (97 aa)

FNLGQVIGQGAFGQVLEVEDK-ETLKHYAMKVLLKSHIMREKKMNYVTIERDAMT-KLNHPNIVKLYLTFQDPGNLFYVVELAPNGDLQKVIAEYHTLCI
| . ...|.||||.|  |..| .. | ||||.. |..| ....| ..  ||. |  . ||| ||||. .||.  .||.. |  |.|.|  ..   ...  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PAAKVLLGQVLLAIAHMHKK-RIMHRDLKPENILLDSENRVKITDFGTAKIFGPDQEFRSERGSFVGSADYVSPETLKE-TPITPSSDLWSYGCIVYALL
  |.    |.|||. . |..  |. |||||||||||..  ||||||| .|   .. . . .  ||.|.  |..||....  . . |.|.|. |. .| ..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

TGEGPFHTESSYATFQRIESND-FKVPDF--VPEDAKDLIE-KLLKLDPTERLGHETYDEDYKPIRDHPFF
||  ||  ..    ||.| . . .|.|.   . . .||||. |||. .|..|||   |... . |..||.|
TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGY--YCNGWEEIKSHPWF
Kinase 81529.m00430.AA Ciliate-E2-Unclassified 59-321 24 1.6e-64 220.63 In-house 1-352 (352) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

FNLGQVIGQGAFGQVLEVEDKETLKHYAMKVLLKSHIMREKKMNYV---TIERDAMTKLN-------------------HPNIVKLYLTFQDPGNLFYVV
......||||.||.| ....|.. . |||| . |..|   |.....     | ..| ...                   ||.|||.. .|||  |.. | 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELAPNGDLQKVIAEYHT-----------------LCIPAAK-----VLLGQVLLAIAHMHKK-RIMHRDLKPENILLDSEN---RVKITDFGTAKIFGPD
|....|||.. | ....                 .   .||      .. |.|... ..|.|  | |||.||||||.|...   ..||.||| .|  . .
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

QEFRSERG-------------SFVGSADYV----SPETLKETPITPS----SDLWSYGCIVYALLTGEGPFHTESSYA----------------TFQRIE
.... ...             .|.|.  |     .|| |..     |    .| || |.| |..|.|. ||  ....                  .| | 
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SNDFKVP--------DFVPEDAKDLIE----KLLKLDPTERLGHETYDEDYKPIRDHPFF
 .....|        . ... |||.|.    |.|| .| .|.       ... |  ||.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-------TFEQILNHPWF
Kinase 81529.m00430.AA RSK 59-321 32 2.7e-58 199.99 In-house 1-271 (271) Show / Hide 
Range on Protein: 59-321
Range on HMM: 1-271/271
Sequence Identity: 32% (90 aa)

FNLGQVIGQGAFG---QVLEVEDKETLKHYAMKVLLKSHIMREKKMNYVTIERDAMTKLNHPNIVKLYLTFQDPGNLFYVVELAPNGDLQKVIAEYHTLC
..| ..||||.|.    .  .. | | .|||||.. |. .    .  . . ||. .   .||.||||.  ||| |... . ...  ||| . .     ..
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

IPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSE----NRVKITDFGTAKIFGPDQEFRSERG---SFVGSADYVSPETLKETPITPSSDLWSYGC
   .|  .  ..|| .. |.. | ||||||||||.|.|      .||.||| ||      . |.| |   .| ..| |. || ||    . ..| ||.| 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAK------QLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGV

IVYALLTGEGPFHTESSYATFQRIESNDFKV-------PDFVPEDAKDLIEKLLKLDPTERLGHETYDEDYKPIRDHPFF
. |  |||  ||.      ... |   .          .||. . ||||. ..|. ||. |||  .  .. . |. ||.|
LMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLG--AGPNGVEQIKQHPWF
Kinase 81529.m00430.AA RSK-Unclassified 59-202 37 7.2e-42 128.97 In-house 1-146 (283) Show / Hide 
Range on Protein: 59-202
Range on HMM: 1-146/283
Sequence Identity: 37% (55 aa)

FNLGQVIGQGAFGQVLEVEDKETLKHYAMKVLLKSHIMREKKMNYVTIERDAMTKLNHPNIVKLYLTFQDPGNLFYVVELAPNGDLQKVIA--EYHTLCI
|     |||| ||.|  |. |.| . |||||| |. ..| .|  ||  |.. |   ||| ||.||  ||    |. . |  . ||. .         .| 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

PAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSENRVKITDFG
  ... .  | .|  ..||. .  |||||.||.|. |  |. |||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFD
Kinase 81529.m00430.AA RSK-Unclassified 219-321 36 3.2e-23 69.34 In-house 181-283 (283) Show / Hide 
Range on Protein: 219-321
Range on HMM: 181-283/283
Sequence Identity: 36% (38 aa)

SFVGSADYVSPETLKETPITPSSDLWSYGCIVYALLTGEGPFHTESSYATFQRIESNDFKVP--DFVPEDAKDLIEKLLKLDPTERLGHETYDEDYKPIR
||.|. .|. || ..    |   | |  | ..| .| |  |.  . .  ||. || |. |.|   ..  ...||| |||.  |  |||    | |   |.
SFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADD--IK

DHPFF
 ||||
RHPFF
Kinase 81529.m00430.AA TyrKc 59-312 22 3.4e-15 22.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 59-312
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FNLGQVIGQGAFGQVLEVEDKETLKHYAMKVLLKSHIMREKKMNYVTIERDAMTKL--NHPNIVKLYLTFQDP-------GNLFYVVELAPNGDLQKVIA
  ||...| ||||.| . . |      | |.| ...      .     |   |.||  .|||||.||    ..       . |. |.|..|.|||.. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EYHT-LCIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSENRVKITDFGTAKIFGPD-------QEFRSE---RGSFVGSADYVSPETLKETPIT
...  || .       |.    .. |.|.. ||||   |.|......|||.||| ..  . |       .  |.     | ..      .||....   |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PSSDLWSYGCIVYALLTGEGPFHTE------SSYATFQRIESN--DFKVPD--------FVPEDAKDLIEKLLKLDPTERLGHETYDEDY
. || ||.|   . ..|  .. . .      | .  ......     . |.          .|  . ....  . || .|   ..  |. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 81529.m00430.AA Pkinase_Tyr 111-202 31 5.7e-07 24.24 Pfam 57-156 (270) Show / Hide 
Range on Protein: 111-202
Range on HMM: 57-156/270
Sequence Identity: 31% (31 aa)

MTKL-NHPNIVKLYLTFQ-DPGN--LFYVVELAPNGDLQKVIAEY----HTLCIPAAKVLLGQVLLAIAHMHKKRIMHRDLKPENILLDSENRVKITDFG
|..| .|||||.||     . .   .. |.|..|.||| .   .     . |...       |.  . .. . |.. ||||   |.|....| |||.|||
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 81529.m00430.AA Pkinase_Tyr 59-75 41 0.008365 10.12 Pfam 1-17 (270) Show / Hide 
Range on Protein: 59-75
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FNLGQVIGQGAFGQVLE
  .|...|.||||.| .
ITFGKKLGEGAFGEVYK
PDK1_PH 81529.m00430.AA PDK1_PH 371-471 37 9.9e-51 174.85 In-house 1-112 (112) Show / Hide 
Range on Protein: 371-471
Range on HMM: 1-112/112
Sequence Identity: 37% (42 aa)

SHMEQFLL-SGEHIIYEGDIQKRVFLSV----KNRRLILTDRPRLFYVDLKENKIKGSITIC-KELEVKIV-----SKTKWNIIIPERTYNLISEDCDIN
....|||. .||||...|...||..|..    |.|.|||||.||||||| ....|||.|... |.|.|..      ......|..|.|||... .....|
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

QWKKVIEEVVAK
.|.. ||.|...
KWCEAIEKVCKR