86001.m00221

Species: T.vaginalis
Alias: 86001.m00221, TvagK0186
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
86001.m00221.AA Protein None 291 None Fasta, JSON
86001.m00221.kin_dom Protein Kinase Domain None 233 None Fasta, JSON

Protein domain

Protein domains of 86001.m00221.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 86001.m00221.AA S_TKc 17-255 28 2.6e-51 177.69 SMART 1-231 (231) Show / Hide
Range on Protein: 17-255
Range on HMM: 1-231/231
Sequence Identity: 28% (72 aa)

FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKTQYENEVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEG--GTPESLIKNKVRP-----IQNKI
..|.. .|   | ..|.. |   .. . .|||.   . ..|.  |   .|||||.|| .|.. ...||..|||.|  |.  ..||.. |.     .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHA

VNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSGYYSTNESHYNVGSYGYLAPEQRTSHAFDPFLADIWSLGVTIYYMTCGLNPFIKQ
  ...|...  .|.||..| | |.||.|||.|.  .|||.||||.  .     .  .|.  |.|||      .... .|.||.|...| | ||  ||  |
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-Q

KNSYKYIIPMFVERSLAEVISGTLEEDPLKRLSLDKIED----ILTARPK
 .    .|     ... . |.. |. || ||..  ..      |      
MQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 86001.m00221.AA CAMK 32-246 17 3.5e-50 159.49 In-house 11-419 (425) Show / Hide
Range on Protein: 32-246
Range on HMM: 11-419/425
Sequence Identity: 17% (73 aa)

YLVFHQVYQ------------QNFVCKIISKK---------------------------------TQYENEVLALTT-------LDHPNIVRLYSHFEEN
.|..|   .            | . .|||.||                                  . ..|.  . .       ||||||..|| ..| .
KLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDP

G-------------------KYYMIL---EYCEGGTP----ESLIKNK--------------VRPI-QNKIVNITKQLVRVFKYIHSKRIAHHDIKPSNI
                    ..||..   |||.||       . |. .               . .       . .|..   .|.||. |.| |.|| ||
HYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENI

LFDKY-----------------GRIKIADFGLSGYYSTNE-------------------------SHYNVGSYGYLA-PEQRTS-------------HAF
|.|.                  . |||.|||.. ..  .|                          .  .|. .| | ||   .             .  
LLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPY

DPFLADIWSLGVTIYYMTCGLNPFIKQ-----------------------KNSYKYIIPM----------------------FVERSLAEVISGTLEEDP
... .|.||.||  | | ||  ||                          |  | .. |.                      ||  .    |.. |. ||
YGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDP

LKRLSLDKI
 ||.... .
EKRMTIEQC

Kinase 86001.m00221.AA Ciliate-E2 17-246 22 1.8e-49 167.96 In-house 1-359 (365) Show / Hide
Range on Protein: 17-246
Range on HMM: 1-359/365
Sequence Identity: 22% (81 aa)

FQIIKGLGNKCFP-----SCYLVFH------------------QVYQQNFVCKIISKK-TQYENEVLALT-----------------TLDHPNIVRLYSH
. .|| .|. .|      . ..| .                  .| .. .  ||..|.  .. . .. .                  .|.||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--ENGKYYMILEYCEGGTPESLIKNK-----------VRPIQNKIVNITKQLVRVF---------------KYIHSKR-IAHHDIKPSNILFDKYGRI
|.   . ..|...|||.||. ...|||.            ..  ..| .|.||....|               .|.|||  | | ||||.||||     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGLSGYYSTNESHYN---------------------------------VGSYGYLAPEQRTS--------HAFDPFLADIWSLGVTIYYMTCGLNP
||.||||| .|....  .                                  .|..||.|||   .        .    . .|||||||..|.| .|  |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FIKQKNSYKYIIPMF------------------VERSLAEVISG----TLEEDPLKRLS-LDKI
|..|.   |. .| .                  .. .    |.      |. || ||..  ..|
FQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI

Pkinase 86001.m00221.AA Pkinase 17-250 26 2.3e-47 168.48 Pfam 1-288 (293) Show / Hide
Range on Protein: 17-250
Range on HMM: 1-288/293
Sequence Identity: 26% (78 aa)

FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKTQYE---------NEVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEGG----TPESLIK--NK
..|.. .|   | ..|.  |. ... ...|||.|... .         .|.  .  |.||||||||  ||.....||..||||||       ..|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VRP--IQNKIVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRI----KIADFGLSG---YYSTNESHYNVGSYGYLAPEQRTSHAFDPFLADIWSL
 .     . . .. .|..|  .|.||..| | |.||.|||.|. | |    ||.||||.    | .    .  .|...|.|||   ..  ..  .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVTIYYMTCGLNPFIKQK-----NSYKYIIPMFVE-------------------------------RSLAEVISGTLEEDPLKRLSLDKIEDIL
|...|.| ||  ||  ..     .. ...| .  .                               ... ..|.. |. || ||..   .|.||
GCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQIL

Kinase 86001.m00221.AA ULK 40-217 28 5.3e-41 140.88 In-house 28-268 (329) Show / Hide
Range on Protein: 40-217
Range on HMM: 28-268/329
Sequence Identity: 28% (69 aa)

QQNFVCKIISKKT---------------QYENEVLALTTLD--------HPNIVRLYSHFEEN--GKYYMILEYCEGGTPESLIK----------NKVRP
.. ..||.|.|..               . .||.  . .|.        |||||.||  ||.     .|.|.|||.||. |..||          .| | 
NEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRL

IQNKIVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKY------------GRIKIADFGLSGYYSTN-----ESHYNV------GSYGYLAPE--QRT-
 ....... ||..  ||..|...| | ||||.||| ..             |..||||||..   . .       .. |      |.  | ||.  |.  
SEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQG

-SHAFDPFLADIWSLGVTIYYMTCGLNPFIKQ-KNSYKYII
    .. . .||||||. .|.|  |  || ..    |..||
EQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQII

Kinase 86001.m00221.AA Ciliate-E2-Unclassified 17-206 25 4e-40 136.86 In-house 1-270 (352) Show / Hide
Range on Protein: 17-206
Range on HMM: 1-270/352
Sequence Identity: 25% (68 aa)

FQIIKGLGNKCFPSCYLVFH------------QVYQQNFVCKIISKKTQYENEVLALTT-------------------LDHPNIVRLYSHFEENGKYYMI
. ||| .|. .| . |.. |             ..|.. ...| .|. .. || ...                     ..||.||... .|.   . |..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCEGGTPESLIKN-KV---------------RPI-QNKIV-----NITKQLVRVFKYIHSK-RIAHHDIKPSNILFDKYG---RIKIADFGLSG----
.||||||. .  ||. |                . .  ....     ....|..  ..|.|.|  | | ||||.|||||. |   .|||.|||.|     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-------------YYSTNESHYNVGSYGYL----APEQRTSHAFDP---FLADIWSLGVTIYYMTCGLNPF
             ... .... ..|...|.    |||   ..  |    . .||||||| .|.|  |  ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF

Kinase 86001.m00221.AA ULK 40-212 28 2.5e-39 137.0 In-house 28-257 (324) Show / Hide
Range on Protein: 40-212
Range on HMM: 28-257/324
Sequence Identity: 28% (66 aa)

QQNFVCKIIS----KKTQYE-----------NEVLALTTLD---HPN--IVRLYSHFEEN--GKYYMILEYCEGGTPESLIKNKVR---------PIQNK
.| . ||.|.    .| ..|           ||.  . .|.   |||  ||.||  ||.     .|.|.|||.||. |..||.. .           ...
NQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQE

IVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKY------------GRIKIADFGLSGYYST-----NESHYNV------GSYGYLAPE--QRT--SHA
.... ||..  ||..|.. | | ||||.|||  .             |..||||||..          .  .. |      |.  | ||.  |.      
AIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKP

FDPFLADIWSLGVTIYYMTCGLNPFIKQKNS
.. . .||||||. .|.|  |  || .. ..
YYDYKCDIWSLGCIFYEMLYGKYPFFSW-FN

Kinase 86001.m00221.AA STE 17-206 20 8.9e-37 127.41 In-house 1-268 (359) Show / Hide
Range on Protein: 17-206
Range on HMM: 1-268/359
Sequence Identity: 20% (57 aa)

FQIIKGLGNKCFPSCYLVFHQ------VYQQN---------FVCKIIS----------------------KKTQYENEVLALTTLD--HPNIVRLYSHFE
...|. .|.  | . |.  .         ...         .  |...                      .. |...|.  .  ..  |||||. | ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------KYYMILEYCEGGTPESLIKNK-VRPI-------------QNKIVNITKQLVRV-FKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSG
 .|       . ....||..||. ...||.|  ..               . |  |..|...   .|.||..| | ||||.|||.     .|..|||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

YYSTN------------------ESHYNVGSYGYLAPEQ--RTSHA-FDPF--LADIWSLGVTIYYMTCGLNPF
  . .                  ..   ||.  . |||   . ...  ..    .|||||| ||  | .|  |.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

Kinase 86001.m00221.AA Ciliate-E2a 17-175 35 7.9e-35 99.96 In-house 1-180 (275) Show / Hide
Range on Protein: 17-175
Range on HMM: 1-180/275
Sequence Identity: 35% (63 aa)

FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKTQYEN--------EVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEGGTPESLIKNKVRPIQN-
. .|| .|. .| | ||. |    ..|. |...|| . .         |.  . .|||||| .||  .| .  ||...||||||. .. ||.. |  .. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-KIVNITKQLV-RVFKYIHSKRIAHHDIKPSNILFD---KYG----RIKIADFGLSGYYSTNES---HYNVGSYGYLAPE
 .|  | .||    . |.|.. | | |.|| ||||.   | .     |||.||||. .....|    .  .|. ||.|||
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPE

Kinase 86001.m00221.AA CAMKL 121-247 33 1.1e-34 107.95 In-house 141-292 (297) Show / Hide
Range on Protein: 121-247
Range on HMM: 141-292/297
Sequence Identity: 33% (51 aa)

KYIHSKRIAHHDIKPSNILFDKYG--RIKIADFGLSGYYST-----NE-SHYNVGSYGYLAPEQRTS-HA-FDPFLADIWSLGVTIYYMTCGLNPFI---
.|.||..|.| |||| |||.|. |   |||.|||.| .|       ..  .   ||. | |||   . .  .| . .||||.||. | | ||  ||    
NYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDT

-------------KQKNSYKYI-IPMFVERSLAEVISGTLEEDPLKRLSLDKIE
             |..   .|. |. .|  ..   |.. |. .| || ... |.
YNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

Kinase 86001.m00221.AA CAMK-Unique 46-206 22 1.8e-33 107.68 In-house 38-293 (363) Show / Hide
Range on Protein: 46-206
Range on HMM: 38-293/363
Sequence Identity: 22% (57 aa)

KIISKKTQ-----------------YENEVLALTTLDHPNIVRLYSH----FEENG---------------KYYMILEYCEGGTPESLIKN---------
.....|.|                 ...|.  . ..|||||..||      |.                  ..|...|||.||.  ..|           
GNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFI

-----------KVRPIQ--NKIVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGR----------------IKIADFGLSGYYSTNESH----YNVG
           . .     . . .|  .|. . .| ||. | | |.|. ||.. . .                 ||..||||. .|..|..       .|
IKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCG

SYGYLAP--------------EQRTSHAFDPFLA---DIWSLGVTIYYMTCGLNPF
.  |.||              |    .  |  .    |||||||. ||| ||  ||
TPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPF

Kinase 86001.m00221.AA MELK 17-206 30 2.7e-31 103.99 In-house 1-200 (254) Show / Hide
Range on Protein: 17-206
Range on HMM: 1-200/254
Sequence Identity: 30% (61 aa)

FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKT------QYENEVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEGGTPESLIKNKVRPIQNKIV
... . .|   |    |  | . .|    ||. |..      . . |. ||  | | .| .||   | . |..|..||| ||     |  . |  ..   
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

NITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSGYYSTNESHY----NVGSYGYLAPEQRTSHAFDPFLADIWSLGVTIYYMTCGLNPF
 . .|.|    |.||.  || |.|| |.||| . ..|. ||||      .  ..      ||  | |||      .    ||.||.|. .| . ||  ||
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF





Kinase 86001.m00221.AA CAMKL 46-92 27 5.9e-14 40.78 In-house 31-106 (297) Show / Hide
Range on Protein: 46-92
Range on HMM: 31-106/297
Sequence Identity: 27% (21 aa)

KIISKKTQYEN--------------------EVLALTTLD---HPNIVRLYSHF-------EENGKYYMILEYCEGG
||| ||   ..                    |.  .  |.   ||||..|| ..       |  .|.|...|||.||
KIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGG

TyrKc 86001.m00221.AA TyrKc 7-250 18 2.1e-10 -54.28 SMART 1-280 (280) Show / Hide
Range on Protein: 7-250
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

EISSILLGRGF--QIIKGLGNKCFPSCYLVFHQVYQQNFV----CKIISKKTQYENEVLALTTL--DHPNIVRLYSHFEEN-------GKYYMILEYCEG
      ||.|.  .. ||  .                  |    .|  . .    .|   .. |  .||||||||    .        . .....||...
ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GTPESLIKNKVRPIQNK-IVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSGYYSTN------ESHYNV----GSYG-----YLAPE
|   . .... . ...|  ...  |  .   |.|||.. | |.   |.| .. ...||.||||| .          .. | .    |. .      .|||
GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

QRTSHAFDPFLADIWSLGVTIY---------YMT-----CGLNPFIKQKNSYKYIIPMFV---------ERSLAEVISGTLEEDPLKRLSLDKIEDIL
    . |  .  |.|| ||...         |       .     |..  . ..  ..              . ....   .||| .| .   | ...
CINYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 86001.m00221.AA Pkinase_Tyr 56-92 34 6e-06 20.83 Pfam 52-92 (270) Show / Hide
Range on Protein: 56-92
Range on HMM: 52-92/270
Sequence Identity: 34% (14 aa)

NEVLALTTL-DHPNIVRLYSHFE-ENGK--YYMILEYCEGG
.|.  ...| .||||||||     . .   .|...||...|
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

Kinase 86001.m00221.AA Ciliate-E2a 188-206 52 0.012685 3.57 In-house 198-216 (275) Show / Hide
Range on Protein: 188-206
Range on HMM: 198-216/275
Sequence Identity: 52% (10 aa)

DIWSLGVTIYYMTCGLNPF
|.||.|| .| . ||  ||
DMWSCGVIFYILLCGKPPF

Kinase 86001.m00221.AA Pkinase_Tyr 137-154 44 1.229388 2.78 Pfam 141-158 (270) Show / Hide
Range on Protein: 137-154
Range on HMM: 141-158/270
Sequence Identity: 44% (8 aa)

NILFDKYGRIKIADFGLS
|.| .. . .||.||||.
NCLVTENNVVKICDFGLA