Gene 86001.m00221 (T.vaginalis)
86001.m00221
Species: T.vaginalis
Alias: 86001.m00221, TvagK0186
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
86001.m00221.AA | Protein | None | 291 | None | Fasta, JSON |
86001.m00221.kin_dom | Protein Kinase Domain | None | 233 | None | Fasta, JSON |
Protein domains of 86001.m00221.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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S_TKc | 86001.m00221.AA | S_TKc | 17-255 | 28 | 2.6e-51 | 177.69 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 17-255 Range on HMM: 1-231/231 Sequence Identity: 28% (72 aa) FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKTQYENEVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEG--GTPESLIKNKVRP-----IQNKI ..|.. .| | ..|.. | .. . .|||. . ..|. | .|||||.|| .|.. ...||..|||.| |. ..||.. |. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHA VNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSGYYSTNESHYNVGSYGYLAPEQRTSHAFDPFLADIWSLGVTIYYMTCGLNPFIKQ ...|... .|.||..| | |.||.|||.|. .|||.||||. . . .|. |.||| .... .|.||.|...| | || || | RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-Q KNSYKYIIPMFVERSLAEVISGTLEEDPLKRLSLDKIED----ILTARPK . .| ... . |.. |. || ||.. .. | MQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 86001.m00221.AA | CAMK | 32-246 | 17 | 3.5e-50 | 159.49 | In-house | 11-419 (425) | Show / Hide |
Range on Protein: 32-246 Range on HMM: 11-419/425 Sequence Identity: 17% (73 aa) YLVFHQVYQ------------QNFVCKIISKK---------------------------------TQYENEVLALTT-------LDHPNIVRLYSHFEEN .|..| . | . .|||.|| . ..|. . . ||||||..|| ..| . KLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDP G-------------------KYYMIL---EYCEGGTP----ESLIKNK--------------VRPI-QNKIVNITKQLVRVFKYIHSKRIAHHDIKPSNI ..||.. |||.|| . |. . . . . .|.. .|.||. |.| |.|| || HYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENI LFDKY-----------------GRIKIADFGLSGYYSTNE-------------------------SHYNVGSYGYLA-PEQRTS-------------HAF |.|. . |||.|||.. .. .| . .|. .| | || . . LLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPY DPFLADIWSLGVTIYYMTCGLNPFIKQ-----------------------KNSYKYIIPM----------------------FVERSLAEVISGTLEEDP ... .|.||.|| | | || || | | .. |. || . |.. |. || YGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDP LKRLSLDKI ||.... . EKRMTIEQC |
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Kinase | 86001.m00221.AA | Ciliate-E2 | 17-246 | 22 | 1.8e-49 | 167.96 | In-house | 1-359 (365) | Show / Hide |
Range on Protein: 17-246 Range on HMM: 1-359/365 Sequence Identity: 22% (81 aa) FQIIKGLGNKCFP-----SCYLVFH------------------QVYQQNFVCKIISKK-TQYENEVLALT-----------------TLDHPNIVRLYSH . .|| .|. .| . ..| . .| .. . ||..|. .. . .. . .|.||||...| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--ENGKYYMILEYCEGGTPESLIKNK-----------VRPIQNKIVNITKQLVRVF---------------KYIHSKR-IAHHDIKPSNILFDKYGRI |. . ..|...|||.||. ...|||. .. ..| .|.||....| .|.||| | | ||||.|||| | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KIADFGLSGYYSTNESHYN---------------------------------VGSYGYLAPEQRTS--------HAFDPFLADIWSLGVTIYYMTCGLNP ||.||||| .|.... . .|..||.||| . . . .|||||||..|.| .| | KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FIKQKNSYKYIIPMF------------------VERSLAEVISG----TLEEDPLKRLS-LDKI |..|. |. .| . .. . |. |. || ||.. ..| FQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI |
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Pkinase | 86001.m00221.AA | Pkinase | 17-250 | 26 | 2.3e-47 | 168.48 | Pfam | 1-288 (293) | Show / Hide |
Range on Protein: 17-250 Range on HMM: 1-288/293 Sequence Identity: 26% (78 aa) FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKTQYE---------NEVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEGG----TPESLIK--NK ..|.. .| | ..|. |. ... ...|||.|... . .|. . |.|||||||| ||.....||..|||||| ..|. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH VRP--IQNKIVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRI----KIADFGLSG---YYSTNESHYNVGSYGYLAPEQRTSHAFDPFLADIWSL . . . .. .|..| .|.||..| | |.||.|||.|. | | ||.||||. | . . .|...|.||| .. .. .|.||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVTIYYMTCGLNPFIKQK-----NSYKYIIPMFVE-------------------------------RSLAEVISGTLEEDPLKRLSLDKIEDIL |...|.| || || .. .. ...| . . ... ..|.. |. || ||.. .|.|| GCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQIL |
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Kinase | 86001.m00221.AA | ULK | 40-217 | 28 | 5.3e-41 | 140.88 | In-house | 28-268 (329) | Show / Hide |
Range on Protein: 40-217 Range on HMM: 28-268/329 Sequence Identity: 28% (69 aa) QQNFVCKIISKKT---------------QYENEVLALTTLD--------HPNIVRLYSHFEEN--GKYYMILEYCEGGTPESLIK----------NKVRP .. ..||.|.|.. . .||. . .|. |||||.|| ||. .|.|.|||.||. |..|| .| | NEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRL IQNKIVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKY------------GRIKIADFGLSGYYSTN-----ESHYNV------GSYGYLAPE--QRT- ....... ||.. ||..|...| | ||||.||| .. |..||||||.. . . .. | |. | ||. |. SEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQG -SHAFDPFLADIWSLGVTIYYMTCGLNPFIKQ-KNSYKYII .. . .||||||. .|.| | || .. |..|| EQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQII |
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Kinase | 86001.m00221.AA | Ciliate-E2-Unclassified | 17-206 | 25 | 4e-40 | 136.86 | In-house | 1-270 (352) | Show / Hide |
Range on Protein: 17-206 Range on HMM: 1-270/352 Sequence Identity: 25% (68 aa) FQIIKGLGNKCFPSCYLVFH------------QVYQQNFVCKIISKKTQYENEVLALTT-------------------LDHPNIVRLYSHFEENGKYYMI . ||| .|. .| . |.. | ..|.. ...| .|. .. || ... ..||.||... .|. . |.. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LEYCEGGTPESLIKN-KV---------------RPI-QNKIV-----NITKQLVRVFKYIHSK-RIAHHDIKPSNILFDKYG---RIKIADFGLSG---- .||||||. . ||. | . . .... ....|.. ..|.|.| | | ||||.|||||. | .|||.|||.| MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ -------------YYSTNESHYNVGSYGYL----APEQRTSHAFDP---FLADIWSLGVTIYYMTCGLNPF ... .... ..|...|. ||| .. | . .||||||| .|.| | || NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF |
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Kinase | 86001.m00221.AA | ULK | 40-212 | 28 | 2.5e-39 | 137.0 | In-house | 28-257 (324) | Show / Hide |
Range on Protein: 40-212 Range on HMM: 28-257/324 Sequence Identity: 28% (66 aa) QQNFVCKIIS----KKTQYE-----------NEVLALTTLD---HPN--IVRLYSHFEEN--GKYYMILEYCEGGTPESLIKNKVR---------PIQNK .| . ||.|. .| ..| ||. . .|. ||| ||.|| ||. .|.|.|||.||. |..||.. . ... NQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQE IVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKY------------GRIKIADFGLSGYYST-----NESHYNV------GSYGYLAPE--QRT--SHA .... ||.. ||..|.. | | ||||.||| . |..||||||.. . .. | |. | ||. |. AIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKP FDPFLADIWSLGVTIYYMTCGLNPFIKQKNS .. . .||||||. .|.| | || .. .. YYDYKCDIWSLGCIFYEMLYGKYPFFSW-FN |
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Kinase | 86001.m00221.AA | STE | 17-206 | 20 | 8.9e-37 | 127.41 | In-house | 1-268 (359) | Show / Hide |
Range on Protein: 17-206 Range on HMM: 1-268/359 Sequence Identity: 20% (57 aa) FQIIKGLGNKCFPSCYLVFHQ------VYQQN---------FVCKIIS----------------------KKTQYENEVLALTTLD--HPNIVRLYSHFE ...|. .|. | . |. . ... . |... .. |...|. . .. |||||. | ... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF ENG-------KYYMILEYCEGGTPESLIKNK-VRPI-------------QNKIVNITKQLVRV-FKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSG .| . ....||..||. ...||.| .. . | |..|... .|.||..| | ||||.|||. .|..|||..| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG YYSTN------------------ESHYNVGSYGYLAPEQ--RTSHA-FDPF--LADIWSLGVTIYYMTCGLNPF . . .. ||. . ||| . ... .. .|||||| || | .| |. QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW |
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Kinase | 86001.m00221.AA | Ciliate-E2a | 17-175 | 35 | 7.9e-35 | 99.96 | In-house | 1-180 (275) | Show / Hide |
Range on Protein: 17-175 Range on HMM: 1-180/275 Sequence Identity: 35% (63 aa) FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKTQYEN--------EVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEGGTPESLIKNKVRPIQN- . .|| .|. .| | ||. | ..|. |...|| . . |. . .|||||| .|| .| . ||...||||||. .. ||.. | .. YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI -KIVNITKQLV-RVFKYIHSKRIAHHDIKPSNILFD---KYG----RIKIADFGLSGYYSTNES---HYNVGSYGYLAPE .| | .|| . |.|.. | | |.|| ||||. | . |||.||||. .....| . .|. ||.||| QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPE |
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Kinase | 86001.m00221.AA | CAMKL | 121-247 | 33 | 1.1e-34 | 107.95 | In-house | 141-292 (297) | Show / Hide |
Range on Protein: 121-247 Range on HMM: 141-292/297 Sequence Identity: 33% (51 aa) KYIHSKRIAHHDIKPSNILFDKYG--RIKIADFGLSGYYST-----NE-SHYNVGSYGYLAPEQRTS-HA-FDPFLADIWSLGVTIYYMTCGLNPFI--- .|.||..|.| |||| |||.|. | |||.|||.| .| .. . ||. | ||| . . .| . .||||.||. | | || || NYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDT -------------KQKNSYKYI-IPMFVERSLAEVISGTLEEDPLKRLSLDKIE |.. .|. |. .| .. |.. |. .| || ... |. YNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM |
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Kinase | 86001.m00221.AA | CAMK-Unique | 46-206 | 22 | 1.8e-33 | 107.68 | In-house | 38-293 (363) | Show / Hide |
Range on Protein: 46-206 Range on HMM: 38-293/363 Sequence Identity: 22% (57 aa) KIISKKTQ-----------------YENEVLALTTLDHPNIVRLYSH----FEENG---------------KYYMILEYCEGGTPESLIKN--------- .....|.| ...|. . ..|||||..|| |. ..|...|||.||. ..| GNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFI -----------KVRPIQ--NKIVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGR----------------IKIADFGLSGYYSTNESH----YNVG . . . . .| .|. . .| ||. | | |.|. ||.. . . ||..||||. .|..|.. .| IKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCG SYGYLAP--------------EQRTSHAFDPFLA---DIWSLGVTIYYMTCGLNPF . |.|| | . | . |||||||. ||| || || TPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPF |
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Kinase | 86001.m00221.AA | MELK | 17-206 | 30 | 2.7e-31 | 103.99 | In-house | 1-200 (254) | Show / Hide |
Range on Protein: 17-206 Range on HMM: 1-200/254 Sequence Identity: 30% (61 aa) FQIIKGLGNKCFPSCYLVFHQVYQQNFVCKIISKKT------QYENEVLALTTLDHPNIVRLYSHFEENGKYYMILEYCEGGTPESLIKNKVRPIQNKIV ... . .| | | | . .| ||. |.. . . |. || | | .| .|| | . |..|..||| || | . | .. YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR NITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSGYYSTNESHY----NVGSYGYLAPEQRTSHAFDPFLADIWSLGVTIYYMTCGLNPF . .|.| |.||. || |.|| |.||| . ..|. |||| . .. || | ||| . ||.||.|. .| . || || HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF |
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Kinase | 86001.m00221.AA | CAMKL | 46-92 | 27 | 5.9e-14 | 40.78 | In-house | 31-106 (297) | Show / Hide |
Range on Protein: 46-92 Range on HMM: 31-106/297 Sequence Identity: 27% (21 aa) KIISKKTQYEN--------------------EVLALTTLD---HPNIVRLYSHF-------EENGKYYMILEYCEGG ||| || .. |. . |. ||||..|| .. | .|.|...|||.|| KIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGG |
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TyrKc | 86001.m00221.AA | TyrKc | 7-250 | 18 | 2.1e-10 | -54.28 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 7-250 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) EISSILLGRGF--QIIKGLGNKCFPSCYLVFHQVYQQNFV----CKIISKKTQYENEVLALTTL--DHPNIVRLYSHFEEN-------GKYYMILEYCEG ||.|. .. || . | .| . . .| .. | .|||||||| . . .....||... ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH GTPESLIKNKVRPIQNK-IVNITKQLVRVFKYIHSKRIAHHDIKPSNILFDKYGRIKIADFGLSGYYSTN------ESHYNV----GSYG-----YLAPE | . .... . ...| ... | . |.|||.. | |. |.| .. ...||.||||| . .. | . |. . .||| GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE QRTSHAFDPFLADIWSLGVTIY---------YMT-----CGLNPFIKQKNSYKYIIPMFV---------ERSLAEVISGTLEEDPLKRLSLDKIEDIL . | . |.|| ||... | . |.. . .. .. . .... .||| .| . | ... CINYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 86001.m00221.AA | Pkinase_Tyr | 56-92 | 34 | 6e-06 | 20.83 | Pfam | 52-92 (270) | Show / Hide |
Range on Protein: 56-92 Range on HMM: 52-92/270 Sequence Identity: 34% (14 aa) NEVLALTTL-DHPNIVRLYSHFE-ENGK--YYMILEYCEGG .|. ...| .|||||||| . . .|...||...| REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG |
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Kinase | 86001.m00221.AA | Ciliate-E2a | 188-206 | 52 | 0.012685 | 3.57 | In-house | 198-216 (275) | Show / Hide |
Range on Protein: 188-206 Range on HMM: 198-216/275 Sequence Identity: 52% (10 aa) DIWSLGVTIYYMTCGLNPF |.||.|| .| . || || DMWSCGVIFYILLCGKPPF |
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Kinase | 86001.m00221.AA | Pkinase_Tyr | 137-154 | 44 | 1.229388 | 2.78 | Pfam | 141-158 (270) | Show / Hide |
Range on Protein: 137-154 Range on HMM: 141-158/270 Sequence Identity: 44% (8 aa) NILFDKYGRIKIADFGLS |.| .. . .||.||||. NCLVTENNVVKICDFGLA |