Gene 94807.m00020 (T.vaginalis)

94807.m00020

Species: T.vaginalis
Alias: 94807.m00020, TvagK0430
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
94807.m00020.AA Protein None 430 None Fasta, JSON
94807.m00020.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 94807.m00020.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 94807.m00020.AA PH 10-107 20 5.9e-08 33.67 SMART 1-82 (82) Show / Hide 
Range on Protein: 10-107
Range on HMM: 1-82/82
Sequence Identity: 20% (20 aa)

LPKRGWLKKKGNNQGLWHNRYVSISDHSIIVSKDEAITNIDIVIPMTPDVTFELVRGATNPRFQIKPSKDAQPILFSACSSEEISEWFNVFRSIQTTC
. |.|||.||.     |. |.. . .....  ||.          .. ...   ||  .   |.|.  .    ..|.. |.||  ||.. ... .  .
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK-------KPKGSIPLSDCTVRE-P--CFEIHH-DR--TYYFQCESEEEMQEWMQAIQKAIHNN
PH 94807.m00020.AA PH 10-105 17 1.1e-05 23.2 Pfam 1-92 (92) Show / Hide 
Range on Protein: 10-105
Range on HMM: 1-92/92
Sequence Identity: 17% (19 aa)

LPKRGWLKKKGNNQGLWHNRYVSISDHSIIVSKDE--------AITNIDIVIPMT--PDVTFELVRGATNPRFQIKPSKDAQPILFSACSSEEISEWFNV
. |.|||.|||   . |. |.. . .  ..  ||.         . ....... .   . .|...                . ..|.| |.||  .| . 
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR------------RTYYFQAESEEEMNDWMQA

FRSIQT
..|.. 
IQSACR
Kinase 94807.m00020.AA AGC 115-365 29 2.5e-145 378.54 In-house 1-395 (395) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-395/395
Sequence Identity: 29% (117 aa)

FQIISVLGRGYYGKVMLCRRY------DNDQLYAIKSIRKSV-INDVD--G-CSVLTE------------KNIMMKIH----------HPFVVN-LCFAF
|... |.|.| .|||.|.|.       |....||.| ..|.. | . .      ..||            .||..|..          |||.|. | ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSDRK--VYLGLEYAS---------GG-ELFYYME---KVGVVPIDDARLYIAE-------IGLALSHLHK-YGIIYRD-LKPENVLFDADGHIKLTDFG
|....  .|. .||..         || |||...    | |. . . || |.||       | ||| .||.  |||.|| |||||.|.|.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKELN---------------------------------------------------GTTGATTFCG--TPDYLAPEVVLQQEYGTKIDEWA--LGILTY
|.||..                                                   ..  ..||||  ||.|.|||..    ||   | |.  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIFGRTPFYNEN----------KSILLQDIV------ESEPFYP----------EDADERIVDFMKRLLEKDPKKRAT----------FEEIKSHPFF
||..|..|||..|          .  . | |       . .. .|          .  ..  .|..|.||.|||.|| .          .||||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 94807.m00020.AA Akt 115-365 42 3.8e-111 356.56 In-house 1-264 (264) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-264/264
Sequence Identity: 42% (112 aa)

FQIISVLGRGYYGKVMLCRRYDNDQLY-AIKSIRKSVINDVDGC-SVLTEKNIMMKIHHPFVVNLCFAFQSDRKVYLGLEYASGGELFYYMEKVGVVPID
|... |||.| .|||.|..  |....| |.|...|..| . .    ..||.||  .. |||.||| ..||.  | |. ..|..||||||.. . .. . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DARLYIAEIGLALSHLHKYGIIYRD-LKPENVLFDADGHIKLTDFGLSK-E-LNGTTGATTFCGTPDYLAPEVVLQQEYGTKIDEWA-LGILTYEMIFGR
 || |.||| ||. |||. .||||| |||||.| |.||||.||||||.| . .  .  ..|||||| |||||. ... .. . | |. ||...|||..||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFYNENKSILLQDIVESEPFYP--EDADERIVDFMKRLLEKDPKKRA-----TFEEIKSHPFF
 ||||...  . . | ...  .|  .  .    |. ..||.||||||      . .|||.||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 94807.m00020.AA SGK 115-365 39 7.50000000001e-107 331.06 In-house 1-283 (283) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

FQIISVLGRGYYGKVMLCRRYDN------------------DQLYAIKSIRK-SVI-------NDVDGCSVLTEK-NIMMKIHHPFVVNLCFAFQSDRKV
|....|.| | .|||.. .. |                   |..||.| ..| ..|       .      ...|. .|. .. ||| ||| .||| . | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLGLEYASGGELFYYMEKVGVVPIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSK-ELNGTTGATTFCGTPDYLAPEVVLQQ
|. ..|. |||.||.. . .  | | || | ||| .|| .||.  ||||||||||.| |..||..||||||.| .   ... .|||||| |||||| . |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

EYGTKIDEWALGILTYEMIFGRTPFYNENKSILLQDIVESEPFYPEDADERIVDFMKRLLEKDPKKR--AT--FEEIKSHPFF
...   | | ||.. |||..|  |||. ||... . |  ..   |        | .. ||.||||||  .   |.|||.||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 94807.m00020.AA S_TKc 115-365 36 5.8e-101 342.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FQIISVLGRGYYGKVMLCRRYDNDQLYAIKSIRKSVINDVDGCSVLTEKNIMMKIHHPFVVNLCFAFQSDRKVYLGLEYASG--GELFYYMEKVGV----
..|. ..|.| .|||..||  . ....||| |.         .... | .|..| |||..|.|  .||.  ..|. .||..|  |.|| |..| |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSKELNGTTGATTFCGTPDYLAPEVVLQQEYGT-KIDEWALGILTYEMI
   |  .|| |...| .|| ..|. |||.|||||||.|.|   |||..||||...|      |||||||.|.||||.    ||. |.| |..|.. |||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

FGRTPFYNENKSILLQDIVESEPFYPEDADERIVDFMKRLLEKDPKKRATFEEIKS-------HPFF
 |..||.  .   ... |.          ..   ||....|.|||.|| |  |.         ||.|
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94807.m00020.AA AktR 115-365 41 1.6e-97 330.33 In-house 1-268 (268) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-268/268
Sequence Identity: 41% (112 aa)

FQIISVLGRGYYGKVMLCRRY-DNDQLYAIKSIRK-SVINDVDGCSVLTEKNIMM-KIHHPFVVNLCFAFQSDRKVYLGLEYASGGELFYYMEKVGVVPI
|... .||.| .|||.|...  ||...||.|.|.|   |.      ..||.|||  .. ||| |.| ..||...| .. .||  |||||..  | .    
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DDARLYIAEIGLALSHLHKY-GIIYRDLKPENVLFDADGHIKLTDFGLSK--ELN-GTTGATTFCGTPDYLAPEVVLQ-QEYGTKIDEWALGILTYEMIF
..|| |.|.| ||| .||.   |||||||||| | | |||.|.|||||||    .  .  |..||||| |.|||.... . ..  .| ||.||. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRTPFYNENKSILLQDIVESE---PFYPEDADERIVDFMK-RLLEKDPKKRAT-----FEEIKSHPFF
| .|||..|. ...| | ...   . ||..  .   |. . .|| |.|.|| .     .|||||||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 94807.m00020.AA RSK 118-365 40 1e-95 324.3 In-house 1-278 (278) Show / Hide 
Range on Protein: 118-365
Range on HMM: 1-278/278
Sequence Identity: 40% (112 aa)

ISVLGRGYYGKVMLCRRY---DNDQLYAIKSIRK--SVINDVDGCSVLTEKNIMMKIH-HPFVVNLCFAFQSDRKVYLGLEYASGGELFYYMEKVGV---
..|||.| |||| |||.    |..|.|| | ..|   | ...|   ..|| ||.. .  |||.|.|  ||| . |.|| .|| .|||||.  .| .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

VPIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDA---DGHIKLTDFGLSKE-LNG-TTGATTFCGTPDYLAPEVVL---QQE-YGTKIDEWALGI
   |.|. |.||| ||..|||. |||.|||||||.|.|    .|||||||||..|.  .  .  . |||.| .|.|||..    ||. ..   | | ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYEMIFGRTPFYN---ENKSILLQDIVESE--PFYP--EDADERIVDFMKRLLEKDPKKRAT-----FEEIKSHPFF
| ||| .|..||..   .|.. ... | . .  .  |  .   .   |. ...|..||.|| .      ||||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 94807.m00020.AA PKC 115-365 41 2.9e-91 296.08 In-house 1-262 (262) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-262/262
Sequence Identity: 41% (110 aa)

FQIISVLGRGYYGKVMLCRRYDNDQLYAIKSIRKSVIN---DVDGCSVLTEKNIM-MKIHHPFVVNLCFAFQSDRKVYLGLEYASGGELFYYMEKVGVVP
|. . |||.| .||||| .| ..|..|||| ..| ||.   ||.  ...||| ..     ||| ..|   ||.  . .  .||  || | . . ...  .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVE--CTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

IDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSKE-LNGTTGATTFCGTPDYLAPEVVLQQEYGTKIDEWALGILTYEMIFGRT
   || | ||| .||  ||. |||||||| .||| |..||||..|||..|| ... . ..||||||||.|||..  ||||  .| ||.|.| |||  |. 
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFYNENKSILLQDIVESEPFYPEDADERIVDFMKRLLEKDPKKRATF--------EEIKSHPFF
||  |.   | | | . .|.|| .  ...|. .| ...|.|.||           ..|..||||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 94807.m00020.AA PKA 115-365 41 1.5e-89 303.86 In-house 1-263 (263) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-263/263
Sequence Identity: 41% (110 aa)

FQIISVLGRGYYGKVMLCRRYDNDQLYAIKSIRKSVINDVDGCS-VLTEKNIMMKIHHPFVVN-LCFAFQSDRKVYLGLEYASGGELFYYMEKVGVVPID
|.|| .||.| .|.|||||  .. . ||.| ..|. | .      |..||||.. |.|||.|. . . || ||. |. .||..|||.|.|. |.|  . .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DARLYIA-EIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSKELNGTTGATTFCGTPDYLAPEVVLQQ-EYGTKIDEWALGILTYEMIFGRTP
.|..|.| .| |||  ||.  |||||||||| | | .||||.|||| .|.. .     | ||||.|||||...    .|  .| |||||| ||| .| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FYNE--NKSILLQDIVESEPFYPEDADERI---VDFMKRLLEKDPKKRA-TFEE----IKSHPFF
||..  ..  . . |.. . ..|.  | .     |. |.||..|..||  ....    || |..|
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 94807.m00020.AA Pkinase 115-365 32 7.6e-87 299.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FQIISVLGRGYYGKVMLCRRYDNDQLYAIKSIRKSVINDVDGCSVLT--EKNIMMKIHHPFVVNLCFAFQSDRKVYLGLEYASGG----ELFYYME--KV
..|....|.| .|.| .|.. .. ...|.| |.|. ...    . .   |  || ...||..| |  .|......|. .||. ||    .|| |..  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GVV--PIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHI----KLTDFGLSKE--LNGTTGATTFCGTPDYLAPEVVL-QQEYGTKIDEWAL
|..  . .... |. .|  .| ..|. |||.|||||||.|.| .|||    |..||||.|   .   . .|||||||.|.||||.. .|.||.|.| |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILTYEMIFGRTPFYNE------NKSILLQDIVESEPFYPEDAD---------------------ERIVDFMKRLLEKDPKKRATFEEIKSHPFF
|.. |||..||.||...      ..  ... | . .. .... .                     |   ||.|..|.|||||| |.|.|. ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 94807.m00020.AA CAMK 120-365 22 4.3e-86 277.32 In-house 1-425 (425) Show / Hide 
Range on Protein: 120-365
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

VLGRGYYGKVMLCRRYDND------------QLYAIKSIRKSVIN--------------------------DVDGCSVLTEKNIMMK-------IHHPFV
.|||| .||| ||..  .             | .||| | |. .                           ..|  .|. | .||.|       ..|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLCFAFQS-------------------DRKVYLGL---EYASGGEL----FYYMEKV---------------GVVPIDDARLYIAEIGLALSHLHKYGI
..|  ....                   |...|. .   ||.|||||    | |  .                | .. ..|| |.  |  |. ..|. .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IYRDLKPENVLFDAD-----------------GHIKLTDFGLSKELNG------------------------TTGATTFCGTPDYLA-PEVVLQ------
. |||||||.|.| .                 . ||..|||.......                        .   .|||||| | | |||...      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QEYGTKIDEWALGILTYEMIFGRTPFYNE-------------NKSILLQDIVESE-PFYPEDADE-----------------------RIVD
        . || |.| |..|...| |  |. ||| .             | . |.. | . .  |.|.  ..                          |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FMKRLLEKDPKKRATFEEIKSHPFF
. ...|..||.||.| |....||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 94807.m00020.AA p70 115-365 35 5.4e-83 282.02 In-house 1-299 (299) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-299/299
Sequence Identity: 35% (106 aa)

FQIISVLGRGYYGKVMLCRRYD---NDQLYAIKSIRKS--VINDVDGCSVL-------------------------TEKNIMMKIHHPFVVNLCFAFQSD
|. . |||.| ||||.. |      . ..|| | .||   |.|  |  .                            | ||   . |||.. | .||| .
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

RKVYLGLEYASGGELFYYMEKVGVVPIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSKE-LNGTTG----------ATTFCG
 | || ||| .|||||.  |. |. . | |. | .|| .|| |||. |||||||||||.. .. ||..||||||.|| ... .             ||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPDYLAPEVVLQQEYGTKIDEWALGILTYEMIFGRTPFYNENKSILLQDIVESE--PFYPEDADERIVDFMKRLLEKDPKKRAT-----FEEIKSHPFF
|. | |||...   ..  .| |.||.| | |  |  ||  ||.      |      .  |    .   |  |.|| ..|..| .      ..|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 94807.m00020.AA Ciliate-E2 115-365 26 6.9e-82 278.36 In-house 1-365 (365) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-365/365
Sequence Identity: 26% (98 aa)

FQIISVLGRGYYGKVMLCRRYDND-----------------------QLYAIKSIRKS-VINDVDGCSVL----------TEKNIMMKIHHPFVVNLCFA
. .| ..|.| .|.| .|... ..                       ..||.|...|. ...     ...           ||||. .. ||.....  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--SDRKVYLGLEYASGGELFYYME-------------------KVGVVPIDDAR-------LYIAEIGLALSHLHKYG-IIYRDLKPENVLFDADGHI
||  .| ..|| .||..||.||.|..                   ... .    ..        |||.| ||| .||. . ||.||.||||.||     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKELN----------------------GTTG----------ATTFCGTPDYLAPEVVL---------QQEYGTKIDEWALGILTYEMIFGRTP
|..||||||...                      .|.|          . |.|||| |.|||..          |..|..|.| |.||.. |||.||..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYNENKSILLQDIVESEPFYPEDADERIV---------------DFMKR----LLEKDPKKRAT-FEEIKSHPFF
|    . |. ..|  ..|.. .| .  ..               |..|.    .|.|||.|| | .|.|. ||.|
F---QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 94807.m00020.AA TyrKc 115-365 21 3.5e-17 55.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FQIISVLGRGYYGKVMLCRRYDNDQLYAIKSIRKSVINDVDGCSVLTEKNIMMKI--HHPFVVNLCFAFQSD-------RKVYLGLEYASGGELFYYMEK
 . . .||.| .|.|.... .   .  |.|.....          . | .||.|.  ||| .|.|  .  ..         ... .||...| |  |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VGV-VPIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSKELNGT-----TGATTFC----GTPD-----YLAPEVVLQQEYGT
 .  .. .|   .   |    ..||. ..| |||   |.| ......| .|||||...         . .       |. .      .|||.    .. |
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KIDEWALGILTYEMI-FGRTPFYN------ENKSILLQDIVESEPFYPED--------ADERIVDFMKRLLEKDPKKRATFEEIKSHPFF
| | |. |.. .|.  .| .| ..      .|. .. .      .  |..        . . . . ||.  . ||..| ||.||  | .|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 94807.m00020.AA S_TK_X 366-426 27 1.9e-14 55.27 SMART 1-79 (79) Show / Hide 
Range on Protein: 366-426
Range on HMM: 1-79/79
Sequence Identity: 27% (22 aa)

EGVDWDAILG--REYMPSYIPQIK----DRFSTQNFDPEFTNEIAVDSFVTPGMTDFGN------------IAGFSFVQ
 |.|||...   .|. | ..|.||    . . | |||||||.| .... . |....  .             .||..| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 94807.m00020.AA Pkinase_Tyr 115-365 23 6e-12 41.1 Pfam 1-270 (270) Show / Hide 
Range on Protein: 115-365
Range on HMM: 1-270/270
Sequence Identity: 23% (64 aa)

FQIISVLGRGYYGKVMLCRRY----DNDQLYAIKSIRKSVINDVD--GCSVLTEKNIMMKI-HHPFVVNLCFAFQ-SDRK--VYLGLEYASGGELFYYME
 ... .||.| .|.|.... .    ....  |.|.. |    . .    . . | .||... ||| .|.|  .    ..   .|. .||. .| |  |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----VGVVPIDDARLYIAEIGLALSHLHKYGIIYRDLKPENVLFDADGHIKLTDFGLSKEL----NG-TTGATTFCGTPDYLAPEVVLQQEYGTKIDEW
|     . ... |   . ..|  ....|.  ..| |||   |.| . ....| .||||.. .    .  ...  .       .|||.    .. || | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVW

ALGILTYEMIF-GRTP-FYNENKSILLQDI-VESEPFY-PEDADERIVDFMKRLLEKDPKKRATFEEIKSHPFF
. |.| .|..  |..| ...   . ... |  . .    ||.. . | | ||.  ..||..| ||.||  | ..
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase 94807.m00020.AA Pkinase_C 385-428 33 2e-06 26.18 Pfam 1-46 (46) Show / Hide 
Range on Protein: 385-428
Range on HMM: 1-46/46
Sequence Identity: 33% (16 aa)

QIKDRFSTQNFDPEFTNEIAVDSF----VTPGMTDFGNIAGFSFVQTG
|.|..  |.|||||||.| ..|..     ..|. .  .  ||..|   
QVKSPTDTSNFDPEFTDEPPMDTPPDWRMSSGDQE--PFRGFTYVNPD