81869.m00190

Species: T.vaginalis
Alias: TvagK0814, 81869.m00190
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI3K

Sequence

Name Sequence Type Origin Length Description Download
81869.m00190.AA Protein None 734 None Fasta, JSON
81869.m00190.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of 81869.m00190.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3_PI4_kinase 81869.m00190.AA PI3_PI4_kinase 489-682 19 2e-45 162.05 Pfam 1-300 (300) Show / Hide
Range on Protein: 489-682
Range on HMM: 1-300/300
Sequence Identity: 19% (59 aa)

VYSAILKYGDDMR--QDALALNTI-----------------------KFIDDHLKGYGLDLC----MSPYKVLPISKVFGMMEFIVGAKAVSKVLEQN--
 |..|.|.|||.|  ||.. .. |                       ..... .|. |.|..    | ||...| ..  ||.|..  .   ....     
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

------------------------------------------NDSISEFWDKSEGD---M--PRQRFIKSSAAYSVVSYVLGVGDRHLDNLLV---SKKG
                                          ...  .||....     .  .|..|..| | ..||.|.||.||||.||..|    ..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

NFLHVDFGYMFG-----IDPKFVPVTVRVVE------QMTNAM------GPDGTNEFLRLCSV-VFVAVRHIADELCCSL-------AMMMKADLPHLPK
.  |.|||..|.      ..|. .|. |         .| .||      .|.|  ...| . . .. |.|. .. . . |       ..|... || ...
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





PI3Kc 81869.m00190.AA PI3Kc 491-733 20 3.1e-36 127.64 SMART 1-336 (336) Show / Hide
Range on Protein: 491-733
Range on HMM: 1-336/336
Sequence Identity: 20% (70 aa)

SAILKYGDDMRQDALALNTIKFIDDHLKGY----GLDLCMSPYKVLPISKVFGMMEFIVGAKAVSKVL--------------------------------
. |.| |||.|||....  .. ... ..      ..||.| |||..|...  ||.|..  .. . ...                                
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-------------------------------EQNNDSISE-FWDKSEGDM-----PRQRFIKSSAAYSVVSYVLGVGDRHLDNLLVS-KKGNFLHVDFGY
                                .. ... . ||... ...      | .|..| |.|..|.|.||.||||.||...  | |. .|.|||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

MFGIDPKFVPVT--------VRVVEQMTNAMG----PDGT-NEFLRLCSVVFVAVRHIADELCCSLAMMMKADL-PHLPKSAAVLSKTMLQKLALD-MSD
.|| .||... .         |   .| ..||    | |   .| ..|  .. |.|. .... . ..||... . |.. ..     |   |.. || .||
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD

EGAGDLIRQ----EVIDAI-TALRPMFAEYIHRFVQK
| |   . |    ..| .   .. . . . .|.. | 
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase 81869.m00190.AA ATR 574-672 33 9.8e-15 46.22 In-house 164-267 (267) Show / Hide
Range on Protein: 574-672
Range on HMM: 164-267/267
Sequence Identity: 33% (35 aa)

RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSK-KGNFLHVDFGYMFGIDPKF-VPVTV--RVVEQMTNAMGPDGTNE-FLRLCSVVFVAVRHIADELCCS
|. ...| |....| |..| |||| ||.|. |  |   |||.  .|.   .| || .|  |. . | ..||| .|.  | | | |.   .|.  |..   
RENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSV

LAMM
.   
WDCF

Kinase 81869.m00190.AA PIKK 574-619 38 8.1e-12 39.64 In-house 186-232 (290) Show / Hide
Range on Protein: 574-619
Range on HMM: 186-232/290
Sequence Identity: 38% (18 aa)

RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSKK-GNFLHVDFGYMFG
|.... | |  ..| |.|| ||||..|... .  |  .|.|||. |.
RENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE

Kinase 81869.m00190.AA DNAPK 574-627 40 1e-09 31.35 In-house 187-241 (301) Show / Hide
Range on Protein: 574-627
Range on HMM: 187-241/301
Sequence Identity: 40% (22 aa)

RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVS-KKGNFLHVDFGYMFGIDPKFVPV
| .|| . |   .  ..||.|||||.| .|    |    .|||. ||    | ||
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPV

Kinase 81869.m00190.AA FRAP 574-615 39 1.2e-07 24.38 In-house 137-179 (251) Show / Hide
Range on Protein: 574-615
Range on HMM: 137-179/251
Sequence Identity: 39% (17 aa)

RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSKK-GNFLHVDFG
|  . .| |  |.. |.|| ||||. |..  .  |  .|.|||
RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase 81869.m00190.AA SMG1 575-603 51 1.9e-07 20.59 In-house 188-216 (242) Show / Hide
Range on Protein: 575-603
Range on HMM: 188-216/242
Sequence Identity: 51% (15 aa)

QRFIKSSAAYSVVSYVLGVGDRHLDNLLV
| . .| |  |.| |..|.||||||| |.
QSYARSTAVMSMVGYIIGLGDRHLDNVLI

Kinase 81869.m00190.AA ATM 574-618 39 6e-07 17.8 In-house 137-182 (304) Show / Hide
Range on Protein: 574-618
Range on HMM: 137-182/304
Sequence Identity: 39% (18 aa)

RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSKKG-NFLHVDFGYMF
|  . .| |  |.| |.||.||||  |.|.  .     |.| |  |
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF