Gene 93680.m00032 (T.vaginalis)

93680.m00032

Species: T.vaginalis
Alias: 93680.m00032, TvagK0951
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CRK7-like

Sequence

Name Sequence Type Origin Length Description Download
93680.m00032.AA Protein None 337 None Fasta, JSON
93680.m00032.kin_dom Protein Kinase Domain None 280 None Fasta, JSON

Protein domain

Protein domains of 93680.m00032.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 93680.m00032.AA S_TKc 16-294 27 8.7e-67 229.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-294
Range on HMM: 1-231/231
Sequence Identity: 27% (81 aa)

FRPIESIGGGSFGSVTKSLDIKNNRIVALKKLKSFSSEQDEERIVNEVTIVQKLNHPNIVKIYDIFYSTSENCYYISMEYCQQ---DLLALLETHT----
.. .. || |.||.| |  ..| .||||.|..|        |.| .|. | .| .||||||.||.|..   ...|. |||| .   ||. ... .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDGMRIKLADFGLATYYTTDHEMTNCGTLAYNPPEKHLESTILTK-TIDVWSAGVLFYQL
   ... . ...|.||..||.|. ...||| ||||.|||. .  .||..|||||. .     .| |||. | .||        .|  .|.|| |...| .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ITHKVLFQSGLQDVITICGAPDPKLWPNVMTFKNYNKCLQWASSNPSLNSLFTENDKSNYGNVIERIKSMLSLYPDQRPLPSALLE-------SKDF
.. . .|.  .| .. ..|                                           ... |. .|   |..||    .|.          |
LCGYPPFP-QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93680.m00032.AA CMGC 16-241 22 5.3e-65 212.2 In-house 1-404 (513) Show / Hide 
Range on Protein: 16-241
Range on HMM: 1-404/513
Sequence Identity: 22% (90 aa)

FRPIESIGGGSFGSVTKSLD--------------IKNNRIVALKKLK-SFSSEQDEE----------RIVNEVTIVQKLN-----------------HPN
.  |. || |..| | |  |              ...|.|||.||.|  |  | ..           |.  |. | ..||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKIYDIFYSTS---------------ENCYYISMEYCQQDLLALLETHT----------LNPTQ------------KKSIM------KQILEALA--YL
|||.|||||.                 .|. |. .||...||. ... .           |.. .            .|..|      .|||..|.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

EKRN--IIHQDLKPANILVQDG--------------------MRIKLADFGLATYYTTDHE----------------------MT-NCGTLAYNPPEKHL
 ...  ||| ||||.|||. .                     .|.|..|||||..| . ..                      .| .  |. | .||  |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

ESTILT---------KTIDVWSAGVLFYQLIT--------HKVLFQ----------------SGLQDVITICGAPD---------------PKLWPNVMT
 ..  |         ..||.||.|  |. ..|        .| ||.                  |.  . ..| |.               .. |||.  
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

FKNYNK
  .|||
LPWYNK
Kinase 93680.m00032.AA CDK 16-294 27 2.1e-58 185.42 In-house 1-284 (284) Show / Hide 
Range on Protein: 16-294
Range on HMM: 1-284/284
Sequence Identity: 27% (88 aa)

FRPIESIGGGSFGSVTKSLDIKNN-----RIVALKKLKSFSS-EQDEERIVN-----EVTIVQKLNHPNIVKIYDIFYSTS---------ENCYYISMEY
.  .| || |..| | |  | ...     .||||||..  .  ...|.  ..     |... ..| ||||||..|.... .         ||  |. .||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CQQDLLALLETHTLNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQ-DG----MRIKLADFGLATYYT-------TDHEMTNCG-TLAYNPPEKH
. .||  ...         |..|.|.|..|.|. ...|.| ||||.|||.  .|    .|.|.||||||  .           ..|.   || | .||  
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LESTILT--KTIDVWSAGVLFYQLIT---HKVLFQSGLQD------VITICGAPDPKLWPNVMTFKNYNKCLQWASSNPSLNSLFTENDKSNYGNVIERI
| |.. .   .||.||.|  |. ..|    | ||. | ..      .. ||| |... ||.|  . .|                             . .
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFP-GDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------------DLL

KSMLSLYPDQRPLPSALLESKDF
 .|| . |..|   .. |... |
NKMLCYDPKKRISAEQALQHPYF
Kinase 93680.m00032.AA Ciliate-E2 16-294 22 2.2e-54 185.06 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-294
Range on HMM: 1-365/365
Sequence Identity: 22% (90 aa)

FRPIESIGGGSFGSVTKSLDIKNNRIVALK-----------------KLKSFSSE--QDEERIVNEVTIVQ----------------KLNHPNIVKIYDI
.  |. || |.|||| |  ..|... .|.|                 |..   .   .. | | .|  | .                .||||||.|.|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYSTSENCYYISMEYCQQ-DLLALLETHTLNPT------------QKKSIMKQILE---------------ALAYLEKRN-IIHQDLKPANILVQDGMRI
|.....|..|. |||||. ||. ... . .. .            . | ||||||.               || || ..| ||| |.|| |||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGLATYYTTDHEMTN---------------------------------CGTLAYNPPEKHL--------ESTILTKTIDVWSAGVLFYQLITHKVL
|..||||...|..|....                                  |||. | .|| .         ...  .. .|.||.||..|.... |  
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQSGLQDVITICGAPDPKLWPNVMTFKNYNKCLQ--WASSNPSLNSLFTE-------NDKSNYGNVIERIKS----MLSLYPDQRPL-PSALLESKDF
|                           ... .|  .  ..|  ..  |        . |.   ...  ||     ||   |..|.  .. .|. . |
F---------------------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 93680.m00032.AA Pkinase 16-212 32 1.2e-53 189.36 Pfam 1-213 (293) Show / Hide 
Range on Protein: 16-212
Range on HMM: 1-213/293
Sequence Identity: 32% (71 aa)

FRPIESIGGGSFGSVTKSLDIKNNRIVALKKLKSFSSEQDEERIVN----EVTIVQKLNHPNIVKIYDIFYSTSENCYYISMEYCQQ-----DLLALLE-
.. .. || ||||.| |  ......|||.|..|   .| ..... .    |. | ..|||||||..||.|..  .. .|. ||||.      || .... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--THTL--NPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDGMRI----KLADFGLAT---YYTTDHEMTNCGTLAYNPPEKHLESTILTKTIDV
    ..   . . |..|.|||..|.|. ...||| ||||.|||. . . |    |..|||||    |      .| |||. | .|| .....  .. .|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSAGVLFYQLITHKVLFQ
||.|...|.... . .|.
WSCGCILYEMLCGRPPFP
Kinase 93680.m00032.AA ULK 16-206 29 4.6e-53 182.59 In-house 1-251 (329) Show / Hide 
Range on Protein: 16-206
Range on HMM: 1-251/329
Sequence Identity: 29% (74 aa)

FRPIESIGGGSFGSVTKSLDIKN----NRIVALKKLKSFSSEQDEER---------IVNEVTIVQKLN--------HPNIVKIYDIFYSTSENCYYISME
.  .. .| |||| | |  ..|.    | .|| |.. ...  |..           . ||. | .||.        |||||| ||.|... .|..|| ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCQQ-DLLALLETH-----------TLNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDG------------MRIKLADFGLATYYTTD-----
||.. ||  .....           .|.  . ....||||... .| |.|||| |.||.|||. .|            ...|.||||.|   . |     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

HEMTNC------GTLAYNPPE---KHLESTILT-KTIDVWSAGVLFYQLIT
 .||        ||  |  |.   ...|    . .. |.|| |..||....
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 93680.m00032.AA ULK 16-206 28 3.4e-51 176.4 In-house 1-247 (324) Show / Hide 
Range on Protein: 16-206
Range on HMM: 1-247/324
Sequence Identity: 28% (71 aa)

FRPIESIGGGSFG-SVTKSLDIKN---NRIVALKKLK--SFSSEQDE-------ERIVNEVTIVQKLN---HPN--IVKIYDIFYSTSENCYYISMEYCQ
.  .. .| ||||  | |  ..|.   | .|| |.    ...  . |       . . ||. |..||.   |||  ||| ||.|... .| .|| ||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

Q-DLLALLETH----------TLNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDG------------MRIKLADFGLATYYTT-----DHEMT
. ||  .....          .|.  . ....|||.... .| |.|||| |.||.|||. .|             ..|.||||.|          .  .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

NC------GTLAYNPPE---KHLESTILT-KTIDVWSAGVLFYQLIT
 .      ||  |  |.   ...|    . .  |.|| |..||....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 93680.m00032.AA CDC2 16-212 35 5.6e-49 148.37 In-house 1-210 (301) Show / Hide 
Range on Protein: 16-212
Range on HMM: 1-210/301
Sequence Identity: 35% (77 aa)

FRPIESIGGGSFGSVTKSLDIKNNRIVALKKLKSFSSEQDE----ERIVNEVTIVQKLN-HPNIVKIYDIFYSTSENCYYISMEYCQQDLLALLE----T
.  || || |..| |.|  | . |.|||||| .   .|...    . .. |  . ..|. ||||||. |....   |  |.  ||. .||  ...    .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIR-LEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPK

-HTLNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDGMRIKLADFGLA-------TYYTTDHEMTNCGTLAYNPPEKHLESTILTKTIDVWSAG
   . |   ||.|.|||......  | |.| |||| |||. .  .||.||||||         |||.||     || | .||  | .   . ..|.|| |
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVV---TLWYRAPEILLGCKRYSTPVDMWSIG

VLFYQL---ITHKVLFQ
 .|. .   .| | ||.
CIFAEMFMDVTKKPLFH
Kinase 93680.m00032.AA CAMK 21-202 19 1e-48 154.67 In-house 1-325 (425) Show / Hide 
Range on Protein: 21-202
Range on HMM: 1-325/425
Sequence Identity: 19% (63 aa)

SIGGGSFGSVTKSLDIKNN------------RIVALKKLK---------------------------SFSSEQDEERIVNEVTIVQK-------LNHPNI
 .| |||| | .  .....            . || | ..                           .  ...|.... .|. | .|       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKIYDIFYS-----------TSEN-------CYYISM---EYCQQ-----DLLALLETH----------------TLNPTQKKSIMKQILEALAYLEKRN
.|.|... .           | ..       ..|. |   |||.      ||.  .  |                 ..  . . ...||..|..|. ..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHQDLKPANILVQDGM-----------------RIKLADFGLATYYTTDHE-------------------------MTNCGTLAYNP-PEKHLE-----
|.| |||| |||..| .                  ||..|||.|.... ...                          | |||..| . ||  .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------STILTKTIDVWSAGVLFY
         .  .. .|.||.||. |
MQNATDEEKPYYGPKCDMWSCGVILY
Kinase 93680.m00032.AA Ciliate-E2-Unclassified 16-213 22 2.6e-45 155.11 In-house 1-272 (352) Show / Hide 
Range on Protein: 16-213
Range on HMM: 1-272/352
Sequence Identity: 22% (63 aa)

FRPIESIGGGSFGSVTKSLDIKNNRIV----ALKKLKSFSSEQD---EERIVNEVTIVQKLN-----------------HPNIVKIYDIFYSTSENCYYI
.. |. || |.||.| |  ..|..  .     .|| ..... |    . .|.|| .......                 ||.......... ..... ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

SMEYC-QQDLLALLET------------------HTLNPTQKK-----SIMKQILEALAYLEKRN-IIHQDLKPANILVQDGM---RIKLADFGLATYYT
 |||| ..||.  ..                   . .   | |      ...|||..| || . | ||| |.|| |||.....   .||..|||.. .| 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

-----------------TDHEMTNCGTLAYN----PPEKHLESTILT---KTIDVWSAGVLFYQLITHKVLFQS
                  ..  |.|||. |     .||   .    .   . .|.|| ||..|.... .  |..
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYD
Kinase 93680.m00032.AA CAMKL 16-206 26 8.1e-44 137.62 In-house 1-231 (297) Show / Hide 
Range on Protein: 16-206
Range on HMM: 1-231/297
Sequence Identity: 26% (64 aa)

FRPIESIGGGSFGSVTKSLDIKN-NRIVALKKLK--SFSS-------------EQDEERIVNEVTIVQKLN---HPNIVKIYDIFYSTSE----NCYYIS
.| .. .| |||| |   ..|.. .. || | ..    .              |.|. ||  |. | ..||   ||||.|.|....  .     ...|. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYCQQD---LLALLETHT-----LNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQ-DGM-RIKLADFGLATYYTT-----DH-EMTNCGTLAY
||||.     |.  .. |      . . . . . .||..|..|. ...|.| |.|| |||.  .|.  ||..|||....|.      ..  .| ||...|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

NPPEKHLESTILTK--T------IDVWSAGVLFYQLIT
 .||      |. .  .      .|.||.||. | ...
MAPE------IFQGNNKPYDGPKVDIWSCGVILYAMVC
Kinase 93680.m00032.AA STE 16-180 24 7e-43 148.78 In-house 1-232 (359) Show / Hide 
Range on Protein: 16-180
Range on HMM: 1-232/359
Sequence Identity: 24% (59 aa)

FRPIESIGGGSFGSVTKSLDI------KNNRI---------VALKKLKSFSSE----------------QDEERIVNEVTIVQKLN--HPNIVKIYDIFY
.. || || |.||.| | ...      |....         .| |...  ...                .....| .|. | .|.|  |||||| |. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----STSENCYYISMEYCQ-QDLLALLET---------------HTLNPTQKKSIMKQILEA-LAYLEKRNIIHQDLKPANILVQDGMRIKLADFGLAT
     . ...  .| |||.    |  ....               |... .| . | .|||.. |.||.. .||| |.||||||.     .||.|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

YYTTD------------------HEMTNCGTLAYNPPE
  | .                  .  | .||  .  ||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 93680.m00032.AA Pkinase_Tyr 16-159 32 4.9e-22 75.26 Pfam 1-158 (270) Show / Hide 
Range on Protein: 16-159
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

FRPIESIGGGSFGSVTKSLDI----KNNRIVALKKLKSFSSEQD--EERIVNEVTIVQKL-NHPNIVKIYDIFYSTSEN-CYYISMEYCQQ-DLLALLET
 . .. .| |.||.| |        ...  || |.||  .....   |   .|. |  .| .|||||. | . .. .|   .|| |||..  |||  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H-----TLNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDGMRIKLADFGLA
|      |.. .. ..  || ....||| .|.|| ||   |.|| ... .| .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 93680.m00032.AA TyrKc 16-243 23 3e-13 -8.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-243
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

FRPIESIGGGSFGSVTKSLDIKNNRIVALKKLKSFSSEQDEERIVNEVTIVQKL--NHPNIVKIYDIFYSTSE-----NCYYISMEYCQQ-DLLALLETH
 . .. .| | || | |   .   . || |.||. .    .| . .|  |  ||  .|||||..| .  . ..       ..| |||.   ||.  |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

T--LNPTQKKSIMKQILEALAYLEKRNIIHQDLKPANILVQDGMRIKLADFGLATYYTTD------HEMTN-----CGT----LAYNPPE--KHLESTIL
   |.. .. |.. || .  .||...|.|| ||   |.|| .. ..| .||||. . . |      ...       .|     .   .||  .. . |. 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

TKTIDVWSAGVL----------FYQL-----ITHKVLFQSGLQDVITICGAP--------DPKLWPNVM------------TFKNYNKCL
.   |||| ||.           |       .. . ...   |     . .          |.   ..|            ||..  .|.
S---DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF