Gene 92580.m00133 (T.vaginalis)

92580.m00133

Species: T.vaginalis
Alias: 92580.m00133, TvagK0974
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
92580.m00133.AA Protein None 330 None Fasta, JSON
92580.m00133.kin_dom Protein Kinase Domain None 209 None Fasta, JSON

Protein domain

Protein domains of 92580.m00133.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92580.m00133.AA Ciliate-E2 55-262 14 2e-28 94.65 In-house 84-365 (365) Show / Hide 
Range on Protein: 55-262
Range on HMM: 84-365/365
Sequence Identity: 14% (46 aa)

SMLLSLKSEFLVNCVDVFE--DSKTFYAAYELPNGTPLIETIH------------TGSRIKEERAAYILNQLLQ---------------AVKYLHQSG--
..| .|.. ........|.  | ...|   |. .|  | . |                ...|. ..||  |.||               |..|||. .  
NILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI

------FGNIQINPQTIFVTPNDDVTITDYSF--LANIPYNERLQTRPE-------------------------------ILENAPPEFFKSGSYVA---
        || .            . |.|  .   .......|..  ..                                ..  .|| .....|     
IHRDIKPENILF------------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK

-----SQANVWSIGVIAYILVTGSHPFKTNTHSYNQSEYIIKESILQQIQIP------------------SYISTSAHNFIQR----SLEIEPTRRFS-I
      .. .||.||| |....| .||             ... . ..|..|                   ..| .. ..|..     |. .|  |.. .
QKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW

DQCIGHLWI
.|.. | |.
EQILNHPWF
Kinase 92580.m00133.AA Ciliate-E2-Unclassified 57-262 20 5.1e-26 87.25 In-house 75-352 (352) Show / Hide 
Range on Protein: 57-262
Range on HMM: 75-352/352
Sequence Identity: 20% (58 aa)

LLSLKSEFLVNCVDVFEDSKTFYAAYELPNGTPLIETIHTGSR-----------------IKEERAA-----YILNQLLQAVKYLHQSGFGNI---QINP
||.....|.|.....|.| ...|  .|. .|  |.. |   .                  . |. |.     ... |.||. .|||...  ||    | |
LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKP

QTIFVTPND---DVTITDYSFLA----------------NIPYNERLQTR---PEILENA--PPEFFKSGSYVAS---QANVWSIGVIAYILVTGSHPFK
. |... |     . |.|...                  .|.......|.   |. .     .|| ...  |  |   .. .|| |||.| ...| .||.
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY

-TNTHSYNQSEY----------IIKESILQQIQIPS--------YISTSAHNFIQ----RSLEIEPTRRFSIDQCIGHLWI
 .|  ...|...          .... . ..||.|.         .| .| .||.    . |.  |  | ...| . | |.
DNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 92580.m00133.AA Ciliate-A9 187-262 33 2.1e-23 51.89 In-house 315-392 (392) Show / Hide 
Range on Protein: 187-262
Range on HMM: 315-392/392
Sequence Identity: 33% (27 aa)

WSIGVIAYILVT-GSHPFKTNTHSYNQSEYIIKESILQ---QIQIPSYISTSAHNFIQRSLEIEPTRRFSIDQCIGHLWI
|| | |.| | . | |||. .  .    .|...  ..|   |.....  |  | ||||. . |.|. | .  ||. | ||
WSCGIIMYMLLCMGKHPFWCPYEKNDDEDYFKM--KIQCNPQWEFWDNCSNNAKNFIQKMTNINPSNRYNAFQCLKHPWI
Kinase 92580.m00133.AA CAMKL 169-262 26 3.2e-21 64.32 In-house 200-297 (297) Show / Hide 
Range on Protein: 169-262
Range on HMM: 200-297/297
Sequence Identity: 26% (27 aa)

APPEFFKS--GSYVASQANVWSIGVIAYILVTGSHPFKTNTHS----YNQSEYIIKESILQQIQ-IPSYISTSAHNFIQRSLEIEPTRRFSIDQCIGHLW
..|| |..   .| . .. .||.||| | .|.|  ||.  |..     |. ..  |. ..     |....| .....|.. |.  |..|..|.|   | |
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M
Kinase 92580.m00133.AA CAMK 169-262 20 2.9e-20 61.37 In-house 286-425 (425) Show / Hide 
Range on Protein: 169-262
Range on HMM: 286-425/425
Sequence Identity: 20% (28 aa)

AP-PEFFKS-------------GSYVASQANVWSIGVIAYILVTGSHPFKTNTHS-------YNQSEYIIKESIL-QQIQ-IPSYIST------------
.. || ...               |.  .. .||.||| ||...|  ||   ...         ...| ..| |.  . . .|.|.|.            
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDD

-----------SAHNFIQRSLEIEPTRRFSIDQCIGHLWI
           .. ..|.. |. .|..|..|.||  | |.
ISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 92580.m00133.AA MELK 57-262 21 3.7e-20 65.3 In-house 51-254 (254) Show / Hide 
Range on Protein: 57-262
Range on HMM: 51-254/254
Sequence Identity: 21% (44 aa)

LLSLKSEFLVNCVDVFEDSKTFYAAYELPNGTPLIETIHTGSRIKEERAAYILNQLLQAVKYLHQSGFGNIQINPQTIFVTPNDDVTITDYSFLANIPYN
| .|. . .     . |  . ..   |   |  . . |    |..|| .  .. |.. |. |.|  |.    . |. .... .  . . |. . |    .
LKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGR

E---RLQTRPEILENAPPEFFKSGSYVASQANVWSIGVIAYILVTGSHPFKTNTHSYNQSEYIIKESILQQIQIPSYISTSAHNFIQRSLEIEPTRRFSI
     |||    .  | ||  .  .|. | | |||.|.. |.|. |  ||     .      . |  .    . | ..| .. . ... | ..|..| |.
KDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMM-----IMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISM

DQCIGHLWI
 . . | |.
KNLLNHPWV
Kinase 92580.m00133.AA PLK1 59-262 26 7.9e-18 54.94 In-house 55-253 (253) Show / Hide 
Range on Protein: 59-262
Range on HMM: 55-253/253
Sequence Identity: 26% (55 aa)

SLKSEFLVNCVDVFEDSKTFYAAYELPNGTPLIETIHTGSRIKEERAAYILNQLLQAVKYLHQSGFGNIQINPQTIFVTPNDDVTITDYSFLANIPYN-E
.|. . .|.  . |||..  |   || .   |.|       | |  . | . |......|||.       .    .|.  . .| | |.    .. |. |
QLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGE

RLQTRPEILENAPPEFFKSGSYVASQANVWSIGVIAYILVTGSHPFKTNTHSYNQSEYIIKESILQQIQIPSYISTSAHNFIQRSLEIEPTRRFSIDQCI
| .|.        ||  .     .    .|||| | |||. |. ||   |.. ..    ||.    . .|||.||. |...|.. |. .||||  |.| .
RKKTLCGTPNYIAPEVLNKKGH-SFEVDIWSIGCIMYILLFGQPPF--ETKCLKETYSRIKK---NEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVL

GHLWI
   ..
NDEFF
Kinase 92580.m00133.AA SNRK 100-262 28 1.6e-17 53.64 In-house 96-254 (254) Show / Hide 
Range on Protein: 100-262
Range on HMM: 96-254/254
Sequence Identity: 28% (47 aa)

IKEERAAYILNQLLQAVKYLHQSGFGNIQINPQT-IFVTPNDDVTITDYSFLANIPYNERLQTRPEILENAPPEFFKSGSYVASQANVWSIGVIAYILVT
..|. |     |...|..| ||       . |   .|      | .||. |       |.|.|    |  . ||     || |   ..||.||| |.|| 
LCEDLARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVC

GSHPFKTNTHSYNQSEYIIKESILQ-QIQIPSYISTSAHNFIQRSLEIEPTRRFSIDQCIGHLWI
|  ||.      | || . .  |.  .  .|. .|.  .. ||. |  .| .| |...   | |.
GQAPFQEA----NDSETLTM--IMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase 92580.m00133.AA QIK 169-262 29 1.1e-15 57.36 In-house 184-272 (272) Show / Hide 
Range on Protein: 169-262
Range on HMM: 184-272/272
Sequence Identity: 29% (28 aa)

APPEFFKSGSYVASQANVWSIGVIAYILVTGSHPFKTNTHSYNQSEYIIKESILQ-QIQIPSYISTSAHNFIQRSLEIEPTRRFSIDQCIGHLWI
| || |.  .|   .. .||.||. |.||.|. ||   |          ....|  . .|| ..|.    .| . | ..|..|..|.| . | |.
AAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQ------NLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 92580.m00133.AA MARK 169-262 30 9.1e-15 44.87 In-house 172-262 (262) Show / Hide 
Range on Protein: 169-262
Range on HMM: 172-262/262
Sequence Identity: 30% (29 aa)

APPEFFKSGSYVASQANVWSIGVIAYILVTGSHPFKTNTHSYNQSEYIIKESILQ-QIQIPSYISTSAHNFIQRSLEIEPTRRFSIDQCIGHLWI
..|| |..  | .  . .|| ||. |..|.|. ||.     ..|..  ... ||  . .||...|....|.||| | . | .| .|...  | |.
MAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD----GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
S_TKc 92580.m00133.AA S_TKc 16-262 18 1.1e-13 24.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-262
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

VETHENI------TVYNAIGKAANRMYNVSRIPKDLAKSTTRNPFSMLLSLKSEFLVNCVDVFEDSKTFYAAYELPNG--TPLIETIHTGSR------IK
 | .. |      .|| .. |  .| . . .|.      ..|.  ..| . . ...|.. |||.| . .|   |. .|    | . |.   |      . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EERAAYILNQLLQAVKYLHQSGF-------GNIQINPQTIFVTPNDDVTITDYSFLANIPYNERLQTR----PEILENAPPEFFKSGSYVAS-QANVWSI
| .|.... |...|..|.|. |.        || ..           . |.|  . . .  .    |.    ||.|                  . .||.
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL--TTFCGTPWYMAPEVL------------GYGKCKCDWWSC

GVIAYILVTGSHPFKTNTHSYNQSEYIIKESILQQIQIPSYISTSAHNFIQRSLEIEPTRRFSIDQCIG-------HLWI
|.| |....|  ||               . ....|      | .| .||.. |. .|..| .. ..         | |.
GCILYEMLCGYPPFP------------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92580.m00133.AA Pkinase 186-262 17 1.5e-09 34.8 Pfam 195-293 (293) Show / Hide 
Range on Protein: 186-262
Range on HMM: 195-293/293
Sequence Identity: 17% (17 aa)

VWSIGVIAYILVTGSHPFKTN--THSYNQSEYIIKESILQQIQIPSYIS---------------------TSAHNFIQRSLEIEPTRRFSIDQCIGHLWI
.||.|.| |....|  ||.    ... .   ..|..    ..  ... .                      ..  || . |.  |..| ...|.  | |.
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 92580.m00133.AA CAMK 35-121 11 9.3e-07 17.04 In-house 38-197 (425) Show / Hide 
Range on Protein: 35-121
Range on HMM: 38-197/425
Sequence Identity: 11% (19 aa)

MYNVSRIPK-------------------------DLAKSTTRNPFSMLLS-------LKSEFLVNCVDVFED-------------------SKTFYAAY-
... .....                         .  .   |.  ... .       |. . .... .|.||                    | .|    
IIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME

--ELPNGT----PLIETIHTG---------------SRIKEERAAYILNQLLQAVKYLHQ
  |.  |      | . |                   |..|. |...  |...||.|.|.
IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS
Kinase 92580.m00133.AA Pkinase 55-124 21 5e-06 22.49 Pfam 52-129 (293) Show / Hide 
Range on Protein: 55-124
Range on HMM: 52-129/293
Sequence Identity: 21% (17 aa)

SMLLSLKSEFLVNCVDVFEDSKTFYAAYELPNGT----PLIETIH--TGSRI--KEERAAYILNQLLQAVKYLHQSGF
.....|.... | . |.|||..  |   |. .|.     | . |.   . ..   |. .  .. |.|....|.|. |.
QIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase 92580.m00133.AA CAMKL 70-121 25 0.000137 10.4 In-house 82-145 (297) Show / Hide 
Range on Protein: 70-121
Range on HMM: 82-145/297
Sequence Identity: 25% (16 aa)

DVFEDSKT------FYAAYELPNGTP--LIETI--HTG--SRIKEERAAYILNQLLQAVKYLHQ
.|.|....      .|   |.  |    | . |  | .   |..|. |  .  |.. ||.|.|.
EVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS
Kinase 92580.m00133.AA MARK 70-123 28 0.001435 7.73 In-house 66-124 (262) Show / Hide 
Range on Protein: 70-123
Range on HMM: 66-124/262
Sequence Identity: 28% (17 aa)

DVFE--DSKT-FYAAYELPNGTPLIETIHTG--SRIKEERAAYILNQLLQAVKYLHQSG
.|.|  .... .|   |.  |..| . |      |..|| |  |  |.. ||.|.|. .
HVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKN
Kinase 92580.m00133.AA QIK 97-123 29 0.348615 0.89 In-house 112-138 (272) Show / Hide 
Range on Protein: 97-123
Range on HMM: 112-138/272
Sequence Identity: 29% (8 aa)

GSRIKEERAAYILNQLLQAVKYLHQSG
|  ..|. |. .  |.. ||.|.|. .
GVPMAENEARRWFWQICSAVHYCHKRN