Gene 93242.m00189 (T.vaginalis)

93242.m00189

Species: T.vaginalis
Alias: TvagK0232, 93242.m00189
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
93242.m00189.AA Protein None 313 None Fasta, JSON
93242.m00189.kin_dom Protein Kinase Domain None 244 None Fasta, JSON

Protein domain

Protein domains of 93242.m00189.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 93242.m00189.AA S_TKc 14-257 28 6.7e-69 236.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-231/231
Sequence Identity: 28% (74 aa)

FTDVSFIAQGGYGSIWKVFSPSYNRQFAIKKVPLEMFKEEELDCFKIIDDTRIVNLYKFYKYDNFIYLVMEYCPY---DLEIYLKNQHE------LSTHE
.. .  | .|..|. .|.   . .|..|||...     . |... |  .   ||.|| ..   ...|.|||||.    ||  |.|..        ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

LARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEYGRIKICNFGLSTIMKDEYKSKTFGGTKLFMPPEIVSKREFNPFAADVWSLGVTFYFMASHQYPFF
 ...|. .. |.. ||...| |.|.||.| |.||  .|||| |||....      .|| ||  .|.||..    ......|.||.|...| |.. . || 
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

STNSEYLFEKIVRGIYETDVIENAQLKVLIAKCLETDPSCRATVDELLK-------MPFI
  . . .|.||.            ..| .| |||. ||. | |. |.|.       .|..
--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93242.m00189.AA CAMK 19-257 18 6.4e-63 201.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 19-257
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

FIAQGGYGSIWKVFSPSYN------------RQFAIKKVP---------------------------------LEMFKEEELDCFKI-------IDDTRI
 . .|..|   ...  . .            ...||| ..                                  . . . |... |        .|   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLYKFYKY-------------------DNFIYLVM---EYCPY-DL--EIYLKNQHE-----------------LSTHELARFMHDMLAAVKACHDRNI
..|| .|                     |...|.||   |||.  .|  ... . .                   .. .| .|... .. ||. ||..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHCDIKPSNFLIDEY-----------------GRIKICNFGLSTIMKD------------------------EYKSKTFGGTKLFMP-PEIVSK------
.|.|.|| | |.|.                  . |||. ||.......                          | ||| ||  .|. ||....      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------REFNPFAADVWSLGVTFYFMASHQYPFFST-------------NSEYLFEKIVRGIY--ETDVIEN----------------------AQLKV
       ..  ....|.||.||  |.| .  .|| .              | . ||||| .| |  . . . .                      .. | 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIAKCLETDPSCRATVDELLKMPFI
|| |.|..||. |.|... |. |..
LIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase 93242.m00189.AA Pkinase 14-257 24 7e-60 210.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

FTDVSFIAQGGYGSIWKVFSPSYNRQFAIKKVPLEMFKE---------EELDCFKIIDDTRIVNLYKFYKYDNFIYLVMEYCPY-----DLEIYLK--NQ
.. .. | .|..|. .|    ......|.|.....  |.          |.   | ..   || || .. ... ||.|||||.      ||  |..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HEL--STHELARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEYGRI----KICNFGLSTI--MKDEYKSKTFGGTKLFMPPEIVSKREFNPFAADVWSL
  .  | .|. ..|  .| ... ||...| |.|.||.|.|||. | |    ||| |||.           .|| ||  .|.||.. ...  . ..|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVTFYFMASHQYPFFST------NSEYLFEKIVRGIYETDVIEN---------------------AQLKVLIAKCLETDPSCRATVDELLKMPFI
|...| |.. . || .       .  .....| ..... |  .                        .| .| .||. ||..| | ...|. |..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 93242.m00189.AA Ciliate-E2 14-257 21 2.3e-52 178.05 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

FTDVSFIAQGGYGSIWKV--FSPSYNR----------------QFAIKKVPLEMFKEEELDCFKIIDDTR-----------------------IVNLYKF
.  .  | ||..||..|.   .  ..                 ...||.. ....|. ..  .| ...                         |...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YK--YDNFIYLVMEYCPY-DLEIYLKNQ-----------HELSTHELARFMHDMLA---------------AVKACHDRN-IAHCDIKPSNFLIDEYGRI
..   || |||||||| . ||. |.||.           . ..  | ...|   |                |.. .| .| | | ||||.| |.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KICNFGLSTIMKDE-----------------YKSKTFG---------------GTKLFMPPEIVS--------KREFNPFAADVWSLGVTFYFMASHQYP
||. ||||.. .|.                 ..|.|.|               ||  .|.|||..        |..   ...|.|||||..|.| . ..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FFSTNSEYLFEKIVRGIYETD------------------VIENAQLKVLIAK----CLETDPSCRAT-VDELLKMPFI
|        ...|  . .. .                       . | || |    .|. ||. | |  ...|. |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 93242.m00189.AA MARK 79-257 37 6.2e-48 154.87 In-house 77-262 (262) Show / Hide 
Range on Protein: 79-257
Range on HMM: 77-262/262
Sequence Identity: 37% (71 aa)

IYLVMEYCP-YDLEIYLKNQ--HELSTHELARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEYG--RIKICNFGLSTIMKDEYKSKTFGGTKLFMPPEI
|||.|||..  .|  |.|..  . |.  |  |. . .. ||. ||..||.|.|||| | |||| |   |||. ||.|.. . . | .|| ||. .|.|||
IYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEI

VSKREFNPFAADVWSLGVTFYFMASHQYPFFSTN--SEYLFEKIVRGIYE-TDVIENAQLKVLIAKCLETDPSCRATVDELLKMPFI
..|.. . ...|.|||||  ||| . ..||  ..   . |..||.|| |.  . .  .... || . | ..|. |.|..|..| |..
FLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVS-KECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 93242.m00189.AA CAMKL 66-257 31 7.2e-47 147.51 In-house 77-297 (297) Show / Hide 
Range on Protein: 66-257
Range on HMM: 77-297/297
Sequence Identity: 31% (70 aa)

IVNLYKFYKYDNF------IYLVMEYCP-YD--LEIYLKNQHE----LSTHELARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEYG--RIKICNFGLS
|. ||  .  ...      ||||||||.  .  |  |.... .    .. ||  |.   ...||. ||...|.| |||| | |.|| |   |||. ||.|
IIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS

TIMKD-----EYKSKTFGGTKLFMPPEIVSK--REFNPFAADVWSLGVTFYFMASHQYPFFST--------NSEYLFEKIVRGIYETDVIENA-QLKVLI
.....     . | ||| |.  .|.|||...  .... ...|.||.||. |.|   ..||           |  ||..|| .| |. ..     ... ||
NMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLI

AKCLETDPSCRATVDELLKMPFI
 | |...|. |.|...... |. 
RKMLQVNPEKRPTIHQIMNHPWM
Kinase 93242.m00189.AA Ciliate-E2-Unclassified 14-257 21 8.6e-45 153.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-352/352
Sequence Identity: 21% (75 aa)

FTDVSFIAQGGYGSIWKV---------------FSPSYNRQFAIKKVPLEMFKEEELDCFKIIDDTR-----------------IVNLYKFYKYDNFIYL
.. .  | |||.|...|.                . .|...   .|   .|....|. . |  .. |                 ||...   . .. ||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYCPY-DLEIYLKNQHE-----------------LSTHELA-----RFMHDMLAAVKACHDRN-IAHCDIKPSNFLIDEYG---RIKICNFGLSTIMK
|||||.. ||. |.|...                  ..  . .     ...   | . . .|  | | | ||||.| |.|. |   .|||. ||.|   .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

DEYK----------------SKTFGGTKLFM----PPEIVSKREFNP---FAADVWSLGVTFYFMASHQYPFFSTNSEY----------------LFEKI
. ..                ..|| ||  .|    .||.  . . .    ...|.||||| .|.|   .|||...|.|                 |...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

VRGIYETDVIEN--------AQLKVLIA----KCLETDPSCRATVDELLKMPFI
  .... .  ..         . | .|     |.|. .|. | | ...|. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 93242.m00189.AA ULK 14-257 22 1.4e-43 150.01 In-house 1-329 (329) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-329/329
Sequence Identity: 22% (76 aa)

FTDVSFIAQGGYGSIWKVFSP----SY---NRQFAIKKVP---LEMFKEE------------ELDCFKIIDDTR--------IVNLYKFYKYD--NFIYL
.     . .| .|   ||.      .    | ..|.|...   . ... |            | .  | ....         || ||.... .  | ||.
YCLNHCLGKGSFG---KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VMEYCPY-DLEIYLKNQHE----------LSTHELARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEY------------GRIKICNFGLSTIMKDE--
.||||.  ||| |.|....          ||  |   |... |.. |. |..|| |.||||.| ||..             |..||. ||..  . ..  
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

--YKSKTFG------GTKLFMPPEIVS----KREFNPFAADVWSLGVTFYFMASHQYPFFSTNSEYLFEKIVRGIYET--------------------DV
     .|.       || |.| |.|..    . ... . .|.||||. || |   ..||..   . ....|..  ..                     |.
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDP

IENAQLKVLIAKCLETDPSCRATVDELLKMPFI
.   ..| || ..|. |.. | . .||...|..
QISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 93242.m00189.AA ULK 14-257 23 2.7e-41 143.5 In-house 1-324 (324) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-324/324
Sequence Identity: 23% (77 aa)

FTDVSFIAQGGYG-SIWKVF-SPSY--NRQFAIKKVP---LEMFKEE------------ELDCFKIID------DTRIVNLYKFYKYD--NFIYLVMEYC
.     . .| .|    | .   .   | ..|.|...   . ..| |            |    |...         || ||.... .  |.||..||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

PY-DLEIYLKNQHE---------LSTHELARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEY------------GRIKICNFGLSTI----MKDEYKSK
.  ||| |.|....         ||  |   |... ... |. |..|| |.||||.| || .             |..||. ||.. .    .... . .
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TFG------GTKLFMPPEIVS----KREFNPFAADVWSLGVTFYFMASHQYPFFSTNSEYLFE---KIVRG-------IYETDVIEN---------AQLK
|.       || |.| |.|..    . ... . .|.||||. || |   .|||||   . ...   | ..        |. . .  .          ..|
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

VLIAKCLETDPSCRATVDELLKMPFI
 || ..|. |.. | . .|....|..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 93242.m00189.AA CAMKK-Unclassified 86-257 26 1.6e-40 129.49 In-house 161-392 (392) Show / Hide 
Range on Protein: 86-257
Range on HMM: 161-392/392
Sequence Identity: 26% (62 aa)

CPYDLEIYLKNQHELSTHELARFMHDMLAAVKACHDRN---------------------IAHCDIKPSNFLIDEYGR-----IKICNFGLSTIMKDEYKS
| .   |  . .  ..   | . . ... ... .|..|                     | | |||| | |||. ..     .||. ||.|.||..| ..
CLFSNQILEMKPYKMHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQK

--KTFGGTKLFMPPEIVSKREF--NPFA-------------------------ADVWSLGVTFYFMASHQYPFFSTNSEYLFE-KIVRGI------YETD
  |   ||. ||.||  || .|  .. .                         ||.|||||||| |. |  ||...| . ||. .|  ..      |...
KLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPH

VIENAQLKVLIAKCLETDPSCRATVDELLKMPFI
   ....| || |... .|  |.|.| .|. |..
C--SHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase 93242.m00189.AA CAMKK 79-257 22 7.6e-40 123.84 In-house 104-396 (396) Show / Hide 
Range on Protein: 79-257
Range on HMM: 104-396/396
Sequence Identity: 22% (67 aa)

IYLV-MEYC--------PYDLEIYLKN------------------QHELSTHE---------------------LARFMHDMLAAVKACH-DRN------
||.| ||||        ||. ..| .|                    ..|  .                     . . . |.. ... .| ...      
IYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYII

-------------IAHCDIKPSNFLIDEYG---RIKICNFGLSTIMK--DEYKSKT----------FGGTKLFMPPEIVSK-RE--------------FN
             | | ||||.| |||| |   ..||. || |.|..  |. .|              ||. ||.||  ||  .              ..
IYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYC

PFAADVWSLGVTFYFMASHQYPFFSTNSEYLFE---KIVRGI--YET-----------DVIENAQLKVLIAKCLETDPSCRATVDELLKMPFI
 .|||.|.||||.| .  .. ||...| . |..   ||.     ...           .  ....|| || ..|| .|  | |...... |..
GKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase 93242.m00189.AA STE 14-257 18 2.5e-38 132.95 In-house 1-359 (359) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-359/359
Sequence Identity: 18% (67 aa)

FTDVSFIAQGGYGSIWKV-------FSPSYNRQ---------FAIKKVP-----------------------LEMFKEEELDCFKIID-DTRIVNLYKFY
......| .|..|.  |        .  . ...         .|||...                       .. ...|   . |  .    ||. |  |
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

KYD-------NFIYLVMEYCP-YDLEIYLKNQHELST--------------HELARFMHDMLAA-VKACHDRNIAHCDIKPSNFLIDEYGRIKICNFGLS
 ..       . ....|||..   |.  .|. ..                 ...|.. .. | .  .  |. .| | ||||.| |.     .|.|.||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

TIMKDEY-----------------KSKTFGGTKLFMPPEIVSKREFNPF------AADVWSLGVTFYFMASHQYPFFSTNSEYLFEKIVRGI--------
... |..                 |..|| ||  .| ||...... .         .|.|||| |   ||  ..|..  .  .    | ...        
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----YETDVIEN----------------------AQLKVLIAKCLETDPSCRATVDELLK--MPFI
      .   ...                        .|  |.|||. ||. |.|...|||   |||
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 93242.m00189.AA TyrKc 14-255 22 1.1e-11 -33.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-255
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

FTDVSFIAQGGYGSIWKVFSPSYNRQFAIKKVP---LEMFKEEELDCFKII--DDTRIVNLYKFYKYD-------NFIYLVMEYCPY-DLEIYLKNQHE-
 |    .  | .| ..|       .| |.|..    .|.|  .|.   . .  .   ||.||     .         ...||||.|. ||  ||.. .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFM-REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LSTHELARFMHDMLAAVKACHDRNIAHCDIKPSNFLIDEYGRIKICNFGLSTIMKDE--------YKSKTF--GGTKLF----MPPEIVSKREFNPFAAD
|.. .|  |...  .     |..|. | |.   | |..| ...||. ||||   .|.        |..|.   ||  ..    |.||   ...|. .. |
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSD

VWSLGVTFYFMASH-QYPFFS-----TNSEYLFEKIVRGIYETDVIE---------NAQLKVLIAKCLETDPSCRATVDELLKMP
||| ||. . . .  | |         . . ..|.. .| .     .          . .  .. .| . ||..| |  |. .  
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF