Gene 86824.m00119 (T.vaginalis)

86824.m00119

Species: T.vaginalis
Alias: 86824.m00119, TvagK0292
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
86824.m00119.AA Protein None 768 None Fasta, JSON
86824.m00119.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of 86824.m00119.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86824.m00119.AA TKL 220-460 27 8.7e-82 278.02 In-house 1-364 (364) Show / Hide 
Range on Protein: 220-460
Range on HMM: 1-364/364
Sequence Identity: 27% (100 aa)

IGTGTFGSVHIGTMNATN--------RKVAVKVLNTQ--ILGGR----------------------QLETFKREVW-TMATLNHPSILRLVGVTLTPP--
|| |.|| |. |. . ..        . ||||.....   .  .                      ... |..|..  |  |.|| |....|. . ||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIVTELL-KGSLYDRLKFLSPTKRSIIALKVAQGMEQLHAAR--------IIHRDLKSANILLDEDDM--------------PRVCD
            .|||.|.  .|||...|    . .|  .|| .|.||. ||. .        ||||||||.|||.||.                . .||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

FGLVGFKTGA---------------------TRTGYVGTAQWMAPEVLRSSPF---------------YDEKVDVYSFGVLLWEMLTLHEPYSGMKQEQI
|||  |...                      |.   .|| .|||||||| ...               |.||.||||||..|||.||  .||.... ...
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPM

V---------MGVIESGLRPLIP---------QNFSHS--KLVQLIERCWSEQPSMRPPFSTIATLL
.         |.|.. ||||.||         .. ..    . .|...||.. |. || |..|   |
IFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 86824.m00119.AA MLK 214-460 34 1.8e-73 250.41 In-house 1-291 (291) Show / Hide 
Range on Protein: 214-460
Range on HMM: 1-291/291
Sequence Identity: 34% (100 aa)

FTIGNTIGTGTFGSVHIGTMNATN---RKVAVKVLNTQI----LGG---RQLETFKREVWTMATLN-HPSILRLVGVTLTP-P-FCIVTELL-KGSLYDR
...   || |.||.|. |.. ...   . ||||  .. |      .   ...|.. |... .  .| ||.| ...|| | | . ||||.| . .||||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKF-----------------LSPTKRSIIALKVAQGMEQLHA-AR--IIHRDLKSANILLDE------DDMPRVCDFGLVGFKTGA-T-RTGYVGTAQWM
|.                   ..     .|| .|.||. ||. |.  |||||||| |||.||      ..  ..||||.. ...   | ...  ||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVL---RSSPFYDEKVDVYSFGVLLWEMLTLHEPYS-GMKQEQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATLL
||||.   |... |.||.||.|.||.||||||  .||. .... .| ..|.. |||| ||...... . .|...||.. |. || |. | . |
APEVIQQFRCEK-YSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEH-WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 86824.m00119.AA LRRK 214-462 29 1.1e-70 241.19 In-house 1-351 (351) Show / Hide 
Range on Protein: 214-462
Range on HMM: 1-351/351
Sequence Identity: 29% (105 aa)

FTIGNTIGTGTFG-SVHIGTMN--------------------------ATNRKVAVKVLNT--------------------------------QILGGRQ
. |.. || |.|| .|. ....                          .   .||.|..|.                                 .   | 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LETFKREVWTMATLNHPSILRLVGVTLTPPFCIVTELL-KGSLYDRLK------F------LSPTKRSIIALKVAQGMEQLHAAR--IIHRDLKSANILL
. .| .||| | .||||.|. |.|...  |.|.|.|..  |.||..|.      |      .|.. .  ||| .| ||| || ..  |||||||| ||||
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DEDDMP------------RVCDFGLVG--FKTGAT-RTGYVGTAQWMAPEVLRSS--PFYDEKVDVYSFGVLLWEMLTLH-EPYSGMK-------QEQIV
 . ...             ..|||. .  . .. . . |.||. .|||||..|      |.||||.||||..||| ||.   |. ...       .||| 
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

MGVIESGLRPLIPQNFSHS-----KLVQLIERCWSEQPSMRPPFSTIATLLMQ
   | .|||| |||.. .       . .||. ||...|  || ||.|   | |
-DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 86824.m00119.AA Dicty4 214-462 38 2.4e-70 233.83 In-house 1-277 (277) Show / Hide 
Range on Protein: 214-462
Range on HMM: 1-277/277
Sequence Identity: 38% (107 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVL-NTQI-LGGRQLETFKREVWTMATLNHPSILRLVGVTL----TP-PFCIVTELL-KGSLYDRLKF---
 .|.. ||.| ||.|. ||   .  .||||.| |... .    |. |..||  |. . || |. . |  .    .|  .|||||.. ||.||  |     
INIEQRIGKGSFGEVYKGTWRGK--EVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

-------LS-PTKRS--IIALKVAQGMEQLHA--ARIIHRDLKSANILLDEDDMPRVCDFGLVG-FKTGA--TR--TGYVGTAQWMAPEVLRSSPFYDEK
       |. |. ..   .|. .|.||  ||.   .||||||||.|.| |..    ||||||   .|..   .   .. .||. ||||||... | |.||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YNEK

VDVYSFGVLLWEMLTLHEPYS--GMKQEQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATL--LMQ
.|||||| .|||.||  |||.  .|  .|.| .| . .||| ||.... | . .||..||.. |. || |. |     |  
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPS-WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 86824.m00119.AA TKL-Unique 216-460 34 5e-67 229.0 In-house 1-290 (290) Show / Hide 
Range on Protein: 216-460
Range on HMM: 1-290/290
Sequence Identity: 34% (102 aa)

IGNTIGTGTFGSVHIGTMNATNRKVAVKVLNT-QILGGRQLETFKREVWTMATLN-HPSILRLVGVTL----TPP-FCIVTE-LLKGSLYDRLK------
..|.||.|..|.|  |. . .  .||.|...    .  . ...|..|| .| .|. || |....|..     .|| .|||.| .  ||||| |       
FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-------FLSPTKRSIIALKVAQGMEQLHAAR--IIHRDLKSANILLDED-----DMPRVCDFGLVGFKTGATRTGYV-----------GTAQWMAPEVL
        |.. .|  .|...||||. ||     |||||||| |.|.|..        ..|||||. |..  ... .            |...|||||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

RSS-PFYDEKVDVYSFGVLLWEMLTLHE------PYSGMKQEQIVMGVIE--SGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATLL
|..   |.||.||||||. |||..| .       ||.|| |||.   | .   ..|| ||..     .  ||..||  .|| || |..| . |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHC-PKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 86824.m00119.AA S_TKc 214-466 27 3.5e-61 210.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 214-466
Range on HMM: 1-231/231
Sequence Identity: 27% (73 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVLNTQILGGRQLETFKREVWTMATLNHPSILRLVGVTLTPPFCIVTELLKG---SLYDRLKF--------
..|...|| |.||.|. .. . |.|.||.|...         |...||.  .   .|| | .| .|  .  ...|.|.. |   .|.|..|         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSPTKRSIIALKVAQGMEQLHAARIIHRDLKSANILLDEDDMPRVCDFGLVGFKTGATRTGYVGTAQWMAPEVLRSSPFYDE-KVDVYSFGVLLWEMLT
 ...     ..  .....| .|  .||||||| .||||||     .|||||  .      | ..||  .||||||     |.  |.|..|.|..|.|||.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC

LHEPYSGMKQEQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIAT---LLMQADFH
   |..   |.| .. .|              . . ..|..|.   |. ||    . .   . ..  . 
GYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86824.m00119.AA TK 214-460 17 3.6e-56 186.45 In-house 1-486 (486) Show / Hide 
Range on Protein: 214-460
Range on HMM: 1-486/486
Sequence Identity: 17% (87 aa)

FTIGNTIGTGTFG---SVHIGTMNATN-------------------------RKVAVKVLN--TQILGGRQLETFKR----------EVWTMATLN----
 |.|...| | ||    |. |...  |                          .||||.|   .     .... . .          |.  |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPSILRLVG-VTLT------------PPFCIVTELLK-GS----LYDRLK-------------------------------------------------
 || |.||.| .|              .|..||.|. . |.    | | |.                                                 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------FLSPTKRSIIALKVAQGMEQLHAA------RIIHRDLKSANILLDEDDM-----------PRVCDFGLV-
                              .|..  .  ... .|.||| ||.       ...||||   |.|..|..             ...||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----GFKTGATRTGYVGTAQ------------------------------WMAPEVLRSSPF--------YDEKVDVYSFGVLLWEMLTLH-EPYSGMK
       .    .. |. . .                              |||||.|..  |        . .| ||.|||||.||..|.  ||| |. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

QE---------QIVMGVIESG--------------LRPLIPQNFSH-------------SKLVQLIERCWSEQPSMRPPFSTIATLL
           | ||  ...|              .|.  |.. .                . .|. .||...|. || ||..   |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 86824.m00119.AA Pkinase 214-451 27 2.1e-55 195.18 Pfam 1-282 (293) Show / Hide 
Range on Protein: 214-451
Range on HMM: 1-282/293
Sequence Identity: 27% (79 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVLNTQILGGRQLETFKR--EVWTMATLNHPSILRLVGVTLTPP-FCIVTELLKG-----SLYDRLK----
..|| .|| |.||.| ...   |...||||... .     ...|  |  |.  |. |||| |.|| ..  ...  ..|.|.. |     .|.|...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

-FL--SPTKRSIIALKVAQGMEQLHAARIIHRDLKSANILLDEDDMP----RVCDFGLVG---FKTGATRTGYVGTAQWMAPEVLRSSPFYDEKVDVYSF
  .  |.     ... ...|.| .|. .|||||||..|||.|... .    ..|||||        .   |...||  .|||||.|... |. |||..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLLWEMLTLHEPYSGM---KQEQIVMGVIESGLR-PLIPQNFSH---------------------SKLVQLIERCWSEQPSMRP
|..|.|||. . |..|    .     | .|.  .. ||  . .                       . . ..|..|.   |. ||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase 86824.m00119.AA TyrKc 214-460 31 4.7e-55 190.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 214-460
Range on HMM: 1-280/280
Sequence Identity: 31% (90 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVLNTQILGGRQLETFKREVWTMATL--NHPSILRLVGVTLT--------PPFCIVTELLK-GSLYDRL--
 | | ..| | || |. ||..   ..||||.|.        .| | ||   |  |  .|| |.||.|| ..        .| .||.|. . |.| |.|  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

--KFLSPTKRSIIALKVAQGMEQLHAARIIHRDLKSANILLDEDDMPRVCDFGLVGFKTGA----TRTGYVGT-----AQ------WMAPEVLRSSPFYD
  . |.. .   ... .|.||| ||  ..|||||   |.|..|.   ...||||  . .       .. |  .     .       |||||..     . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

EKVDVYSFGVLLWEMLTL-HEPYSGM----KQEQIVMGVIESGLRPLIPQNF-------SHSKLVQLIERCWSEQPSMRPPFSTIATLL
.| ||.||||..||..|.  .||.||    .  | |.  ...| |. .|.|         .... |....|| |.|..|| ||.|  ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 86824.m00119.AA DRK 214-462 39 4.4e-52 174.69 In-house 1-258 (258) Show / Hide 
Range on Protein: 214-462
Range on HMM: 1-258/258
Sequence Identity: 39% (104 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVLNTQILG-GRQLETFKREVWTMATLNHPSILRLVGVTLTPP-FCIVTELL-KGSLYDRLK----FLSPT
  ||| || | .| |  ||   |  .|||| |          |  |.||.  |  | || |    |  . ||  ||..| . .||||  |      ..  
IKIGNRIGRGNYGEVFRGTWRGT--QVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWP

KRSIIALKVAQGMEQLHAAR--IIHRDLKSANILLDEDDMPRVCDFGLVG-FKT----GATRTGYVGTAQWMAPEVLRSSPFYDEKVDVYSFGVLLWEML
 .  ... .| ||  ||     |||||||| | | ||     | ||||   ||     ....|  .||  | ||||||. . | || |||||.. |||..
LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQR-YTEKADVYSFAIVLWECV

TLHEPYSGMKQEQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATLLMQ
|   || ||   |.|. |   |.|| .||. .  | .||. .||.| |. || .  .   |  
TRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCP-PKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 86824.m00119.AA Dicty4-Unclassified 214-460 31 2.3e-47 160.27 In-house 1-263 (263) Show / Hide 
Range on Protein: 214-460
Range on HMM: 1-263/263
Sequence Identity: 31% (85 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVLNTQILGGR--QLETFKREVWTMATLNHPSILRLVGVTLTP-----PFCIVTELL-KGSLYDRLK-FLS
  |   || | |  || |  |   . |||| .|      |   .. ||.||  .  . ||  ... |  . |      .|||.|.. || |        |
IQIDQFIGKGHFSKVHKG--NWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

PTKRSI---------IALKVAQGMEQLHAARIIHRDLKSANILLDEDDMPRVCDFGLVGFKTGATRTGYVG-TAQWMAPEVLRSSPFYDEKVDVYSFGVL
  ...|         .|. .||||  ||   .||||.||.|||.| .   .. |||.            .. |  | .||.|.    |  | ||||....
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSYAMM

LWEMLTLHEPYSGMK-QEQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATLL
|.|..|  ||| .      .   | . .||| || |     . .||  ||.. |  || .  |   |
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNC-DNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 86824.m00119.AA TK-Unique 214-460 27 4e-46 157.05 In-house 1-294 (294) Show / Hide 
Range on Protein: 214-460
Range on HMM: 1-294/294
Sequence Identity: 27% (81 aa)

FTIGNTIGTGTFGSVHIGTMNATN-----RKVAVKVLNTQILGGRQLETFKREVWTMATLN-HPSILRLVGVTLTP--PFCIVTELLKGS----------
...|..||.| || |. |..  ..     .|... ...   . . .   |..|   |  |  || |....|.. ..  |..|. | . ..          
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-L-------------------YDRLKFLSPTKRSIIALKVAQGMEQLHA--ARIIHRDLKSANILLDEDDMPRVCDFGLV------GFKTGATRTGYVGT
                     ..|. ..||     .|  .|.||| |.    .|.|||| . |.|| || .  .||||.       |     .. | .  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

AQWMAPEVLR--SSPFYDEKVDVYSFGVLLWEMLTL-HEPYSGMKQEQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATLL
. |||||.|.    ... .| ||.|||||.||..||   ||.||.... .|  |. | |.. |.. .   . .|...||.. |..|| |..|.  |
R-WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase 86824.m00119.AA Shk 318-456 41 3.3e-39 136.59 In-house 113-258 (269) Show / Hide 
Range on Protein: 318-456
Range on HMM: 113-258/269
Sequence Identity: 41% (62 aa)

GMEQLHA--ARIIHRDLKSANILLDEDDMPRVCDFGLVG-FKTGA----TRTGYVGTAQWMAPEVLRSSPFYDEKVDVYSFGVLLWEMLTLHEPYS-GMK
||  ||.   .|||||||.|| | |..    |||||.    |..        |  ||. ||||||.   |. .||.|||||| .|||.||  |||.   .
GMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPY-NEKADVYSFGIILWEILTCQEPYPKHHS

Q-EQIVMGVIESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTI
  .. . .. .  .|| ||  .  | | .||..||   |. || |. |
EYDKFYEAICNKKERPPIPDDCPKS-LKHLIQKCWDHNPQRRPSFNEI
Kinase 86824.m00119.AA Pkinase_Tyr 214-352 34 1.1e-29 101.1 Pfam 1-157 (270) Show / Hide 
Range on Protein: 214-352
Range on HMM: 1-157/270
Sequence Identity: 34% (55 aa)

FTIGNTIGTGTFGSVHIGTMN----ATNRKVAVKVLNTQILGGRQ--LETFKREVWTMATL-NHPSILRLVGVTL--TPP--FCIVTELLKG-SLYDRLK
 |.| ..| | ||.|. ||..     |. .||||.|  .    .|  .| | ||. .| .| .|| |.||.|| .    |   .||.|. .. .|.| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

F-------LSPTKRSIIALKVAQGMEQLHAARIIHRDLKSANILLDEDDMPRVCDFGL
        |..     ... .|.||| |.. ..|||||   |.|..|.   ..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase 86824.m00119.AA Pkinase_Tyr 370-460 40 1.6e-23 80.33 Pfam 180-270 (270) Show / Hide 
Range on Protein: 370-460
Range on HMM: 180-270/270
Sequence Identity: 40% (38 aa)

WMAPEVLRSSPFYDEKVDVYSFGVLLWEMLTLH-EP-YSGMKQEQIVMGVI-ESGLRPLIPQNFSHSKLVQLIERCWSEQPSMRPPFSTIATLL
|||||... .  . .| ||.|||||.||..|.  .| | ||. |. |.  | |.| |  .|.|  . .. .|. .|| ..|..|| || |   |
WMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYRMPCPEN-CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 86824.m00119.AA Shk 214-296 33 4.2e-07 21.87 In-house 1-84 (269) Show / Hide 
Range on Protein: 214-296
Range on HMM: 1-84/269
Sequence Identity: 33% (29 aa)

FTIGNTIGTGTFGSVHIGTMNATNRKVAVKVLNTQILGGRQLETFKREVWTMATLNHPSILRLVGV-T-LTPPFCIVTELL-KGSL
 .    .|.| ||.|  |.     ..|||||.  | .    .  |. ||  |. . || |.   |  |       |||||  ||.|
INREDFLGQGSFGKVYKGRCRG--KEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNL