Gene 89650.m00223 (T.vaginalis)

89650.m00223

Species: T.vaginalis
Alias: TvagK0403, 89650.m00223
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
89650.m00223.AA Protein None 403 None Fasta, JSON
89650.m00223.kin_dom Protein Kinase Domain None 245 None Fasta, JSON

Protein domain

Protein domains of 89650.m00223.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89650.m00223.AA AGC 102-346 25 3.6e-130 338.45 In-house 1-395 (395) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-395/395
Sequence Identity: 25% (100 aa)

FTIIKTIGRGFSGEVLLAMKK------SDDQLYAIKVLHKSA--------NCERAITE------------RNVLIRAK----------SPFIVK-LYYAF
| ..|.||.|  |.| |. ||      . ...||.||| |.           |...||            ||.| ...          .||||| |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSTSK--FYLVLDYIS--------TGDLATLIHKSLQ----NIPVELSQIIIGE-------IALALEHLHS-LGIVYRD-LKPENVLITSQGHIKLTDFG
|. ..   |.|..|..         |.. ...|.  .      . | ..... |       |.||||.||| .||..|| |||||.|....|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

ISRDLGDGE---------------------------------------------------LTKTLCG--SYSYVAPEMIMGKCYDTTIDWWS--LGVIAY
 .  . ...                                                   .|.|.||  .  |.|||..    |. . ||||  ||.. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QLFYNKLPFKGEN----------EKLLFDSII------NDEPKLP-----------FIQQGLQEFVSALLTKDPKKRLT------------DVFAHPFM
.. . . || |.|          .. .|..|.      |...|.|           .. . .. ... ||.|||.|||.            .. .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 89650.m00223.AA S_TKc 102-346 31 4.5e-87 296.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-231/231
Sequence Identity: 31% (83 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKSANCERAITERNVLIRAKSPFIVKLYYAFQSTSKFYLVLDYIST--GDLATLIHKSLQN-----IP
..|...||.|  |.| .. .|......|||...     |... |...| . . |.|||||..||. ...|.|..|...  ||| ..|.|   .     .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

VELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGISRDLGDGELTKTLCGSYSYVAPEMIMGKCYDT-TIDWWSLGVIAYQLFYNKL
    . .. .|..|||..||.||..|||||||.|...  |||..|||..| |      .|.||.  |.|||..    |..  .||||.|.| | ... . 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFKGENEKLLFDSIINDEPKLPFIQQGLQEFVSALLTKDPKKRLT-DVFA-------HPFM
||   .....|. |           . . .|.. .|.|||.||.| ....       ||..
PFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 89650.m00223.AA Akt 102-346 37 3.4e-84 269.05 In-house 1-264 (264) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-264/264
Sequence Identity: 37% (100 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLY-AIKVLHKSA-----NCERAITERNVLIRAKSPFIVKLYYAFQSTSKFYLVLDYISTGDLATLIHKSLQNIPV
|...| .|.|  | |.|. ||.....| |.||| |.        | ..||||.| . ..||||.|.|.||.  | |.|.||.. |.| .....  . .. 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRK-RRFSE

ELSQIIIGEIALALEHLHSLGIVYRD-LKPENVLITSQGHIKLTDFGISR-D-LGDGELTKTLCGSYSYVAPEMIMGKCYDTTIDWWS-LGVIAYQLFYN
.     . || ||.||||| .|.||| |||||.|. ..|||.||||| .. . . |.. |||.||.  | |||.. |. .. . |||. ||.. | . . 
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

KLPFKGENEKLLFDSIINDEPKLP---FIQQGLQEFVSALLTKDPKKRL-------TDVFAHPFM
 .||  .. . .|. | | . | |   .|..  . ..| ||.|||||||        .. .||. 
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 89650.m00223.AA RSK 105-346 35 5.1e-84 285.45 In-house 1-278 (278) Show / Hide 
Range on Protein: 105-346
Range on HMM: 1-278/278
Sequence Identity: 35% (99 aa)

IKTIGRGFSGEVLLAMKK---SDDQLYAIKVLHKSANCERAI------TERNVLIRAK-SPFIVKLYYAFQSTSKFYLVLDYISTGDLATLIHKSLQN--
.|  |.|  |.| |  |.     .|.|| |||.|.  . |.       ||||.| | . .||||.|.||||  .|.||...|.. |.| | . |  .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

IPVELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITS---QGHIKLTDFGISRD-LGD-GELTKTLCGSYSYVAPEMIM---GKC-YDTTIDWWSLGV
.  .  .... ||.||.||||..||..|||||||.| ..   .||||||||| ..    | ...|.| |..  |.||||..   ... .|   |||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IAYQLFYNKLPFKG---ENEKLLFDSIINDE--PKLP---FIQQGLQEFVSALLTKDPKKRLT-------DVFAHPFM
. | ..  ..||.|   .| | ... | . .  ...|   .. |  .......|..||.|||.       .. .||..
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 89650.m00223.AA SGK 102-346 34 1.6e-78 242.02 In-house 1-283 (283) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

FTIIKTIGRGFSGEVLLAMKKSD------------------DQLYAIKVLHKSANC------------ERAITER-NVLIRAKSPFIVKLYYAFQSTSKF
| ..|.|| |  |.|... .|.|                  |..||.||| | .                  .|| ..|   |.||||.| |||| . | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVLDYISTGDLATLIHKSLQNIPVELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGISR-DLGDGELTKTLCGSYSYVAPEMIMG
|.|.||.  |..   . .  .  |   . .   ||..|||.|||. |.||||||||.|  .|||..||||| .  .  . . |.| ||.  | |||.. .
YFVMDYVNGGEMFYHLQRE-KHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

KCYDTTIDWWSLGVIAYQLFYNKLPFKGENEKLLFDSIINDEPKLP-FIQQGLQEFVSALLTKDPKKRL------TDVFAHPFM
. .| | |||.|| . | . | . ||   | ....| ||| . ..| ...    .    ||.|||||||       ..  ||| 
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 89650.m00223.AA Pkinase 102-346 27 1.9e-75 261.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-293/293
Sequence Identity: 27% (80 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKS-ANCERAIT-----ERNVLIRAKSPFIVKLYYAFQSTSKFYLVLDYISTG----DLATLIH-KSL
..|...||.| .|.| ....|.. ...|.|.. |. ....  .|     |  .. | ..|.||.||..|.. .. |.|..|   |    ||...|. .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QNI--PVELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHI----KLTDFGISRD--LGDGELTKTLCGSYSYVAPEMIM-GKCYDTTIDWWSL
 ..  . .  . .. .|. .||..|| ||..|||||||.|| ..|||    |..|||...   .  .. ..|.||.. |.||| |. |. |.. .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIAYQLFYNKLPFKGE------NEKLLFDSIINDEPKLPFI-----Q-----------------QGLQEFVSALLTKDPKKRLT--DVFAHPFM
|.| |...  ..||.|.      ... ... |   ... ..                        . ...|.. .|.||||||.|  ... ||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 89650.m00223.AA RSK-Unclassified 102-346 30 1.2e-73 230.58 In-house 1-283 (283) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-283/283
Sequence Identity: 30% (88 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKSA-----NCERAITERNVLIRAKSPFIVKLYYAFQSTSKFYLVLDYISTGDLATLIH--KSLQNIP
|  .. ||.|  |.| |  ||  .|.||.|||||.         ...||.|..   . ||||.||..||.  . ||...|   ||.       |.   . 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKE-KCFC

VELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGISRDL----------------------GDGELTKTLCGSYSYVAPEMIMGKCY
 .. .. . |. .|||.|| ....||||||.|..    ||..||||. | .                        .|  |.  ||.  |.||||| .   
EDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGH

DTTIDWWSLGVIAYQLFYNKLPFKGENEKLLFDSIINDEPKLP---FIQQGLQEFVSALLTKDPKKRL-------TDVFAHPFM
   .||| ||.. | .     |..|.|.  .|  |   . |.|   .| .  .. . .||.. | |||        |. .||| 
TKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 89650.m00223.AA Ciliate-E2-Unclassified 102-346 25 5.1e-73 248.9 In-house 1-352 (352) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKSANCE--------------RAITERN-------------VLIRAKSPFIVKLYYAFQSTSKFYLVL
..|||.||.|  |.| .. .|...|.||.| ..|. ..                .. ...              |.  ..|||||..|.||.. ..|.|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYISTGDLATLIHKS--------------LQNIPVELSQI-------IIGEIALALEHLHSLG-IVYRDLKPENVLITSQG---HIKLTDFGISR-----
.|.  |||   | |.              .|.  ..  |.       .. .| ..||.||. . |..||.||||.|....|   .||..|||||.     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---DLGDG---------ELTKTLCGSYSYV----APEMIMGKCYDTT----IDWWSLGVIAYQLFYNKLPFKGENEKL----------------LFDSII
   | ...         ....| ||...|     |||...|. ||..    .|.||||||.|.. ....||...|..                 |.. |.
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

ND---EPKLPF------IQQGLQEFVS----ALLTKDPKKR--LTDVFAHPFM
.     || |.      ...  ..|..     .| |.|.||  . ... ||..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 89650.m00223.AA AktR 102-346 33 1.2e-68 234.34 In-house 1-268 (268) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-268/268
Sequence Identity: 33% (89 aa)

FTIIKTIGRGFSGEVLLAMKK-SDDQLYAIKVLHK-----SANCERAITERNVLI-RAKSPFIVKLYYAFQSTSKFYLVLDYISTGDLATLIHKSLQNIP
|...| .|.|  |.| |. ||  ....||.|...|         ...|||||...  .. ||||||.|.||. .| .....|.  |.| . ..|. . . 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQ-HLKKKKKFS

VELSQIIIGEIALALEHLHSL-GIVYRDLKPENVLITSQGHIKLTDFGISR---DLGDGELTKTLCGSYSYVAPEMIMG-KCYDTTIDWWSLGVIAYQLF
 | ..... .| ||||.||.   |.|||||||| |. . ||.|.|||| |.   .  . |.....||.  |.|||||.  | .. ..|||..|.  | . 
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

YNKLPFKGENEKLLFDSIINDE-PKLPF---IQQGLQEFVS-ALLTKDPKKRLT-------DVFAHPFM
.   ||  .| . .|..|.. .  | |.   . . .....   || |.|.|||.       ..  ||. 
TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 89650.m00223.AA Ciliate-E2 102-346 22 1.3e-68 234.31 In-house 1-365 (365) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

FTIIKTIGRGFSGEVLLAMKKSDD-----------------------QLYAIKVLHKSA-----NCERAI----------TERNVLIRAKSPFIVKLYYA
. .|| ||.|  | | .. .....                       ..||.|...|.      . .. .           |.|.| . ..|.|.|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--STSKFYLVLDYISTGDLATLI----HKSLQNIP------VELSQIIIGEIAL---------------ALEHLHSLG-IVYRDLKPENVLITSQGHI
||  .....|||..|.. |||  .|    .|....|.       .  . |. .|.                |||.||| . |..||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGISRDLGDG--------------------------------ELTKTLCGSYSYVAPEMIMGKC---------YDTTIDWWSLGVIAYQLFYNKLP
|..|||.|... |                                 ....|.||.. |.|||...||          ||. .|.|||||| |.. ..|.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FKGENEKLLFDSIINDEPKLP-----------------FIQQGLQ--EFVSA----LLTKDPKKRLT---DVFAHPFM
|        .. |.. . ..|                 . .  ..   . .     .| |||.||.|   ... ||..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 89650.m00223.AA MAST 102-243 40 6e-60 181.53 In-house 1-149 (337) Show / Hide 
Range on Protein: 102-243
Range on HMM: 1-149/337
Sequence Identity: 40% (60 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKSANCER-----AITERNVLIRAKSPFIVKLYYAFQS--TSKFYLVLDYISTGDLATLIHKSLQNIP
| .|| |..|  | | |. .|.  ...|.||. ..    .     .. |||.|  .. ||.||..|.||.  . . ..|..| . || |.|..    . |
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGIS
... ...| |. |.|| ||| ||| |||||.|.||.| ||||||||| |
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase 89650.m00223.AA MAST 102-243 42 1.7e-59 190.28 In-house 1-146 (334) Show / Hide 
Range on Protein: 102-243
Range on HMM: 1-146/334
Sequence Identity: 42% (62 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKSANCER-----AITERNVLIRAKSPFIVKLYYAFQSTSKFYLVLDYISTGDLATLIHKSLQNIPVE
|..|| |..|  | | |. .|.  ...|.||. ||    .      ..|||.|  ...||.||..|.||.... ..|..| . ||.|.|.| .. . ...
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLH-MYGYFDEW

LSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGIS
. ...| |..|.|| ||| ||| |||||.|.||.| ||||||||| |
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase 89650.m00223.AA MAST 253-346 30 1.3e-19 59.59 In-house 222-334 (334) Show / Hide 
Range on Protein: 253-346
Range on HMM: 222-334/334
Sequence Identity: 30% (34 aa)

KTLCGSYSYVAPEMIMGKC-YDTTIDWWSLGVIAYQLFYNKLPFKGENEKLLFDSIINDE---PKLPFI---------QQGLQEFVSALLTKDPKKRL--
| .||.  | ||| | |.  .  ..||||.|.| |...    || ...  ..|..|.|..    ..|.          .   |. .. ||. ||.|||  
KQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

T----DVFAHPFM
.    .|  ||| 
NNGADEVKQHPFF
Kinase 89650.m00223.AA MAST 253-346 33 2.4e-15 42.72 In-house 226-337 (337) Show / Hide 
Range on Protein: 253-346
Range on HMM: 226-337/337
Sequence Identity: 33% (37 aa)

KTLCGSYSYVAPEMIMGKC-YDTTIDWWSLGVIAYQLFYNKLPFKGENEKL-LFDSIIN--DEPKLPFI---------QQGLQEFVSALLTKDPKKRL--
|  ||.  | ||| | |.  |  ..||||.|.| | .     || |..    .|..|||  .|   | .         .   |. .. ||...|||||  
KQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

---TDVFAHPFM
    ..  ||| 
NGADEIKQHPFF
Kinase 89650.m00223.AA TyrKc 102-346 22 9.7e-15 15.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-346
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

FTIIKTIGRGFSGEVLLAMKKSDDQLYAIKVLHKSANCERAITERNVLIRA--KSPFIVKLYYAFQST-------SKFYLVLDYISTGDLATLIHKSLQN
 | .|..|.|. ||| ... |   .  |.|.|...|  |  . | ... .   . | ||.|| .  .           ..|. | . |||   ..|.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IPVELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGISRDLGDG-------ELTKT----LC---GSYSYVAPEMIMGKCYDTTIDW
....    .   ||   |.||| ... |||   |.|.......| .||| |||..|.       .  ..     .     .   ||| |. ... |  | 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGVIAYQLF-YNKLPFKG------ENEKLLFDSIINDEPKLPFI---------QQGLQEFVSALLTKDPKKRLTDVFAHPFM
|| ||  . .| | . |  |      .|. .. .    . .. |            . . .  .     ||..| |    | ..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 89650.m00223.AA Pkinase_Tyr 102-254 26 1.9e-11 39.41 Pfam 1-171 (270) Show / Hide 
Range on Protein: 102-254
Range on HMM: 1-171/270
Sequence Identity: 26% (46 aa)

FTIIKTIGRGFSGEVLLAMKK----SDDQLYAIKVLHKSANCER-----AITERNVLIRA-KSPFIVKLYYAFQ-STSK--FYLVLDYISTGDLATLIHK
 |..|..|.|  ||| ..  |    ....  |.|.|  .|  |       . | ...    . | ||.|| .          |.|. |   ||| .  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---LQNIPVELSQIIIGEIALALEHLHSLGIVYRDLKPENVLITSQGHIKLTDFGISRDL-GDGEL-TKT
     |.....    .  .|| ..|.|.| ... |||   |.|.|.....| .||| .||.  |..  .|.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKR