Gene 86001.m00247 (T.vaginalis)

86001.m00247

Species: T.vaginalis
Alias: TvagK0680, 86001.m00247
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
86001.m00247.AA Protein None 447 None Fasta, JSON
86001.m00247.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of 86001.m00247.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86001.m00247.AA NEK 9-264 39 5.2e-121 408.31 In-house 1-286 (286) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-286/286
Sequence Identity: 39% (113 aa)

FTILKQLGKGSYGTVYKAKRNSDGQS-----YALKVVDLGSMNQKQREDSI-NEIRIMASVSSPFIISFHESSIIGR--KLVIVSEYAK-LGDLSNA---
..|.|..|.||.|.|||..| |||.      |..| ...|.|..|...... ||.|| ..  .| |.....| |     .| || ||.   |||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISRRKQKKRQFKEETIWRFLIQMLEGLRVLHER-----GIVHRDLKSANILLSAPDL----FKIGDLGISTVLA-QRQLAKT-QIGTPMYLAPEIWKRRP
| ..|||.  | ||.||...|||. .|. .|.|      |.|||.|..|| |.. .      ||||.||| ||   ...|.| |.||| |..||... .|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDSKCDIWSLGVLLYEMATF--RYPFNAK--TAQDLSVKVCTT-KAPRIPPI--YSDDLINVIMSMLQQNPVLRPSVQDILAVPAV
|..|.||||||..||||.|.  . ||.|.      | .|..   . |.||.   ||.|| |.| .||| .| .|||...||. | .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 86001.m00247.AA S_TKc 9-264 29 1e-81 278.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSYALKVVDLGSMNQKQREDSINEIRIMASVSSPFIISFHESSIIGRKLVIVSEYAKL--GDLSNAISRRKQKKRQ
..||...|||..|.|||.. ...|. .|.|...         |. ..||.|. .   |.|. ....     .| .| ||.    |||   | .|. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLSAPDLFKIGDLGISTVLAQRQLAKTQIGTPMYLAPEIWKRRPYDS-KCDIWSLGVLLYEMA
  | | ...... |....|  .|..||.||||| .||||.     ||.| |....|      .|..||| |.|||.    .|.  |||.||.|..||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TFRYPFNAKTAQDLSVKVCTTKAPRIPPIYSDDLINVIMSMLQQNPVLRPSVQDILA-------VPAV
. . ||   . | .  |..           |..... |. .|| .|  ||.. ..|.        | .
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86001.m00247.AA NEK1 9-264 38 1.1e-79 271.04 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-276/276
Sequence Identity: 38% (107 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSYALKVVDLGSMNQKQREDSINEIRIMASVSSPFIISFHESSIIGRK--LVIVSEYAKLGDLSNAISRRKQKKRQ
....||.|.||.| ....|. .||| |..|   .  | .| ||.| ||  | |    | |... || . . .  |.|| ||.  |||  .| |.| |   
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLS--APD---------------LFKIGDLGISTVLAQR-QLAKTQIGTPMYLAPEIWKRRPYDS
| | .|  . .|.  .|   | | | |||.|| || |.    .               | |.|| ||. .|     .|.| |||| || |||.  .||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KCDIWSLGVLLYEMATFRYPFNAKTAQDLSVKVCTTKAPRIPPIYSDDLINVIMSMLQQNPVLRPSVQDILAVPAV
| ||||||. |||  |   ||.|.  . |  |.|    | ||| || .| . . .|.. || .||||..||  | .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 86001.m00247.AA ULK 9-264 27 3.6e-74 252.71 In-house 1-324 (324) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-324/324
Sequence Identity: 27% (89 aa)

FTILKQLGKGSYG-TVYKA--KRNSD-GQSYALKVVDLGSMNQKQREDS--------INEIRIMASVS---SPF--IISFHESSIIG--RKLVIVSEYAK
. . ..|||||.| .|||.  |.. . .| .| |..|. .||.|. |.         .|||.||       .|.  |. ... .       . |. ||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

LGDLSNAISRRKQ-----KKRQFKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLSAPD------------LFKIGDLGISTVL----AQRQLAKT
 |||.. | ..|      .|. . |. .  |..| ..|.. ||...|.|||.| .|||.. ..             .||.| | . ..     . |. .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QI------GTPMYLAPEIWKRR----PYD-SKCDIWSLGVLLYEMATFRYPFNAKTAQDLSVK-------------VCTTKAPRIP-----PIYSDDLIN
.       |||.| ||.|....    ||. .||||||||...||| . .|||..  ..|.  .                ..  ..|     |. |.....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

VIMSMLQQNPVLRPSVQDILAVPAV
 |. ||| ..  | | ..|.. | .
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 86001.m00247.AA ULK 9-264 26 7.4e-74 251.68 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-329/329
Sequence Identity: 26% (87 aa)

FTILKQLGKGSYGTVYKAK-RNSD---GQSYALKVVDLGSMNQKQREDS--------INEIRIMASVS----SPF----IISFHESSIIG--RKLVIVSE
. . ..|||||.|.|||..  ...   .. .| |..|. .||||. |.         .|||.||        ...    |. ... .       . |. |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAKLGDLSNAISRRKQ------KKRQFKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLSAPD------------LFKIGDLGISTVLAQR----Q
|   |||.. |...|       .|. . |. .  |..| |.|.. ||...|.|||.| .|||.. ..             .||.| | . ..       |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LAKTQI------GTPMYLAPEIWKRR----PYD-SKCDIWSLGVLLYEMATFRYPFNAKTAQDLSVKVCTT--------------KAPRIP-----PIYS
...|.       |||.| ||.|....    ||. .||||||||...||| . ..||.|  ..|.  . ..               . ...|     |. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DDLINVIMSMLQQNPVLRPSVQDILAVPAV
..... |  ||| ..  | | ..... | .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 86001.m00247.AA Pkinase 9-264 26 9.3e-74 256.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSYALKVVDLGSMNQKQREDSIN--EIRIMASVSSPFIISFHESSIIGRKLVIVSEYAKLG----DLSNAISRRKQ
..|....|.||.|.|||... ..|. .|.|.... . . ....  ..  ||.||.....|.|. ....   .... .| ||.  |    ||.  ||.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KKRQF--KEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLS-APDL---FKIGDLGISTV--LAQRQLAKTQIGTPMYLAPEIWK-RRPYDSKCDIW
... |   |... ... |.|.||  .|..||.|||||..|||..  ...   .||.| |.. .  .   . ..|  ||| |.|||. . ...|..|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVLLYEMATFRYPFNAK----TAQDLSVKVCTTKAPRIPPIYS-----------------------DDLINVIMSMLQQNPVLRPSVQDILAVPAV
|.|..||||.. | ||  .    .  |  ...| .. |...  ..                       .... .| ..|...|  ||. ..||  | .
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 86001.m00247.AA NEK4 9-264 37 6.6e-68 231.91 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-257/257
Sequence Identity: 37% (96 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSYALKVVDLGSMNQKQREDSINEIRIMASVSSPFIISFHESSIIGRK--LVIVSEYAKLGDLSNAISRRKQKKRQ
. ..|. |||||| |.  .   |.  | .| ..|    ...| .   |....     | |... ||  |.    | ||  .   ||| .    ..||   
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQF

FKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLSAPDLFKIGDLGISTVLA-QRQLAKTQIGTPMYLAPEIWKRRPYDSKCDIWSLGVLLYEMATF
 .|. .    .|   .|  .||. |.|||||  || |    . ||||.||| ||    ..||| |||| |. ||..  |||| | ||||||  .|||.| 
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

RYPFNAKTAQDLSVKVCTTKAPRIPPIYSDDLINVIMSMLQQNPVLRPSVQDILAVPAV
.  |.||    |  ..   . | .|| || || | .  ||.. |  |||. ||.  | .
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 86001.m00247.AA STE 9-264 22 5.4e-66 225.56 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

FTILKQLGKGSYGTVYKAKRN------SDGQS---------YALKVVDLGSMNQ---------------KQREDSINEIRIMASVS--SPFIISFHESSI
.......|||..||||||...      . |.          .| |...| . |.               ..... ..||.||   .  .|.|. .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IGR-------KLVIVSEYAKLGDLSNAISRRKQKKRQFK----------EETIWRFLIQMLEG-LRVLHERGIVHRDLKSANILLSAPDLFKIGDLGIST
 .        .| |. ||   | |.  | ... ......          |. | ... | |.| |  ||. .|.|||.|.|||||      |. | |...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLAQ-----------------RQLAKTQIGTPMYLAPEIWKR------RPYDSKCDIWSLGVLLYEMATFRYPF---NAK---TAQDLSVKVCT------
 |..                  |  .| .||| . |||. ..       .|| |||||||| .. |||| ..|.   .      .   . ...       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---TKAPRIPP-------------------IYSDDLINVIMSMLQQNPVLRPSVQDILA--VPAV
    . |..|.                    .|..... |   || .|  ||.... |    | .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 86001.m00247.AA CAMK 14-264 19 6e-64 204.67 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-264
Range on HMM: 1-425/425
Sequence Identity: 19% (85 aa)

QLGKGSYGTVYKAKRNSDG------------QSYALKVVDLGSMN--------------------------QKQREDSINEIRIMAS-------VSSPFI
.||.||.|.|..... ...            | .| |..|   .                           .| |.   .||.|| .       .. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISFHESSI------------IGRK--------LVIVS---EYAKLG----DLSNAISRRKQKK-----------RQFKEETIWRFLIQMLEGLRVLHERG
|...|                 .|        ...|    ||.  |    || . | .....            . |.|.   |.  |...... .|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKSANILLSAPD-----------------LFKIGDLGISTVLAQ------------------------RQLAKTQIGTPMYLA-PEIWKR-----
|||||||  ||||.  .                   || | | .... .                         |. ||. ||| | | ||. ..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RPYDSKCDIWSLGVLLYEMATFRYPFNAK-------------TAQDLSVKVCTTKAPRIPPIYSD-----------------------DLI
         ..|. |||.||.||.|| | . ..||...             . ..|  |... |   .||  |.                       . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NVIMSMLQQNPVLRPSVQDILAVPAV
. | .||| .|  |......|. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 86001.m00247.AA Ciliate-E2 9-264 23 9.8e-64 217.66 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FTILKQLGKGSYGTVYKAKRNSDG-----------------------QSYALKVVDLGSMNQKQREDSIN-EIR----------IMASVSSPFIISFHES
. ..|..|.|..|.|||.|. ...                       . ||.|..     .|. .|..|. ||.          |. ....|.|| ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SI--IGRKLVIVSEYAKLGDLSNAISRRKQKK-------RQFKEETIWRFLIQMLE---------------GLRVLHERG-IVHRDLKSANILLSAPDLF
 .     .. .| ||.. |||   |  .|.|.        .|.|. | ..  | |.               .|. ||... |.|||.|  |||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDLGISTVLAQR--------------------------------QLAKTQIGTPMYLAPEIWKRRP---------YDSKCDIWSLGVLLYEMATFRYP
|| |.|.|. . .                                 ....|..|||.|.|||| .. .         || |||||||||.|||| . ..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNAKTAQDLSVKVCTTKAPRI---------------PPIYSDDLINVIMS----MLQQNPVLRPS-VQDILAVPAV
|          | |  . |                 .   |.. .. |      ||| .|  |..  ..||  |  
F------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 86001.m00247.AA NEK2 9-264 28 6e-61 203.92 In-house 1-319 (319) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-319/319
Sequence Identity: 28% (92 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSYALKVVDLGSMNQKQREDSINEIRIMASVSSPFIISFHESSIIGRK---LVIVSEYAKLGDLSNAISRRKQKKR
  .|. .|.||.|...| .| |||   . |  . |.|. | .   ..|. |      |.|. .    || |.   | || ||   ||||  |.. .. ..
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYD-WIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQ

QFKEETIWRFLIQMLEGLRVLHE------------------RG---IVHRDLKSANILLSAPDL------------------------------------
 . || ||| . |..  |.. |                    |   | |||.| ||| |.. .                                     
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---FKIGDLGISTVLA-QRQLAKTQIGTPMYLAPEIWKRRPYDSKCDIWSLGVLLYEMATFRYPFNAKTAQDLSVKVCTTKAPRIPPIYSDDLINVIMSM
    | || |   .|    . |.| .||| |  ||  ....|. | ||||.| |.|||.. . || |.  . |..|.   .  ||| .||..|  .| .|
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LQQNPVLRPSVQDILAVPAV
.  ..  |||.  ||. | .
INVDHYHRPSIEEILQHPQI
Kinase 86001.m00247.AA Ciliate-E2-Unclassified 9-264 24 1.2e-58 201.21 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSY-------ALKVVDLGSMNQK----QREDSINEIR-------------IMASVSSPFIISFHESSIIGRKLVIV
..|.||.|.|..|.|||.......  |         ....  ....|    . .. .|..              |. .  .|||. ...      .. ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

SEYAKLGDLSNAIS-------------RRKQKKRQFKEETIW-----RFLIQMLEGLRVLHERG-IVHRDLKSANILLSAPD---LFKIGDLGISTVLA-
 ||.. |||.. |.             ........| |. .      ... | |.||  ||. . |.|||.|  |||..        || |.|||  .  
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------QRQLAKTQIGTPMYL----APEIWKRRPYD----SKCDIWSLGVLLYEMATFRYPFN---------------------AKTAQDL
               ..|...|..|||.|.    |||. ..  ||     |||||||||.|||| . .|||.                         . .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SVKVCTTKAPR--IPPIYSDDLINVIM----SMLQQNPVLRPSVQDILAVPAV
  ...  |.|   || . |.  .. |     .||. ||  |.. ..||  |  
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 86001.m00247.AA Pkinase_Tyr 9-205 25 5.1e-24 81.98 Pfam 1-210 (270) Show / Hide 
Range on Protein: 9-205
Range on HMM: 1-210/270
Sequence Identity: 25% (55 aa)

FTILKQLGKGSYGTVYKAKRN----SDGQSYALKVVDLGSMNQKQ--REDSINEIRIMASV-SSPFIISFHESSI-IGRK--LVIVSEYAKLGDLSNAIS
 |..|.||.|..|.|||.. .    ....  | |..   .  ..|  ||| ..|..|| .  . | |....   .  |.   . || ||...||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RRKQKKRQFKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLSAPDLFKIGDLGISTVL----AQ-RQLAKTQIGTPMYLAPEIWKRRPYDSKCDIW
...  |.... ...  . .|  .|.  |......||||   |.|.. .   ||.| | .  .       |.  ..       .||| .. . . .| |.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVW

SLGVLLYEMATF
| |||..|. |.
SFGVLMWEIFTY
Kinase 86001.m00247.AA TyrKc 9-264 22 1e-17 63.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FTILKQLGKGSYGTVYKAKRNSDGQSYALKVVDLGSMNQKQREDSINEIRIMASV--SSPFIISFHESSIIG-------RKLVIVSEYAKLGDLSNAISR
 | .|.|| | .|.|||.. .   .  | |..  ..     ||| ..|.||| ..  . | |. ..   . .         | || ||...||| . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKQKKRQFKEETIWRFLIQMLEGLRVLHERGIVHRDLKSANILLSAPDLFKIGDLGISTVLAQR-------QLAKTQ--IGTPM-----YLAPEIWKRRP
.. |   .. ..   | .|  .| . ||.....||||   |.|....   ||.| | |  .          .  ...   |. .      .||| .. . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDSKCDIWSLGVLLYEMATFRYPFNA------KTAQDLSVKVCTTKAPRIPPI--------YSDDLINVIMSMLQQNPVLRPSVQDILAVPAV
. .| |.|| ||...|. |.  .         ...|..  .| . . ...||          .|.. ... .  . .|  ||. ..|  .   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF