Gene 94757.m00041 (T.vaginalis)
94757.m00041
Species: T.vaginalis
Alias: 94757.m00041, TvagK0341
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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94757.m00041.AA | Protein | None | 933 | None | Fasta, JSON |
94757.m00041.kin_dom | Protein Kinase Domain | None | 254 | None | Fasta, JSON |
Protein domains of 94757.m00041.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 94757.m00041.AA | TKL | 27-274 | 27 | 3.5e-86 | 292.63 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 27-274 Range on HMM: 1-364/364 Sequence Identity: 27% (104 aa) IGKGGYGEVWLATHNR--------TGQKCAVKKLFLEDLEGQNL-------------------------NFFVREVTILASC-HDFFLLPFIGFTDSCP- ||.||.|||. .... ||. ||||. .. .. |...|. .. .. |. ...|.|. ..| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHP-NIVQFMGYCCCPPC -------------FTIVTEFVPSGSLFEALHHKHGAPTLSASNKTLIAIGIAHGMIELHKQN--------IIHRDLKSLNILLDDRLL------------ . ||.|..| |||.. || . . .|..|| || || .| |||||||| |||.|. . GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD --PKICDFGISRFGNQGDD-------------------TMTKEIGTPHWMAPEIFESN----------------HYTEKVDVYAYGMILWEMLTESVPFR .||||||.||| .| . | ...||| |||||... . |.||.|||..|..|||.|| .|.. WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY GRTAIQVA---------TAVVTKNERPPIP------------SSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTF . ... |. |..||||| ..|| ..||.| ||| ||||||||..| .. DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 94757.m00041.AA | TKL-Unique | 23-274 | 32 | 5.7e-79 | 268.67 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 23-274 Range on HMM: 1-290/290 Sequence Identity: 32% (97 aa) MDKRIGKGGYGEVWLATHNRTGQKCAVKKLF-LEDLEGQNLNFFVREVTILASCH-DFFLLPFIGFTD----SCP-FTIVTEFVPSGSLFEALH------ . || ||||.| ...... . |.|... .||.. . . | .||... | ... ..|.. . | . ||.|..| ||| . || FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN ----HKHGAPTLSASNKTLIAIGIAHGMIELHKQN--IIHRDLKSLNILLDDR-----LLPKICDFGISRFGNQGDDTMTKEI---------GTPHWMAP .. .|. ... .|| || ||. || . ||||||||.|.|.| . . ||||||.|.| .. ... ..|. |.. |||| NNNNNNC---KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP EIFES--NHYTEKVDVYAYGMILWEMLTESV------PFRGRTAIQVATAVVT--KNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTF |.... ..|.||.|||..|..|||..| . |..| . .|.. .| . .| |||||..|| .|.||| ||..||..|||| .|.. EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | 94757.m00041.AA | MLK | 21-274 | 33 | 1.1e-78 | 267.77 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 21-274 Range on HMM: 1-291/291 Sequence Identity: 33% (97 aa) FTMDKRIGKGGYGEVWLATHNRTGQK-----CAVKKLF-------LEDLEGQNLNFFVREVTILASCH-DFFLLPFIGF-TDS-CPFTIVTEFVPSGSLF .. . ||.|..|.||... .. |||. . .. | .... ..|.. || .| | ... |.| ||.|... |||. IQFHEWIGSGSFGKVWKGRW--RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY EALHHKHGAPT-----------LSASNKTLIAIGIAHGMIELHKQN---IIHRDLKSLNILLDD------RLLPKICDFGISRFGNQGDDTMTKEIGTPH . || . . . . . . .| .|.|| ||.. |||||||| |||.|. . ||||||.||. .| ...|.. .||. NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA WMAPEIF---ESNHYTEKVDVYAYGMILWEMLTESVPFR-GRTAIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTF |||||.. ... |.||.||. .|..|||||| ||.. . ....| |. ...||||||.|| . ||.. ||. ||.|||||.|| . WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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Kinase | 94757.m00041.AA | Dicty4 | 21-270 | 38 | 3.7e-74 | 246.75 | In-house | 1-269 (277) | Show / Hide |
Range on Protein: 21-270 Range on HMM: 1-269/277 Sequence Identity: 38% (106 aa) FTMDKRIGKGGYGEVWLATHNRTGQKCAVKKL--FLEDLEGQNLNFFVREVTILASCHDFFLLPFIGFTD---SCP--FTIVTEFVPSGSLFEALHH--- . ..|||||..||| ..| |.. ||||| .... || | .||.|... .. | | | | . ||||..|.|.|.. || INIEQRIGKGSFGEVYKGTWR--GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS ---KHGAPTLSASNK-TLIAIGIAHGMIELHKQN--IIHRDLKSLNILLDDRLLPKICDFGISR----FGNQGDDTMTKEIGTPHWMAPEIFESNHYTEK . . .. . ..|. .| ||. || | |||||||| |.| |. . |.||||.|. ...| .|| .||| |||||. .. |.|| EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEK VDVYAYGMILWEMLTESVPFR--GRTAIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQI .||| .|..|||.|| |. .. |.. ||. | .|||||..|| ...||| ||| ||..||||..| ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEI |
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Kinase | 94757.m00041.AA | HH498 | 65-274 | 36 | 1.7e-67 | 212.89 | In-house | 49-284 (284) | Show / Hide |
Range on Protein: 65-274 Range on HMM: 49-284/284 Sequence Identity: 36% (86 aa) FVREVTILASCHDFFLLPFIGFT--DSCPFTIVTEFVPSGSLFEAL--------------HHKH-GAPTLSASNKTLIAIGIAHGMIELHK---QNIIHR |.||| |. . |.. . | | |||... |||| | | .. | |.. .|||| || . |||| FCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHR DLKSLNILLDDRLLPKICDFGISRFGNQ-GDDTMTKEIGTPHWMAPEIFE-SNHYTEKVDVYAYGMILWEMLTESVPFRGRTAIQVATAVVTKNERPPIP || | |||.. .. |||.||| .. .||.||| .| . |||||.| . |..||||. |.|..|||.| ||| . | . . ||||| DLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIP SS----CPGTLRKLIQLCWDRDPEKRPSFKQIYNTF . | ||| ||. || ||.| || QTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL |
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Kinase | 94757.m00041.AA | Dicty5 | 94-280 | 40 | 2.6e-61 | 209.77 | In-house | 76-260 (260) | Show / Hide |
Range on Protein: 94-280 Range on HMM: 76-260/260 Sequence Identity: 40% (76 aa) IVTEFVPSGSLFEALHHKHG--APTLSASNKTLIAIGIAHGMIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISRFGNQGDDTMTKEIGTPHWMAPEI .|||.. .||||..| . .. . .||.|| .| || |||||||||.|.|. .. || |||.||| || ..||. |||.|. HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDN-RYHMTMHVGTQCWMACEL FESNHYTEKVDVYAYGMILWEMLTESVPFRGRTAIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTFCDRKVM | .. |..|.|||..| .||||.| |. . . . | | ||| || || . .|| || | .||||| | .| .... FNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIP-VMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYF--ESII |
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Kinase | 94757.m00041.AA | S_TKc | 21-279 | 26 | 3.7e-59 | 203.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 21-279 Range on HMM: 1-231/231 Sequence Identity: 26% (70 aa) FTMDKRIGKGGYGEVWLATHNRTGQKCAVKKLFLEDLEGQNLNFFVREVTILASCHDFFLLPFIGFTDSCPFTIVTEFVPS--GSLFEALHHKHGAPT-- ... . ||||..|.|....|..||...|.|.. . . ||. || . | .. .... .. . .|.|... |.||. .... . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LSASNKTLIAIGIAHGMIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISRFGNQGDDTMTKEIGTPHWMAPEIFESNHYTE-KVDVYAYGMILWEML .. .. |. .. .|...||||||| |||||. ||||||..|. | .|||..||||.. .|. |.|... | ||.||| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TESVPFRGRTAIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYN----TFCDRKV . ||. . .. .. . .. .|. |...||||||. .. . |. . CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 94757.m00041.AA | Pkinase_Tyr | 21-274 | 31 | 4.1e-59 | 200.81 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 21-274 Range on HMM: 1-270/270 Sequence Identity: 31% (85 aa) FTMDKRIGKGGYGEVWLATHN----RTGQKCAVKKLFLEDLEGQN--LNFFVREVTILASC-HDFFLLPFIGF-T-DSCP--FTIVTEFVPSGSLFEALH |..| .|.| .|||...| . |....|||.| |. .. . | ||. |. . | .. ..| | .. | ||.|..| |.| . |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR HK-HGAPTLSASNKTLIAIGIAHGMIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISRFGNQGDDTM-TKEIGTP---HWMAPEIFESNHYTEKVDVY . .. . |. . . ... || || |. .|.||||| |.|... . |||||| .| . ||. .| |.. ||||| . . .|.| ||. KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW AYGMILWEMLT-ESVP-FRGRTAIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTF ..| .||..| | . | . .| .. ...| |.| || . .|...||. |||.||.|..|.. . SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | 94757.m00041.AA | LRRK | 91-276 | 38 | 1.5e-57 | 197.51 | In-house | 129-351 (351) | Show / Hide |
Range on Protein: 91-276 Range on HMM: 129-351/351 Sequence Identity: 38% (87 aa) PFTIVTEFVPSGSLFEALHHKHGAP------TLSASNKTLIAIGIAHGMIELHKQN--IIHRDLKSLNILL---D---------DRLLPKICDFGISR-F |...|.|..| |.| . ||.|. . .| . | ||. || || ||..| |||||||| |||| . . ||.|||||| | PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF GNQGDDT--MTKEIGTPHWMAPEIFESN---HYTEKVDVYAYGMILWEMLTES-VPFRGRT-A-----IQVATAVVTKNERPPIPSS-CPG-----TLRK | . . . |.| |||||| | ||||||.|..|||||| || . ||.. . . ... ||.||.. ||. . . --QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQD LIQLCWDRDPEKRPSFKQIYNTFCD |||.||. ||.|||.| || . . LIQHCWQHDPKKRPHFSQIVKRLSQ |
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Kinase | 94757.m00041.AA | Pkinase | 21-274 | 26 | 1.4e-56 | 199.12 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 21-274 Range on HMM: 1-293/293 Sequence Identity: 26% (78 aa) FTMDKRIGKGGYGEVWLATHNRTGQKCAVKKLFLEDLEGQNLNFFVR--EVTILASC-HDFFLLPFIGFT--DSCPFTIVTEFVPSG----SLFEALH-H .. ..||.|..|.|....| ||.. |||.. ... . . . .| |. |.... |.. . .... .. . .|.|... | .||. .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTW KHGAPTLSASNKTLIAIGIAHGMIELHKQNIIHRDLKSLNILLDDRLLP----KICDFGISRFG-NQGDDTMTKEIGTPHWMAPEIFE-SNHYTEKVDVY .||. ..| .. |. |. .|...|||||||. |||.|.. . ||||||.... . . || |||..||||. ...|. |||.. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW AYGMILWEMLTESVPFRGR------TAIQVATAVVTKNERPPIPSSCP-------------------GTLRKLIQLCWDRDPEKRPSFKQIYNT--F ..| ||.|||. ||.|. . .|. . . . ..| .|. .....| |...||.|||...|| . | SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 94757.m00041.AA | Dicty4-Unclassified | 21-274 | 35 | 1.4e-55 | 188.78 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 21-274 Range on HMM: 1-263/263 Sequence Identity: 35% (96 aa) FTMDKRIGKGGYGEVWLATHNRTGQKCAVKKLFLEDLEGQ--NLNFFVREVTILASCHDFFLLPFIGFTDSCP------FTIVTEFVPSGSLFEALHHKH |. |||| .| | | ||||. . | .|| || | |. | | . ||.|| ..| ||| | | IQIDQFIGKGHFSKVHKG--NWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYC-INPRSHKSTMCIVMEFMHKGNLFEVIHSKP GAPTLSASNKT----LIAIGIAHGMIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISRFGNQGDDTMTKEIGTPHWMAPEIFESNHYTEKVDVYAYGM . . .|. || || || |.||||.|| |||.| || |||||| .|| ||| | .||. |. | ||| |.| SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDF-NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAM ILWEMLTESVPFRGRT-AIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTF .|.|..| |. . . .| | | || ||..|. ..||| || || |||.. || . MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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Kinase | 94757.m00041.AA | DRK | 21-276 | 35 | 4.3e-55 | 185.03 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 21-276 Range on HMM: 1-258/258 Sequence Identity: 35% (92 aa) FTMDKRIGKGGYGEVWLATHNRTGQKCAVKKLFLEDLE-GQNLNFFVREVTILASCHDFFLLPFIGF-TDSCPFTIVTEFVPSGSLFEALHHKHGAPTLS |||.|.||||.. | | . |||.||. . || | ||.... |.| . . |..|. | ||| || . .. IKIGNRIGRGNYGEVFRGTWR--GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDE--SIEMD ASNKTLIAIGIAHGMIELHKQN--IIHRDLKSLNILLDDRLLPKICDFGIS-RFGNQGDDTMTK-EIGTPHWMAPEIFESNHYTEKVDVYAYGMILWEML . ... .| ||| || | |||||||| | | |. |. ||| | || . . .. .||| | |||. . |||| ||| .. .|||.. WPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV TESVPFRGRTAIQVATAVVTKNERPPIPSSCPGTLRKLIQLCWDRDPEKRPSFKQIYNTFCD | |. | || .| .|||.| || .|.. ||. || |||. .. TRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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Kinase | 94757.m00041.AA | TyrKc | 21-274 | 28 | 1.7e-54 | 188.24 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 21-274 Range on HMM: 1-280/280 Sequence Identity: 28% (83 aa) FTMDKRIGKGGYGEVWLATHNRTGQKCAVKKLFLEDLEGQNLNFFVREVTILASC--HDFFLLPFIGF-TDS-------CPFTIVTEFVPSGSLFEALHH |..| .| | .|||...| . ...|||.| . . | || |. . | .. ..| |.. | ||.|..| |.| . |. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK KHGAPTLSASNKTLIAIGIAHGMIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISRFGNQG-------DDTMTKE-IGTP-----HWMAPEIFESNHY ... |. . . ... || || ||..|.||||| |.|..... ||.||| ||.. . | ..|| |. ||||| . . . HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF TEKVDVYAYGMILWEMLTESVPFRGR-----TAIQVATAVVTKNERPPIPSS--------CPGTLRKLIQLCWDRDPEKRPSFKQIYNTF |.| ||...| .||..| . | . . | . .|.|.| . || . .... ||..|||.||.|..|. | TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 94757.m00041.AA | STE | 21-275 | 20 | 7.7e-51 | 175.21 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 21-275 Range on HMM: 1-359/359 Sequence Identity: 20% (74 aa) FTMDKRIGKGGYGEVWLATHN------RTGQK---------CAVKKLFLEDLE---------------GQNLNFFVREVTILASCH--DFFLLPFIGF-- .. ..||||..|.| .| .. .||.. .|.|.. ||. . .... . .|. |. |. . ..| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF -----TDSCP-FTIVTEFVPSGSLFEALHHKHGA-----------PTLSASNKTLIAIGIAHG-MIELHKQNIIHRDLKSLNILLDDRLLPKICDFGISR .... |. |... ||| . ..||.| ... | |. | .| . ||...|||||.|. |||| |.||||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG FGNQ----------------GDDTMTKEIGTPHWMAPEIFES------NHYTEKVDVYAYGMILWEMLTESVPFRGRTAIQVATAVVTK----------- .. .. . .||| |||||. . ..|..|.|.. | ..||.| .|. . .. . .. QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC ---NERPPIPS-------------------SCPGTLRKLIQLCWDRDPEKRPSFKQIYN---TFC .. ||.|. .. .. |..| ..||.|||. .| . | IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |