Gene 82727.m00037 (T.vaginalis)

82727.m00037

Species: T.vaginalis
Alias: 82727.m00037, TvagK0988
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
82727.m00037.AA Protein None 1209 None Fasta, JSON
82727.m00037.kin_dom Protein Kinase Domain None 507 None Fasta, JSON

Protein domain

Protein domains of 82727.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82727.m00037.AA PEK 226-736 17 1.5e-70 240.69 In-house 1-655 (655) Show / Hide 
Range on Protein: 226-736
Range on HMM: 1-655/655
Sequence Identity: 17% (124 aa)

FVKINNLGKGGY-GSVIEARKKADDDRHYAVKCIPLASLA----------------EVKE-MKREVAFLSKFQHRYIVNFYSSWVE--------------
| .|  |||||. |.|.... |. |...||.| |.| .                  .. | . ||| .|....|..||  ...| |              
FEEIQCLGKGGFGGQVYKVQNKL-DGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMW

---SVTEDAAKE-------------------------------IKKTFDLADEEEEETDDSGDTTTVSRSRSFN--------------------TTPRSP
   |.|.. ...                               ......  ...|..  .|..   .| . |..                    |  .. 
QLDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENE

RSVRRNDDSGSTTSIT----------------GEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEEDIPIEDASNSSNDG-EAGLI
...  ...|.. .|                  ..  | ............|.. .. .|..  . ..  .... .||...|  .|.  ..|..  ... .
SHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQS

GSSPPNADNQQIQMIFD--------------HSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCARSKSD
. .. .... | |   .              ...  |... |... ..   ..                                               
HKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ-----------------------------------------------

SSGRILLPKTFPSLSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKS--------------------------------------FFETAPKLEES
                         ...| |.||||.|...||.|.... .                                      . ........ 
-------------------------YQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKD

KQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND-----VKLGDFGLSR-----------------------LIEAKKSLKLGDVDELA---KEAT
  ||| |.|||.| |||.  .|||||||.|||.|....     || |||||.                        .........   .   .   .. .
QCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMW

GTAQ--------------------GSFPYTAPEITKGK-----KYDKKSDMYSFGIIFFEIWCYFPTQM-ERRKILFDLID-NKQFPPQMM----TDDFK
 ...                    |   | .||  .|.     .|..|.|||| |||||| | .| |.| || |.| || | . ||| ..     .....
-SNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYP

LQREIILNLLD-EPEKRQTCEQLLEKMPL
 |...|. .|.  |..| . .|.|.   .
KQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase 82727.m00037.AA GCN2 518-736 31 8.9e-54 184.98 In-house 261-511 (511) Show / Hide 
Range on Protein: 518-736
Range on HMM: 261-511/511
Sequence Identity: 31% (82 aa)

TFPSLSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLS
...... .|....||.|. | |.|||| |. .||... .. ....          ||. |.|||.|.|||.  .|||||||.|||.|  ..|| |||||.
QHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD-----ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLA

RL-------------------------IEAKKSLKLGDVDELAKEA------------TGTAQGSFPYTAPEITKGKKYDKKSDMYSF-GIIFFEIWCY-
                           .|....   .. .  . .             .||.     |..||..  ..|..| ||||  ||||||.| . 
TNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPF----YMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPP

FPTQMERRKILFDLIDNKQFPPQMM---TDDFKLQREIILNLLD-EPEKRQTCEQLLEKMPL
|.||||| .|| .|  . .||...      . | |...|  .|.  | ||.. .|||.   |
FCTQMERVQILKQLR-SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase 82727.m00037.AA STE 226-737 12 2.4e-47 163.61 In-house 1-359 (359) Show / Hide 
Range on Protein: 226-737
Range on HMM: 1-359/359
Sequence Identity: 12% (79 aa)

FVKINNLGKGGYGSVIEARKKADDDRH--------------YAVKCIPLASL-----------------AEVKEMKREVAFLSKFQ--HRYIVNFYSSWV
. .|  .|||..|.|  |... ... |              .|.| ..| .                   |... ..|. ...|..  | .||..| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ESVTEDAAKEIKKTFDLADEEEEETDDSGDTTTVSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDN
   ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

ESDSKSEYEEEDIPIEDASNSSNDGEAGLIGSSPPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPP
                                                                                                    
----------------------------------------------------------------------------------------------------

LIDLLTDSPCARSKSDSSGRILLPKTFPSLSDSKSKKSKKSKKQ-HFLFIQMELCSQSTLKDLMSDK-SFFETAP-------KLEESKQWRICREILEA-
                                         .|. . |.| ||...  .| |..  | . ... .       ...||   .|||.||.. 
-----------------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGL

LSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLSRLIEAKKS----------LKLGDVDELAKEATG----TAQGSFPYTAPEITKG------KKYDKK
|.|.|. ..||||.||.||..     ||| |||..  .. . .                     | ..    |  |.  . |||. ..      |.|| |
LYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCI----------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

SDMYSFGIIFFEIWCYFPTQMERRKI--LFDLIDNK-------------QFPPQMMTDDF-------------------KLQREIILNLLD-EPEKRQTC
.|..|.|.   |  .  |  ..      .|  ..|.             . ||.  ..                     .  .. | . |. .|.|| | 
CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

EQLLEK-MPLY
.|||.   |  
SQLLKSEHPFI
Kinase 82727.m00037.AA Ciliate-E2-Unclassified 226-736 11 5.7e-38 129.31 In-house 1-352 (352) Show / Hide 
Range on Protein: 226-736
Range on HMM: 1-352/352
Sequence Identity: 11% (71 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIP-------LASLAEVKEMKREVAFLSKFQHRYIVNFYSSWVESVTEDAAKEIKKTFDLADEEEEETD
. .|  .|.||.|.| ....| ..   || | .        .  . .  |...|   . . .. |...                                
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-K------------------------------

DSGDTTTVSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEEDIPIEDASNSSNDGE
                                                                                                    
----------------------------------------------------------------------------------------------------

AGLIGSSPPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCARSKSDSSGRILLPKT
                                                                                                    
----------------------------------------------------------------------------------------------------

FPSLSDSK---------------SKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSF--------FETAPK---LEESKQW-----RICREILEALSYIH
       .                |.    ...  ..| ||.| . .|.. ......        |..  .   ..| .       .....||..|.|.|
-----Y-NKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH

QSK-VIHRDLKPQNIFIDDKN---DVKLGDFGLSRLIEAKKSLKLGDV--------DELAKEATGTAQ--GSFPYTAPEITKGKKYD----KKSDMYSFG
... .||||.||.||..|...    .|. |||.|. ..     . ..         .....  .|| .    . |||||. .|..||    .|.|..|.|
HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMP-Q-YTAPEVLQGQNYDHSKAYKCDIWSLG

IIFFEI----WCYFPTQMER-------------RKILFDLI-DNKQFPPQMMT----DDFKLQREIILN------LLDEPEKRQTCEQLLEKMPL
.|..|.    .... .. |              ||.|.. | ..... | .      ..   . . ..|      |   |.|| | ||.|.   .
VILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 82727.m00037.AA S_TKc 226-737 13 3.5e-35 124.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 226-737
Range on HMM: 1-231/231
Sequence Identity: 13% (69 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAEVKEMKREVAFLSKFQHRYIVNFYSSWVESVTEDAAKEIKKTFDLADEEEEETDDSGDTTT
. ... .|||..|.|  .|.|  ..|..|.|.|.                                                                  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------------------------------------------------------------------

VSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEEDIPIEDASNSSNDGEAGLIGSS
                                                                                                    
----------------------------------------------------------------------------------------------------

PPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCARSKSDSSGRILLPKTFPSLSDS
                                                                    ....    . ..     .   . | . .  | 
--------------------------------------------------------------------EHIRREIQILKK-----HHPNIVKLYDVFQD-

KSKKSKKSKKQHFLFIQMELCSQ--STLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLSRLIEAK
           ..|.. ||.|..   .|.|.. ..    .  .. |   ......|..|| |.|. ..|||||||.||..|.   .|..||||.|..   
-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---

KSLKLGDVDELAKEATGTAQGSFPYTAPEITKGKKYDK-KSDMYSFGIIFFEIWC-YFPTQMERRKILFDLIDNKQFPPQMMTDDFKLQREIILNLLD-E
                 |  |.  | |||.    .|.| |.|..|.|.|..|  | | | .    . .|..|              .  ...| ..|. .
----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKD

PEKRQTCEQLLE------KMPLY
|||| |. ..|.      ..|  
PEKRPTA-EALQDEWDIKCHPWF
Kinase 82727.m00037.AA TKL 543-675 23 3.9e-34 119.73 In-house 117-282 (364) Show / Hide 
Range on Protein: 543-675
Range on HMM: 117-282/364
Sequence Identity: 23% (42 aa)

MELCSQST-LKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSK--------VIHRDLKPQNIFIDDKND--------------VKLGDFGLSRL
||.|.  . | .|               ..  |....|  ...| |...        .||||||..||..|...               .|..|||||| 
MEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

IEAKKSLKLGDVDEL-------AKEATGTAQGSFPYTAPEITKGK----------------KYDKKSDMYSFGIIFFEI
.. ... . .  ..         ...|.|  |.. . |||. .|.                .|..|.|.|||||...||
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 82727.m00037.AA Pkinase 539-674 29 1.2e-32 116.52 Pfam 75-204 (293) Show / Hide 
Range on Protein: 539-674
Range on HMM: 75-204/293
Sequence Identity: 29% (43 aa)

LFIQMELCSQS----TLKDLMSDKSFFETAPKL--EESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDV----KLGDFGLSRLIEAKKSLKL
. . ||.|        |.|..|     .   ..  .|    .....||..| |.|. ..|||||||.||.||.....    |..||||.....       
IYMVMEYCEGGLYVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------

GDVDELAKEATGTAQGSFPYTAPEITK-GKKYDKKSDMYSFGIIFFE
    .  .. . |  |. .| |||. . |..|..|.||.|.|.|..|
----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE
Kinase 82727.m00037.AA Ciliate-E2 526-736 22 9.8e-31 102.72 In-house 96-365 (365) Show / Hide 
Range on Protein: 526-736
Range on HMM: 96-365/365
Sequence Identity: 22% (65 aa)

KSKKSKKSKKQHFLFIQMELCSQSTLKDLMS--DKSFFET-----APKLEESK--QWRICR-----------EILEALSYIHQSK-VIHRDLKPQNIFID
| . . ..|... ... ||.|.. .|.|..   .|....       ....| |   . |..           .|..|| |.|. . .||||.||.||.. 
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

DKNDVKLGDFGLSR-----------LIEAKKSLKLG--------DVDELAKEATGTAQ-----------GSFPYTAPEITKGKK---------YDKKSDM
    .|. |||||.           . ..|. .  .        . |          |           |. .| |||| .|||         ||.|.|.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDI

YSFGIIFFEIWCYFPTQMERRKILFDLIDNKQFPPQMMT-----------DDFKLQRE----IIL----NLLDEPEKRQT-CEQLLEKMPL
.|.|.|..|  .  |       .   .  . .||.. ..           . .|.  |    |       |  .|||| |  ||.|.   .
WSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 82727.m00037.AA ULK 543-675 25 3.8e-29 98.94 In-house 99-249 (329) Show / Hide 
Range on Protein: 543-675
Range on HMM: 99-249/329
Sequence Identity: 25% (40 aa)

MELCSQSTLKDLMSDK-SFFETA---PKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND------------VKLGDFGLSRLIEAK---
||.| . .|..... .  . |.     .|.|..   ... ||... ..|. ..||||.||||| |....             .|..|||... ..     
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

KSLKLGDVDELAKEATGTAQ---GSFPYTAPEITK----GKKYD-KKSDMYSFGIIFFEI
. . .  | |         .   |.  | ||.| .    .|.|. .|.|..|.|.||.|.
QQMMMTCVNE---------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM
Kinase 82727.m00037.AA ULK 543-675 23 1.1e-27 95.34 In-house 96-245 (324) Show / Hide 
Range on Protein: 543-675
Range on HMM: 96-245/324
Sequence Identity: 23% (38 aa)

MELCSQSTLKDLMS-DKSFFETA---PKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND------------VKLGDFGLSRLIE-----
||.| . .|....  .| . |      .|.|..   ... |.... ..|. ..||||.||||| | ...             .|..|||... ..     
MEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

--AKKSLK-LGDVDELAKEATGTAQ---GSFPYTAPEITK----GKKYD-KKSDMYSFGIIFFEI
    ....                .   |.  | ||.| .    .|.|. .|.|..|.|.||.|.
QQMCQTCVNE--------------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM
Kinase 82727.m00037.AA HRI 529-689 34 3e-27 92.76 In-house 383-567 (613) Show / Hide 
Range on Protein: 529-689
Range on HMM: 383-567/613
Sequence Identity: 34% (65 aa)

KSKKSKKQHF-LFIQMELCSQSTLKDLMSDKSFF------ETA-PKLEES--KQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND----VKLGDF
... . | |. |.|||.||. ..|.| .|           ||. |    .     .|  .|.| . |||   ..|||.||.|||  |. .    || |||
RGQTEFKYHYMLHIQMQLCE-LSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDF

GLSR---LIEAKKSLKL---GDVDELAKEATGTAQ-----GSFPYTAPEITKGKKYDKKSDMYSFGIIFFEIWCYFPTQMERRKIL
|| .   | | |  ..     | |.  ..  .|       |   | .||   | .|| |||||| |.| || .  | | ||| ..|
GLACEDILQEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVL
Kinase 82727.m00037.AA STE-Unique 522-617 33 1.4e-22 76.66 In-house 353-457 (616) Show / Hide 
Range on Protein: 522-617
Range on HMM: 353-457/616
Sequence Identity: 33% (36 aa)

LSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSF---FETAPKLEESKQWRICREILEALSYIHQSK--VIHRDLKPQNIFIDDKN-----DVKL
|| | |.| |  | |. . |.||.|. .||...    .          ..|.   .. ..|||.| |.|  .  .||||||| |||.. .       ||.
LSTSSSRK-KPPKEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKI

GDFGLS
.|||..
CDFGHA
Kinase 82727.m00037.AA STE-Unique 648-736 22 1.1e-17 58.88 In-house 514-616 (616) Show / Hide 
Range on Protein: 648-736
Range on HMM: 514-616/616
Sequence Identity: 22% (23 aa)

YTAPEITKGK-----KYDKKSDMYSFGIIFFEIWCYFPTQMERRKI--LFDLIDNKQFPPQ------MMTDDFKLQREIILNLLD-EPEKRQTCEQLLEK
|..||.. ..      || |.|..|.|...|.. | .|....|  .  .......  ..|          .  ..|...|  .|. .| .| . .|||..
YMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHH

MPL
  |
FWL
Kinase 82727.m00037.AA GCN2 226-348 20 9.5e-16 51.25 In-house 1-148 (511) Show / Hide 
Range on Protein: 226-348
Range on HMM: 1-148/511
Sequence Identity: 20% (30 aa)

FVKINNLGKGGYGSVIE-ARKKADDDRHYAVKCIPL--ASLAEVKE--MKREVAFLSKFQHRYIVNFYSSWVE------------SVTEDAAKEIKKTFD
|. |  ||||| |.|.  .| .. | | ||.| .|.  ..    ..  ..|||..|.. .|...|  | .|.|            . .......  .. .
FEEICCLGKGGFGQVVKNVRNMH-DGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESE

---------LADEEEEETDDSGDTTTVSRSRSFNTTPRSPRSVRRNDDS
          .....|| .....  . | | ..|.  ... ..   ...
CFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWD
Kinase 82727.m00037.AA TyrKc 226-734 11 1.1e-13 -1.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 226-734
Range on HMM: 1-280/280
Sequence Identity: 11% (64 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAEVKEMKREVAFLSKF--QHRYIVNFYSSWVES------------VTEDAA--------KEI
 ...  || | .| | ... |    .  |||..   .   .... ||   ..|.  .|  ||..|   ...            |.| ..        .. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KKTFDLADEEEEETDDSGDTTTVSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEE
...                                                                                                 
RPK-------------------------------------------------------------------------------------------------

DIPIEDASNSSNDGEAGLIGSSPPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCA
                                                                                                    
----------------------------------------------------------------------------------------------------

RSKSDSSGRILLPKTFPSLSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFI
                                                               |  ..   .|  | .  .|.|. ..|||||   |. .
---------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV

DDKNDVKLGDFGLSRLIEAK-KSLKLGDVDELAKEATGTAQGS--FPY--TAPEITKGKKYDKKSDMYSFGIIFFEIW----CYFPTQ----MERRKILF
.... || .|||||| |. . ..   | . .  . .... .|   .|.  .|||  . .|.  ||| .|||.  .||        | .    |. . .. 
GENHTVKISDFGLSRDIYDDDQQ---G-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI-

DLIDNKQFPPQMMT--------DDFKLQREIILNLLDE-PEKRQTCEQLLEKM
 ....   .||.             .. . |..   .| ||.| | ... |..
EYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 82727.m00037.AA ULK 226-288 23 4e-12 39.36 In-house 1-81 (324) Show / Hide 
Range on Protein: 226-288
Range on HMM: 1-81/324
Sequence Identity: 23% (19 aa)

FVKINNLGKGGYG-SVIEARKKADD--DRHYAVKCIPLASLAEVKEM----------KREVAFLSKFQ------HRYIVNFY
..... |||| .|  | ..|.| ..  . ..|.|.|.. .. . | .          |.|.  . |.       | .|| .|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLY
Kinase 82727.m00037.AA HRI 226-295 38 2.3e-11 35.53 In-house 1-71 (613) Show / Hide 
Range on Protein: 226-295
Range on HMM: 1-71/613
Sequence Identity: 38% (28 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPL--ASLAEVKEMKREVAFLSKFQHRYIVNFYSSWVESV
| .   .|||||| |   | | | . |||.| |    .   ..  | |||  |   ||  || .  .|.| |
FEQKEIIGKGGYGRVYKVRHKLDKQ-HYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHV
Kinase 82727.m00037.AA Pkinase_Tyr 543-678 28 4.9e-11 37.99 Pfam 86-210 (270) Show / Hide 
Range on Protein: 543-678
Range on HMM: 86-210/270
Sequence Identity: 28% (39 aa)

MELCSQSTLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLSRLIEAKKSLKLGDVDELAKEATGTA
||..    |.|   ...  |  ..|  .    .|..| ....| .. . |||||   |. ....| || .||||.|.|         . |.    ..| .
MEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--------YNDDYY-YRKRGGG

QGSFPYTAPEITKGKKYDKKSDMYSFGIIFFEIWCY
    . .|||  . .|.  ||| .|||.  .||  |
KLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 82727.m00037.AA ULK 226-288 21 6.6e-10 30.85 In-house 1-84 (329) Show / Hide 
Range on Protein: 226-288
Range on HMM: 1-84/329
Sequence Identity: 21% (18 aa)

FVKINNLGKGGYGSVIEARKKADD---DRHYAVKCIPLASLAEVKEM----------KREVAFLSKF--------QHRYIVNFY
..... |||| .| | ..|.| ..   .  .|.| |.. .. . . .          |.|.  . |         .| .|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLY
Kinase 82727.m00037.AA Pkinase 226-294 20 8e-10 35.82 Pfam 1-72 (293) Show / Hide 
Range on Protein: 226-294
Range on HMM: 1-72/293
Sequence Identity: 20% (15 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAEVKEMK----REVAFLSKFQHRYIVNFYSSWVES
....  .|.|..|.| ....| . .  .|||.|.. .  . |..     .|.. . ...| .|| .| .. ..
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK
Kinase 82727.m00037.AA STE-Unique 227-293 24 8.1e-09 26.86 In-house 1-72 (616) Show / Hide 
Range on Protein: 227-293
Range on HMM: 1-72/616
Sequence Identity: 24% (18 aa)

VKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAE------VKEMKREVAFLSKFQHRYIVNFYSSWVE
. ....|.|. | |  .. | | .| .|.| |.|  .        |. . .|.  .... | .||. | .| .
NCQQMIGRGSFGNVHNCQNKKDCFR-CAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase 82727.m00037.AA Ciliate-E2 226-291 13 1.6e-08 25.34 In-house 1-101 (365) Show / Hide 
Range on Protein: 226-291
Range on HMM: 1-101/365
Sequence Identity: 13% (14 aa)

FVKINNLGKGGYGSVIEARKKADDD----------------------RHYAVKCIPLASLAEVKEMKREV-------------AFLSKFQHRYIVNFYSS
. .|. .|.|..||| ..... ..                         ||.|..    . ..| ....                |.. .| .|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

W
.
F
Kinase 82727.m00037.AA Pkinase_Tyr 226-288 22 5.5e-07 24.28 Pfam 1-70 (270) Show / Hide 
Range on Protein: 226-288
Range on HMM: 1-70/270
Sequence Identity: 22% (16 aa)

FVKINNLGKGGYGSVIEARKK---ADDDRHYAVKCI-PLASLAE--VKEMKREVAFLSKF-QHRYIVNFY
 ...  ||.| .|.| ... |    ... . |||.. . |.  .   ... ||.. .... .|  ||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 82727.m00037.AA TKL 232-288 16 7.2e-05 13.48 In-house 1-91 (364) Show / Hide 
Range on Protein: 232-288
Range on HMM: 1-91/364
Sequence Identity: 16% (15 aa)

LGKGGYGSVIEARKKADD-------DRHYAVKCIPLASLAE--------------------------VKEMKREVA-FLSKFQHRYIVNFY
.|.||.| |  .. .  .       ..  ||| ..  .  |                           .. ..|..  .|...|  || |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM