Gene 94503.m00020 (T.vaginalis)

94503.m00020

Species: T.vaginalis
Alias: 94503.m00020, TvagK0429
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
94503.m00020.AA Protein None 417 None Fasta, JSON
94503.m00020.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of 94503.m00020.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 94503.m00020.AA PH 4-98 17 2.9e-07 31.37 SMART 1-82 (82) Show / Hide 
Range on Protein: 4-98
Range on HMM: 1-82/82
Sequence Identity: 17% (17 aa)

PLLSGKLKRRYAEASMWKQCTCELYPTKLLILSFDGKQVEKEIPINGLTEIHFEESPDSRVFTLGIDKNVCSFQVENIEKLQEWKKMIKYLTFKR
....| |...      ||.. . |..  |..   .     ..||.... ..   .     .|..   ...  || |. | .||| . |. .. . 
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDC-TVRE-P-----CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
PH 94503.m00020.AA PH 4-96 16 0.000919 16.22 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4-96
Range on HMM: 1-92/92
Sequence Identity: 16% (16 aa)

PLLSGKLKRRYAEASMWKQCTCELYPTKLLILSFDGKQVEKEIPINGLTEIHFEESP-DSRVFTLGIDKN-VCSFQVENIEKLQEWKKMIKYLTF
. ..| |...    . ||.. . | ...|..   |..   . ||.... ..   ... .  .| . .  . .  || |. | ...| . |...  
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
Kinase 94503.m00020.AA AGC 106-361 29 1.9e-121 315.35 In-house 1-395 (395) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-395/395
Sequence Identity: 29% (118 aa)

FVVEKELGAGFFGHVLLVRHK------QTKKLYALKCLSKKF---LINEDQEDSAKTE------------RDVLIMAR----------HPFVVK-ICFAF
| . | .| | || | |||.|      .|.|.||.|.|.||    ........ ..||            |..| ...          |||.||   ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDSSQ--LYIGLEYIS---------GR-YLFRLIQ---EEYSITLPELRFYVAE-------ISLGLEHLHS-QGIIYRD-LKLENVLVCKNGHIKLSDFG
|| .   ||. .||..         |   ||  .|    | . . .. ||| ||       | |.||.||| .|||.|| ||.||.|  ..|||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKKLLNYK-----------------------------------------------GELTKTDTFCG--IDEYIAPEMILGKPYGFELDWWC--LGILMY
|.|.. |..                                               ..  .| ||||    ||.|||..    ||.. |||.  ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELCFHETPFVGKNGK----------ETYDRIM------KEEPYFP----------AAMPEMPKNLIKLLLNKNPAKRAN----------FETIRNHEMF
|. .  .|| |.|            |....||      .... ||            . .  |.||| ||.|.|.||            .| |.||. |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 94503.m00020.AA Akt 106-361 40 1.8e-90 289.4 In-house 1-264 (264) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-264/264
Sequence Identity: 40% (109 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLY-ALKCLSKKFLINEDQEDSAKTERDVLIMARHPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQEEYSITLP
| . | ||.| || |.||. |.|.|.| |.| |.|. .|. .|   .|||| .| . .|||.|.  ..||..  ||. ..|..|  || ..| .  .. .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

ELRFYVAEISLGLEHLHSQGIIYRD-LKLENVLVCKNGHIKLSDFGLAKKL-LNYKGELTKTDTFCGIDEYIAPEMILGKPYGFELDWWC-LGILMYELC
. |||.|||.|..|||||..||||| ||.||.|. |.|||.| ||||.|.  . .     ||.||||  ||.|||...|. ..   |||  ||..|||..
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDH---DKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

FHETPFVGKNGKETYDRIMKEEPYFP--AAMPEMPKNLIKLLLNKNPAKR----AN-FETIRNHEMF
.   ||  .. .. .. |. ..  ||   .     |.||. ||||.| ||     |  . |..|. |
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 94503.m00020.AA SGK 106-361 36 7.5e-83 255.62 In-house 1-283 (283) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-283/283
Sequence Identity: 36% (104 aa)

FVVEKELGAGFFGHVLLVRHKQT------------------KKLYALKCLSKKFLI-------NEDQEDSAKTER-DVLIMARHPFVVKICFAFQDSSQL
|   | .| | || |..|.||..                  .|.||.| |.|.  |       .  ..   ..|| ..|   .||| |.  .|||    |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YIGLEYISGRYLFRLIQEEYSITLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMI
|  ..|. |  .|  .| | .   .. |||.||| . ||.|||| ||||||| ||.|    ||..| ||||.|       . ..| ||||  || |||..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIK---TNDTTFTFCGTPEYLAPEVL

LGKPYGFELDWWCLGILMYELCFHETPFVGKNGKETYDRIMKEEPYFPAAMPEMPKNLIKLLLNKNPAKR--AN--FETIRNHEMF
...|.. . ||||||...||. .   ||  .| .. || |....  .|  |    . ||..||.|.| ||  ..  |. |.||  |
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 94503.m00020.AA S_TKc 106-361 30 1.3e-82 281.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLYALKCLSKKFLINEDQEDSAKTERDVLIMARHPFVVKICFAFQDSSQLYIGLEYISG--RYLFRLIQEEYS---
. . ...| | || | ..||| |....|.|...          .... |...| . .||..||.  .||| . ||. .||..|    ||..|..  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMILGKPYGF-ELDWWCLGIL
   ..  . |||...| ..||..||.|||.|||| ||.|...  |||..|||||..|          .||||  .|.|||..   .||. . ||| .|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MYELCFHETPFVGKNGKETYDRIMKEEPYFPAAMPEMPKNLIKLLLNKNPAKRANFETIRN-------HEMF
.||..  ..||   . ......|.          ..  |..|. .|.|.|.||     . .       |. |
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94503.m00020.AA AktR 106-361 37 2.7e-80 273.08 In-house 1-268 (268) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-268/268
Sequence Identity: 37% (102 aa)

FVVEKELGAGFFGHVLLVRHK-QTKKLYALKCLSKKFLINEDQEDSAKTERDVLI-MARHPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQEEYSITL
|.| | || | || | ||..| ...|.||.| ..||..|.. |.. . |||.... ...||| ||  ..||. ..|.. .||. |  ||. .. .  .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PELRFYVAEISLGLEHLHSQ-GIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMILG-KPYGFELDWWCLGILMYELC
 . ||| |.| |.||.||..  ||||||| || |  ..||.|..||||.| |.. . .  |...|||  ||.|||||.  |....  |||..||. ||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

FHETPFVGKNGKETYDRIMKEE---PYFPAAMPEMPKNLIK-LLLNKNPA---K--RANFETIRNHEMF
.  .||  || .. ...| ...   . .|.   .  |.||.  ||.|||    .  ....| |..|  |
TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 94503.m00020.AA Ciliate-E2b 106-361 34 1.6e-79 241.27 In-house 1-272 (272) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-272/272
Sequence Identity: 34% (95 aa)

FVVEKELGAGFFGHVLLVRH-KQTKKLYALKCLSKKFLINEDQEDSAKTERDVLIMARHPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQEEY--SIT
... |.|| | || | ||.  |.||..||.|| ||  .| .  |..   |  || .. |||..|   .|.|. ..|  .|...|  || .| |     . 
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

LPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMIL-----GKPYGFELDWWCLGILM
  . .||.|.| |.|| ||.|.|||||.| ||..|...|..|| |.|.|| .   .. .|.| | .|  .| ||| |      ||.|... | | .||  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YELCFHETPFVGK--NGKETYDRIMKE--EPYFPAAMPEMPK--NLIKLLLNKNPAKRA--NFETIRNHEMF
||. .   |.  .  .  | |  |.|.  |  ||. . .  .  .|.  .|.|.|  |    ...  .|. |
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 94503.m00020.AA RSK-Unclassified 106-349 36 7e-79 247.31 In-house 1-266 (283) Show / Hide 
Range on Protein: 106-349
Range on HMM: 1-266/283
Sequence Identity: 36% (97 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLYALKCLSKKFLINEDQEDSAKTERDVLIMARHPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQ--EEYSITL
|.. . .| | || | ||| |.|...||.| |.|. .|       . ||.... .  |||.|.  ..|| .  ||  .||  |  .||  |   |  .. 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

PELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTK------------------TDTFCGIDEYIAPEMILGKPYG
 . |||..|. . ||.|| ...|||||| .|..  . ||..|.||.| ..  . |    |                  |  |||  ||.||||| .   .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

FELDWWCLGILMYELCFHETPFVGKNGKETYDRIMKEEPYFP--AAMPEMPKNLIKLLLNKNPAKR
   ||| |||.|||. |  .|. | |  ||.  | |..  ||    .    . ||| ||..|||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKR
Kinase 94503.m00020.AA PKC 106-361 38 1.5e-78 254.23 In-house 1-262 (262) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-262/262
Sequence Identity: 38% (102 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLYALKCLSKKFLINEDQEDSAKTERDVLIMA-RHPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQEEYSITLP
|   | || | || |.|...|.|...|| |.| |   |  |  ... ||. ||  | .||| ..    ||  . |.  .||. |  |   ||.     ..
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

ELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMILGKPYGFELDWWCLGILMYELCFHE
  ||| |||...|  ||..|||||||||.|||. . ||||. |||..|  ...    ..|.||||  .||||| . ...||.  ||| .|.||||.    
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNG---DTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQ

TPFVGKNGKETYDRIMKEEPYFPAAMPEMPKNLIKLLLNKNPAKRANF--------ETIRNHEMF
 || |..  |  . ||...|..|  . .  ....| ...|||.||           . || |  |
SPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 94503.m00020.AA RSK 110-361 37 8.8e-78 264.71 In-house 2-278 (278) Show / Hide 
Range on Protein: 110-361
Range on HMM: 2-278/278
Sequence Identity: 37% (105 aa)

KELGAGFFGHVLLVRHK---QTKKLYALKCLSKKFLINEDQ-EDSAKTERDVLIMAR-HPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQEEYS---I
|.|| | .| | |.| .   .|...|| | |.|. ... .     ..|||..| . . |||.|.   |||. . ||. .||..|  ||. .|.| .   .
KVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCF

TLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCK---NGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMIL---GKP-YGFELDWWCLG
.  | .|| |||.| .||||.||||.||||.||.|      .|||||.|||..|.. . ....|.|  ||.  ||.||||.    ..  ..   ||| ||
SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--FCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILMYELCFHETPFVG---KNGKETYDRIMKEE--PYFP--AAMPEMPKNLIKLLLNKNPAKRAN-----FETIRNHEMF
.||||. .  .|| |   .| ||. .||.| .  . .|  . . .  |.||. .| ..|.|| .      | |..|. |
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 94503.m00020.AA Delta 106-361 38 2.7e-76 259.8 In-house 1-259 (259) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-259/259
Sequence Identity: 38% (102 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLYALKCLSKKFLINEDQEDSAKTERDVLIMA-RHPFVVKICFAFQDSSQLYIGLEYISGRYLFRLIQEEYSITLP
|...| || | || |.|.  |...| ||.||| |  .. .|  ..   || ||..| .|||. ..  .||  ..|.  .||. |  |   ||.     . 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

ELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMILGKPYGFELDWWCLGILMYELCFHE
  ||| .|| .||. ||..|||||||||.|||. ..||||. |||..|. ..     .|..||||  .|||||.| |. | .  |||  |.||||.    
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGE---KKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQ

TPFVGKNGKETYDRIMKEEPYFPAAMPEMPKNLIKLLLNKNPAKRANF-----ETIRNHEMF
 || |..  | .. |....|..|  . .  |...| |....| ||          ||.| .|
SPFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase 94503.m00020.AA Pkinase 106-361 30 3.2e-71 247.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLYALKCLSKKFLINEDQEDSAKT--ERDVLIMARHPFVVKICFAFQDSSQLYIGLEYISGR----YLFRLIQ--E
..... .|.| || | . .|| | |..|.|...|.  ...... ..    |  .. . .||..|..  .|.|.. .|. .||  |      ||..|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EYSI--TLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHI----KLSDFGLAKKLLNYKGELTKTDTFCGIDEYIAPEMIL-GKPYGFELDW
. ..  .  |..||. .|  |||..||.|||.||||.||.|. .||||    |..||||||..       . ..||||  .|.||| |. |..|| . |.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WCLGILMYELCFHETPFVGK------NGKETYDRIMKEEPYFPAA---------------------MPEMPKNLIKLLLNKNPAKRANFETIRNHEMF
| .|...||... ..|| |.      . .. ..|||. .. |.                       ..|  | .|| .|.|.|.|| ..| | .|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 94503.m00020.AA p70 106-361 33 6.8e-71 241.83 In-house 1-299 (299) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-299/299
Sequence Identity: 33% (101 aa)

FVVEKELGAGFFGHVLLVRHKQ---TKKLYALKCLSK-KFLINEDQEDSAK-------------------------TERDVLIMARHPFVVKICFAFQDS
|   | || | .| |..||  .   | |.|| | | | | ..|.   ....                          || .|    |||...  .|||. 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

SQLYIGLEYISGRYLFRLIQEEYSITLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNYKGEL--------TKTDTFC
. ||  |||..|  || .  ..        .|| .||.. |||||..|||||||| ||..  . ||..| |||| |. .. .|.           | |||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIH-DGAVDEEDPENVNATHTFC

GIDEYIAPEMILGKPYGFELDWWCLGILMYELCFHETPFVGKNGKETYDRIMKEE--PYFPAAMPEMPKNLIKLLLNKNPAKRAN-----FETIRNHEMF
|  || |||..... .. . ||| ||.|||       || | | |.| | |.|    .  |.   .  . ||| || ..|..| .      . |. |. |
GTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 94503.m00020.AA TyrKc 106-361 21 1.5e-15 28.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FVVEKELGAGFFGHVLLVRHKQTKKLYALKCLSKKFLINEDQEDSAKTERDVLIMA--RHPFVVKICFAFQDS-------SQLYIGLEYISGRYLFRLIQ
 . .|.|| |.|| | . . |       ...  |.   .   .     |  .. .   .|| .|..  .  ..        .|.| .|| ..  |   ..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EEYS-ITLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKLLNY--KGELTKTDTFCG----IDE------YIAPEMILGKP
.    .....|  .   |. | |.|||...| |||   |.|| .|...| |||||.... ..  .|    .|.                  ||| |  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGFELDWWCLGILMYELC-FHETPFVG-----KNGKETYDRIMKE-EPYFPAA--------MPEMPKNLIKLLLNKNPAKRANFETIRNHEMF
. .. | |  |..|.|.. . ..|  |     .. .| . ....   .  |.         .|.   ...|   . .|..| .|..|  || |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 94503.m00020.AA Pkinase_Tyr 200-254 38 1.3e-08 29.83 Pfam 107-161 (270) Show / Hide 
Range on Protein: 200-254
Range on HMM: 107-161/270
Sequence Identity: 38% (21 aa)

SITLPELRFYVAEISLGLEHLHSQGIIYRDLKLENVLVCKNGHIKLSDFGLAKKL
..|...|  . ..|. |.|.|.|...| |||   |.|| .|...| .|||||. .
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 94503.m00020.AA Pkinase_Tyr 106-120 46 0.366547 4.56 Pfam 1-15 (270) Show / Hide 
Range on Protein: 106-120
Range on HMM: 1-15/270
Sequence Identity: 46% (7 aa)

FVVEKELGAGFFGHV
 .  |.||.| ||.|
ITFGKKLGEGAFGEV