Gene 84758.m00046 (T.vaginalis)

84758.m00046

Species: T.vaginalis
Alias: TvagK0381, 84758.m00046
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
84758.m00046.AA Protein None 207 None Fasta, JSON
84758.m00046.kin_dom Protein Kinase Domain None 117 None Fasta, JSON

Protein domain

Protein domains of 84758.m00046.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84758.m00046.AA AGC 1-117 25 6.1e-61 155.29 In-house 192-395 (395) Show / Hide 
Range on Protein: 1-117
Range on HMM: 192-395/395
Sequence Identity: 25% (54 aa)

GHIKLTDFGLAKDLYNEE---------------------------------------------------LTSTFCG--TSEYLAPEIIRHEKYGIEVDWW
||||||||||.| . |..                                                   .|.||||  | ||.||||.    || ..|||
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWW

S--LGILTYELLFNKTPFCHPN----------KSRLFQNIL------EKEVQYP----------AGVQTSIIEFINGLLQKDKRKRLT----------FK
|  ||.| ||.|. ..||.. |          .  .||.|.      ...|..|            .      .|..||.|| .|||.          ..
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

QMQNLEFF
. .| ..|
EIKNHPWF
Kinase 84758.m00046.AA SGK 1-117 42 2e-52 159.93 In-house 162-283 (283) Show / Hide 
Range on Protein: 1-117
Range on HMM: 162-283/283
Sequence Identity: 42% (52 aa)

GHIKLTDFGLAK-DLYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQ
||..||||||.| .   .. |.||||| ||||||..|.. .. .||||.||.. ||... . || . ||. ...||. .. | | ... .  . |.||||
GHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQ

KDKRKRLTFK----QMQNLEFF
||..|||  |    . .|  ||
KDPKKRLGTKRDFMEIKNHPFF
Kinase 84758.m00046.AA Akt 1-117 37 7.1e-45 141.33 In-house 138-264 (264) Show / Hide 
Range on Protein: 1-117
Range on HMM: 138-264/264
Sequence Identity: 37% (47 aa)

GHIKLTDFGLAK-D-LYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWS-LGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYP--AGVQTSIIEFIN
|||.||||||.| . . . . | ||||| |||||||.    ..  ||||. ||...||...   || . .. ..|..|....|..|    ..     .|.
GHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLIS

GLLQKDKRKRL-----TFKQMQNLEFF
|||.||. |||     . .. .. ..|
GLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 84758.m00046.AA PKC 1-117 36 5.2e-42 133.86 In-house 137-262 (262) Show / Hide 
Range on Protein: 1-117
Range on HMM: 137-262/262
Sequence Identity: 36% (46 aa)

GHIKLTDFGLAKD-LYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQ
||||..|||..|. ..|.. ||||||| .|.||||.. ..||  ||||..|.| ||..  . ||   .   |||.|..... ||      . . . |...
GHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMT

KDKRKRLTF--------KQMQNLEFF
|.  |||          . ..   ||
KNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 84758.m00046.AA Ciliate-E2 3-117 24 1.6e-38 129.83 In-house 195-365 (365) Show / Hide 
Range on Protein: 3-117
Range on HMM: 195-365/365
Sequence Identity: 24% (44 aa)

IKLTDFGLAKDLYNE--------------------------------ELTSTFCGTSEYLAPEIIRHEK---------YGIEVDWWSLGILTYELLFNKT
||..||||.|.. ..                                ... |.||| .|.||||.. .|         |. ..|.||||.. ||.||.|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFCHPNKSRLFQNILEKEVQYP------------------AGVQTSIIEFING----LLQKDKRKRLT-FKQMQNLEFF
||        .|.|.......|                    .  . . .|.     .||||  ||.| ..|  | ..|
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 84758.m00046.AA Pkinase 1-117 29 4.3e-38 135.78 Pfam 145-293 (293) Show / Hide 
Range on Protein: 1-117
Range on HMM: 145-293/293
Sequence Identity: 29% (45 aa)

GHI----KLTDFGLAKD--LYNEELTSTFCGTSEYLAPEIIR-HEKYGIEVDWWSLGILTYELLFNKTPFCHP------NKSRLFQNILEKEVQYPAGVQ
|||    |..||||||   . | . ..|||||..|.|||.|| ...|| .||.||.|.. ||.|. ..||..       ..  ....|..... ..    
GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWW

---------------------TSIIEFINGLLQKDKRKRLTFKQMQNLEFF
                      . ..||...|.||  ||.|..|  . ..|
CSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 84758.m00046.AA Ciliate-E2-Unclassified 1-117 28 3.7e-37 126.44 In-house 184-352 (352) Show / Hide 
Range on Protein: 1-117
Range on HMM: 184-352/352
Sequence Identity: 28% (49 aa)

GHIKLTDFGLAK--------DLYN---------EELTSTFCGTSEYL----APEIIRHEKYG----IEVDWWSLGILTYELLFNKTPFCHPNKSR-----
..||..|||..|        | .|         .....||||| .|.    |||... ..|.    ...|.||||.. ||.||.. ||  .|.       
YYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLI

-----------LFQNILEKEVQYPA--------GVQTSIIEFIN----GLLQKDKRKRLTFKQMQNLEFF
           |.|||..|..|.|         ... . ..|||     .|.|.  ||.||.|  |  .|
TQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 84758.m00046.AA RSK 1-117 31 2.8e-36 126.85 In-house 144-278 (278) Show / Hide 
Range on Protein: 1-117
Range on HMM: 144-278/278
Sequence Identity: 31% (42 aa)

GHIKLTDFGLAKDLYNE--ELTSTFCGTSEYLAPEIIR---HEK-YGIEVDWWSLGILTYELLFNKTPFCH---PNKSRLFQNILEKE--VQYP--AGVQ
|||||||||..| . ..  ..| |||.| ||.|||...   ... ..  .||||||.| ||.|. ..|| .    |.. ....|....  .  |  . . 
GHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLS

TSIIEFINGLLQKDKRKRLT-----FKQMQNLEFF
.   ..|...|..|  |||.      .. .. ..|
QEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 84758.m00046.AA AktR 1-117 35 2.3e-35 123.8 In-house 139-268 (268) Show / Hide 
Range on Protein: 1-117
Range on HMM: 139-268/268
Sequence Identity: 35% (46 aa)

GHIKLTDFGLAK---DLYNEELTSTFCGTSEYLAPEIIRH-EKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKE---VQYPAGVQTSIIEF
||.|.|||||.|   .  ..|.. .|||| ||.|||.|.  . ..  ||||..||. ||...  .|| | |. ..||.|..|.   ..||. .     ..
GHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDL

IN-GLLQKDKRKRLT-----FKQMQNLEFF
|. .||.|. .|||.     ...  .  .|
IQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 84758.m00046.AA Alpha 1-106 42 2.9e-31 106.12 In-house 137-243 (259) Show / Hide 
Range on Protein: 1-106
Range on HMM: 137-243/259
Sequence Identity: 42% (46 aa)

GHIKLTDFGLAK-DLYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQ
||||..|||. | .. ... | ||||| .|.|||||  . ||. ||||. |.| ||..    ||       |||.| |..| ||       .. . |.| 
GHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLT

KDKRKRL
|   |||
KHPNKRL
Kinase 84758.m00046.AA Delta 1-117 39 4.1e-30 106.28 In-house 137-259 (259) Show / Hide 
Range on Protein: 1-117
Range on HMM: 137-259/259
Sequence Identity: 39% (48 aa)

GHIKLTDFGLAK-DLYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQ
||||. |||..| ..| |. .|||||| .|.|||||. .||   ||||| |.| ||.|  . ||   .   ||. |.. .  ||  ..    . ...|..
GHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFE

KDKRKRLTF-----KQMQNLEFF
.|  |||        ....  ||
RDPEKRLGVQYCPKGDIRQHCFF
Kinase 84758.m00046.AA S_TK_X 118-178 22 8.6e-11 43.1 SMART 1-79 (79) Show / Hide 
Range on Protein: 118-178
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

KGLNFNDVLA--LKVQPSFIPKCD----NQGVPSNFDTEFTTEQPADSFVMPVYGSA------------EKYPGFSYME
.|........   ...| |.||.     ...  ||||.||| |.| .. . |.  ..            ....||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 84758.m00046.AA S_TKc 1-117 16 3.9e-08 -57.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-117
Range on HMM: 1-231/231
Sequence Identity: 16% (42 aa)

G---------------------------------------------------------------------------------------------------
                                                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

-----------------------------HIKLTDFGLAKDLYNEELTSTFCGTSEYLAPEIIRHEKYGI-EVDWWSLGILTYELLFNKTPFCHPNKSRL
                             |||..|||||. |      .||||| .|.|||..   .||  ..||||.|.. ||.|  ..||.  .  ..
YQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMM

FQNILEKEVQYPAGVQTSIIEFINGLLQKDKRKRLTFKQMQN-------LEFF
|..|.            . ..||...|||| .||.|  .  .        ..|
FKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF