Gene 80378.m00184 (T.vaginalis)

80378.m00184

Species: T.vaginalis
Alias: TvagK0940, 80378.m00184
External Links:
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
80378.m00184.AA Protein None 203 None Fasta, JSON
80378.m00184.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of 80378.m00184.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 80378.m00184.AA CMGC 9-199 17 2.5e-28 89.42 In-house 206-513 (513) Show / Hide 
Range on Protein: 9-199
Range on HMM: 206-513/513
Sequence Identity: 17% (57 aa)

LHGDLKPENILIDP-----------SIQITNSDMFLNTANPQPRYLQ----------VKLIDLESGSKYYSW------------------------GHKL
.| |||||||||..           |                    .          .|..|  .  .| .                             
IHRDLKPENILINHNCELITRMMWKS--------------------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHY

ITTIYYRAPEVILGLP----------WGHEIDQWSLGCIAFELYFG-------KISFSPGESE------------ANLFGIQHMIGQFPEKMINE-----
. | .|||||..|| .          .. .|| ||.||| .|.| |       .  . ||.||              || |  ..| .. .||.      
VVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHF

-----CT--------------------------IPKFKRLFENGLINPKNISTESYEALVGCTPL----------------------------YKLEMDS
                                 ...| |.. .  .. ...   . . |. . |                              .. .|.
NFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDP

DLKDLILKLLSFDPFHRPSLDEILNHPFL
.. ||. |.| .||  |.. ...|.||..
QAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 80378.m00184.AA DYRK 68-199 29 1.1e-27 98.28 In-house 169-320 (320) Show / Hide 
Range on Protein: 68-199
Range on HMM: 169-320/320
Sequence Identity: 29% (46 aa)

YYRAPEVILGLPWGHEIDQWSLGCIAFELYFGKISFSPGESEANLFG-IQHMIGQFPEKMINECTIPKFKRLFEN-------------------GLINPK
.|||||||||.| . .|| ||||||  ||. |.. | |||.| ...  |. ..| .|..||.. . .. .. |..                   . ....
FYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF-PGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCH

NISTESYEALVGCT---PLYKLEMDSDLKDLILKLLSFDPFHRPSLDEILNHPFL
....  .. . | .   |. .   |...||.|.|.| .||  |..  . |.||..
PTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 80378.m00184.AA Ciliate-E2 9-199 18 3.4e-25 83.44 In-house 183-365 (365) Show / Hide 
Range on Protein: 9-199
Range on HMM: 183-365/365
Sequence Identity: 18% (45 aa)

LHGDLKPENILIDPSIQITNSDMFLNTANPQPRYLQVKLIDLESGSKYYS----------------------------------WGHKLITTIYYRAPEV
.| |.||||||.                        .|.||.    ||                                    . . .. | .| |||.
IHRDIKPENILF------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

ILGLP---------WGHEIDQWSLGCIAFELYFGKISFSPGESEANLFGIQHMIGQFPEKMINECTIPKFKRLFENGLIN--PKNISTESYEALVGCTPL
. | .         .....| ||||.| .|. |||  |                                 .  ... |.  ...   . .  ..   . 
LNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CK

Y--KLEMDSDLKDLILK----LLSFDPFHRPS-LDEILNHPFL
.  ... . . |||| |    .|  ||  |..  ..|||||..
WKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 80378.m00184.AA Pkinase 9-199 25 6.7e-25 89.13 Pfam 130-293 (293) Show / Hide 
Range on Protein: 9-199
Range on HMM: 130-293/293
Sequence Identity: 25% (51 aa)

LHGDLKPENILIDPSIQITNSDMFLNTANPQPRYLQVKLIDLESG----SKYYSWGHKLITTIYYRAPEVIL-GLPWGHEIDQWSLGCIAFELYFGKISF
.| ||||||||||   .|                  ||..|  .        .|  . .  |..|.|||||. | ..|...| ||.||| .|...|.  |
IHRDLKPENILIDNNGHIDA---------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF

SPGE----SEANLFGIQHMIGQ--FPEKMINECTIPKFKRLFENGLINPKNISTESYEALVGCTPLYKLEMDSDLKDLILKLLSFDPFHRPSLDEILNHP
. |.    . ..   .  .|..  ...   ..|.|. |. ..                     . .   ......||.| ..| .||  ||. ..||.||
P-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FL
..
WF
Kinase 80378.m00184.AA CLK 69-199 33 5.8e-24 68.1 In-house 213-350 (350) Show / Hide 
Range on Protein: 69-199
Range on HMM: 213-350/350
Sequence Identity: 33% (46 aa)

YRAPEVILGLPWGHEIDQWSLGCIAFELYFGKISFSPGESEANLFGIQHMIG-QFPEKMINECT-IPKFKRLFENGLINPKNISTESYEALVGCTPLYKL
||||||||||.|    | || ||| |||| |   |   ..   |  ..   | ..|  ||         .. | ..  .  . .  .      | || ..
YRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGRYVMENCKPLKQY

EMDSD-----LKDLILKLLSFDPFHRPSLDEILNHPFL
    |     | ||| |.| .||. |......| ||| 
MDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 80378.m00184.AA Ciliate-E2-Unclassified 9-199 22 1.7e-20 67.78 In-house 166-352 (352) Show / Hide 
Range on Protein: 9-199
Range on HMM: 166-352/352
Sequence Identity: 22% (50 aa)

LHGDLKPENILIDPSIQITNSDMFLNTANPQPRYLQVKLIDLESGSKYY--------------SWGHKLITTI----YYR----APEVILGLPWG----H
.| |.||||||.| . .                 ...|.||. . .||                | .....|.    .|     ||||. |   .    .
IHRDIKPENILFDNNGK----------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAY

EIDQWSLGCIAFELYFGKISFSPGESEANLFGIQHMIGQ-----FPEKMINECTIPKFKRLFENGLINPKNISTESYEALVGCTPLYKLEMDSDLKDLIL
..| ||||.|..|. ||.  |.   .| . . |.  | .       .. |... | ..|  . .                           .   ||.| 
KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQ----------------------IPKHWSPEAKDFIN

----KLLSFDPFHRPSLDEILNHPFL
    |.|  .|  |.....|||||..
DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 80378.m00184.AA DYRK2 66-110 57 5.7e-18 54.71 In-house 165-208 (318) Show / Hide 
Range on Protein: 66-110
Range on HMM: 165-208/318
Sequence Identity: 57% (26 aa)

TIYYRAPEVILGLPWGHEIDQWSLGCIAFELYFGKISFSPGESEA
. .|||||||||.. | .|| ||.|||. ||| |.. | ||| |.
SRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF-PGENEN
Kinase 80378.m00184.AA STE 3-199 19 2.5e-15 50.66 In-house 168-359 (359) Show / Hide 
Range on Protein: 3-199
Range on HMM: 168-359/359
Sequence Identity: 19% (47 aa)

LRSIGRLHGDLKPENILIDPSIQITNSDMFLNTANPQPRYLQVKLID------LES-----------------GSKYYSWGHKLITTIYYRAPEVILG--
| | .. | |.|| |||.                        |||.|      |..                 ..| ...         . |||||..  
LHSHHIIHRDIKPANILL------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-----WMAPEVIQQNG

----LPWGHEIDQWSLGCIAFELYFGKISFSPGESEANLFGIQHMIGQFP----EKMINECTIPKFKR---------------LFENGLINPKNISTESY
     . .   | ||||| . |.  ||  .. .    ..| |. ... ..      .|.. ..|...                .                
QGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTT----------------

EALVGCTPLYKLEMDSDLKDLILKLLSFDPFHRPSLDEILN--HPFL
         |. .. ...|| | | |  || .||. .. |.  |||.
---------YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 80378.m00184.AA DYRK1 9-140 32 2.3e-12 39.25 In-house 126-238 (321) Show / Hide 
Range on Protein: 9-140
Range on HMM: 126-238/321
Sequence Identity: 32% (43 aa)

LHGDLKPENILIDPSIQITNSDMFLNTANPQPRYLQVKLIDLESGSKYYSWGHKLITTIYYRAPEVILGLPWGHEIDQWSLGCIAFELYFGKISFSPGES
.| ||||||||.                   |.  ..|.||  |  .      . |   .||.|||.||...  .|| ||||||  |.  |   ||  . 
IHCDLKPENILLC-----------------NPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNE

EANLFGIQHMIGQFPEKMINECTIPKFKRLFE
   .  |  ..|  |..||..   || .. ||
VDQMNKIVEVLGMPPKHMIDQA--PKAHKYFE
Kinase 80378.m00184.AA PRP4 68-104 56 2.4e-11 37.84 In-house 170-206 (320) Show / Hide 
Range on Protein: 68-104
Range on HMM: 170-206/320
Sequence Identity: 56% (21 aa)

YYRAPEVILGLPWGHEIDQWSLGCIAFELYFGKISFS
.|||||.|.| |    || || ||  .||| ||| |.
FYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFP
S_TKc 80378.m00184.AA S_TKc 1-199 15 1.1e-09 -34.64 SMART 2-231 (231) Show / Hide 
Range on Protein: 1-199
Range on HMM: 2-231/231
Sequence Identity: 15% (48 aa)

MILRSIGR-----------------------------------------------------------LHG------------------------------
 ||| ||.                                                           . |                              
EILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMY

-----------------DLKPENILIDPSIQITNSDMFLNTANPQPRYLQVKLIDLESGSKYYSWGHKLITTIYYRAPEVILGLPWGH-EIDQWSLGCIA
                 ||||||||.|                      ..|..|  .  ..    . .. | .|.||||.   ..|. ..| ||.||| 
QICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FELYFGKISFSPGESEANLFGIQHMIGQFPEKMINECTIPKFKRLFENGLINPKNISTESYEALVGCTPLYKLEMDSDLKDLILKLLSFDPFHRPSLDEI
.|.. |.  |.      ... . ..||                                                ....||.| |.| .|| .||.  |.
YEMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LN-------HPFL
|.       ||..
LQDEWDIKCHPWF
Kinase 80378.m00184.AA CDK4 66-111 43 5.4e-09 26.78 In-house 172-216 (290) Show / Hide 
Range on Protein: 66-111
Range on HMM: 172-216/290
Sequence Identity: 43% (20 aa)

TIYYRAPEVILGLPWGHEIDQWSLGCIAFELYFGKISFSPGESEAN
|. |||||| |  .    .| ||.||| .|.|  .  | .|.||..
TLWYRAPEVLLQSYYNTPVDMWSVGCIFAEMYCRRPLF-CGQSEKD
Kinase 80378.m00184.AA CDK4 167-199 30 9.6e-08 22.41 In-house 258-290 (290) Show / Hide 
Range on Protein: 167-199
Range on HMM: 258-290/290
Sequence Identity: 30% (10 aa)

EMDSDLKDLILKLLSFDPFHRPSLDEILNHPFL
.|.   .||..| |.... .|.|  . |.||..
HMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 80378.m00184.AA PRP4 172-199 46 1.2e-05 16.73 In-house 293-320 (320) Show / Hide 
Range on Protein: 172-199
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

LKDLILKLLSFDPFHRPSLDEILNHPFL
.|||. |.|  ||  | .. | | |||.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 80378.m00184.AA DYRK1 173-199 40 2.8e-05 13.92 In-house 295-321 (321) Show / Hide 
Range on Protein: 173-199
Range on HMM: 295-321/321
Sequence Identity: 40% (11 aa)

KDLILKLLSFDPFHRPSLDEILNHPFL
||||...| .|| .| .  ..| |.|.
KDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 80378.m00184.AA DYRK2 10-19 90 0.000743 8.05 In-house 125-134 (318) Show / Hide 
Range on Protein: 10-19
Range on HMM: 125-134/318
Sequence Identity: 90% (9 aa)

HGDLKPENIL
|.||||||||
HCDLKPENIL
Kinase 80378.m00184.AA CLK 10-20 72 0.001273 5.93 In-house 137-147 (350) Show / Hide 
Range on Protein: 10-20
Range on HMM: 137-147/350
Sequence Identity: 72% (8 aa)

HGDLKPENILI
| |||||||..
HTDLKPENICF
Kinase 80378.m00184.AA DYRK2 169-199 29 0.003321 5.9 In-house 288-318 (318) Show / Hide 
Range on Protein: 169-199
Range on HMM: 288-318/318
Sequence Identity: 29% (9 aa)

DSDLKDLILKLLSFDPFHRPSLDEILNHPFL
| .. | |.. .  ||  | . ...|.||..
DENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 80378.m00184.AA DYRK 9-20 66 0.004236 7.76 In-house 126-137 (320) Show / Hide 
Range on Protein: 9-20
Range on HMM: 126-137/320
Sequence Identity: 66% (8 aa)

LHGDLKPENILI
.|.|||||||..
IHCDLKPENIML
Kinase 80378.m00184.AA CDK4 10-20 72 0.059768 2.23 In-house 133-143 (290) Show / Hide 
Range on Protein: 10-20
Range on HMM: 133-143/290
Sequence Identity: 72% (8 aa)

HGDLKPENILI
| ||||.|||.
HRDLKPQNILV
Kinase 80378.m00184.AA PRP4 9-20 66 0.122089 1.88 In-house 128-139 (320) Show / Hide 
Range on Protein: 9-20
Range on HMM: 128-139/320
Sequence Identity: 66% (8 aa)

LHGDLKPENILI
|| |.|| |||.
LHADIKPDNILV