Gene 86319.m00281 (T.vaginalis)

86319.m00281

Species: T.vaginalis
Alias: TvagK0899, 86319.m00281
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
86319.m00281.AA Protein None 2194 None Fasta, JSON
86319.m00281.kin_dom Protein Kinase Domain None 321 None Fasta, JSON

Protein domain

Protein domains of 86319.m00281.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86319.m00281.AA PIKK 1856-2122 31 3.8e-85 289.17 In-house 1-290 (290) Show / Hide 
Range on Protein: 1856-2122
Range on HMM: 1-290/290
Sequence Identity: 31% (90 aa)

KICQMEEPTLIFMSQQRPKRISLRDETGNSHRFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNHTICFRKILN
 |  | .   .  . |.||.|..|   | ....|||  .|||.| |.|.. ...|. |. |. |. |  .. ..|.. .. . ||||||...   . |..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

ELYE-----SRNLGMP----------------LNDILDILGQDSRYNPQKKCQLFCEKIIPK-FPPLSHLWFLDNFKDASQWFVARQNYTRSTAVWSMVG
....      ..   .                .  ...   .. .  |. .     ...  . .|.. . ||.  | |. .|. .|.|||||.||..|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YIVGLGDRHLENILFNKTNGSVVHVDFCYMFDKAKT-LPTPECVPFRLTQNVVDAMGALGVEGSFTSSCILMMDSLKAKANKIVTTLQTF
|| ||||||.|||......| .||.|| . | .|.. ||.|| ||||||.| |.|||. |||| |...|.  |  .. . ... |.. .|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 86319.m00281.AA ATR 1856-2122 38 1.4e-82 280.69 In-house 2-267 (267) Show / Hide 
Range on Protein: 1856-2122
Range on HMM: 2-267/267
Sequence Identity: 38% (102 aa)

KICQMEEPTLIFMSQQRPKRISLRDETGNSHRFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNHTICFRKILN
 |  ...   |. | |.||.|||.   |  .  .||  |||||| | |.| . .| ..  | . | | . |  .... ||.. ..||||| |.  | ||.
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

ELYESRNLGMPLNDILDILGQDSRYNPQKKCQLFCEKIIPKFPPLSHLWFLDNFKDASQWFVARQNYTRSTAVWSMVGYIVGLGDRHLENILFNKTNGSV
.|.. .   |   ..     . ||    .| . | | ..|. ||. | ||.  | |. ||. .|.|| ||.|||.|||||.|||||| .|||..| || .
KLWKEKKQYMQFYQLRQCMDKKSREE-WEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC

VHVDFCYMFDKAKTLPTPECVPFRLTQNVVDAMGALGVEGSFTSSCILMMDSLKAKANKIVTTLQTF
||||.  .| . ...  || ||||||.|.| .||... .| |   |. .|  .. . . |.  ...|
VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 86319.m00281.AA PI3Kc 1887-2177 24 4e-69 236.86 SMART 1-336 (336) Show / Hide 
Range on Protein: 1887-2177
Range on HMM: 1-336/336
Sequence Identity: 24% (81 aa)

RFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNHTICFRKILNELYESRNL-------------------GMPL
....| .||||.|||||.. . .|... .|| || |   |. ........| |.||||...  ...|...... ...                   .|..
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

NDILDILGQDSRYNPQK----KCQLFCEKIIPKFPPLSHLWFLDNFKDAS-QWFVARQNYTRSTAVWSMVGYIVGLGDRHLENILFNKTNGSVVHVDFCY
..... . ..    ...    ....|.... |..||  . ||...|.|..  |. || |.|||.|...||.|| |.||||..||.. ...| ..|.|| .
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

MFDKAKTLPTP-----ECVPFRLTQNVVDAMG----ALGVEGSFTSSCILMMDSLKAKANKIVTTLQTFVQDPL-LEWKKV--SKDFEEMAAQRT---IK
.|......|..     | ||||||.. |..||      |..| | . |   .  ..  .|.|.......| ||.  .|..   ........ .      .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

EVERRVMG-----FSEDR-ARKFSTEFFVRDLIQKA
|. ...|      . |.  . ....  .. ......
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 86319.m00281.AA PI3_PI4_kinase 1885-2132 25 1.1e-68 239.3 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1885-2132
Range on HMM: 1-300/300
Sequence Identity: 25% (78 aa)

SHRFLCKRDDDLR--KDMRMMEFA-----------------------SFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNHTICFRKILNELYE
 ..|..|..||||  .|||||..                        ...|... .|. .| | ..|. .... .....|.||||...  |..|. . ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

SRNLGMPLNDILDILGQDSRYNPQ-----KKCQLFCEKIIPKFPPLSHLWFLDNFKDA-SQWFVARQNYTRSTAVWSMVGYIVGLGDRHLENILF--NKT
  ..... . . ..   .....       .| ..| ..| ....| .. ||.....||   |. ||.|..|| |....|.|| |.||||..||..  .||
--KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKT

NGSVVHVDFCYMFD--KAKTLPTPECVPFRLTQ------NVVDAM------GALGVEGSFTSSCILMMDSLKAKANKIVTTL-------QTFVQDPLLEW
.| ..|.|| ..|.  | |... || ||||.|.      . |.||      . .| .| | ..|  .. .|   .| ....|       ...|.|.|..|
TGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMW

KK
..
RS
Kinase 86319.m00281.AA ATM 1997-2130 44 1.4e-40 127.14 In-house 115-248 (304) Show / Hide 
Range on Protein: 1997-2130
Range on HMM: 115-248/304
Sequence Identity: 44% (59 aa)

FPPLSHLWFLDNFKDASQWFVARQNYTRSTAVWSMVGYIVGLGDRHLENILFNKTNGSVVHVDFCYMFDKAKTLPTPECVPFRLTQNVVDAMGALGVEGS
| |    . .. | |   ||  |  |||| |  |.||||.||||||  ||| |     .||.|    |.. | ||||| ||||||  .|| ||  |||| 
FQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV

FTSSCILMMDSLKAKANKIVTTLQTFVQDPLLEW
|   |   |. ..     ..|     . ||| .|
FRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW
Kinase 86319.m00281.AA FRAP 2015-2132 44 5.7e-34 119.19 In-house 133-251 (251) Show / Hide 
Range on Protein: 2015-2132
Range on HMM: 133-251/251
Sequence Identity: 44% (53 aa)

WFVARQNYTRSTAVWSMVGYIVGLGDRHLENILFNKTNGSVVHVDFCYMFDKAKTLPT-PECVPFRLTQNVVDAMGALGVEGSFTSSCILMMDSLKAKAN
||  | ||||| |. ||.||| ||||||. ||. ..  | .||.||   |. | .    || .|||||   | || | |.|| .   | | |. .. . .
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

KIVTTLQTFVQDPLLEWKK
 ..  |  || |||. |. 
SVMAVLEAFVYDPLFYWRL
Kinase 86319.m00281.AA DNAPK 2033-2132 32 2.3e-25 89.13 In-house 201-301 (301) Show / Hide 
Range on Protein: 2033-2132
Range on HMM: 201-301/301
Sequence Identity: 32% (33 aa)

GYIVGLGDRHLENILFNKTNGSVVHVDFCYMFD-KAKTLPTPECVPFRLTQNVVDAMGALGVEGSFTSSCILMMDSLKAKANKIVTTLQTFVQDPLLEWK
..| | |||||.| . |  || .. .|| . |      || ||  |||||   .  |  ... | . .. |  |  .. . |  . .   |..||.. ||
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

K
.
N
Kinase 86319.m00281.AA SMG1 2015-2074 58 3.8e-24 76.75 In-house 183-242 (242) Show / Hide 
Range on Protein: 2015-2074
Range on HMM: 183-242/242
Sequence Identity: 58% (35 aa)

WFVARQNYTRSTAVWSMVGYIVGLGDRHLENILFNKTNGSVVHVDFCYMFDKAKTLPTPE
|.   | | ||||| ||||||.|||||||.|.|   | | |||.|.   |.| | |  ||
WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase 86319.m00281.AA DNAPK 1856-1955 34 2.3e-14 48.53 In-house 3-102 (301) Show / Hide 
Range on Protein: 1856-1955
Range on HMM: 3-102/301
Sequence Identity: 34% (34 aa)

KICQMEEPTLIFMSQQRPKRISLRDETGNSHRFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNHTICFRKILN
.|   .|   .  |  ||||| .|      | |. |   ||| | |        ||..| |  |  |   .  ..|. .    ||||||. |   . |||
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDILN
Kinase 86319.m00281.AA FATC 2162-2194 42 7.2e-14 47.45 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2162-2194
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

RKFSTEFFVRDLIQKAQDPNNLSRMWEGWQAYL
 . |.|  |..||| | ||.||..|. ||....
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 86319.m00281.AA FRAP 1886-1946 32 3.7e-09 29.95 In-house 2-62 (251) Show / Hide 
Range on Protein: 1886-1946
Range on HMM: 2-62/251
Sequence Identity: 32% (20 aa)

HRFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNH
. || |  .|.| | | |     .|  |. . . ... .|.  .||. |  . ||| ||.|
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH
Kinase 86319.m00281.AA ATM 1887-1948 32 9e-07 17.24 In-house 1-62 (304) Show / Hide 
Range on Protein: 1887-1948
Range on HMM: 1-62/304
Sequence Identity: 32% (20 aa)

RFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWVNHTI
| | |  ||||.|  |       | .|      | | . .  . .| |  . | .||   ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTI
Kinase 86319.m00281.AA SMG1 1865-1944 28 0.000126 11.08 In-house 2-81 (242) Show / Hide 
Range on Protein: 1865-1944
Range on HMM: 2-81/242
Sequence Identity: 28% (23 aa)

LIFMSQQRPKRISLRDETGNSHRFLCKRDDDLRKDMRMMEFASFVNNVLESDKKCRHRLISMNVFSIVCLNEKNGLIEWV
 |   . .||..      | |  .| |  .||  | |.| | | || .     .          .|.  |  . ||| ||
TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV