Gene 91913.m00065 (T.vaginalis)
91913.m00065
Species: T.vaginalis
Alias: TvagK0828, 91913.m00065
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 91913.m00065.AA | Protein | None | 282 | None | Fasta, JSON |
| 91913.m00065.kin_dom | Protein Kinase Domain | None | 187 | None | Fasta, JSON |
Protein domains of 91913.m00065.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 91913.m00065.AA | Ciliate-E2 | 14-241 | 15 | 6.3e-18 | 58.12 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 14-241
Range on HMM: 1-365/365
Sequence Identity: 15% (60 aa)
LLFKRIIATTKHGKVFLV-EWLKYNQV-----------------FTLKRIERSHYGSNRIDIIRS---LY--------------------HSNIVNVYKT
| ..| . .|.|... |.. .|. .. | .. . | | .| . .. | ||.. | .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
YL--REKYIYLLMDYCPI-DVHRFIEQRGVISESR--------FIEAAYSMLQSV------------------QAMHSKS-ISHNNIRPSKFLLDKYGRI
. ...||| |.|| | .|... . . |..| | | . . .||| | | .| |. |. |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I
QISDFSNATQYDESTQ--------------------------------------KKEFAHA------------------KSVDVWCLGVTFYYMLTG-LL
|.|| ....||.. | .. ...|.|.|||..|.||.| .
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
ITNLYFDHEDIMSKDFSQIKY-----------------------PQGTSKDTIMLISE----CLNSCEKARPS-VDCLLQSSIF
. ||| .. |.... ||. .|. .. |.. . .|. .|
F--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
|
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| Kinase | 91913.m00065.AA | S_TKc | 14-241 | 22 | 5.4e-16 | 57.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-241
Range on HMM: 1-231/231
Sequence Identity: 22% (59 aa)
LLFKRIIATTKHGKVFLVEWLKYNQVFTLKRIERSHYGSNRIDIIRSLYHSNIVNVYKTYLREKYIYLLMDYCPI---DVHRFIEQRGV------ISESR
. |.| |||... . | .... .|.| . |.| .. | |||. | .. ...|. |.||. |....|..|| ..| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H
FIEAAYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDFSNATQYDESTQKKEFA------------HAK-SVDVWCLGVTFYYMLTGLLITNLYF
.| ... .. .||. | | . |. |||. .| |.|| |.|. . | . | ..|.| .|...| ||.|
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP---
DHEDIMSKDFSQIKYPQGTSKDTIMLISECLNSCEKARPSVDCLLQ-------SSIF
... | | |.. . .|. ||. . ||.. .|| |
-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 91913.m00065.AA | Pkinase | 26-126 | 25 | 1.4e-15 | 56.14 | Pfam | 13-131 (293) | Show / Hide |
Range on Protein: 26-126 Range on HMM: 13-131/293 Sequence Identity: 25% (30 aa) GKVFLVEWLKYNQVFTLKRIERSHYGSNR---------IDIIRSLYHSNIVNVYKTYLREKYIYLLMDYCPI-----DVHRFIE--QRGVI--SESRFIE |.|.. . ...... .|.|...| |. | | ..| | ||| | .. ....||. |.||. | ...|. ..|.. || . GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF AAYSMLQSVQAMHSKSISH .| .|. .. .||..| | YMYQILRGLEYCHSMGIIH |
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| Kinase | 91913.m00065.AA | Ciliate-E2-Unclassified | 15-241 | 15 | 1.4e-13 | 43.51 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 15-241
Range on HMM: 2-352/352
Sequence Identity: 15% (56 aa)
LFKRIIATTKHGKVFLVEWLKYN-----------QVFTLKRIERSHYGSNRIDIIRSLYHSNIVN------------------VYKTYL--REKYIYLLM
. ..| . .|||.... | . |.. | |.... .| .... .. . .... |.. | ...||. |
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
DYCP----IDVHRFIEQ--------------RGVISESRFI-----EAAYSMLQSVQAMHSKS-ISHNNIRPSKFLLDKYG---RIQISDFSNAT-----
.||. .. .. .. | ..| . .. || . .|.| | | .| |. |.|. | .| |.||...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN
--------------------------QYD------ESTQKKEFAHA--KSVDVWCLGVTFYYMLTGLLITNLYF----------------------DHED
.| | |... | ...|.|.||| .|.||.| . .. ...
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY---PFYDNNCEQHQQLITQWINNAYRKQLYQN
IMSKDFSQIKYPQ-----GTSKDTIMLIS----ECLNSCEKARPSVDCLLQSSIF
|. |.... |.|. . |. . .|. .|. . . |.. . .|. .|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | 91913.m00065.AA | CAMK | 19-156 | 15 | 1.5e-11 | 32.72 | In-house | 1-249 (425) | Show / Hide |
Range on Protein: 19-156 Range on HMM: 1-249/425 Sequence Identity: 15% (39 aa) IIATTKHGKVFLVEWLKYN------------QVFTLKRIERSHYGS---------------------------------NRIDIIRS-------LYHSNI .. . |||.|.. . . | . | |... . . |.| .. | | || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNVYKTYLR-------------------EKYIYLLM---DYCP-----IDVHRFIEQR---------------GVISESRFIEAAYSMLQSVQAMHSKSI .. | .| .|..|. | .||. .|. .| .. | ..|. ... |. .||. | IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI SHNNIRPSKFLLDKY-----------------GRIQISDFSNATQYDES | . | |||. . | |.|| |...|.. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG |
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| Kinase | 91913.m00065.AA | CMGC | 55-155 | 16 | 3.8e-10 | 28.58 | In-house | 72-256 (513) | Show / Hide |
Range on Protein: 55-155
Range on HMM: 72-256/513
Sequence Identity: 16% (31 aa)
IDIIRSL-----------------YHSNIVNVYKTYLREK-----------------YIYLLMDYCPIDVHRFIEQRG---------VISESR-------
| | . | | |||. | . ... ..|| ..|.. | ...|.. ||
IKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHR
-----FIEAA------YSMLQSVQ--AMHSKS--ISHNNIRPSKFLLD--------------------KYGRIQISDFSNATQYDE
| .|... .||. | | . |. |.. | ||. | || .|..|..
RPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
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| Kinase | 91913.m00065.AA | MELK | 16-147 | 21 | 8.5e-09 | 25.86 | In-house | 3-141 (254) | Show / Hide |
Range on Protein: 16-147
Range on HMM: 3-141/254
Sequence Identity: 21% (30 aa)
FKRIIATTKHGKVFLVEWLKYNQVFTLKRIERSHYGSN------RIDIIRSLYHSNIVNVYKTYLREKYIYLLMDYCP-IDVHRFIEQRGVISESRFIEA
| | .|| | . || .| ... . |.. .| ...| | .| .| |. |...|.||| .. .| .. ..|.
VHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHF
AYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDF
.. .. .||. .| ...| .|.| . .... ||
FRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDF
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| Kinase | 91913.m00065.AA | SLK | 55-161 | 20 | 1.4e-08 | 24.96 | In-house | 47-155 (259) | Show / Hide |
Range on Protein: 55-161 Range on HMM: 47-155/259 Sequence Identity: 20% (23 aa) IDIIRSLYHSNIVNVYKTYLREKYIYLLMDYCP---IDVHRFIEQRGVISESRFIEAAYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDFSNAT |||. .. | |||..|..| .. .......|. .| .| .. |.. .. |..... .||. . | ... |. | ... || . IDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNI-MVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSA QYDESTQKKE . . ||.. KNKHTMQKRD |
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| Kinase | 91913.m00065.AA | KHS | 55-160 | 26 | 2.5e-07 | 20.57 | In-house | 47-153 (258) | Show / Hide |
Range on Protein: 55-160 Range on HMM: 47-153/258 Sequence Identity: 26% (28 aa) IDIIRSLYHSNIVNVYKTYLREKYIYLLMDYCPIDVHRFIEQ-RGVISESRFIEAAYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDFSNATQY | ... |.||| . |||.. ... |.|| | . | .|| . || .. .||. | |. || ..| ... || ..| IMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQI DESTQKK . |. TATIAKR |
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| Kinase | 91913.m00065.AA | CDC2 | 55-147 | 25 | 5.8e-07 | 16.88 | In-house | 51-147 (301) | Show / Hide |
Range on Protein: 55-147 Range on HMM: 51-147/301 Sequence Identity: 25% (25 aa) IDIIRSLY-HSNIVNVYKTYLREKYIYLLMDYCPIDVHRFIE----QRGVISESRFIEAAYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDF | .. | | ||| . . .|. .|. | .. . .. ..... . .| .|| | |.. | | .. |. |.|| |.|.|.|| ISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADF |
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| Kinase | 91913.m00065.AA | PLK1 | 55-160 | 22 | 8.9e-07 | 18.02 | In-house | 50-156 (253) | Show / Hide |
Range on Protein: 55-160 Range on HMM: 50-156/253 Sequence Identity: 22% (24 aa) IDIIRSLYHSNIVNVYKTYLREKYIYLLMDYCPID-VHRFIEQRGVISESRFIEAAYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDFSNATQY |.| |.| | .||.... . ....|.... | . .|. | | | .....| .| . | | .. |. ...| || ||. IQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKC DESTQKK ... .| EYDGERK |
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| Kinase | 91913.m00065.AA | Pkinase | 166-241 | 20 | 2e-06 | 24.11 | Pfam | 191-293 (293) | Show / Hide |
Range on Protein: 166-241 Range on HMM: 191-293/293 Sequence Identity: 20% (22 aa) KSVDVWCLGVTFYYMLTGLLITNLYFDHE------DIMSKDFSQIK------YPQGTS-------------------KDTIMLISECLNSCEKARPSVDC ..||.| .|...|.||.| . |... | | . . . .|. | .. . .|. ||. . | ||. .. PKVDMWSCGCILYEMLCGR----PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ LLQSSIF .||. | ILQHPWF |
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| Kinase | 91913.m00065.AA | CAMKL | 55-103 | 26 | 1.3e-05 | 13.72 | In-house | 63-127 (297) | Show / Hide |
Range on Protein: 55-103 Range on HMM: 63-127/297 Sequence Identity: 26% (17 aa) IDIIRSLY---HSNIVNVYKTYLREKY------IYLLMDYCP---IDVHRFIEQR----GVISES | | ..| | ||. | .. ... ||| | ||. .| . .|... | ..|. IQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEH |
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| Kinase | 91913.m00065.AA | TyrKc | 14-235 | 15 | 2.7e-05 | -137.04 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-235 Range on HMM: 1-280/280 Sequence Identity: 15% (44 aa) LLFKRIIATTKHGKVFLVEWLKYNQVF--TLKRIERSHYGSNRID------IIRSL--YHSNIVNVYKTYLRE-------KYIYLLMDYCP-IDVHRFIE . ..... |.|.. .| || .|| | | | ..| | |||. | . . . ....| |.| | . .. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR QRGV-ISESRFIEAAYSMLQSVQAMHSKSISHNNIRPSKFLLDKYGRIQISDFSNATQYDES--------TQKKEF-AHAK------------------- .. .. . ... .. . . ||| . | . |... ... |||| . .. . .| ..| KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT -SVDVWCLGVTFYYMLTGLLITNLY-------FDHEDIMS--KDFSQIKYPQG--------TSKDTIMLISECLNSCEKARPS----VDCL ||| ||. . ..| . | . .... |. . |. ... .....| . . ||. ..|. TKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 91913.m00065.AA | CAMKL | 164-183 | 40 | 0.001681 | 6.87 | In-house | 213-232 (297) | Show / Hide |
Range on Protein: 164-183 Range on HMM: 213-232/297 Sequence Identity: 40% (8 aa) HAKSVDVWCLGVTFYYMLTG ... ||.| .||. | |..| DGPKVDIWSCGVILYAMVCG |
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| Kinase | 91913.m00065.AA | PLK1 | 164-241 | 23 | 0.004286 | 5.72 | In-house | 176-253 (253) | Show / Hide |
Range on Protein: 164-241 Range on HMM: 176-253/253 Sequence Identity: 23% (18 aa) HAKSVDVWCLGVTFYYMLTGLLITNLYFDHEDIMSKDFSQIKYPQGTSKDTIMLISECLNSCEKARPSVDCLLQSSIF |. ||.| .| .| .| | .| . . . |. |. || . |. ..|| .. .|. | HSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 91913.m00065.AA | CAMK | 166-185 | 40 | 0.018283 | 2.95 | In-house | 313-332 (425) | Show / Hide |
Range on Protein: 166-185 Range on HMM: 313-332/425 Sequence Identity: 40% (8 aa) KSVDVWCLGVTFYYMLTGLL ...|.| .|| | ||.| . PKCDMWSCGVILYIMLCGYP |
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