93242.m00137

Species: T.vaginalis
Alias: TvagK0224, 93242.m00137
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
93242.m00137.AA Protein None 350 None Fasta, JSON
93242.m00137.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of 93242.m00137.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93242.m00137.AA Ciliate-E2-Unclassified 56-259 20 2.2e-22 74.45 In-house 73-352 (352) Show / Hide
Range on Protein: 56-259
Range on HMM: 73-352/352
Sequence Identity: 20% (56 aa)

DLLISIDDPKMVHIFKYYEYNNYIYLLMEFCP----FDLERQVKG-----------MEKKVDITLNKYV--------TDVIYAVKSFHDKS-LAHCHIKP
..|.....|  |. | . .  ..||. ||.|.    ..  .. |.           |...  .| .. .          .. . .. | |    |  |||
QILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP

SKFFIDKFG---RIKIGDFLDSIICEEDNE-------------DLKVETKR-SKMYQ----SPEMIKNKKYNP---FAADIWALGVTIYNIYTNKYPFQI
.  ..|. |   .||| ||  |.  ...|.             . .  |.  . .|.    .||......|.    ...|||.||| .| . ...|||. 
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYD

TDSVS----------------LQTKIETGNFSKEEIA---DHYILEIVS---------KCLIPDPSKRFTIDQILNLSFF
... .                |. .|  .|... .     .....             |.|  .|.|| |..||||  .|
NNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 93242.m00137.AA Ciliate-E2 14-259 17 4e-22 72.71 In-house 1-365 (365) Show / Hide
Range on Protein: 14-259
Range on HMM: 1-365/365
Sequence Identity: 17% (65 aa)

IIYLHTIGTKTDTTVFLVSSKQYQSNFALT------------------KIPKSRFDQQMIDLLISIDDPK-----------------------MVHIFKY
.. .  ||. .  .|.... .. | .||.                   .. . .. ...|  . ....                          . .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--YNNYIYLLMEFCPF-DLER---------------QVKGMEKKVDITLNKYVTDVI------------YAVKSFHDKS-LAHCHIKPSKFFIDKFGR
..   .|.||| ||.|   ||.                . | .  |  ... |......             |... | |    |  |||.  ..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKIGDFLDSIICEEDNED--------LKVETKR-----------------------SKMYQSPEMIKNKKY--------NPFAADIWALGVTIYNIYTNK
||| ||  | .. .||..        .. . |                        . .|..||....|||          ...|||.|||..|   ..|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPFQITDSVSLQTKIETGNFSKE----------------EIADHYIL--EIVSK----CLIPDPSKRFT-IDQILNLSFF
.||        | .|. ....                  .  ..      . .|    .|  ||.||.| ..||||  .|
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 93242.m00137.AA CAMK 107-259 17 7e-20 60.09 In-house 183-425 (425) Show / Hide
Range on Protein: 107-259
Range on HMM: 183-425/425
Sequence Identity: 17% (43 aa)

KYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKF-----------------GRIKIGDFLDSIICEEDN---------------------EDLKVETKR-S
.|.  .. ||.  |..  .|. .||    .|.                  . ||| ||  ........                     |. | .|   .
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT

KMYQS-PEMIKN-------------KKYNPFAADIWALGVTIYNIYTNKYPFQIT-------------DSVSLQTKIETGNFSKEEIADHY---------
  | . ||...              |.| ....|.|..||  |   . ..||.               .   |  || .|... ..              
PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEW

---------------ILEIVSKCLIPDPSKRFTIDQILNLSFF
                   ..|.| .||.||.||.|.||  ..
WDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 93242.m00137.AA PLK1 60-259 24 3.6e-19 59.43 In-house 55-253 (253) Show / Hide
Range on Protein: 60-259
Range on HMM: 55-253/253
Sequence Identity: 24% (50 aa)

SIDDPKMVHIFKYYEYNNYIYLLMEFCP----FDLERQVKGMEKKVDITLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIICEE
... ...|......| ....|...| |     ..|... | .    .     |.  .. ...  |.. . |  .|    |..   ..|||||     ||.
QLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAI---TEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEY

DNEDLKVETKRSKMYQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTIDQILN
| |  |        |  ||.. |||   |  |||..|  .| .   . ||          .|   ...  ... .   ... | | |||..| ||.|.||
DGERKKTLC-GTPNYIAPEVL-NKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLN

LSFF
  ||
DEFF

Kinase 93242.m00137.AA S_TKc 14-259 19 1e-18 69.4 SMART 1-231 (231) Show / Hide
Range on Protein: 14-259
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

IIYLHTIGTKTDTTVFLVSSKQYQSNFALTKIPKSRFDQQMIDLLISIDDPKMVHIFKYYEYNNYIYLLMEFCPF---DLERQVKGMEK------KVDIT
   | .||  .  .|...  |  .  .|. .|.  .  .. |..| . . |  |... ...  ...|. ||.|.    || .  | . .          .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

LNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIICEEDNEDLKVETKRSKMYQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYP
  .|.  .. |..  |..   |. .||.  ..|.  .|||.||  . .              .  | .||..   .|.....|.|..|...|  .. . |
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP

FQITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTIDQILN-------LSFF
|.  .   .  ||           ..  .....|||  ||.|| |. ..|.         .|
FP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 93242.m00137.AA CAMKL 170-259 22 2e-17 52.04 In-house 199-297 (297) Show / Hide
Range on Protein: 170-259
Range on HMM: 199-297/297
Sequence Identity: 22% (23 aa)

YQSPEMIKN--KKYNPFAADIWALGVTIYNIYTNKYPFQ----------ITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTIDQILNLS
|..||...   |.|. ...|||..||. |.. . ..||            .    .....  ... .    .     . .| | ..|.||.||.||.|  
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

FF
..
WM

Kinase 93242.m00137.AA NEK 170-259 35 5.5e-16 53.13 In-house 190-286 (286) Show / Hide
Range on Protein: 170-259
Range on HMM: 190-286/286
Sequence Identity: 35% (35 aa)

YQSPEMIKNKKYNPFAADIWALGVTIYNIYTN--KYPFQIT--DSVSLQTKIETGNFSKEEIADH--Y---ILEIVSKCLIPDPSKRFTIDQILNLSFF
| |||...||.|| . .|||.||. .| . |   | ||. .  .  || .||  |    . | .|  |     ...|..| .||..| ...|||...| 
YMSPEVCQNKPYN-NKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase 93242.m00137.AA ULK 67-259 19 8.5e-16 51.7 In-house 81-329 (329) Show / Hide
Range on Protein: 67-259
Range on HMM: 81-329/329
Sequence Identity: 19% (48 aa)

VHIFKYYEYN--NYIYLLMEFCPF-DLERQVKGMEK-------KVDIT---LNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKF------------GR
|  ....|    |.||. ||.|.  |||   |   |       |  ..     ..  . . . |  |..   |. |||.   |..             |.
VKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGV

IKIGDFLDSIICEED--NEDLKVETK------RSKMYQSPEMIK----NKKYNPFAADIWALGVTIYNIYTNKYPFQI--TDSV-----SLQTK------
.||.||  .  ...|  .... . ..       . .| .|. ..    .|.|. . .||| ||. .| . ..|.||.   .| .     .|  .      
LKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQ

-IETGNFS-----KEEIADHYILEIVSKCLIPDPSKRFTIDQILNLSFF
 |.. ..      .. .    . .. ...|. |...|.......|  .|
QIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 93242.m00137.AA Pkinase 170-259 20 1.5e-14 52.52 Pfam 177-293 (293) Show / Hide
Range on Protein: 170-259
Range on HMM: 177-293/293
Sequence Identity: 20% (24 aa)

YQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQIT------DSVSLQTKIETGNFSKEEIAD---------------------HYILEIVSKCLIP
| .|| |.  .| . ..|.|..|...|  .. . ||.        |   .  .|  . .. ..  .                        ......|| .
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPSKRFTIDQILNLSFF
||.|| |..|||.  .|
DPKKRPTAEQILQHPWF

Kinase 93242.m00137.AA MARK 170-259 26 6.7e-14 42.0 In-house 171-262 (262) Show / Hide
Range on Protein: 170-259
Range on HMM: 171-262/262
Sequence Identity: 26% (26 aa)

YQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQ--ITDSVSLQTKIETGNFS-----KEEIADHYILEIVSKCLIPDPSKRFTIDQILNLSFF
| .||... |.|. ...|||.|||  | . . ..||     | . |. || .|...       |. .     .... | ..|..| ||..|.. ...
YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRN-----LIQRLLTVNPEERPTIEEIMKHPWM

Kinase 93242.m00137.AA ULK 68-259 20 7.4e-14 45.61 In-house 76-324 (324) Show / Hide
Range on Protein: 68-259
Range on HMM: 76-324/324
Sequence Identity: 20% (52 aa)

HIFKYYEY----N-NYIYLLMEFCPF-DLERQVKGMEKKVDIT----------LNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKF------------
|| |.|..    | |.||. ||.|.  |||   |   |.   |            ..  . . . |  |..   |. |||.   | .             
HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPN

GRIKIGDFLDSIICEE--DNEDLKVETK------RSKMYQSPEMIK----NKKYNPFAADIWALGVTIYNIYTNKYPFQI--TDSV----SLQTK-----
|..||.||  . ....   ....  ...       . .| .|. ..    .|.|. . .||| ||. .| . ..||||.   .| .    .|. .     
GVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQ

--IETGNFSKE-----EIADHYILEIVSKCLIPDPSKRFTIDQILNLSFF
  |.. .. .       .    . .. ...|. |...|.....|.|  .|
IYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 93242.m00137.AA MELK 55-259 21 1.1e-13 42.84 In-house 48-254 (254) Show / Hide
Range on Protein: 55-259
Range on HMM: 48-254/254
Sequence Identity: 21% (45 aa)

IDLLISIDDPKMVHIFKYYEYNNYIYLLMEFCP-FDLERQVKGMEKKVDITLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIIC
.| | ..   .. ... | | .. |...||.||  ..   .   ..  .    ..   .. |.   | .  ||  .||  ...|   ..|. ||      
MDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT

EEDNEDLK-VET-KRSKMYQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTID
   . |   ..|   |  |  ||.|. |.|    ||.|..|. .| .     ||.      .  ||  | . . .       ... . |  || ||  . 
-KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMK

QILNLSFF
..||  . 
NLLNHPWV

TyrKc 93242.m00137.AA TyrKc 6-259 16 1.2e-05 -131.13 SMART 1-280 (280) Show / Hide
Range on Protein: 6-259
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

ISFLK-----QHGIIYLHTIGTKTDTTVFLVSSKQYQSNFALTKIPKSRFDQQMIDLLISI--DDPKMVHIFKYYEYN-------NYIYLLMEFCPF-DL
|...|     . |..|. |      ..|   . | .          .  | .  . .. ..  . |  | .. .             ....||..|  ||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---------REDFMRE-ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

ERQVKGMEKKVDI-TLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIICEED-----NEDLKVETK--RSKM-----YQSPEMIK
    .  ..|.   .| .. ...       |.| . |  .      ... ...||.||  |   ..|     ..| .. ..   .|.       .|| |.
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

NKKYNPFAADIWALGVTIYNIYTN-KYPFQI-----TDSVSLQTKIETGNF-SKEEI--------ADHYILEIVSKCLIPDPSKRFTIDQILNLSFF
 .|.. .. |.|. ||... |.|. . |         .   .  ....|.   . .         .   . .| ..|   ||..| |  .|   ..|
YGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 93242.m00137.AA Pkinase 67-147 23 3.726571 1.63 Pfam 63-156 (293) Show / Hide
Range on Protein: 67-147
Range on HMM: 63-156/293
Sequence Identity: 23% (22 aa)

VHIFKYYEYNNYIYLLMEFCPF-----DLERQVK-GMEKKV---DITLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRI----KIGDF
| .. ..|....||. ||.|.      || . ..  .....   . .. .|.. .. ...  |...  |. .||. ..||. | |    ||.||
VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF