Gene 93242.m00137 (T.vaginalis)
93242.m00137
Species: T.vaginalis
Alias: TvagK0224, 93242.m00137
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93242.m00137.AA | Protein | None | 350 | None | Fasta, JSON |
| 93242.m00137.kin_dom | Protein Kinase Domain | None | 205 | None | Fasta, JSON |
Protein domains of 93242.m00137.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 93242.m00137.AA | Ciliate-E2-Unclassified | 56-259 | 20 | 2.2e-22 | 74.45 | In-house | 73-352 (352) | Show / Hide |
Range on Protein: 56-259 Range on HMM: 73-352/352 Sequence Identity: 20% (56 aa) DLLISIDDPKMVHIFKYYEYNNYIYLLMEFCP----FDLERQVKG-----------MEKKVDITLNKYV--------TDVIYAVKSFHDKS-LAHCHIKP ..|.....| |. | . . ..||. ||.|. .. .. |. |... .| .. . .. . .. | | | ||| QILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP SKFFIDKFG---RIKIGDFLDSIICEEDNE-------------DLKVETKR-SKMYQ----SPEMIKNKKYNP---FAADIWALGVTIYNIYTNKYPFQI . ..|. | .||| || |. ...|. . . |. . .|. .||......|. ...|||.||| .| . ...|||. ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYD TDSVS----------------LQTKIETGNFSKEEIA---DHYILEIVS---------KCLIPDPSKRFTIDQILNLSFF ... . |. .| .|... . ..... |.| .|.|| |..|||| .| NNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 93242.m00137.AA | Ciliate-E2 | 14-259 | 17 | 4e-22 | 72.71 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 14-259 Range on HMM: 1-365/365 Sequence Identity: 17% (65 aa) IIYLHTIGTKTDTTVFLVSSKQYQSNFALT------------------KIPKSRFDQQMIDLLISIDDPK-----------------------MVHIFKY .. . ||. . .|.... .. | .||. .. . .. ...| . .... . .. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YE--YNNYIYLLMEFCPF-DLER---------------QVKGMEKKVDITLNKYVTDVI------------YAVKSFHDKS-LAHCHIKPSKFFIDKFGR .. .|.||| ||.| ||. . | . | ... |...... |... | | | |||. .. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- IKIGDFLDSIICEEDNED--------LKVETKR-----------------------SKMYQSPEMIKNKKY--------NPFAADIWALGVTIYNIYTNK ||| || | .. .||.. .. . | . .|..||....||| ...|||.|||..| ..| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK YPFQITDSVSLQTKIETGNFSKE----------------EIADHYIL--EIVSK----CLIPDPSKRFT-IDQILNLSFF .|| | .|. .... . .. . .| .| ||.||.| ..|||| .| PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 93242.m00137.AA | CAMK | 107-259 | 17 | 7e-20 | 60.09 | In-house | 183-425 (425) | Show / Hide |
Range on Protein: 107-259
Range on HMM: 183-425/425
Sequence Identity: 17% (43 aa)
KYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKF-----------------GRIKIGDFLDSIICEEDN---------------------EDLKVETKR-S
.|. .. ||. |.. .|. .|| .|. . ||| || ........ |. | .| .
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT
KMYQS-PEMIKN-------------KKYNPFAADIWALGVTIYNIYTNKYPFQIT-------------DSVSLQTKIETGNFSKEEIADHY---------
| . ||... |.| ....|.|..|| | . ..||. . | || .|... ..
PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEW
---------------ILEIVSKCLIPDPSKRFTIDQILNLSFF
..|.| .||.||.||.|.|| ..
WDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 93242.m00137.AA | PLK1 | 60-259 | 24 | 3.6e-19 | 59.43 | In-house | 55-253 (253) | Show / Hide |
Range on Protein: 60-259 Range on HMM: 55-253/253 Sequence Identity: 24% (50 aa) SIDDPKMVHIFKYYEYNNYIYLLMEFCP----FDLERQVKGMEKKVDITLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIICEE ... ...|......| ....|...| | ..|... | . . |. .. ... |.. . | .| |.. ..||||| ||. QLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAI---TEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEY DNEDLKVETKRSKMYQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTIDQILN | | | | ||.. ||| | |||..| .| . . || .| ... ... . ... | | |||..| ||.|.|| DGERKKTLC-GTPNYIAPEVL-NKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLN LSFF || DEFF |
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| Kinase | 93242.m00137.AA | S_TKc | 14-259 | 19 | 1e-18 | 69.4 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-259 Range on HMM: 1-231/231 Sequence Identity: 19% (52 aa) IIYLHTIGTKTDTTVFLVSSKQYQSNFALTKIPKSRFDQQMIDLLISIDDPKMVHIFKYYEYNNYIYLLMEFCPF---DLERQVKGMEK------KVDIT | .|| . .|... | . .|. .|. . .. |..| . . | |... ... ...|. ||.|. || . | . . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H LNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIICEEDNEDLKVETKRSKMYQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYP .|. .. |.. |.. |. .||. ..|. .|||.|| . . . | .||.. .|.....|.|..|...| .. . | ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP FQITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTIDQILN-------LSFF |. . . || .. .....||| ||.|| |. ..|. .| FP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 93242.m00137.AA | CAMKL | 170-259 | 22 | 2e-17 | 52.04 | In-house | 199-297 (297) | Show / Hide |
Range on Protein: 170-259 Range on HMM: 199-297/297 Sequence Identity: 22% (23 aa) YQSPEMIKN--KKYNPFAADIWALGVTIYNIYTNKYPFQ----------ITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTIDQILNLS |..||... |.|. ...|||..||. |.. . ..|| . ..... ... . . . .| | ..|.||.||.||.| YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP FF .. WM |
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| Kinase | 93242.m00137.AA | NEK | 170-259 | 35 | 5.5e-16 | 53.13 | In-house | 190-286 (286) | Show / Hide |
Range on Protein: 170-259 Range on HMM: 190-286/286 Sequence Identity: 35% (35 aa) YQSPEMIKNKKYNPFAADIWALGVTIYNIYTN--KYPFQIT--DSVSLQTKIETGNFSKEEIADH--Y---ILEIVSKCLIPDPSKRFTIDQILNLSFF | |||...||.|| . .|||.||. .| . | | ||. . . || .|| | . | .| | ...|..| .||..| ...|||...| YMSPEVCQNKPYN-NKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | 93242.m00137.AA | ULK | 67-259 | 19 | 8.5e-16 | 51.7 | In-house | 81-329 (329) | Show / Hide |
Range on Protein: 67-259 Range on HMM: 81-329/329 Sequence Identity: 19% (48 aa) VHIFKYYEYN--NYIYLLMEFCPF-DLERQVKGMEK-------KVDIT---LNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKF------------GR | ....| |.||. ||.|. ||| | | | .. .. . . . | |.. |. |||. |.. |. VKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGV IKIGDFLDSIICEED--NEDLKVETK------RSKMYQSPEMIK----NKKYNPFAADIWALGVTIYNIYTNKYPFQI--TDSV-----SLQTK------ .||.|| . ...| .... . .. . .| .|. .. .|.|. . .||| ||. .| . ..|.||. .| . .| . LKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQ -IETGNFS-----KEEIADHYILEIVSKCLIPDPSKRFTIDQILNLSFF |.. .. .. . . .. ...|. |...|.......| .| QIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 93242.m00137.AA | Pkinase | 170-259 | 20 | 1.5e-14 | 52.52 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 170-259 Range on HMM: 177-293/293 Sequence Identity: 20% (24 aa) YQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQIT------DSVSLQTKIETGNFSKEEIAD---------------------HYILEIVSKCLIP | .|| |. .| . ..|.|..|...| .. . ||. | . .| . .. .. . ......|| . YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DPSKRFTIDQILNLSFF ||.|| |..|||. .| DPKKRPTAEQILQHPWF |
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| Kinase | 93242.m00137.AA | MARK | 170-259 | 26 | 6.7e-14 | 42.0 | In-house | 171-262 (262) | Show / Hide |
Range on Protein: 170-259 Range on HMM: 171-262/262 Sequence Identity: 26% (26 aa) YQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQ--ITDSVSLQTKIETGNFS-----KEEIADHYILEIVSKCLIPDPSKRFTIDQILNLSFF | .||... |.|. ...|||.||| | . . ..|| | . |. || .|... |. . .... | ..|..| ||..|.. ... YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRN-----LIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 93242.m00137.AA | ULK | 68-259 | 20 | 7.4e-14 | 45.61 | In-house | 76-324 (324) | Show / Hide |
Range on Protein: 68-259 Range on HMM: 76-324/324 Sequence Identity: 20% (52 aa) HIFKYYEY----N-NYIYLLMEFCPF-DLERQVKGMEKKVDIT----------LNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKF------------ || |.|.. | |.||. ||.|. ||| | |. | .. . . . | |.. |. |||. | . HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPN GRIKIGDFLDSIICEE--DNEDLKVETK------RSKMYQSPEMIK----NKKYNPFAADIWALGVTIYNIYTNKYPFQI--TDSV----SLQTK----- |..||.|| . .... .... ... . .| .|. .. .|.|. . .||| ||. .| . ..||||. .| . .|. . GVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQ --IETGNFSKE-----EIADHYILEIVSKCLIPDPSKRFTIDQILNLSFF |.. .. . . . .. ...|. |...|.....|.| .| IYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 93242.m00137.AA | MELK | 55-259 | 21 | 1.1e-13 | 42.84 | In-house | 48-254 (254) | Show / Hide |
Range on Protein: 55-259 Range on HMM: 48-254/254 Sequence Identity: 21% (45 aa) IDLLISIDDPKMVHIFKYYEYNNYIYLLMEFCP-FDLERQVKGMEKKVDITLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIIC .| | .. .. ... | | .. |...||.|| .. . .. . .. .. |. | . || .|| ...| ..|. || MDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT EEDNEDLK-VET-KRSKMYQSPEMIKNKKYNPFAADIWALGVTIYNIYTNKYPFQITDSVSLQTKIETGNFSKEEIADHYILEIVSKCLIPDPSKRFTID . | ..| | | ||.|. |.| ||.|..|. .| . ||. . || | . . . ... . | || || . -KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMK QILNLSFF ..|| . NLLNHPWV |
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| TyrKc | 93242.m00137.AA | TyrKc | 6-259 | 16 | 1.2e-05 | -131.13 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 6-259
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)
ISFLK-----QHGIIYLHTIGTKTDTTVFLVSSKQYQSNFALTKIPKSRFDQQMIDLLISI--DDPKMVHIFKYYEYN-------NYIYLLMEFCPF-DL
|...| . |..|. | ..| . | . . | . . .. .. . | | .. . ....||..| ||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---------REDFMRE-ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL
ERQVKGMEKKVDI-TLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRIKIGDFLDSIICEED-----NEDLKVETK--RSKM-----YQSPEMIK
. ..|. .| .. ... |.| . | . ... ...||.|| | ..| ..| .. .. .|. .|| |.
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN
NKKYNPFAADIWALGVTIYNIYTN-KYPFQI-----TDSVSLQTKIETGNF-SKEEI--------ADHYILEIVSKCLIPDPSKRFTIDQILNLSFF
.|.. .. |.|. ||... |.|. . | . . ....|. . . . . .| ..| ||..| | .| ..|
YGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 93242.m00137.AA | Pkinase | 67-147 | 23 | 3.726571 | 1.63 | Pfam | 63-156 (293) | Show / Hide |
Range on Protein: 67-147 Range on HMM: 63-156/293 Sequence Identity: 23% (22 aa) VHIFKYYEYNNYIYLLMEFCPF-----DLERQVK-GMEKKV---DITLNKYVTDVIYAVKSFHDKSLAHCHIKPSKFFIDKFGRI----KIGDF | .. ..|....||. ||.|. || . .. ..... . .. .|.. .. ... |... |. .||. ..||. | | ||.|| VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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