Gene 89276.m00200 (T.vaginalis)

89276.m00200

Species: T.vaginalis
Alias: 89276.m00200, TvagK0792
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
89276.m00200.AA Protein None 2187 None Fasta, JSON
89276.m00200.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of 89276.m00200.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Rapamycin_bind 89276.m00200.AA Rapamycin_bind 1712-1811 42 6.1e-56 178.47 Pfam 1-100 (100) Show / Hide 
Range on Protein: 1712-1811
Range on HMM: 1-100/100
Sequence Identity: 42% (42 aa)

EIIRIAVSWWELWFGVLDDASRAYLIKQDVNEMLSLLLPAHEITEKEPKTYYEIAFVAQFGESLQRAKKMLMDYKKTNDDIHLIQAWGIYISIFNQLKPV
| ||.|..|.|.|.. |..|||.|.  .....|...|.| ||. ||.|.|. ||.||.|||..||.|..... ||.|.|. .| ||| || ..|......
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase 89276.m00200.AA FRAP 1879-2128 52 2.3e-113 382.9 In-house 2-251 (251) Show / Hide 
Range on Protein: 1879-2128
Range on HMM: 2-251/251
Sequence Identity: 52% (132 aa)

YTFLLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYELIKQRREKNNVPVEIEYQTTMKACPNFEQIEGA
| |||| ||| | ||||||||| |||| .| .   |  | |. | .|||  . | |||| .| |   ||.. |.| ..   |||.   . |......   
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPLM

DKMFAFKKGLSATKGDDLKAILLLNSSDSTHWIERRTAYTTSLSMTSMAGYILGLGDRHLSNIMIKNKTAKLVHIDFGDCFEVAQHREKAPEKVPFRLTR
.|   |.  .  |||.||| .| | |  |  |.|||| || ||   |||||||||||||.||||.   | |.||||||||||||  ||| |||.||||||
NKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR

ILTNALEVSRIEGTFRSCCENVMELIRNNGEQINGILEVFIYDPLAQWSE
.|.||.|.  |||..|  || ||. || . | .  .|| |.||||  |  
MLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 89276.m00200.AA PIKK 1849-2118 39 1.1e-106 360.68 In-house 1-290 (290) Show / Hide 
Range on Protein: 1849-2118
Range on HMM: 1-290/290
Sequence Identity: 39% (115 aa)

KIDKIDQKLSVMKSKQRPRRMAIYGTDGIRYTFLLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYELIK
 |  .|. . ||..||.|... | | ||  | .|.| ||| |.|.||||||...|..  . .   | || |.||.|||.. . | |.||.||.|  |..|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

QRREKNNVPVEIE--------------------YQTTMKACPNFEQIEGADKMFAFKKGLSATKGDDLKAILLLNSSDSTHWIERRTAYTTSLSMTSMAG
|...| .   |.|                    .    . |..       .|  .| . ...|..|..| .... ..|.. | |||..|| |.   .|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHLSNIMIKNKTAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILTNALEVSRIEGTFRSCCENVMELIRNNGEQINGILEVF
|||||||||..||||.  |...||||||.|||.|  |...|||||||||| ..||...  .|| ||.||| ||...|.. | . ...|||
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 89276.m00200.AA PI3_PI4_kinase 1878-2128 22 6.3e-63 220.16 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1878-2128
Range on HMM: 1-300/300
Sequence Identity: 22% (71 aa)

RYTFLLKAHEDTR--LDERVMQLF-----------------------GFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYELIKQRRE
 | |..| ..| |   |.|.||..                       ...|..  .     ........| .||.  . |.|.|| || |  |...  ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

KNNVPV-----------EIEYQTTMKACPNFEQIEGADKMFAFKKGLSATKGDDLKAILLLNSSDS-THWIERRTAYTTSLSMTSMAGYILGLGDRHLSN
| . .            .... . |            .|   | . .. |....|   .. .. |  . | |.|. ...|.   ....||||.||||..|
KCKHKHFNKEHKMWMKMWPDWWHLM----------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDN

IMI--KNKTAKLVHIDFGDCFE-VAQHREKAPEKVPFRLTR------ILTNAL------EVSRIEGTFRSCCENVMELIRNNGEQINGIL-------EVF
||.  . .| .|.|||||.||. ....... ||.||||.|.       . .|.      ..|. .|.||..|. .....| ... .   |       | .
IMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM

IYDPLAQWSE
..|.|  |..
VHDGLPMWRS
Kinase 89276.m00200.AA PI3Kc 1880-2176 22 1.3e-61 211.97 SMART 1-336 (336) Show / Hide 
Range on Protein: 1880-2176
Range on HMM: 1-336/336
Sequence Identity: 22% (77 aa)

TFLLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYELIKQRREKNNVPVEIEYQTTMKA-----------
 ...|...| | |.|.||.|. .|..  . .   ...| ...|..||.  . |.|.||.|| |. .. | .... ..|  .. | .|.            
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYH-QWFMFDMLVPEIQKNMY

-----------CPNFEQIEGADKMFAFKKGLSATKGDDLKAILLLNSSDS-THWIERRTAYTTSLSMTSMAGYILGLGDRHLSNIMIKNKTAKLVHIDFG
           ..  ..     .   | . ....|...|.  .. .. |.   | |.|. .| |.   .|..||||.||||..|||.. || ...|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFEVAQHREKAP----EKVPFRLTRILTNALE----VSRIEGTFRSCCENVMELIRNNGEQINGILEVFIYDPL-AQWSEN--VSETNSAQFVTDRIHS
..|. .. ... .    |.||||||. . .. .    .|  .| ||.||. .....| . ..|  ..|...|||.  .|. .    .   ..|  |    
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSD

KLDGTDF------EGEKLDVKEQVDRLIHEATDMKNL
..  . |      .  . .. ..  |.. .. .....
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 89276.m00200.AA ATR 1849-2118 27 3.2e-44 148.34 In-house 2-267 (267) Show / Hide 
Range on Protein: 1849-2118
Range on HMM: 2-267/267
Sequence Identity: 27% (74 aa)

KIDKIDQKLSVMKSKQRPRRMAIYGTDGIRYTFLLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYELIK
 |  .|. . .. | |.|..... |.||  |  . | ..| | | | |.    ||..        .. . . || ||||  | . | || |  |.  ...
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

QRREKNNVPVEIEYQTTMKACPNFEQIEGADKMFAFKKGLSATKGDDLKAILLLNSSDSTHWIERRTAYTTSLSMTSMAGYILGLGDRHLSNIMIKNKTA
.  .   .  .      .. |      |  .|. .|.. |   .    .   .    |.. |   | .|  |    .| |||.||||||  ||.|.  . 
KLWKEKKQYMQFY---QLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING

KLVHIDFGDCFEVAQHREKAPEKVPFRLTRILTNALEVSRIEGTFRSCCENVMELIRNNGEQINGILEVF
 .||.|.   |   .  |  || ||||||. . ...   . .| ||  || .| ..|.. ..| .... |
ECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 89276.m00200.AA ATM 2006-2129 49 4.7e-43 135.18 In-house 129-251 (304) Show / Hide 
Range on Protein: 2006-2129
Range on HMM: 129-251/304
Sequence Identity: 49% (61 aa)

DSTHWIERRTAYTTSLSMTSMAGYILGLGDRHLSNIMIKNKTAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILTNALEVSRIEGTFRSCCENVMELIR
|   | |.| ||| |    |. ||||||||||  ||.|  . | ||||| |  ||  .     || ||||||| .   . .  .|| || |||  || .|
DPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP-TPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMR

NNGEQINGILEVFIYDPLAQWSEN
|  | .  | || .||||  |  |
NSQETLLTIVEVLLYDPLFDWTMN
Kinase 89276.m00200.AA FATC 2155-2187 69 1.7e-21 71.92 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2155-2187
Range on HMM: 1-33/33
Sequence Identity: 69% (23 aa)

EKLDVKEQVDRLIHEATDMKNLCQMWRGWFPWW
|.|.| .||||||.|||| .|||||. || |||
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 89276.m00200.AA DNAPK 2028-2128 34 2.6e-18 63.12 In-house 201-301 (301) Show / Hide 
Range on Protein: 2028-2128
Range on HMM: 201-301/301
Sequence Identity: 34% (35 aa)

GYILGLGDRHLSNIMIKNKTAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILTNALEVSRIEGTFRSCCENVMELIRNNGEQINGILEVFIYDPLAQWS
..||| ||||| | |.   .   . ||||  |  |      ||  ||||||  .| .    | | ...     |  .|          .||| ||.  | 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

E
 
N
Kinase 89276.m00200.AA DNAPK 1848-1946 34 2.8e-18 63.0 In-house 2-100 (301) Show / Hide 
Range on Protein: 1848-1946
Range on HMM: 2-100/301
Sequence Identity: 34% (34 aa)

IKIDKIDQKLSVMKSKQRPRRMAIYGTDGIRYTFLLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYEL
..|   | .  || |  ||.|. | | |     |. |  || |.| |. |||   |           . |   |||.||.|   | | || | ..  ..
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI
Kinase 89276.m00200.AA SMG1 2016-2070 47 2.6e-13 40.28 In-house 189-242 (242) Show / Hide 
Range on Protein: 2016-2070
Range on HMM: 189-242/242
Sequence Identity: 47% (26 aa)

AYTTSLSMTSMAGYILGLGDRHLSNIMIKNKTAKLVHIDFGDCFEVAQHREKAPE
.|  |  . || |||.||||||| |..|   |   ||||.  |||  .   ..||
SYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase 89276.m00200.AA SMG1 1857-1952 30 1.1e-10 31.45 In-house 1-98 (242) Show / Hide 
Range on Protein: 1857-1952
Range on HMM: 1-98/242
Sequence Identity: 30% (30 aa)

LSVMKSKQRPRRMAIYGTDGIRYTFLLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVTNCSTVYELIK--QRRE
. ..  | .|...   | ||  | .| |  ||  ||||.||    .| .                | | ||    | | ||     .. | |  | ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQRE
Kinase 89276.m00200.AA ATM 1882-1938 36 1.1e-07 20.22 In-house 3-59 (304) Show / Hide 
Range on Protein: 1882-1938
Range on HMM: 3-59/304
Sequence Identity: 36% (21 aa)

LLKAHEDTRLDERVMQLFGFINRLVNNSTIPMKQHLGITTYNVIPLTGQVGFIGWVT
| |  .| | |  . | |   | |.   |   |  | | || |.||    | . | |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT