Gene 85323.m00078 (T.vaginalis)

85323.m00078

Species: T.vaginalis
Alias: TvagK0287, 85323.m00078
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
85323.m00078.AA Protein None 1089 None Fasta, JSON
85323.m00078.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 85323.m00078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85323.m00078.AA TKL 226-471 24 6.1e-71 241.99 In-house 1-364 (364) Show / Hide 
Range on Protein: 226-471
Range on HMM: 1-364/364
Sequence Identity: 24% (90 aa)

LGSGGFGTVFMGTRIS--------TGELIAVKEVRSDKLSISTW-------------------------ASLYSEVANMANLKNRYVLELVGAHIKEP--
.||||||.|. |.           ||. .|||  .|.  . .|.                           .  |.  | .|.   .. ..|. . .|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YRIITRFCPGRSLFDRIHRCPQHPLPPARLTALAYQVASGMAFLHSNG--------IVHRDLKTMNILLDESDA--------------
            . |.. .||| ||....|        . ..  .|...|.||..|||..        |.|||||. |||.||                 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

ARIADFGLSGNMRDNKD--------------------LYGTLGTPHYTAPEVLARK----------------RYGPKVDSYSFGIVLWEMETGLIPFREK
. |.||||| .|  ...                    ..   ||| . |||||  .                 | .|.| |||||||||. |. .|... 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

THK---------EIIDHVVNRGWRLPLS------------RTVPDSLRRLITRCWSENPAERPEFEEIVALF
 .          |..  |...| |.|.              ..|.|...|...||...| .|| |.||.  .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase 85323.m00078.AA Pkinase 220-471 25 5.3e-66 230.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 220-471
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

IIVGKTLGSGGFGTVFMGTRISTGELIAVKEVRSDKLSISTWASLYS--EVANMANLKNRYVLELVGAHI--KEPYRIITRFCPGR----SLFDRIHRCP
. .|...|||.||.|. .....||.. |||... .. . . . ..    |.. |..|.  ....| ..    ...| ... .|.|     .|||.|..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWR

QHPL--PPARLTALAYQVASGMAFLHSNGIVHRDLKTMNILLDESDAA----RIADFGLSGN--MRDNKDLYGTLGTPHYTAPEVLA-RKRYGPKVDSYS
. ..  ..  .   .||...|....||.||.|||||  |||.|. .      .|.||||.       |  ...  |||.| ||||.  .. |||||| .|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGIVLWEMETGLIPFREK------THKEIIDHVVNRGWRLPLSRTVP-------------------DSLRRLITRCWSENPAERPEFEEIVAL--F
.|..|.|| .|  ||...      .....|. .  . .. . . . .                   .... .|..|.  .|..|| .|.|.    |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 85323.m00078.AA S_TKc 220-471 25 1.7e-62 214.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 220-471
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

IIVGKTLGSGGFGTVFMGTRISTGELIAVKEVRSDKLSISTWASLYSEVANMANLKNRYVLELVGAHIKEPYRIITRFCPG--RSLFDRIHRCPQHP---
  .....|.|.||.|. .. ..||.. |.|...          ....|.. . . .  ..  | ..   . . ... .|.|   .|||.|.... |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPPARLTALAYQVASGMAFLHSNGIVHRDLKTMNILLDESDAARIADFGLSGNMRDNKDLYGTLGTPHYTAPEVLARKRYGP-KVDSYSFGIVLWEMET
 .|. .   ..||........||.||.|||||  ||||||     |.||||.  .      .   |||.| |||||    ||. |.| .|.|..|.|| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GLIPFREKTHKEIIDHVVNRGWRLPLSRTVPDSLRRLITRCWSENPAERPEFEEIVA---------LF
|  ||.  ..........            ..... .| .|.  .|..||   |. .          |
GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase_Tyr 85323.m00078.AA Pkinase_Tyr 220-471 29 1.7e-62 212.32 Pfam 1-270 (270) Show / Hide 
Range on Protein: 220-471
Range on HMM: 1-270/270
Sequence Identity: 29% (79 aa)

IIVGKTLGSGGFGTVFMGTRI----STGELIAVKEVRSDKLSIST--WASLYSEVANMANL-KNRYVLELVGAHI--KEP--YRIITRFCPGRSLFDRIH
|. ||.||.| ||.|..||      .|.   ||| .  .. . .   .... .|.. | .| ..  .. |.|. .  .||  . |.. ..|. .| |  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RC--PQHPLPPARLTALAYQVASGMAFLHSNGIVHRDLKTMNILLDESDAARIADFGLSGNMRDNKDLY-----GTLGTPHYTAPEVLARKRYGPKVDSY
.   ...||.. .|   ..|.|.||..|.|....|||| . |.|..|.  ..|.||||.  .  |.| |     |.      .|||... ...  | | .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGIVLWEMET-GLIP-FREKTHKEIIDHVVNRGWRLPLSRTVPDSLRRLITRCWSENPAERPEFEEIVALF
|||...||. | | .| . . .  |.....  .| |.|  .  || . .|...|| ..|..|| |.||.  .
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc 85323.m00078.AA TyrKc 220-471 28 1e-59 205.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 220-471
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

IIVGKTLGSGGFGTVFMGTRISTGELIAVKEVRSDKLSISTWASLYSEVANMANL--KNRYVLELVGAHIK--------EPYRIITRFCPGRSLFDRIHR
|  ||.||.| ||.|. || .   .  ||| ...|.      . ...|   | .|  ..  .. |.|. ..        ||. |.. ..|. .| |....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CPQHPLPPARLTALAYQVASGMAFLHSNGIVHRDLKTMNILLDESDAARIADFGLSGNMRDN------KDLYGTL---GTP-----HYTAPEVLARKRYG
.  . |... |   ..|.|.||..|||....|||| . |.|..|   ..|.||||| .  |       || | .    |.        .|||..  ... 
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PKVDSYSFGIVLWEM-ETGLIPFRE-----KTHKEIIDHVVNRGWRLPLSRT--------VPDSLRRLITRCWSENPAERPEFEEIVALF
.| | .|||...||.   |  |  .     .. .|.| .| ... |.|             || . .....|| |.|..|| |.||. .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 85323.m00078.AA MLK 220-471 27 3.8e-59 202.81 In-house 1-291 (291) Show / Hide 
Range on Protein: 220-471
Range on HMM: 1-291/291
Sequence Identity: 27% (80 aa)

IIVGKTLGSGGFGTVFMGTRISTGEL-----IAVKEVRSDK----------LSISTWASLYSEVANMANLKNRYVLELVGAHIKEPYR--IITRFCPGRS
| . . .|||.|| |. |.    ...     .|||.||...            . . . . . .    |  . .. ...|. ...|.   |.. .|.| |
IQFHEWIGSGSFGKVWKGRWR--NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNN--HPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LFDRIHRCPQHPL------------PPARLTALAYQVASGMAFLHSNG---IVHRDLKTMNILLDE------SDAARIADFGLSGNMRDNKD-LYGTLGT
|.. .|  . ..             ... .   |.|.|.||..|||.    |.|||||  |||.||       . ..|.|||.|  . ....   .. ||
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGT

PHYTAPEVL---ARKRYGPKVDSYSFGIVLWEMETGLIPFR-EKTHKEIIDHVVNRGWRLPLSRTVPDSLRRLITRCWSENPAERPEFEEIVALF
. . ||||.      .|  |.| .|.|.||||| |. .|.. .    .|.  |.. | |.|.  | |... .|...||...|..|| | .||  .
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 85323.m00078.AA TK 220-471 15 2.9e-57 190.18 In-house 1-486 (486) Show / Hide 
Range on Protein: 220-471
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

IIVGKTLGSGGFG---TVFMGTRISTG-------------------------ELIAVKEVRSD-KLSISTWAS--------------LYSEVANMAN--L
|..||.||.| ||   .|..|. .. .                         .  ||| ....   |                    . .| . | .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KNRYVLELVG-AHIK------------EPYRIITRFCPGRS----LFDRIHRCP----------------------------------------------
.   .. |.|  . .            ||. |.. ..|. .    | |  ..|.                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------QHPLPPARLTALAYQVASGMAFLHSN------GIVHRDLKTMNILLDESDA-----------ARIADFGLSG
                            .|.|....|   ..|.|.||..|||.      ..||||| . |.|..|..            ..||||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

N------MRDNKDLYGTLGTPHY-----------------------------TAPEVLA---------RKRYGPKVDSYSFGIVLWEMET-G-LIPFREK
.       ....| . .  ....                             .|||.|.          ... .| | .|||...||. | |   .  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TH---------KEIIDHVVNR-----------GWRLPLS--RTVP--------------DSLRRLITRCWSENPAERPEFEEIVALF
..         .|.......            | |...      |              . . .|...||...|..|| |....  .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 85323.m00078.AA Dicty4 220-473 30 5.9e-56 185.18 In-house 1-277 (277) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-277/277
Sequence Identity: 30% (85 aa)

IIVGKTLGSGGFGTVFMGTRISTGELIAVKEV--RSDKLSISTWASLYSEVANMANLKNRYVLELVGAHI---KEP--YRIITRFCPGRSLFDRIHR---
| ... .|.|.||.|. |  .  |   |||    . .... ..  ..  ||. |... .  .. . || .    .|    | | ..|  .|.  .|    
INIEQRIGKGSFGEVYKG--TWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

--CPQHPLPPARLTA---LAYQVASGMAFLHS-N-GIVHRDLKTMNILLDESDAARIADFGLSG---NMRDNKD-LYGTLGTPHYTAPEVLARKRYGPKV
   .  .|.  . ..   .|  .| ||. ||. |  |.|||||. |.| |..  . ..|||||       |.|| . .. ||| ..||||.. ..|  |.
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DSYSFGIVLWEMETGLIPFR--EKTHKEIIDHVVNRGWRLPLSRTVPDSLRRLITRCWSENPAERPEFEEIVAL--FKK
| |||||||||. |. .|.    .   .... |.| . |.|..  .|.|...||..||...|  || ||||.       
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 85323.m00078.AA TKL-Unique 222-471 28 4.8e-54 185.86 In-house 1-290 (290) Show / Hide 
Range on Protein: 222-471
Range on HMM: 1-290/290
Sequence Identity: 28% (82 aa)

VGKTLGSGGFGTVFMGTRISTGELIAVKEVRSDKLSISTWASLYSEVANMANLK-NRYVLELVGAHI----KEP-YRIITRFCPGRSLFDRIHR------
.....|.||.|.|. |.  ..   | .... .|. ....   ...||  | .|.    .. ..|. .    ..| . |.. .||| || | .|.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMM-QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--CPQHPLPPARLTALAYQVASGMAFLHSNG--IVHRDLKTMNILLDES-----DAARIADFGLSGNMR-DNKDLYGTL---------GTPHYTAPEVLA
   . ..|....   .| ..|.|| .||...  | |||||. |.|.|.        ..|.||||| .   .||  ....         |.. . ||||| 
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

R--KRYGPKVDSYSFGIVLWEMETGLI------PFREKTHKEIIDHVVN--RGWRLPLSRTVPDSLRRLITRCWSENPAERPEFEEIVALF
.  . |  |.| |||||||||. |. |      |... ......  |    .. |.|..   | ..| ||..||  .| .|| |.||.   
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 85323.m00078.AA CAMK 225-467 17 2.3e-50 160.1 In-house 1-419 (425) Show / Hide 
Range on Protein: 225-467
Range on HMM: 1-419/425
Sequence Identity: 17% (73 aa)

TLGSGGFGTVFMGTRISTG------------ELIAVKEVRSDKLS--------------------------ISTWASLYSEVANMAN-------LKNRYV
|||.|.||.|. .....|.            .  |.| .  .||.                           .. .....|.. | .       |. . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELVGAHI--------------------KEPYRIIT---RFCPGR----SLFDRIHRCPQ-------------HPLPPARLTALAYQVASGMAFLHSNGI
. |  .                      .. . ...    .|.|      |||.| . ..             . .. .    .  |..|.....||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKTMNILLDESD----------------A-ARIADFGLSGNMRD------------------------NKDLYGTLGTPHYTA-PEVLARKR----
||||||  |||||...                .   |.|||..  ...                        .. ..   |||.| | |||| .|.    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGPKVDSYSFGIVLWEMETGLIPFREKTHKEIID-------------HVVNRGWRLP-----------------------LSRTVPDSLR
          ||||.|  | |..|  | .|  ||......||..              . .  .. |                        . .| .. .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECK

RLITRCWSENPAERPEFEEI
 || ..   .| .|.  |..
DLIRKMLQVDPEKRMTIEQC
Kinase 85323.m00078.AA CAMKL 221-468 28 4.4e-48 151.44 In-house 2-292 (297) Show / Hide 
Range on Protein: 221-468
Range on HMM: 2-292/297
Sequence Identity: 28% (83 aa)

IVGKTLGSGGFGTVFMGTR-ISTGELIAVKEVRSDKLSISTWAS-------------LYSEVANMANLK---NRYVLELVGAHIKEP-------YRIITR
..||||| |.||.| ..|  . |||  |.| .  .|..  .|..             .. |.. |  |.      .  |      .        . ... 
RIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVME

FCPGRS--LFDRIHRCPQ--HPLPPARLTALAYQVASGMAFLHSNGIVHRDLKTMNILLDESD--AARIADFGLSGNMRD-----NKDLYGTLGTPHYTA
 |.| .  |||.| . .    ..|.     .  |. |.....||.||||||.|  ||||||..   . |.|||.|  .|.     .. |    |.|.| |
YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMA

PEVLAR--K-RYGPKVDSYSFGIVLWEMETGLIPFREKT-------HKEIIDHVVNRGWRLP-LSRTVPDSLRRLITRCWSENPAERPEFEEIV
||....  |  .|||||  | |..|  | .|  ||.. |       ..    . ...|   |     |. ..|.|| .    || .||  ..|.
PEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM
Kinase 85323.m00078.AA STE 221-466 20 1.5e-47 164.32 In-house 1-350 (359) Show / Hide 
Range on Protein: 221-466
Range on HMM: 1-350/359
Sequence Identity: 20% (72 aa)

IVG-KTLGSGGFGTVFMGTRI------STGEL---------IAVKEVRSDKLS---------------ISTWASLYSEVANMANLK--NRYVLELVGAHI
  | . .|.|.||||. . ..      .|||.         .|.|... .. .               .. . ..  |.  | ...    .. .  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KEP--------YRIITRFCPGRSLFDRIH---RCPQ---------HPLPPARLTALAYQVASG-MAFLHSNGIVHRDLKTMNILLDESDAARIADFGLSG
||           |.  ...| || | |.    |..         |..|   . . ..|.  | ...|||..|.|||.|  ||||     . ..|||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

NMRD--------------------NKDLYGTLGTPHYTAPEVLAR------KRYGPKVDSYSFGIVLWEMETGLIPFREKTHK----------------E
.. |                    .. . ||     . ||||. .      | |. |.| .|.|....|| ||  |. . ..                 |
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

IIDHVVN-RGWRLPL-----------------SRTVPDSLRRLITRCWSENPAERPEFEE
 .  .||    .||                  .. . ....  | .|   .| .||  ..
QL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 85323.m00078.AA LRRK 220-473 23 5.2e-45 155.84 In-house 1-351 (351) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-351/351
Sequence Identity: 23% (83 aa)

IIVGKTLGSGGFG-TVFMGTRIS--------------------------TGELIAVKEVRSD--------------------------------KLSIST
.. .. .|.|||| .|. .. ..                           .. .|.|    |                                  ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

WASLYSEVANMANLKNRYVLELVGAHIKEPYRIITRFCPGRSLFDRIHRCPQHP-------LPPARLTALAYQVASGMAFLHSNG--IVHRDLKTMNILL
  ..  ||. | .|.  ... |.|  | .|..... . |  .| ...|   |..       ...  .  .|.|.|.||..|||.   |.|||||. ||||
FREFRHEVWIMSHLNHPNIVSLKGFCI-HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DESD------------AARIADFGLSG--NMRDNKDLYGTLGTPHYTAPEVLA---RKRYGPKVDSYSFGIVLWEMETGL-IPFREKT-H-----KEIID
 .|.             | |||||.|.      .. . | .|.| . |||..    .. |  ||| ||||..|||  |.. .||.| .        |.| 
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

HVVNRGWRLPLSRT-VPD-----SLRRLITRCWSENPAERPEFEEIVALFKK
  ...| | ... .  |      ..  ||. ||...| .|| |..||   . 
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 85323.m00078.AA UTK 220-365 28 9.3e-27 88.57 In-house 1-175 (296) Show / Hide 
Range on Protein: 220-365
Range on HMM: 1-175/296
Sequence Identity: 28% (50 aa)

IIVGKTLGSGGFGTVFMGTR--IS--TGE-LIAVKEVRSDKLSISTWA---SLYSEVA---NMANLK-NRYVLELVGAHIKE-PYRIITRFCPGRSLFD-
.. |..||.| ||.|.....  .|   .| . |||. .... .  . .    .  | .    |....  ..|| ||| . .| |  |.|..... .| . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

-RIHRC----PQHPLPPARLTALAYQVASGMAFLHSNGIVHRDLKTMNILLDES-------DAARIADFG---LS
 | ||     ..| |   ...  |...|.||..||| |.|||||   |.|....         ..|||||   .|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMS
Kinase 85323.m00078.AA UTK 384-471 36 4.4e-19 61.94 In-house 206-296 (296) Show / Hide 
Range on Protein: 384-471
Range on HMM: 206-296/296
Sequence Identity: 36% (33 aa)

TAPEVLARK-RYGPKVDSYSFGIVLWEM-ETGLIPFREKTHKEIIDHVVNRG-WRLPLSRTVPDSLRRLITRCWSENPAERPEFEEIVALF
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MAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM