Gene 96209.m00066 (T.vaginalis)

96209.m00066

Species: T.vaginalis
Alias: TvagK0347, 96209.m00066
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
96209.m00066.AA Protein None 1105 None Fasta, JSON
96209.m00066.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 96209.m00066.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96209.m00066.AA TKL 216-463 27 4.5e-92 312.19 In-house 1-364 (364) Show / Hide 
Range on Protein: 216-463
Range on HMM: 1-364/364
Sequence Identity: 27% (103 aa)

IASGGFGDVFLGVRVSDD--------TVVAVKRLHNQQFDKEGL-------------------------EMFKGEVAILAHLRHFAILPFVGACTKPP--
| ||||| |. |.    .        ..||||... .. |.. .                         . .. |. ..  |||  |..|.|.|. ||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIITKFMSGDSLFARLHAKDANSRLTPTQLSIIALGVAYGMQYLHSQN--------MVHRDLKSLNILLDEDNL-------------
            .||.. ...| ||. .||         . |.  .||..| ||.||||.|        ..|||||| |||.||..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKIADFGMARTKT-------------------SNNEMVSGGIGTSQWMAPEVLMSQ----------------NFDEKSDVYSYGIILWEMLTGDVPYRG
 .||.||| .|...                   .|... .  .|| .|||||||. |                 ..||.||||.||.|||.||. .||..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LRDIQVA---------MTVINQNNRPKIP------------KSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
.  ...          | |.. ..|| ||            ..||. ..| .  ||..||.||| |..|...|
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 96209.m00066.AA MLK 210-463 35 1e-91 311.04 In-house 1-291 (291) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-291/291
Sequence Identity: 35% (105 aa)

IKFQKKIASGGFGDVFLGVRVSDD---TVVAVKRLHNQQFDKEGL-----EMFKGEVAILAHLRHFA----ILPFVGACTKP-P-FCIITKFMSGDSLFA
|.|...| ||.||.|..|.    |    .||||| .   |   .      . |. |. .|..|.|      | .|.|.|..| . |||.. ...| ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLHAKDANSR-----------LTPTQLSIIALGVAYGMQYLHSQN---MVHRDLKSLNILLDE------DNLPKIADFGMARTKTSNNEMVSGGIGTSQW
 ||... ..             .. ..  .|| .| ||.||||.     .|||||| |||.||      .   ||.||| .| .... .   . .||  |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

MAPEVL---MSQNFDEKSDVYSYGIILWEMLTGDVPYR-GLRDIQVAMTVINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
|||||.    .. ..||.||.|.|..||||||. |||. ..  ...|. |.. ..|| ||..||  ..|..  ||..||||||.|  ||| |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 96209.m00066.AA TKL-Unique 212-463 34 1.7e-83 283.67 In-house 1-290 (290) Show / Hide 
Range on Protein: 212-463
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

FQKKIASGGFGDVFLGVRVSDDTVVAVKRLH-NQQFDKEGLEMFKGEVAILAHLR-HFAILPFVGACT----KPP-FCIITKFMSGDSLFARLH------
| .|| .||.| |. |.  ...  ||.|..| |  . .| .. |. || ..  |. |  |. ..|.|.    .|| .||.. ...| ||   ||      
FWNKIGEGGYGQVYKGKWRGYP--VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-AKDANSRLTPTQLSIIALGVAYGMQYLHSQN--MVHRDLKSLNILLDED-----NLPKIADFGMARTKTSNNEMVSGGI---------GTSQWMAPEVL
     |. |.. |   .|. .| || |||. .  . ||||||.|.|.|..     .  ||.||| .......|.| ....         |. .|||||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

MS--QNFDEKSDVYSYGIILWEMLTGDV------PYRGLRDIQVAMTVIN--QNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
..    ..|||||||.||.|||..|...      ||.|. ..|.. .|     | ||.|| .||... . |. |||.|| .|| |..|.  |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 96209.m00066.AA Dicty4 210-465 38 5.9e-82 273.13 In-house 1-277 (277) Show / Hide 
Range on Protein: 210-465
Range on HMM: 1-277/277
Sequence Identity: 38% (107 aa)

IKFQKKIASGGFGDVFLG-VRVSDDTVVAVKRL--HNQQFDKEGLEMFKGEVAILAHLRHFAILPFVGACT----KP-PFCIITKFMSGDSLFARLHA--
|.....| .|.|| |..| .| ..   |||| |  ||| || . |. |. ||.|.. .||  |. | ||||    .|  .|| | .|.  .|.  ||.  
INIEQRIGKGSFGEVYKGTWRGKE---VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

--KDANSRLT-PTQLS--IIALGVAYGMQYLHSQN--MVHRDLKSLNILLDEDNLPKIADFGMAR---TKTSNNEMVSGGIGTSQWMAPEVLMSQNFDEK
  .  .  |  |. ..   .|. .| ||..||. |   .|||||| |.| |...  |..||| ..   . ....   .. .||  ||||||.|.| ..||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

SDVYSYGIILWEMLTGDVPYR--GLRDIQVAMTVINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQT--LET
.||||.||.|||.||.. ||   .    |..  | |  .||.||..|| .... |  ||. || .|| |  |.|   ||.
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 96209.m00066.AA TyrKc 210-463 30 1.7e-75 258.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-280/280
Sequence Identity: 30% (87 aa)

IKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFDKEGLEMFKGEVAILAHL--RHFAILPFVGACTK--------PPFCIITKFMSGDSLFARLHA
|.. ||. .| || |..|.     . |||| |..       .|.|  |  |. .|  .|  |. ..|.||.        .| .|.. .|.. .|  .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KDANSRLTPTQLSIIALGVAYGMQYLHSQNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSN-------NEMVS----GGI--GTSQWMAPEVLMSQNF
.  .  |.. .|  ... .| ||.||||.| .||||   |.|..|..  ||.|||..|  ..           ..    ||       |||||...   |
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DEKSDVYSYGIILWEMLT-GDVPYRGL----RDIQVAMTVINQNNRPKIPKS--------CPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
 .||||.|.|. .||..| |. || |      . | ..  . | .|...|..        ||. . . .. ||| ||..|| |..|.. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 96209.m00066.AA Pkinase_Tyr 210-463 33 2.3e-74 252.5 Pfam 1-270 (270) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-270/270
Sequence Identity: 33% (91 aa)

IKFQKKIASGGFGDVFLGVRV----SDDTVVAVKRLHNQQFDKEG--LEMFKGEVAILAHL-RHFAILPFVGACT--KPP--FCIITKFMSGDSLFARLH
|.| ||. .| ||.|..|.      .... |||| | ... ..|   .|.|  |..|. .| .|  |. ..|.||  . |   .|.. .| . .|   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AK-DANSRLTPTQLSIIALGVAYGMQYLHSQNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSNNEM-VSGGIGTS--QWMAPEVLMSQNFDEKSDVYS
.. . . .||. .|  ... .| ||.||.|.|..||||   |.|..|.|  ||.|||.||. ..  .  ...| |     |||||...   | .||||.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIILWEMLT-GDVP-YRGLRDIQVAMTVINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
.|. .||..| |. | | |. . .|   .  ...| ..|. ||. . . ...||| || .|| |. |.. |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 96209.m00066.AA HH498 210-463 34 7.8e-73 230.14 In-house 1-284 (284) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-284/284
Sequence Identity: 34% (98 aa)

IKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFDKEGL------EMFKGEVAILAHLRHFAILPFVGACTKPP--FCIITKFMSGDSLFARL----
|.|..|| || ||.|..|       .|||||   . |   .        ||  || |.  | |.    ||.||   |  | |.| . .. ||| .|    
IEFHEKIGSGSFGKVYKGEWR--NKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

----------HAKDANSR-LTPTQLSIIALGVAYGMQYLHS---QNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSNNEMVSGG-IGTSQWMAPEVLM
          |    | | . .    .|.. || ||.|||.   .  .|||| | |||..||   ..||||  | . .  .      .|   ||||||  
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFS

-SQNFDEKSDVYSYGIILWEMLTGDVPYRGLRDIQVAMTVINQNNRPKIPKS----CPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
 .| ...| ||.||....|||.|. ||.  .  .  |  . ..  || || .     |.     |  |||  |  ||||  ||  |
QCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 96209.m00066.AA Dicty4-Unclassified 210-463 37 5.1e-70 238.94 In-house 1-263 (263) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-263/263
Sequence Identity: 37% (100 aa)

IKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFD--KEGLEMFKGEVAILAHLRHFAILPFVGACTKP-----PFCIITKFMSGDSLFARLH----
|.  . |  | |  |  |.    |  |||| .   .|    | .. || ||.||  . |   .   |.|  |      .||.. ||    ||   |    
IQIDQFIGKGHFSKVHKGNWKGKD--VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

AKDANSRLTPTQLSIIALGVAYGMQYLHSQNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSNNEMVSGGIG-TSQWMAPEVLMSQNFDEKSDVYSYGI
 ..   .|  |    .|. .| |||.||. |..|||.|| |||.| ..  ||||||..|    |  |    |. |  | .||.||   .  |||||||..
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTT--IAGTPKWESPECLMHESYNQKSDVYSYAM

ILWEMLTGDVPYRGLR-DIQVAMTVINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTL
.|.|..||| || .    . .|  |     ||||| .|. .. | |  ||| || ||| .  |.| |
MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 96209.m00066.AA Pkinase 210-463 25 1.3e-68 239.05 Pfam 1-293 (293) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-293/293
Sequence Identity: 25% (74 aa)

IKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFDKEGLEMFKG--EVAILAHLRHFAILPFVGAC-TKPPFCIITKFMSGD----SLFARLH--AK
... .|| ||.|| |........  .||||..  .  ... ..      |..|...|.|  |. . ... .|.  .... .. |.    .||....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DANSRLTPTQLSIIALGVAYGMQYLHSQNMVHRDLKSLNILLDEDNLP----KIADFGMARTK-TSNNEMVSGGIGTSQWMAPEVLM-SQNFDEKSDVYS
 . . ... ..  ... .. |..|.||.. .|||||. |||.|... .    ||.||| |. . . ||.  ..  ||. .|||||.. .|  . |.|..|
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

YGIILWEMLTGDVPYRGL------RDIQVAMTVINQNNRPKIPKSCP-------------------QNLAKFIRLCWHSDPHKRPDFTTIVQT--L
.|.||.|||.|  |..|       ...|.   .    ..  .|..|.                   ... .||. |.. ||.||| .. |.|   .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 96209.m00066.AA TK 210-463 19 3.9e-68 227.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 210-463
Range on HMM: 1-486/486
Sequence Identity: 19% (95 aa)

IKFQKKIASGGFG---DVFLGVRVSDD-------------------------TVVAVKRLHNQ-QFDKEGLEM--------------FKGEVAILAH--L
|.. ||. .| ||   .|..|   ...                         | |||| |.     ..|  ..              .  | ... |  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHFAILPFVGACTK-------------PPFCIITKFMS-GD---SLFARLHAKDA---------------------------------------------
.|  |. ..|.||.             .|..|.. .|. ||   ||   |....                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NSRLTPTQLSIIALGVAYGMQYLHSQ------NMVHRDLKSLNILLDEDNL-----------PKIADFG---
                            ...||. ||  ... .| ||.||||.      |.|||||   |.|..|.|             ||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MARTKTSNNEMVSGGIGTSQ--------------------------WMAPEVLMSQ---------NFDEKSDVYSYGIILWEMLT-GDVPYRGLR
     .||   |. . .. . ..                            |||||.|...          | .||||.|.|. .||..| |..|| |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DI---------QVAMTVINQN--------------NRPKIPKSCP--------------QNLAKFIRLCWHSDPHKRPDFTTIVQTL
.          |  |  . .               .|.. |. ||              . .. ... ||| || .||.|..... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 96209.m00066.AA RAF 210-465 30 1.6e-63 204.76 In-house 1-282 (282) Show / Hide 
Range on Protein: 210-465
Range on HMM: 1-282/282
Sequence Identity: 30% (88 aa)

IKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFDKEGLEM---FKGEVAILAHLRHFAILPFVGACTKPP---FCIITKFMSGDSLFARLHAKDAN
.. ...| || || |. |    |   ||||.|  ..   | .     || |||..   ||  || | |  .||    . |.|..  . ||. ..| ..  
VMVMTRIGSGSFGTVYRGHWHGD---VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETR

SRLTPTQLSIIALGVAYGMQYLHSQNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSNN----EMVSGGIGTSQWMAPEVLM--------------SQN
 ..   .|  |.. |. || |||. | .|||||| ||.|.||.  || |||... ||  .    . .    .   ||||||                   
EKFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP

FDEKSDVYSYGIILWEMLTGDVPY---RGLRDIQVAMT--VINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTLET
.  .|||||.||...|..|.  ||      ||  . |      .  . |. . ||. . . .  || ... .|| |  |..... 
YSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase 96209.m00066.AA LRRK 210-465 26 1.6e-62 214.0 In-house 1-351 (351) Show / Hide 
Range on Protein: 210-465
Range on HMM: 1-351/351
Sequence Identity: 26% (94 aa)

IKFQKKIASGGFG-DVFLGVRVSD--------------------------DTVVAVKRLHN--------------------------------QQFDKEG
.|....| .||||  |. .   .                           .. ||.| ..                                  ..  . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LEMFKGEVAILAHLRHFAILPFVGACTKPPFCIITKFMSGDSLFARLHAKDANS------RLTPTQLSIIALGVAYGMQYLHSQN--MVHRDLKSLNILL
.  |  ||.|. ||.|  |.. .| | . |.|... ...  .|  .||.|  ..      ..... .  ||| .| ||.||||.|   .|||||| ||||
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DEDNLP------------KIADFGMAR-TKTSNNEMVSGGIGTSQWMAPEVLMSQ---NFDEKSDVYSYGIILWEMLTGD-VPYRGLR--D----IQVAM
 . . .            ||||||  |  ..  .. ..|  |. .|||||..      ...||.|.||.|.|||| ||..  |....   |    .    
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

TVINQNNRPKIPKS-CPQ-----NLAKFIRLCWHSDPHKRPDFTTIVQTLET
  |.   ||.|| . ||.      . . | .||. || ||| |..||..|..
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 96209.m00066.AA DRK 210-465 37 1.4e-61 207.29 In-house 1-258 (258) Show / Hide 
Range on Protein: 210-465
Range on HMM: 1-258/258
Sequence Identity: 37% (98 aa)

IKFQKKIASGGFGDVFLGV-RVSDDTVVAVKRLHNQQFD-KEGLEMFKGEVAILAHLRHFAILPFVGACTKPP-FCIITKFMSGDSLFARLHAKDANSRL
|| .  |  |..|.||.|  |    | ||||.| |   .  . |  |. |. ..  |||  |  | |.|. ||  ||.. .|.  ||   ||  |    .
IKIGNRIGRGNYGEVFRGTWR---GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH--DESIEM

TPTQLSIIALGVAYGMQYLHSQN--MVHRDLKSLNILLDEDNLPKIADFGMAR--TKTSNNEMVSGGIGTSQWMAPEVLMSQNFDEKSDVYSYGIILWEM
    .  ... .| || |||. |   .|||||| | | ||    |.|||| .    |          .||  | ||||| .| . || ||||..|.|||.
DWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC

LTGDVPYRGLRDIQVAMTVINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQTLET
.|   || |    || . |     || .|. ||   .. .  ||  ||  || .  ... || 
VTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 96209.m00066.AA S_TKc 210-468 26 3.5e-55 190.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 210-468
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

IKFQKKIASGGFGDVFLGVRVSDDTVVAVKRLHNQQFDKEGLEMFKGEVAILAHLRHFAILPFVGACTKPPFCIITKFMSG--DSLFARLHAKDA---NS
 .. .|| .|.|| |.... .... .||.|...         |... |..|| . .|  |  . ...    ..... ...|   .|| ... .     ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

RLTPTQLSIIALGVAYGMQYLHSQNMVHRDLKSLNILLDEDNLPKIADFGMARTKTSNNEMVSGGIGTSQWMAPEVLMSQNFDE-KSDVYSYGIILWEML
.... .   ..  .. ...|.||.. .|||||  ||||||    ||.|||.||         .  .||  .||||||    ..  |.|..| |.||.|||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGDVPYRGLRDIQVAMTVINQNNRPKIPKSCPQNLAKFIRLCWHSDPHKRPDFTTIVQ----TLETGTI
.|  |..   ..|. . .|            .. .  ||| |.. || |||    . |          .
CGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF