Gene 94687.m00127 (T.vaginalis)

94687.m00127

Species: T.vaginalis
Alias: TvagK0116, 94687.m00127
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
94687.m00127.AA Protein None 385 None Fasta, JSON
94687.m00127.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of 94687.m00127.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94687.m00127.AA CAMK 60-268 17 6.8e-38 119.18 In-house 76-425 (425) Show / Hide 
Range on Protein: 60-268
Range on HMM: 76-425/425
Sequence Identity: 17% (60 aa)

KDIESQVGILGSLS-------HPNIQNLYDVIIE-------------------NDDLYAIY-------------D-------KEFFSLES----IIDKNA
| ... . |. .|.       |||| .||.|.                     ....| .              |       .. .. |     |. .. 
KNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERG

KLSENLSRQIFFHILSAIIYLHSQKIVHLDINPDNIFFNKR-----------------NIAFLGSFFKASRVSE------------------------NS
...|   |..|  |.||. |.||..|||.|. |.|| ....                 |   .  |  | .. .                        . 
RFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ

TFINPPGVANFMP-PEVFTG-------------KPYDPYKVDVWSLGITLLLCLTNTTPYEAD-------------TYEGVVHLINTTDPI-IESF----
 .  . |   .|. |||. |             |||...|.|.||.|. |  .|. . |...|             ...   . | . .   ....    
KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPI

-------------------IPQGAKDVLNACFKRNPAERPTAAEIFQMPWV
                   . | .|| .. . ...| .|.|.... . ||.
SCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 94687.m00127.AA Ciliate-E2 55-268 18 2.3e-37 125.81 In-house 62-365 (365) Show / Hide 
Range on Protein: 55-268
Range on HMM: 62-365/365
Sequence Identity: 18% (60 aa)

NLLSIKDIESQVG----------ILGSLSHPNIQNLYDVIIENDDLYAIYDKEFFSLESIID---------------KNAKLSENLSRQIFFHILS----
.......|  ..           || .|.|||| ..|.. .|.|| .  .  |...  .  |               .  ...|.  ..|. .||.    
QIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKT

-----------AIIYLHSQK-IVHLDINPDNIFFNKRNIAFLGSFFKASRVSEN----------STFINPP-----------------------GVANFM
           |. ||||.. |.| || |.||.|      ..  |  . .....            ...                         | ...|
KAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM

PPEVFTGKPYDP--------YKVDVWSLGITLLLCLTNTTPYEADTYEGVVHLINTTDPIIESF--------------------IPQGAKDVLNA----C
.||.. ||.||         ||.|.||||..|  .|.. .|.          ...  .  |. .                    ..| .|| ..     .
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM

FKRNPAERPT-AAEIFQMPWV
....| .|.| . .|.. || 
LQKDPEKRITGWEQILNHPWF
Kinase 94687.m00127.AA Ciliate-E2-Unclassified 68-268 21 3.7e-35 119.4 In-house 74-352 (352) Show / Hide 
Range on Protein: 68-268
Range on HMM: 74-352/352
Sequence Identity: 21% (61 aa)

ILGSLSHPNIQNLYDVIIENDDLYAIYDK-EFFSLESIIDKNAK-----------------LSENLSR-----QIFFHILSAIIYLHSQK-IVHLDINPD
|| .. ||.| .....    . .| .... |  .|. .| |. |                 ..|. ..     ..| .||... |||... |.| || |.
ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPE

NIFFNKRN---IAFLGSFFKASRVSEN---------------STFINPP-GVANFM----PPEVFTGKPYDP---YKVDVWSLGITLLLCLTNTTPYEAD
||.|.. .      .  |. ...  .|               .  ..   |  |.|    .|||. |. ||    ||.|.||||. |  .|... |... 
NILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN

TYEG----------------VVHLINT--TDPIIESF------IPQGAKDVLN----ACFKRNPAERPTAAEIFQMPWV
..|                 .   |.   ..   ...      ... ||| .|     ..| || .|.|. .|.. || 
NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
S_TKc 94687.m00127.AA S_TKc 29-268 23 2.5e-23 84.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-268
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

YQK------------YLASKGNDIKEQFTGYRF----IRLTSNLLSIKDIESQVGILGSLSHPNIQNLYDVIIENDDLYAIYDKEFF---SLESIIDKNA
|..            |.. . .      || ..    |.        ..|.. . || .  |||| .||||. . |.|| . .       .| ..|.|. 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

K------LSENLSRQIFFHILSAIIYLHSQKIVHLDINPDNIFFNKRNIAFLGSFFKASRVSENSTFINPPGVANFMPPEVFTGKPYDPYKVDVWSLGIT
.      ..|   | ..  |..|. |.||..|.| |. |.||....     .. |  | ..          |  ..|.|||.   .|.. |.|.||.|..
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LLLCLTNTTPYEADTYEGVVHLINTTDPIIESFIPQGAKDVLNACFKRNPAERPTAAEIFQ-------MPWV
|  .|.  .|..  ... . ..|           .. ||| .. |....|..|||| |..|       .||.
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94687.m00127.AA SNRK 74-268 28 3.7e-23 72.44 In-house 57-254 (254) Show / Hide 
Range on Protein: 74-268
Range on HMM: 57-254/254
Sequence Identity: 28% (56 aa)

HPNIQNLYDVIIENDDLYAIY---D-KEFFSLESIIDKNAKLSENLSRQIFFHILSAIIYLHSQKIVHLDINPDN-IFFNKRNIAFLGSFFKASRVSENS
||||  ||.||     || |    |  ...    |.  .  |.|.| |. |  |. || | |  ..|| |. |.| .||.|  .  |  |  . .     
HPNIVRLYEVIDTQTKLYLILELGDGYDMYDY--IMKHEKGLCEDLARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGE

TFINPPGVANFMPPEVFTGKPYDPYKVDVWSLGITLLLCLTNTTPYEADTYEGVVHLINTTDPIIESFIPQGAKDVLNACFKRNPAERPTAAEIFQMPWV
      |   .  ||.  |  ||   ||.||||. | . .    |..       .  |      . . . .. .|...   .|.|  | .  ||   .||
KLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase 94687.m00127.AA CAMKL 178-268 28 4.4e-23 70.37 In-house 198-297 (297) Show / Hide 
Range on Protein: 178-268
Range on HMM: 198-297/297
Sequence Identity: 28% (29 aa)

NFMPPEVFTG--KPYDPYKVDVWSLGITLLLCLTNTTPYEADTY-------EGVVHLINTTDPIIES---FIPQGAKDVLNACFKRNPAERPTAAEIFQM
..|.||.| |  |||| .|||.||.|..|   .. . | ..|||           .... ..   .    ...  ..| .    ..|| .|||. .| . 
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWV
||.
PWM
Kinase 94687.m00127.AA STE 100-268 20 6.8e-22 74.18 In-house 123-359 (359) Show / Hide 
Range on Protein: 100-268
Range on HMM: 123-359/359
Sequence Identity: 20% (51 aa)

SLESIIDKN--------------AKLSENLSRQIFFHILSA-IIYLHSQKIVHLDINPDNIFFNKRNIA---FLGSFFK--------------ASRVSEN
||..||...               ...|.. . | . || .   ||||..|.| || |.||..    ..   . |.. .              .......
SLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKR

STFINPPGVANFMPPEVFTG------KPYDPYKVDVWSLGITLLLCLTNTTPYEADTYEGVVHLIN----------------TTDPIIES----------
 ||.  |    .| ||| ..      |.|| .|.|.||||.|..  .|   |.   ..  .  .|.                 . | ...          
NTFVGTP----WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISY

---------FIPQGAKDVLNACFKRNPAERPTAAEIFQ--MPWV
            .  || .| |....| .|||| .  .   |..
GGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 94687.m00127.AA MARK 179-268 34 3.4e-20 62.88 In-house 171-262 (262) Show / Hide 
Range on Protein: 179-268
Range on HMM: 171-262/262
Sequence Identity: 34% (32 aa)

FMPPEVFTGKPYDPYKVDVWSLGITLLLCLTNTTPYEADT--YEGVVHLINTTDPIIESFIPQGAKDVLNACFKRNPAERPTAAEIFQMPWV
.|.||.| .|||| .|||.||||. |   .. . |...||  |.     |.. .. | .... .... ..  .. || ||||. || . ||.
YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 94687.m00127.AA Pkinase 178-268 23 4e-19 68.69 Pfam 176-293 (293) Show / Hide 
Range on Protein: 178-268
Range on HMM: 176-293/293
Sequence Identity: 23% (28 aa)

NFMPPEVFTGKPYDPYKVDVWSLGITLLLCLTNTTPYEAD------TYEGVVHLINTTDPIIESFIP---------------------QGAKDVLNACFK
..|.|||  | .|...|||.||.|..|   |.  .|.  .      .   .. .|  ...  ... .                     . .||... |..
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

RNPAERPTAAEIFQMPWV
..|..||||..|.| ||.
KDPKKRPTAEQILQHPWF
Kinase 94687.m00127.AA ULK 179-268 23 9.4e-17 55.09 In-house 217-329 (329) Show / Hide 
Range on Protein: 179-268
Range on HMM: 217-329/329
Sequence Identity: 23% (27 aa)

FMPPEVFT----GKPYDPYKVDVWSLGITLLLCLTNTTPYEADTYEGVV-----HLINTTDPI--------IE-------SFIPQGAKDVLNACFKRNPA
.| |...     .|||. ||.|.||||. .  .|.. .|..|  ..  .      ||| ..|.        ..         | .  || .  ...... 
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

ERPTAAEIFQMPWV
.| .  |.|..||.
DRISWEELFNHPWF
Kinase 94687.m00127.AA ULK 179-268 20 7e-15 49.29 In-house 213-324 (324) Show / Hide 
Range on Protein: 179-268
Range on HMM: 213-324/324
Sequence Identity: 20% (23 aa)

FMPPEVFT----GKPYDPYKVDVWSLGITLLLCLTNTTPYEADTYEGVVH--------------LINTTDPIIE---SFIP--QGAKDVLNACFKRNPAE
.| |...     .|||. ||.|.||||. .  .|.. .|.... ..  ..              .|...   .    . ..  .  || .  ...... .
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD

RPTAAEIFQMPWV
| .  |||..||.
RISWEEIFNHPWF
Kinase 94687.m00127.AA RSK 177-268 24 4.6e-14 48.1 In-house 172-278 (278) Show / Hide 
Range on Protein: 177-268
Range on HMM: 172-278/278
Sequence Identity: 24% (26 aa)

ANFMPPEVFT---GKP-YDPYKVDVWSLGITLLLCLTNTTPYEA---DTYEGVVHLINTTD--PIIE--SFIPQGAKDVLNACFKRNPAERPT-----AA
...|.||. .   ..  .|   .|.||||. .   ||  .|. .   .. . .   | . .  . ..  ... | ||| ......|.|. |..     |.
IEYMAPEMLKRANQQGGHDK-ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAE

EIFQMPWV
|| | || 
EIKQHPWF
Kinase 94687.m00127.AA ULK 62-153 27 5.1e-13 41.86 In-house 57-184 (329) Show / Hide 
Range on Protein: 62-153
Range on HMM: 57-184/329
Sequence Identity: 27% (35 aa)

IESQVGILGSLS--------HPNIQNLYDVIIENDD--LYAIYD-KEFFSLESIIDKNAK----------LSENLSRQIFFHILSAIIYLHSQKIVHLDI
... . |.  |         ||||  |||.  . ..  .| |..  .   ||..| || |          |||.  .|.| .||..  .||...|.| ||
LKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDI

NPDNIFFNKRN---------------IA
 |.||  .. .               ||
KPQNILIHNGQPKTDSKKVHPNGVLKIA
Kinase 94687.m00127.AA ULK 59-153 26 3.6e-12 39.53 In-house 54-180 (324) Show / Hide 
Range on Protein: 59-153
Range on HMM: 54-180/324
Sequence Identity: 26% (34 aa)

IKDIESQVGILGSLS---HPN--IQNLYDVIIENDD--LYAIYD-KEFFSLESIIDKNAK---------LSENLSRQIFFHILSAIIYLHSQKIVHLDIN
.. ... . |.  |    |||  |  |||.  . ..  .| |..  .   ||..| || |         |||.  .|.| .|...  .||...|.| || 
WQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIK

PDNIFFNKRN---------------IA
|.||  .. .               ||
PQNILIHNGQPKTDSKKVHPNGVLKIA
Kinase 94687.m00127.AA CAMKL 66-152 33 3.5e-11 31.8 In-house 63-168 (297) Show / Hide 
Range on Protein: 66-152
Range on HMM: 63-168/297
Sequence Identity: 33% (36 aa)

VGILGSLS---HPNIQNLYDVI------IENDDLYAIYDKEFFS-----LESIIDKN----AKLSENLSRQIFFHILSAIIYLHSQKIVHLDINPDNIFF
. |. .|.   ||||  ||.||      ||....| .   |  |     |   |.|.     ...|.  |..|  |.||. |.||..||| || |.|| .
IQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM--EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL

NKRN---I
 ...   |
DENGNNNI
Kinase 94687.m00127.AA Pkinase 66-151 27 1.9e-10 38.01 Pfam 51-145 (293) Show / Hide 
Range on Protein: 66-151
Range on HMM: 51-145/293
Sequence Identity: 27% (26 aa)

VGILGSLSHPNIQNLYDVIIENDDLY---AIYDKE--FFSLESIID--KNAKL--SENLSRQIFFHILSAIIYLHSQKIVHLDINPDNIFFNKRN
. |. .|.||||  |||.  ..|..|      ..    ..| ..|   .. ..  ||.  . ..  ||... |.||..|.| |. |.||......
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG
Kinase 94687.m00127.AA MARK 100-145 43 2.9e-09 26.62 In-house 88-135 (262) Show / Hide 
Range on Protein: 100-145
Range on HMM: 88-135/262
Sequence Identity: 43% (21 aa)

SLESIIDKN--AKLSENLSRQIFFHILSAIIYLHSQKIVHLDINPDNI
.| . | .    .|.|.. |.||  |.||. |.||. ||| || |.||
ELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENI
TyrKc 94687.m00127.AA TyrKc 47-271 15 2e-06 -118.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-271
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

YRFIR-----------------------LTSNLLSIKDIESQVGILGSL--SHPNIQNLYDVIIEN-------DDLYAIYD-KEFFSLESIIDKNAK-LS
 ....                       | ..   ..|. .   |. .|  .|||| .|| |...        . |. .    .  .| . . |. . |.
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

ENLSRQIFFHILSAIIYLHSQKIVHLDINPDNIFFNKRNIAFLGSF----FKASR----VSENSTFI----NPP--GVANFMPPEVFTGKPYDPYKVDVW
     .. . | .   ||||....| |.   |.  ......  . |    .  .     .|.         .         |.||..  . . . | |||
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVW

SLGITL--LLCLTNTTPYEA-----DTYEGVVHLINTT--DPIIESF-------IPQGAKDVLNACFKRNPAERPTAAEIFQMPWVQSY
| |...  .. .   .||.       . . |.... .    |. ..         |.   ..   | ...|..||| .||     ..  
SFGVCMWEIFTYG-QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 94687.m00127.AA RSK 111-151 31 3e-06 19.19 In-house 101-141 (278) Show / Hide 
Range on Protein: 111-151
Range on HMM: 101-141/278
Sequence Identity: 31% (13 aa)

LSENLSRQIFFHILSAIIYLHSQKIVHLDINPDNIFFNKRN
.||.  ....  | .|. .||.|.|.| |. |.|| .. ..
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES
Kinase 94687.m00127.AA MARK 58-84 37 0.020209 3.92 In-house 42-68 (262) Show / Hide 
Range on Protein: 58-84
Range on HMM: 42-68/262
Sequence Identity: 37% (10 aa)

SIKDIESQVGILGSLSHPNIQNLYDVI
..| ... . |. .|.||||  |..||
WMKNVMREIEIMKKLDHPNIIKLFHVI
Kinase 94687.m00127.AA STE 59-91 21 0.347255 0.09 In-house 72-113 (359) Show / Hide 
Range on Protein: 59-91
Range on HMM: 72-113/359
Sequence Identity: 21% (9 aa)

IKDIESQVGILGSLS--HPNIQNLYDVIIEN-------DDLY
...|.  . |.  ..  |||| . |.  . .       |.|.
MQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELW