Gene 85335.m00147 (T.vaginalis)
85335.m00147
Species: T.vaginalis
Alias: TvagK0827, 85335.m00147
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 85335.m00147.AA | Protein | None | 281 | None | Fasta, JSON |
| 85335.m00147.kin_dom | Protein Kinase Domain | None | 186 | None | Fasta, JSON |
Protein domains of 85335.m00147.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | 85335.m00147.AA | S_TKc | 14-240 | 21 | 1.9e-15 | 49.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-240
Range on HMM: 1-231/231
Sequence Identity: 21% (55 aa)
LAYKRIITSTKYGKVFLVEWLKYNQMFSLQKIERSHYEQNAINIIRNLYHFNVIKVYKTYMREKFVYLLMDYCPF---DVKRYIEERGI------LSESR
|.| . .|||... . | .. . . .| .. |.| .. | |..| | .. ...|. |.||. |...||..|| ..| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H
FAEAAYYMIQSIRSMHSKRICHNSIRPSKFLVDKYGRVQISKFNHAVQYKNTEEKEF------------KHAK-SVDVWGLGVTFYFMLTGRLITDLYFD
. .| ... . .||..|.| . |. |.|. .. |. | | |. . | .. | ..|.| .|...| ||.|. .
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP----
EEIAMTKVFSHIIFPSNVSNECIHLITACLNNNEKSRASLDNLLE-------SPLF
.. .| |. | |....| ||. . . | . .|. | |
QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 85335.m00147.AA | Ciliate-E2 | 165-240 | 22 | 1.1e-12 | 39.83 | In-house | 275-365 (365) | Show / Hide |
Range on Protein: 165-240 Range on HMM: 275-365/365 Sequence Identity: 22% (22 aa) KSVDVWGLGVTFYFMLTGRLITDLYFDEEIAMTKVFS-HIIFP------------------SNVSNECIHLITA----CLNNNEKSRAS-LDNLLESPLF ...|.| |||..|.||.|.. . . | || ..|.||..|| .|. ... | . . .|. | | YKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | 85335.m00147.AA | Pkinase | 165-240 | 20 | 1.2e-12 | 45.86 | Pfam | 191-293 (293) | Show / Hide |
Range on Protein: 165-240 Range on HMM: 191-293/293 Sequence Identity: 20% (21 aa) KSVDVWGLGVTFYFMLTGRLITD----------LYFDEEIAMTKVFSHIIFPSNVS-----------------NECIHLITACLNNNEKSRASLDNLLES ..||.|..|...| ||.||.. . .. ..| .... ... ....| ||...|. ||. . |.| . . .|.. PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH PLF | | PWF |
|||||||||
| Kinase | 85335.m00147.AA | Ciliate-E2-Unclassified | 157-240 | 17 | 1.5e-11 | 36.4 | In-house | 239-352 (352) | Show / Hide |
Range on Protein: 157-240 Range on HMM: 239-352/352 Sequence Identity: 17% (20 aa) EEKEFKHA--KSVDVWGLGVTFYFMLTGRLITD---------------------LYFDEEIA-MTKVFSHII--FPSNVSNECIHLIT----ACLNNNEK .... | ...|.|.||| .|.||.|.. . .... .. ...... .| ..|.|....|. .|..| . QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPN SRASLDNLLESPLF .| ... .|. |.| KRITFEQILNHPWF |
|||||||||
| Kinase | 85335.m00147.AA | CAMKL | 159-240 | 22 | 4.5e-11 | 31.44 | In-house | 209-297 (297) | Show / Hide |
Range on Protein: 159-240 Range on HMM: 209-297/297 Sequence Identity: 22% (21 aa) KEFKHAKSVDVWGLGVTFYFMLTGRLITDLY-------FDEEIAMTKVFSHIIFPS---NVSNECIHLITACLNNNEKSRASLDNLLESPLF .. ... ||.| .||. |.|..|.| | .. . |. .. .| || .|..|| |. | . |........ | . NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | 85335.m00147.AA | AGC | 163-240 | 18 | 9.1e-11 | 22.55 | In-house | 280-395 (395) | Show / Hide |
Range on Protein: 163-240
Range on HMM: 280-395/395
Sequence Identity: 18% (21 aa)
HAKSVDVWG--LGVTFYFMLTG----------------RLITDLYFDEEIAMTKVFSHIIFP----------SNVSNECIHLITACLNNNEKSRAS----
. |..| |. ||. .| |||| | ... .. . . . . || ...|.|. .||. .|. . . |
YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGN
------LDNLLESPLF
. . . | |
DFGDKGAEEIKNHPWF
|
|||||||||
| Kinase | 85335.m00147.AA | SNRK | 164-240 | 31 | 9.3e-11 | 31.18 | In-house | 178-254 (254) | Show / Hide |
Range on Protein: 164-240 Range on HMM: 178-254/254 Sequence Identity: 31% (24 aa) AKSVDVWGLGVTFYFMLTGRLITDLYFDEEIAMTKVFSHIIFPSNVSNECIHLITACLNNNEKSRASLDNLLESPLF | ||.| ||| | .. |.. . | | . |. ||.|| ||. | . | ||||... ... APAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV |
|||||||||
| Kinase | 85335.m00147.AA | ULK | 167-240 | 29 | 3.3e-10 | 31.92 | In-house | 237-329 (329) | Show / Hide |
Range on Protein: 167-240 Range on HMM: 237-329/329 Sequence Identity: 29% (27 aa) VDVWGLGVTFYFMLTGRLI-----TDLY---FDEEIAMTKVFSH------IIFP-----SNVSNECIHLITACLNNNEKSRASLDNLLESPLF .|.| ||. || ||.|. .|.| ..| ... . || ..|.||. || .| .|| | | . |.. |.| CDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
|||||||||
| Kinase | 85335.m00147.AA | ULK | 167-240 | 26 | 6.1e-10 | 31.53 | In-house | 233-324 (324) | Show / Hide |
Range on Protein: 167-240 Range on HMM: 233-324/324 Sequence Identity: 26% (25 aa) VDVWGLGVTFYFMLTGRLI--TDLYFDEEIA-----------MTKVFS-HIIFP-----SNVSNECIHLITACLNNNEKSRASLDNLLESPLF .|.| ||. || ||.|. .. . |... .... | || ..|.||. || .| .|| | | . ... |.| CDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
|||||||||
| Kinase | 85335.m00147.AA | Ciliate-E1 | 20-166 | 11 | 8e-10 | 28.61 | In-house | 1-174 (202) | Show / Hide |
Range on Protein: 20-166 Range on HMM: 1-174/202 Sequence Identity: 11% (20 aa) ITSTKYGKVFLV--EWLK---YNQMFSLQKIERS----HYEQNAIN-IIRNLY-HFNVIKVYKTYM--REKFVYLLMDYCPFDVKRYIE----------- | . .. || .. . . | . . .. .. ..|.. .. | . ....|...... .. ......| |.|.. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --ERGILSESRFAEAAYYMIQSIRSMHSKRICHNSIRPSKFLVDKYGRVQISKFNHAV--QYKNTEEKEFKHAKS . . ... . . .. .|. . .|...|.| | |.. |....|. ....| . ........ .|. .. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTH |
|||||||||
| Kinase | 85335.m00147.AA | Ciliate-E2 | 25-126 | 15 | 9.2e-08 | 22.71 | In-house | 12-184 (365) | Show / Hide |
Range on Protein: 25-126 Range on HMM: 12-184/365 Sequence Identity: 15% (26 aa) YGKVFLV-EWLK--------------------YNQMFSLQKIERSHYEQNAINIIRNLY--------------------HFNVIKVYKTYM--REKFVYL .|.|... |.. ..... . .... ..|. . ... | |.|| | .. .. .|| FGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYL LMDYCPF-DVKRYIEERGILSESR--------FAEAAYYMIQSI------------------RSMHSKR-ICH |.|| | . ||... . . . |..|.| | . ...||| |.| VMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH |
|||||||||
| Pkinase | 85335.m00147.AA | Pkinase | 14-126 | 21 | 9.5e-08 | 28.48 | Pfam | 1-131 (293) | Show / Hide |
Range on Protein: 14-126 Range on HMM: 1-131/293 Sequence Identity: 21% (28 aa) LAYKRIITSTKYGKVFLVEWLKYNQMFSLQKIERSHYEQNA---------INIIRNLYHFNVIKVYKTYMREKFVYLLMDYCPF-----DVKRYIE--ER . .|.| | .|.|.. . ...... . .|...| . . | | ..| | |... | ...... .|. |.||. | ..||. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GIL--SESRFAEAAYYMIQSIRSMHSKRICH | . || .| ... . .||..|.| GCFYFSEWECKFYMYQILRGLEYCHSMGIIH |
|||||||||
| Kinase | 85335.m00147.AA | CAMK | 207-240 | 21 | 2e-06 | 16.29 | In-house | 384-425 (425) | Show / Hide |
Range on Protein: 207-240 Range on HMM: 384-425/425 Sequence Identity: 21% (9 aa) SNVSNE--------CIHLITACLNNNEKSRASLDNLLESPLF ...|.| |..|| .|. . . |.... |. | . DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
|||||||||
| Kinase | 85335.m00147.AA | CAMK | 156-184 | 34 | 1e-05 | 13.67 | In-house | 304-332 (425) | Show / Hide |
Range on Protein: 156-184 Range on HMM: 304-332/425 Sequence Identity: 34% (10 aa) TEEKEFKHAKSVDVWGLGVTFYFMLTGRL | |.. . ...|.| .|| |.||.|.. TDEEKPYYGPKCDMWSCGVILYIMLCGYP |
|||||||||
| Kinase | 85335.m00147.AA | CAMKL | 55-87 | 30 | 2.2e-05 | 12.99 | In-house | 63-104 (297) | Show / Hide |
Range on Protein: 55-87 Range on HMM: 63-104/297 Sequence Identity: 30% (13 aa) INIIRNLY---HFNVIKVYKTYMREKF------VYLLMDYCP |.| . | | |.|| | .. ... .|| | ||. IQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCS |
|||||||||
| TyrKc | 85335.m00147.AA | TyrKc | 14-238 | 15 | 3.1e-05 | -138.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-238
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)
LAYKRIITSTKYGKVFLVEWLKYNQMFSLQ---KIERSHYEQNA----INIIRNL--YHFNVIKVYKTYMRE-------KFVYLLMDYCPF-DVKRYIEE
. .... . .|.|.. .| .| | ... . . ..| ..| | |... | . . . ....| |.| | | |. .
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK
RGILSESRFAEAAYYMIQSIRSM---HSKRICHNSIRPSKFLVDKYGRVQISKFNHAVQYKNT-------EEKEFK---HAK------------------
.. .. ....| . | |||.. | . ||.. ..| || | . .. . . | ..|
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF
--SVDVWGLGVTFY--FMLTGRLITD-----LYFDEEIAMTKVFSHIIFPSN--------VSNECIHLITACLNNNEKSRASLDNLLESP
||| ||. . | . . . . .| |. | | | . | ... | . . ..| . .. |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
|||||||||
| Kinase | 85335.m00147.AA | MARK | 205-240 | 30 | 0.000239 | 10.31 | In-house | 227-262 (262) | Show / Hide |
Range on Protein: 205-240 Range on HMM: 227-262/262 Sequence Identity: 30% (11 aa) FPSNVSNECIHLITACLNNNEKSRASLDNLLESPLF .|..|| || .|| |. | . |........ | . IPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
|||||||||
| Kinase | 85335.m00147.AA | MARK | 164-184 | 47 | 0.000248 | 10.26 | In-house | 184-204 (262) | Show / Hide |
Range on Protein: 164-184 Range on HMM: 184-204/262 Sequence Identity: 47% (10 aa) AKSVDVWGLGVTFYFMLTGRL .. ||.| ||| |||..|.. GPKVDIWSLGVVLYFMVCGYF |
|||||||||
| Kinase | 85335.m00147.AA | MARK | 55-87 | 33 | 0.000287 | 10.05 | In-house | 50-85 (262) | Show / Hide |
Range on Protein: 55-87 Range on HMM: 50-85/262 Sequence Identity: 33% (12 aa) INIIRNLYHFNVIKVYKTYM--REKF-VYLLMDYCP |.| . | | |.|| ... |. .|| |.|.. IEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYAS |
|||||||||
| Kinase | 85335.m00147.AA | CAMK | 19-126 | 14 | 0.00167 | 6.36 | In-house | 1-202 (425) | Show / Hide |
Range on Protein: 19-126 Range on HMM: 1-202/425 Sequence Identity: 14% (30 aa) IITSTKYGKVFLVEWLKYN------------QMFSLQKIERS-----------------------------HYEQNA----INIIRN-------LYHFNV .. . .|||.|.. . . | . |... . . |.| .. | | |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IKVYKTYMR-------------------EKFVYLLM---DYCP-----FDVKRYIEER---------------GILSESRFAEAAYYMIQSIRSMHSKRI || | .| .|..|. | .||. .|. || |. | ..|. . ... .. .||. | IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI CH .| VH |
|||||||||
| Kinase | 85335.m00147.AA | ULK | 62-103 | 28 | 0.003641 | 7.0 | In-house | 75-120 (329) | Show / Hide |
Range on Protein: 62-103 Range on HMM: 75-120/329 Sequence Identity: 28% (13 aa) Y-HFNVIKVYKTYMRE--KFVYLLMDYCPF-DVKRYIEERGILSES . | |..| |. .. . .|. |.||. | . ||.... |.|. NHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPED |
|||||||||
| Kinase | 85335.m00147.AA | Ciliate-E2-Unclassified | 25-126 | 16 | 0.005164 | 6.32 | In-house | 12-167 (352) | Show / Hide |
Range on Protein: 25-126 Range on HMM: 12-167/352 Sequence Identity: 16% (26 aa) YGKVFLVEWLKYN------QMFSLQKIERSHYEQ--------NAINIIRNLYHFN---------------VIKVYKTYM--REKFVYLLMDYCP-FDVKR .|||.... | . .| . |.. . ... ...|.. . ||.. ..|.. |. .. .|. |.||. | . FGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQ YIEER-----------------GILSESRFA-----EAAYYMIQSIRSMHSK-RICH ||..| |..| . ... .| . ..|.| |.| YIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIH |
|||||||||
| Kinase | 85335.m00147.AA | ULK | 55-103 | 23 | 0.039711 | 3.42 | In-house | 61-126 (324) | Show / Hide |
Range on Protein: 55-103 Range on HMM: 61-126/324 Sequence Identity: 23% (16 aa) INIIRNLY------HFNVIKVYKTYMRE--KFVYLLMDYCPF-DVKRYIEER---------GILSES |.|.. | | ...| |. .. ...|. |.||. | . ||... ..|||. IQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQ |
|||||||||