Gene 97026.m00040 (T.vaginalis)

97026.m00040

Species: T.vaginalis
Alias: 97026.m00040, TvagK0352
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
97026.m00040.AA Protein None 1085 None Fasta, JSON
97026.m00040.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 97026.m00040.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 97026.m00040.AA TKL 227-474 25 6.6e-84 285.07 In-house 1-364 (364) Show / Hide 
Range on Protein: 227-474
Range on HMM: 1-364/364
Sequence Identity: 25% (97 aa)

IGAGGFGTVFKATRLS--------TGEVVAVKELRRDR-----------------------LTMSSWASLYAEVETMASVR--HQFVLELVG-AHITQP-
|| ||||.|.|..           ||..|||| ....                         ...||.    |.|.|   |  |. .. ..| .   .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YRIITRFCPGKSLFDRLHRLGPNGVPLTANELTKIAYQVALGMSHLHSMN--------IVHRDLKTLNILLDEYND------------
            . |.. .||| ||...||           . . ..|...|.||..|||||        |.|||||. |||.|| .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--GFVADFGLSGIMKDNQE--------------------LVGGVGTPHYTAPEVLMHS----------------RYGPKVDTFSYGVVLWEMLMRKVPYA
    ..|||||  |. ...                    .   .||| . |||||. .                 | .|.| .|.|.||||.| |..||.
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

EMSQVQIY---------EHVVTRGWRLPIP------------NDTPDGMKKLITRCWNKNPNDRPNFDEIIDLF
..   ...         . |. .| |.|||            .|.|..||||...||. .|..||.|.||.. .
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase 97026.m00040.AA Pkinase 221-474 26 1.7e-69 242.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

IRMDSQIGAGGFGTVFKATRLSTGEVVAVKELRRDRLTMSSWASLYA--EVETMASVRHQFVLELVGAHITQPYRI-ITRFCPGK----SLFDRLHRLGP
..  ..||.|.||.|.|... .||..||||......  .. . ..    |.. |....| ....| ..  . ..   .. .|.|     .|||....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

NGVPL--TANELTKIAYQVALGMSHLHSMNIVHRDLKTLNILLDEYNDGF-----VADFGLSGI--MKDNQELVGGVGTPHYTAPEVLM-HSRYGPKVDT
.. ..  . .|. ...||.. |. ..|||.|.|||||  |||.|  |.       ..||||.       |. . . .|||.| ||||.. .. |||||| 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSYGVVLWEMLMRKVPYAEM------SQVQIYEHVVTRGWRLPIPNDTP-------------------DGMKKLITRCWNKNPNDRPNFDEIIDL--F
.|.|..|.||| .. |. .       .| |... .  . .. ..|.. .                   . .|..|..|..|.|..||....|     |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 97026.m00040.AA MLK 221-474 31 1.3e-63 217.63 In-house 1-291 (291) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-291/291
Sequence Identity: 31% (92 aa)

IRMDSQIGAGGFGTVFKATRLSTG---EVVAVKELR-RDRLTMSS----WASLYAEVETMASVRHQF----VLELVGAHITQPYR--IITRFCPGKSLFD
|.    ||.|.|| |.|..   .     .||||. | | .  .|.       .  |..  . ..|.     . ...|. . .|.   |.. .|.| ||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLHRLGP----------NGVPLTANELTKIAYQVALGMSHLHSMN---IVHRDLKTLNILLDE------YNDGFVADFGLSGIMKDNQE-LVGGVGTPHY
 ||   .          | .  .   . ..|.|.| ||. ||||    |.|||||  |||.||      . .  ..|||.|  ......   .  ||. .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

TAPEVL---MHSRYGPKVDTFSYGVVLWEMLMRKVPYA-EMSQVQIYEHVVTRGWRLPIPNDTPDGMKKLITRCWNKNPNDRPNFDEIIDLF
 ||||.    ...|  |.| .|.|||||||| |.|||. .... .|   |.  | |.|||.. |...|||...||| .|..||.|..|.  .
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 97026.m00040.AA Pkinase_Tyr 221-474 30 1.3e-63 216.08 Pfam 1-270 (270) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-270/270
Sequence Identity: 30% (83 aa)

IRMDSQIGAGGFGTVFKATRL----STGEVVAVKELRRDRLTMSS--WASLYAEVETMASV-RHQFVLELVGAHI--TQP--YRIITRFCPGKSLFDRLH
|... ..|.| ||.|.|.|      .|.  |||| | ..  . .   .... .|...| .  .|. .. |.|. .   .|  . |.. ..|. .| | |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RLGPNGVPLTANELTKIAYQVALGMSHLHSMNIVHRDLKTLNILLDEYNDGFV--ADFGLSGIM-KDNQE---LVGGVGTPHYTAPEVLMHSRYGPKVDT
.  ... |||  .| ....|.| ||..|.|.|..|||| . |.|..|  ...|  .||||.  . .| .      ||      .|||.......  | | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

FSYGVVLWEMLM-RKVP-YAEMSQVQIYEHVVTRGWRLPIPNDTPDGMKKLITRCWNKNPNDRPNFDEIIDLF
 |.||..||..   . | |..||  ..||..  .| |.|.| ..|| . .|...||...|.||| | ||.  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc 97026.m00040.AA TyrKc 221-474 28 1.4e-63 218.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

IRMDSQIGAGGFGTVFKATRLSTGEVVAVKELRRDRLTMSSWASLYAEVETMASV--RHQFVLELVGAHIT--------QPYRIITRFCPGKSLFDRLHR
|... ..| | ||.|.|.|     . |||| |. |       . .. | . | ..  .|. .. |.|. ..        .|. |.. ..|. .| |.|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LGPNGVPLTANELTKIAYQVALGMSHLHSMNIVHRDLKTLNILLDEYNDGFVADFGLSGIMKDN-------QELVGGV--GTP-----HYTAPEVLMHSR
 .|.   |.  .| ....|.| ||..|||.|..|||| . |.|..| .   ..|||||   .|        .  .     |.        .|||......
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGPKVDTFSYGVVLWEMLMR-KVPYAE-----MSQVQIYEHVVTRGWRLPIPND--------TPDGMKKLITRCWNKNPNDRPNFDEIIDLF
. .| | .|.||..||.. . . || .     ||  ...|.| ... |.|.| .         || | .....||. .|.|||.| ||...|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 97026.m00040.AA S_TKc 221-474 26 5e-62 213.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

IRMDSQIGAGGFGTVFKATRLSTGEVVAVKELRRDRLTMSSWASLYAEVETMASVRHQFVLELVGAHITQPYRIITRFCPG--KSLFDRLHRLGPNG--V
 ..  .|| |.||.|.|..  .||..||.|...          ... |.. . . .| ..  | ..  .. . ... .|.|   .|||.... |..|  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

PLTANELTKIAYQVALGMSHLHSMNIVHRDLKTLNILLDEYNDGFVADFGLSGIMKDNQELVGGVGTPHYTAPEVLMHSRYGP-KVDTFSYGVVLWEMLM
|..  .  ...||..... ..||..|.|||||  ||||||     ..||||. ..         .|||.| |||||    ||. |.|  | |..|.||| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

RKVPYAEMSQVQIYEHVVTRGWRLPIPNDTPDGMKKLITRCWNKNPNDRPNFDEIID---------LF
.. |.    . .......            .. .| .| .|..|.|..||   |.            |
GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 97026.m00040.AA TKL-Unique 223-474 31 4.3e-60 205.94 In-house 1-290 (290) Show / Hide 
Range on Protein: 223-474
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

MDSQIGAGGFGTVFKATRLSTGEVVAVKELR-RDRLTMSSWASLYAEVETMASVR-HQFVLELVGAHI----TQP-YRIITRFCPGKSLFDRLHR---LG
  . ||.||.|.|.|..    |. ||.| .     .  ..   .. || .|   . | ... ..|. .    ..| . |.. .||| || | ||.   . 
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---PNGVPLTANELTKIAYQVALGMSHLHSMN--IVHRDLKTLNILLDEY-----NDGFVADFGLSGIMK-DNQELVGG---------VGTPHYTAPEVL
   .|  .|. .   |.| ..|.|| .||. .  | |||||..|.|.|.      .   ..||||| . . .|.. ...         .|.. . |||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

MH--SRYGPKVDTFSYGVVLWEMLMRKV------PYAEMSQVQIYEHVVT--RGWRLPIPNDTPDGMKKLITRCWNKNPNDRPNFDEIIDLF
.   . |  |.| .|.|.||||.. ||.      || .|.| |..| | .  .. |.||||. |   ..||..||. .| .||.|||||   
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 97026.m00040.AA Dicty4 221-476 33 5.7e-59 195.37 In-house 1-277 (277) Show / Hide 
Range on Protein: 221-476
Range on HMM: 1-277/277
Sequence Identity: 33% (94 aa)

IRMDSQIGAGGFGTVFKATRLSTGEVVAVKEL--RRDRLTMSSWASLYAEVETMASVRHQFVLELVGAHIT---QP--YRIITRFCPGKSLFDRLHR---
|  .. || |.||.|.|.|    |  |||| |  . . .  .   .. .||. |.. ||  .. . || .    .|    | | ..|  .|.  ||    
INIEQRIGKGSFGEVYKGT--WRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

LGPNGVPLTANELTK---IAYQVALGMSHLHS--MNIVHRDLKTLNILLDEYNDGFVADFGLSG----IMKDNQELVGGVGTPHYTAPEVLMHSRYGPKV
     ..|     ..   .|  .|.|| .||.   .|.|||||. |.| |. .   |.|||||     .   .. . . .||| ..||||.|| .|  |.
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DTFSYGVVLWEMLMRKVPYA--EMSQVQIYEHVVTRGWRLPIPNDTPDGMKKLITRCWNKNPNDRPNFDEIIDL--FEN
| .|.| ||||.| |. ||.   |. .|... |.  . |.|||...|.  |.||..||...|. || | |||     | 
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 97026.m00040.AA TK 221-474 16 1.1e-57 191.64 In-house 1-486 (486) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

IRMDSQIGAGGFG---TVFKATRLSTG-------------------------EVVAVKELRRDRLTMSSWASL--------------YAEVETMAS---V
|..  ..|.| ||   .|.|..  . .                         . |||| |. .  . .    .               ||.. | .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHQFVLELVG-AHIT------------QPYRIITRFCPGKS----LFDRLHRLGPNGVP-----------------------------------------
.|. .. |.|  .              .|. |.. ..|. .    | | |..  |.. .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTANELTKIAYQVALGMSHLHSM------NIVHRDLKTLNILLDEYND-----------GFVADFG---
                               ||  .|  ...|.| ||..|||.      |.||||| . |.|..| |              .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSGIM--KDNQELVGGVGTPH-------------------------YTAPEVLM---------HSRYGPKVDTFSYGVVLWEMLM--RKVPYAEM
     |.  .  .|.   ... ||.                          ..|||.|.         . .. .| | .|.||..||...  .. .| .|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SQ---------VQIYEHVVTR-------------GWRLPIPNDTP--------------DGMKKLITRCWNKNPNDRPNFDEIIDLF
|           ...|....              . |.| | . |              . .  |...||...|.|||.|... . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 97026.m00040.AA CAMK 226-472 18 6.6e-51 161.88 In-house 1-421 (425) Show / Hide 
Range on Protein: 226-472
Range on HMM: 1-421/425
Sequence Identity: 18% (77 aa)

QIGAGGFGTVFKATRLSTG------------EVVAVKELRRDRLT--------------------------MSSWASLYAEVETMAS-------VRHQFV
..| |.||.|..... .|.            . ||.| . ...|.                           .. .... |.| | .       ..|  .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELVGAHI------------TQP---------YRIIT---RFCPGK----SLFDRLHRLGPNG-----------VPLTANELTKIAYQVALGMSHLHSMN
. |  .              |           . ...    .|.|      |||.. . |..|             .|  |  ..  |.. .. ..||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKTLNILLDEYNDGF-----------------VADFGLSGIMKD------------------------NQELVGGVGTPHYTA-PEVLMHSR---
|||||||  |||||. ||..                 ..|||.. ....                        .| .   .|||.| | ||||  ..   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YGPKVDTFSYGVVLWEMLMRKVPYAEM-------------SQVQIYEHVVTRGWRLPIPNDTP----------------------DGMK
           ||||.|  | ||.|  ||  . |. .              .. ...| . .  .. | |  .|                      .  |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

KLITRCWNKNPNDRPNFDEIID
 || .. ...|..|.. ... .
DLIRKMLQVDPEKRMTIEQCLN
Kinase 97026.m00040.AA RAF 221-476 26 1.8e-49 158.38 In-house 1-282 (282) Show / Hide 
Range on Protein: 221-476
Range on HMM: 1-282/282
Sequence Identity: 26% (77 aa)

IRMDSQIGAGGFGTVFKATRLSTGEVVAVKELRRDRLTMSSWAS---LYAEVETMASVRHQFVLELVGAHITQP---YRIITRFCPGKSLFDRLHRLGPN
... ..||.| ||||...    .   |||| |.   .| .  .       ||  .   ||  .|   |         | |.| .| . ||. ..|   . 
VMVMTRIGSGSFGTVYRGHWHGD---VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETR

GVPLTANELTKIAYQVALGMSHLHSMNIVHRDLKTLNILLDEYNDGFVADFGLSGI-----MKDNQELVGGVGTPHYTAPEVLM--------------HS
 . .  ..|  |. ||..||. ||. ||.|||||. ||.|.| .   . ||||  .      . ||..    .   . ||||                . 
-EKFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDEN

RYGPKVDTFSYGVVLWEMLMRKVPY-AEMSQVQIYEHVVTRGWRLP----IPNDTPDGMKKLITRCWNKNPNDRPNFDEIIDLFEN
 | .. | .|.|.|..|.. |. || .. ..   .   . ||  .|    . .|.|  |..|.. || .....|| | .|.   . 
PYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase 97026.m00040.AA TKL-ciliate1 221-474 25 1.2e-48 164.65 In-house 1-279 (279) Show / Hide 
Range on Protein: 221-474
Range on HMM: 1-279/279
Sequence Identity: 25% (73 aa)

IRMDSQIGAGGFGTVFKATRLSTGEVVAVKELRRDRLTM--SSWASLYAEVETMASVRHQF-VLELVGAHIT-QPYRIITRFCPGKSLFDRLHRLGPNGV
| |   || | |. |.|    |   .||....  . .          . |...   .  .   ..|.|       . ||. .|.. ..|| .||.    .
ITMGQKIGSGHFCNVYKGRCNSY--DVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIY

PLTANELTKIAYQVALGMSHLHSMN--IVHRDLKTLNILLDEYNDGFVADFGLSGI-------MKDNQEL---VGGVGTPHYTAPEVLM-----HSRYGP
..      .. . .| ||..||. .  ..||||| .|||.|| ..    .|.   |         . |..   ..  .|.|. |||..         .  
MIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINE

KVDTFSYGVVLWEMLMRKVPY-AEMSQVQIYEHVVTRG--WRL---PIPNDTPDGMKKLITRCWNKNPNDRPNFDEIIDLF
|.| ..||.|....  || |.   || . |   .        |    |. |.|. . .|. ||| .|||.||||.|||.  
KIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase 97026.m00040.AA LRRK 221-476 25 2.5e-47 163.57 In-house 1-351 (351) Show / Hide 
Range on Protein: 221-476
Range on HMM: 1-351/351
Sequence Identity: 25% (88 aa)

IRMDSQIGAGGFG-TVFKATRLS--------------------------TGEVVAVKELRRD--------------------------------RLTMSS
..  .||| |||| .|..|.  .                           .. ||.| . ||                                . .. .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

WASLYAEVETMASVRHQFVLELVGAHITQPYRIITRFCPGKSLFDRLHRLGPNG---VP--LTANELTKIAYQVALGMSHLHSMN--IVHRDLKTLNILL
  ..  ||  | . .|  .. |.|  | .|..... . |  .| ..||    .|   ..  .. . . |||.|.| || .||| |  |.|||||. ||||
FREFRHEVWIMSHLNHPNIVSLKGFCI-HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DEYNDGF------------VADFGLSGIMKDNQE--LVGGVGTPHYTAPEVLM---HSRYGPKVDTFSYGVVLWEMLMRK-VPYAEMS-Q-----VQIYE
 . ....            .||||.|.. .  ..  . | ||.| . |||..     . |  |||..|.|..||| | |.  |. |..         . |
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

HVVTRGWRLPIPND-TPD-----GMKKLITRCWNKNPNDRPNFDEIIDLFEN
  ...| | .||..  |       ...||. ||. .|..|| | .|..  . 
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 97026.m00040.AA STE 221-469 21 3.9e-47 162.91 In-house 1-350 (359) Show / Hide 
Range on Protein: 221-469
Range on HMM: 1-350/359
Sequence Identity: 21% (76 aa)

IRMDSQIGAGGFGTVFKATRL------STGEV---------VAVKELRRDR-------------LTM--SSWASLYAEVETMASVR--HQFVLELVGAHI
 .  ..|| |.||||.|| .       .||||         .|.|... ..              ..  . . ..  |...|   .  |... .  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TQP--------YRIITRFCPGKSLFDRLH-RLGPNG---------VPLTANELTKIAYQVALG-MSHLHSMNIVHRDLKTLNILLDEYNDGFV--ADFGL
             |.  ...| || | .. . |...          ..  ... .|..|.  | ...|||..|.|||.|  ||||       |  .|||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDFGV

SGIMKDN-----------------QELVGGVGTPHYTAPEVLMHSR------YGPKVDTFSYGVVLWEMLMRKVPYAEMSQVQIYEHVVTR---------
.|.. |.                 |.    |||| . ||||..  .      |. |.|  | | ...||.  |.|...|.  . . .  .          
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----GWRLPIPNDTP-------------------DGMKKLITRCWNKNPNDRPNFDE
     |   |.|...                    . .|  | .| .|.||.||. ..
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ