Gene 89294.m00064 (T.vaginalis)

89294.m00064

Species: T.vaginalis
Alias: 89294.m00064, TvagK0841
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MOK

Sequence

Name Sequence Type Origin Length Description Download
89294.m00064.AA Protein None 470 None Fasta, JSON
89294.m00064.kin_dom Protein Kinase Domain None 286 None Fasta, JSON

Protein domain

Protein domains of 89294.m00064.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89294.m00064.AA RCK 12-296 42 3.4e-127 405.76 In-house 2-298 (298) Show / Hide 
Range on Protein: 12-296
Range on HMM: 2-298/298
Sequence Identity: 42% (126 aa)

RVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYRAIDEVNKLPEVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEVNLYELVRD---NQKPYD
 .| .||.|.. .|.| .| .|... | |..|.... ..|...|.|.  ||.|  |||||||.|||.|| ..  .. ||.|. |||.. .|    .|.  
QIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLP

EKT--ALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKS--------TLELKLCDFGSTRQTSTSGPYTEYVSTRWYRAPECILTSGSYGPEVDIWAVG
|..      .||.|..||.||... ||||.|||| |...|        .  .|..|||. |      |||.||||||||||||.|... |   .||||||
ENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVG

CMLYELVTSRPLFPGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSRLLVYNPSDRITAQDALEHPVF
|  ||| . ||||||  |||||  |..| |||. . . ....  . |. | ||| ... | .|.| .|.  |.|.  .| ..|. ||||| ||.|| |
CIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLAS-QMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 89294.m00064.AA MOK 12-296 43 5.5e-113 355.57 In-house 2-283 (283) Show / Hide 
Range on Protein: 12-296
Range on HMM: 2-283/283
Sequence Identity: 43% (124 aa)

RVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYRAIDEVNKLPEVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEVNLYELVRDNQKPYDEKT
. | |.|||.|.|| |..  .  . .| |..|... .|..||.| |.  .| |. ||||..| ||.|| ..| .||  |||..|.|||.|    .  .| 
KAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQKK

ALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTSTSGPYTEYVSTRWYRAPECILTSGSYGPEVDIWAVGCMLYELVTSRPLF
  . .|||.|||  ||   .||||||||| .. .    ||| |||| |      |||||.||||||||||.|| | |  ..|.|.|||. ||..  .|||
IMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDH--LKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSRLLVYNPSDRITAQDALEHPVF
||  |.|||..|| |.|||   .| ||. |    ... || .    . ||.| ..   .... ..  | | .||||. .. || |
PGVNEVDQISKIHDVMGTPCQKILNKFK-NQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 89294.m00064.AA CMGC 11-296 21 4.4e-108 356.4 In-house 1-513 (513) Show / Hide 
Range on Protein: 11-296
Range on HMM: 1-513/513
Sequence Identity: 21% (112 aa)

IRVICKLGEGSFAEVFKVKNPKTQ--------------QLFAVKRLKKRYRAIDEV----------NKLPEVLYLRALQ----------------GHPNI
  .| |.|||....|.| .. .|.              .. |.|..|..   ...             | |. .|. |.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKLYEVIFDNQSG---------------FVALRFELMEVNLYELVRDNQKPYDE-KTALL------------------LI------YQLLKSLA--FMHS
.|||... ...|                 . | ||.|. .||.. ..||..| . .   |                  ..      ||.|..|.  ..||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

KN--LFHRDVKPENCMVNKSTLE-------------------LKLCDFGSTRQTST----------------------SGPYTEYVSTRWYRAPECILTS
..   .||| |||| ..|. .                     ||.||||. |....                      . |||.||.|||||||| .| .
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

---------GSYGPEVDIWAVGCMLYELVTS--------RPLFP-----------GKHEIDQIARIHNVVGTPS---------------RDVLAKFRQNP
         . |....|.|.|||...|..|         .||||           ||..|||...| .| |||.                .   .. ..|
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

NT--------------QISFS----------FPQRVPQDLHKLLPV-----------------------------------MSSGFIDLLSRLLVYNPSD
.               ..| .          ||.. |.....| |                                    ... .||||...|.|.|..
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RITAQDALEHPVF
||||..||.|| |
RITAEQALQHPYF
Kinase 89294.m00064.AA S_TKc 11-296 25 3.8e-88 300.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-296
Range on HMM: 1-231/231
Sequence Identity: 25% (78 aa)

IRVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYRAIDEVNKLPEVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEV---NLYELVRDNQKP-
 ... |.|.|.|..|.|... ||....|.|..|         . . |.  |.   .||||.|||.|. |   ... . .|...    .|... ...... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----YDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTSTSGPYTEYVSTRWYRAPECILTSGSYGP-EVDIWAVGCML
    ..| .|  ..||... |...||..  |||.|||| ....   ..|.||||. ||       | .. |.||.||| .    .||. ..|.|..||.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

YELVTSRPLFPGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSRLLVYNPSDRITAQDALE-------HP
||... .|.||      |.... ...|                                     |. ..|.....|...|..|.|| .||.       ||
YEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

VF
 |
WF
Kinase 89294.m00064.AA Pkinase 11-296 28 1.5e-87 301.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-296
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

IRVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYRAIDE-VNKLP--EVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEV-----NLYELVR-
.... |.|.|||..|.| .. .|....|||..||| .  .. ....   |. ... | .||||..||..  |  .. . . .|..|       |..... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

DNQKPY--DEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLEL----KLCDFGSTRQ--TSTSGPYTEYVSTRWYRAPECILTSGSYGPEVD
......  .|...   .||.|. |...||..  |||.||||.... .. ..    |.||||. .|  .  .. .| .. |.||.||| |...  |||.||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWAVGCMLYELVTSRPLFPGK----HEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSRLLVYNPSDRITAQD
.|..||.|||... ||.|||.    . .||...| .. |.| .    . . ...    .  . .  . . .. . .|. ..|.....| ..|..|.||..
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQ

ALEHPVF
.|.|| |
ILQHPWF
Kinase 89294.m00064.AA MAK 12-296 34 2.4e-87 278.07 In-house 2-352 (352) Show / Hide 
Range on Protein: 12-296
Range on HMM: 2-352/352
Sequence Identity: 34% (124 aa)

RVICKLGEGSFAEVFKVKN------------------------------PKTQQLFAVKRLKKRYRAIDEVNKLPEVLYLRALQGHPNIIKLYEVIF---
 .| .|| |.. .| . |                                .|. . |.|| || .   .|  .| ||  |..|. ||||.|| |||    
QMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDSE

DNQSGFVALRFELMEVNLYELVRDNQK-PYDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKS----------------TLELKLCDFGSTRQT
...  ||   || |. |||... | ..    | .    .|| |  |||||  . |||| |||| |.. .                   .|. |||  | .
NDHLYFV---FEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREI

STSGPYTEYVSTRWYRAPECILTSGSYGPEVDIWAVGCMLYELVTSRPLFPGKHEIDQIARIHNVVGTPSRDV----------------------LAKFR
    ||| |||||||||||  | |..|.  .|.|||||   || | ||||||  |||||  |  | ||| .|                       ||   
RSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAH--

QNPNTQISFSFPQRVP---QDLHKLLPVMSS-GFIDLLSRLLVYNPSDRITAQDALEHPVF
     .. | ||| ||     | .|.|  |.   |.|.  .| ..|  | |||.....| |
-----MMNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 89294.m00064.AA CDK 12-296 29 2.8e-81 259.75 In-house 2-284 (284) Show / Hide 
Range on Protein: 12-296
Range on HMM: 2-284/284
Sequence Identity: 29% (94 aa)

RVICKLGEGSFAEVFKVKNPKTQ-----QLFAVKRLKKRYR-AIDEVNKLP-----EVLYLRALQGHPNIIKLYEVIFDNQSG---------FVALRFEL
  ..|.|||....|.| .. .|.     |. | |...       .|   .|     |. .|. |  ||||.||..|. ....           . . || 
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MEVNLYELVRDNQKPYDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTL----ELKLCDFGSTRQTS-------TSGPYTEYVSTRWYRAPE
|.  |... .             ...|||. |...||..  ||| || | ..|.        ||. |||  |  .        . .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

CILTSGSYG--PEVDIWAVGCMLYELVT---SRPLFPGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSR
  | |  |.  ...|.|.||| ..|..|    .|||||. ||||. .| .. |||. |.   . . |.                           |||..
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

LLVYNPSDRITAQDALEHPVF
.|.|.|. ||.|..||.|| |
MLCYDPKKRISAEQALQHPYF
Kinase 89294.m00064.AA CDC2 12-296 33 2.7e-71 218.23 In-house 2-301 (301) Show / Hide 
Range on Protein: 12-296
Range on HMM: 2-301/301
Sequence Identity: 33% (101 aa)

RVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYRAIDE---VNKLPEVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEVNLYELVR-DNQ--K
  | |.|||.. .|.| |. .|.|. |.|. .  .   ..      . |  .| .|. ||||.|| .||.      . . || .. .| .. .  ..  |
QKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNK

PYDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTST-SGPYT--EYVSTRWYRAPECILTSGSYGPEVDIWAVGCMLY
. .. .   ..||.|. ..| |..  .||| || |  ..|.   .|. |||  |  .. . .||    | |.||||||  | .  |  .||.|..|| ..
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---VTSRPLFPGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPV---------MSSGFIDLLSRLLVYNPSDRITAQDA
|.   || .|||.|. ||||. .|  ..|||. . .    |.|  .   .||.  |||| |..|          .    ||||...|.|.|..||.|..|
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN--TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEA

LEHPVF
|.|| |
LQHPYF
Kinase 89294.m00064.AA MAPK 61-296 34 6e-70 238.7 In-house 58-328 (328) Show / Hide 
Range on Protein: 61-296
Range on HMM: 58-328/328
Sequence Identity: 34% (94 aa)

LRALQGHPNIIKLYEVIFDN----QSGFVALR-----FELMEVNLYELVRDNQKPYDEKTALLLIYQLLKS--LAFMHSKNLFHRDVKPENCMVNKSTLE
|| . .|.|||||....       |.    ..     .|||| .|. . . .| | ...    ..||.|.   | ..|| |  ||| ||.|  || .  .
LRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCD

LKLCDFGSTRQTSTSGPY---------------TEYVSTRWYRAPECILT--SGSYGPEVDIWAVGCMLYELVT-SRPLFPGKHEIDQIARIHNVVGTPS
||.||||  |.. ..  .               ||||.|||||||| .|   .  |   ||.|.||| . |..|  .||||||. |||. .| .|.||||
LKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPS

RDVLAKFR--QNPNTQISFS--FPQRVPQDLHKLLPV----MSSGFIDLLSRLLVYNPSDRITAQDALEHPVF
.... .    ... . |.    .|.. .....|..|      ..  ||||...|| .|..|||...||.|| |
EEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 89294.m00064.AA ERK7 12-296 33 3.7e-68 232.12 In-house 2-292 (292) Show / Hide 
Range on Protein: 12-296
Range on HMM: 2-292/292
Sequence Identity: 33% (99 aa)

RVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYR-AIDEVNKLPEVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEVNLYELVRDNQKPYDEK
 .. .|| | .  | |.   .|.|  |.|.    .| ..|      |...|.....|||||.|..||  .    . | || ||  |   .|   .   . 
EIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIR-KGNILKDI

TALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTSTSG-------PYTEYVSTRWYRAPECILTSGSYGPEVDIWAVGCMLYE
     .||||. . .||| |. |||.|| | ... |   .|.||||  |  .            |||| ||||||||  | |  | . || | .|| | |
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LVTSRPLFPGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSRLLVYNPSDRITAQDALEHPVF
... .|.|||   ..|| .| .... |..  ..    .   ..  . .|. .. |....|  .   |||| ||||.||  |.||..||.||  
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 89294.m00064.AA GSK 11-296 27 7.7e-67 202.96 In-house 1-328 (328) Show / Hide 
Range on Protein: 11-296
Range on HMM: 1-328/328
Sequence Identity: 27% (91 aa)

IRVICKLGEGSFAEVFKVKNP----KTQQL----FAVKRLKKRYRAIDEVNKLPEVLYLRALQ--GHPNIIKL---YEVIFDNQSG---FVA-LRFELME
.. . . | |||  |.. ..      |..     .|.|.  .. |         |.  .. |    ||||..|   ..   .....   ..  | .| |.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYK----CNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMP

VNLYELVRD---NQKPYDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTST--SGPYTEYVSTRWYRAPECILTSGSY
 .||.. |.   |... ....  |. ||....||. ||..  |||.||.|  |. .| .||.||||| .|  .  . | . |  .| ||||| |. .  |
QTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNY

GPEVDIWAVGCMLYELVTSRPLFPGKHEIDQIARIHNVVGTPSR-DVLAKFRQNPNTQIS-FSFPQRVPQDLHK-------------------LLPV-MS
.  .|.| .|| . |... .|||||. ..||. .| .. |||.. .. . . ..|...   .||.|  |. . |                   .. .  .
TCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHT

SG--FIDLLSRLLVYNPSDRITAQDALEHPVF
     |||.|..|||.|. |... .|. || |
DMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 89294.m00064.AA CDKL 13-296 33 1.8e-64 219.32 In-house 3-286 (286) Show / Hide 
Range on Protein: 13-296
Range on HMM: 3-286/286
Sequence Identity: 33% (96 aa)

VICKLGEGSFAEVFKVKNPKTQQLFAVKRLKK-RYRAIDEVNKLPEVLYLRALQGHPNIIKLYEVIFDNQSGFVALRFELMEVNLYELVRDNQKPYDEKT
 . |.||||   |.| .|  |.|. |.|. |  ..  .   . . |.  |. |  |.||  | ||    . .   | || .. .. ..   ...  ||. 
KLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLK-HENIVNLIEVF--RRKRKLHLVFEYCDHTVLHELEEYPNGVDEHV

ALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTSTSG-PYTEYVSTRWYRAPECILTSGSYGPEVDIWAVGCMLYELVTSRPL
    ..|.||...| |. |  |||.||||  .. .  ..||||||  |. . .|  ||.|| ||||||||  .   .||..|||||.||.. |...  ||
VRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGKHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQ-RVPQDLHKLLPVMS-SGFIDLLSRLLVYNPSDRITAQDALEHPVF
.||. .|||  .|  ..|.   .    |..||   .  .||.   .. | | .|  | .  .|..  .|  .|..|.|......|| |
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNP-FFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 89294.m00064.AA TyrKc 11-296 23 4e-13 -10.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-296
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

IRVICKLGEGSFAEVFKVKNPKTQQLFAVKRLKKRYRAIDEVNKLPEVLYLRAL-QGHPNIIKLYEVIFDN-----QSGFVALRFELMEV-NLYELVRDN
|. . ||||| | ||.| .     .  ||| ||.    . .   . |   .. |   ||||..|| |. .       .. . . .|.|.  .| .  |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDF--MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

QKPYDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTSTS------GPYT-------EY--VSTRWYRAPECILTSGSY
..    |. |   .|  .  .. ||||. |||    ||.|..     | .||| .|           . |        .   .  ||. |||||   | .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GPEVDIWAVGCMLYELVTS-RPLFPG---KHEIDQIARIHNVVGTPSRDVLAKFRQNPNTQISFSFPQRVPQDLHKLLPVMSSGFIDLLSRLLVYNPSDR
 .. |.|. | ...|. |   .  ||   .      ..... | .  |  . .   .    .||              . ...   .. ..   ..|.||
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYR--MPQPPNDY-P-MSF--------------VCCPDEMYQIMKQCWHEDPEDR

ITAQDALEHPVF
 | ..   |  |
PTFSEI--HECF
Kinase 89294.m00064.AA Pkinase_Tyr 11-206 28 1.1e-07 26.6 Pfam 1-209 (270) Show / Hide 
Range on Protein: 11-206
Range on HMM: 1-209/270
Sequence Identity: 28% (62 aa)

IRVICKLGEGSFAEVFKVKNP----KTQQLFAVKRLKKRYRAID--EVNKLPEVLYLRALQGHPNIIKLYEVIF-DNQ-SGFVALRFELMEV-NLYELVR
|. . |||||.| ||.| .      .|..  ||| ||  .   .      . |.  .. |  ||||..|| |.  . . .  . . .|.|.  .|..  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

DN---QKPYDEKTALLLIYQLLKSLAFMHSKNLFHRDVKPENCMVNKSTLELKLCDFGSTRQTSTSGPYTEYVST-------RWYRAPECILTSGSYGPE
..   ..| . |. |   .|  | ... .|||. |||.   ||.|.. ..  | |||| .|   ..  |  |...       .|. ||||| ..  .  .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTK

VDIWAVGCMLYELVT
 |.|. |  ..|..|
SDVWSFGVLMWEIFT
Kinase 89294.m00064.AA MAPK 11-44 17 0.055393 2.38 In-house 1-40 (328) Show / Hide 
Range on Protein: 11-44
Range on HMM: 1-40/328
Sequence Identity: 17% (7 aa)

IRVICKLGEGSFAEVFKVKNPKTQQL------FAVKRLKK
 . . ..|.|..  |....  .|.|        |.|.. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISR