Gene 84394.m00078 (T.vaginalis)
84394.m00078
Species: T.vaginalis
Alias: TvagK0788, 84394.m00078
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 84394.m00078.AA | Protein | None | 2092 | None | Fasta, JSON |
| 84394.m00078.kin_dom | Protein Kinase Domain | None | 236 | None | Fasta, JSON |
Protein domains of 84394.m00078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Rapamycin_bind | 84394.m00078.AA | Rapamycin_bind | 1609-1682 | 29 | 8e-06 | 20.08 | Pfam | 1-79 (100) | Show / Hide |
Range on Protein: 1609-1682 Range on HMM: 1-79/100 Sequence Identity: 29% (23 aa) ELMRVACTRFELCYNCIRDTLF---EPNEFTT--KYLHQLFEQNSKENETFLDVSFSREFGNLLNLLEEWVKKYEETKD ||.||| .|. .... . . .. . ..| .| |. .|. ||. .|| .|| |. ||..||..|.| ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGD |
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| Kinase | 84394.m00078.AA | FRAP | 1768-2017 | 44 | 2.2e-88 | 299.92 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 1768-2017 Range on HMM: 1-251/251 Sequence Identity: 44% (114 aa) EYDFLLKAHEDTRLDERVMQLFDFINTF------SSQKKMRLSTYKVTPLTGNVGLIGWVPDCTTLANLIMTQRNRSKISNNREMESSFELAHVENEKEF || |||| ||| | |||||||| ||. . .| . . | . || | ||||||..| || || |.. .| | | ... . .. EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE----YNIMD-RMCNDY YEIPLERRRKLFVDGQKSTKGDDLQQVLLLQSSNSSDWVTRRTQYAASLASTSMVGYVIGIGDRHLNNIMLDAKSGKLIHIDYSDCFEIRMHDSVFPETV ..|| . .| . |||.||. .| | | || | ||| | ||| ||.||..|.||||. ||||. .||..|||. ||||. | ||| . DHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKI PFRLTRILVNALEAKRIEGTFRTTSISIMRDMQSRGDQILALLEVFIYDPLLQWIP ||||||.||||.|| |||..| |. .|. . . ..| || |.||||. |. PFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 84394.m00078.AA | PIKK | 1739-2007 | 31 | 2.1e-87 | 296.66 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1739-2007 Range on HMM: 1-290/290 Sequence Identity: 31% (90 aa) YMSKISQNLEIIESLHRPRKVKIYGDNGVEYDFLLKAHEDTRLDERVMQLFDFINTF------SSQKKMRLSTYKVTPLTGNVGLIGWVPDCTTLANLIM . . . .... .. .|.| | | .| || .|.| ||| |.|.|||||| ..|| ..... ..||.|.|.. . |||.||..|.|| .. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK TQRNRSKISNNREMESSFEL-------------AHVENEK--EFYEIPLERRRKLFVDGQKSTKGDDLQQVLLLQSSNSSDWVTRRTQYAASLASTSMVG . . .|. . | .. .. .|.. .. . ||. . ..| . |..|... ... .... .| .||. |. |.|. .||| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YVIGIGDRHLNNIMLDAKSGKLIHIDYSDCFEIRMHDSVFPETVPFRLTRILVNALEAKRIEGTFRTTSISIMRDMQSRGDQILALLEVF |..|.||||..|||.|. .|...|||. .||| | . .||.||||||| .|||... .|| || . ...|. | . . .....||| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 84394.m00078.AA | PI3_PI4_kinase | 1768-2017 | 22 | 3.6e-60 | 211.01 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1768-2017 Range on HMM: 1-300/300 Sequence Identity: 22% (69 aa) EYDFLLKAHEDTR--LDERVMQLF-----------------------DFINTFSSQKKMRLS------TYKVTPLTGNVGLIGWVPDCTTLANLIMTQRN .| |..| ..| | |.|.||.. ..|.. ..... . .|.. |. . |.|.|||.|||..... | .. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV RSKISN---NREMESSFELAHVENEKEFYEIPLERRRKLFVDGQKSTKGDDLQQVLLLQSSNS-SDWVTRRTQYAASLASTSMVGYVIGIGDRHLNNIML . |. . .. |. .... ... .......| .. |....| |... .. . .| ..|.... |.| ..|.|..|.||||..|||. KCKHKHFNKEHKMWMKMWPDWWHLM-------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMV --DAKSGKLIHIDYSDCFE-IRMHDSVFPETVPFRLTR------ILVNAL------EAKRIEGTFRTTSISIMRDMQSRGDQILALL-------EVFIYD | ..|.|.|||. .||. |. .||.||||.|. .|.|. . . .|.||.. ...| . . .. ...|| | ...| KDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHD PLLQWIP .|. | GLPMWRS |
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| Kinase | 84394.m00078.AA | PI3Kc | 1770-2085 | 21 | 3.2e-50 | 174.09 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1770-2085
Range on HMM: 1-336/336
Sequence Identity: 21% (76 aa)
DFLLKAHEDTRLDERVMQLFDFINTFSSQK------KMRLSTYKVTPLTGNVGLIGWVPDCTTLANLIMTQRN-------------------RSKISNNR
...|...| | |.|.||.| .|. .. .... .||. |. . |.|.|||.|.||... .. . .. . |.
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM
EMESSFELAHVENEKEFYEIPLERRRKLFVDGQKSTKGDDLQQVLLLQSSNSS-DWVTRRTQYAASLASTSMVGYVIGIGDRHLNNIMLDAKSGKLIHID
| . .. |.. . .. . .... |.| ...|...|.. .. .. ... ||...|.... |.| .||.|. ||||||..||||| |.|...|||
YMMIWHQQACHWMMMYQ-HMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID
YSDCFEIRMHDSVFP----ETVPFRLTRILVNALE----AKRIEGTFRTTSISIMRDMQSRGDQILALLEVFIYDPLLQWIPLVGSGHSSFGSPLPEGQG
. ..|. . .|. |.||||||. .|.. . .| |||. ...| | . ..|..|.|...|||.. ..
FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----------------
ERSPSVETVHRIKDKLQRT-DGDKNVVRS---------LEEQVDSLIKQACDPTNLCRMH
.... ...... |... . .|. ..|..... . .. ...
-----EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 84394.m00078.AA | ATR | 1738-2007 | 28 | 3.6e-40 | 134.3 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1738-2007 Range on HMM: 1-267/267 Sequence Identity: 28% (79 aa) VYMSKISQNLEIIESLHRPRKVKIYGDNGVEYDFLLKAHEDTRLDERVMQLFDFINTF------SSQKKMRLSTYKVTPLTGNVGLIGWVPDCTT----L |.. . . .||. || .|.|. . | .| | . | ..| | | | |. . || . .. . . || | || . ..| || . | | AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL ANLIMTQRNRSKISNNREMESSFELAHVENEKEFYEIPLERRRKLFVDGQKSTKGDDLQQVLLLQSSNSSDWVTRRTQYAASLASTSMVGYVIGIGDRHL | .. ... . | . | | | |. | | .| .. . . . .| . | | | |. .||||.||.|||| DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIF------------HDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHT NNIMLDAKSGKLIHIDYSDCFEIRMHDSVFPETVPFRLTRILVNALEAKRIEGTFRTTSISIMRDMQSRGDQILALLEVF .||..| | ..|.|| | | ||.||||||. .|... . . .| || . ||. |. . |.|..... | DNILIDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 84394.m00078.AA | ATM | 1899-2015 | 41 | 2.1e-28 | 87.58 | In-house | 133-248 (304) | Show / Hide |
Range on Protein: 1899-2015 Range on HMM: 133-248/304 Sequence Identity: 41% (48 aa) WVTRRTQYAASLASTSMVGYVIGIGDRHLNNIMLDAKSGKLIHIDYSDCFEIRMHDSVFPETVPFRLTRILVNALEAKRIEGTFRTTSISIMRDMQSRGD | .| | | | |.|||..|.|||| ||.. .| |.||| || |||||||||| .| . .|| || | | . WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE-QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE QILALLEVFIYDPLLQW .| . || .|||| | TLLTIVEVLLYDPLFDW |
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| Kinase | 84394.m00078.AA | DNAPK | 1917-2017 | 33 | 2.6e-18 | 63.12 | In-house | 201-301 (301) | Show / Hide |
Range on Protein: 1917-2017 Range on HMM: 201-301/301 Sequence Identity: 33% (34 aa) GYVIGIGDRHLNNIMLDAKSGKLIHIDYSDCFEIRMHDSVFPETVPFRLTRILVNALEAKRIEGTFRTTSISIMRDMQSRGDQILALLEVFIYDPLLQWI ... ||||||||| | | | ||. | || |||||| .| . | | .. |. |. ... . .||| ||.. | HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK P N |
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| Kinase | 84394.m00078.AA | FATC | 2060-2092 | 54 | 1e-16 | 56.57 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2060-2092 Range on HMM: 1-33/33 Sequence Identity: 54% (18 aa) VVRSLEEQVDSLIKQACDPTNLCRMHPGWNPWL . | |.||| ||..| || |||.| .|| ||. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 84394.m00078.AA | SMG1 | 1902-1949 | 59 | 2.7e-16 | 50.37 | In-house | 185-233 (242) | Show / Hide |
Range on Protein: 1902-1949 Range on HMM: 185-233/242 Sequence Identity: 59% (29 aa) RRTQ-YAASLASTSMVGYVIGIGDRHLNNIMLDAKSGKLIHIDYSDCFE | || || | | |||||.||.||||| |...| | .|||| ||| RVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE |
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| Kinase | 84394.m00078.AA | DNAPK | 1738-1830 | 31 | 9.5e-14 | 46.24 | In-house | 2-100 (301) | Show / Hide |
Range on Protein: 1738-1830 Range on HMM: 2-100/301 Sequence Identity: 31% (31 aa) VYMSKISQNLEIIESLHRPRKVKIYGDNGVEYDFLLKAHEDTRLDERVMQLFDFINTF------SSQKKMRLSTYKVTPLTGNVGLIGWVPDCTTLANL | . .. || ||... | | | |. | || |.| |. ||| | .|. . |.|| . |.| ||| || .| .. VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI |
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| Kinase | 84394.m00078.AA | SMG1 | 1747-1827 | 36 | 1e-10 | 31.57 | In-house | 1-87 (242) | Show / Hide |
Range on Protein: 1747-1827 Range on HMM: 1-87/242 Sequence Identity: 36% (32 aa) LEIIESLHRPRKVKIYGDNGVEYDFLLKAHEDTRLDERVMQLFDFINTF----SSQKKMRLST--YKVTPLTGNVGLIGWVPDCTTL . |. .|.|. | | | .| | || ||||.|| .|| | | | |||| ||| || | | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL |
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| Kinase | 84394.m00078.AA | ATM | 1772-1820 | 32 | 0.002376 | 6.11 | In-house | 3-57 (304) | Show / Hide |
Range on Protein: 1772-1820 Range on HMM: 3-57/304 Sequence Identity: 32% (18 aa) LLKAHEDTRLDERVMQLFDFINTF------SSQKKMRLSTYKVTPLTGNVGLIGW | | .| | | . | | || ..|. . |||| || | . | LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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