92207.m00089

Species: T.vaginalis
Alias: 92207.m00089, TvagK0847
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI3K

Sequence

Name Sequence Type Origin Length Description Download
92207.m00089.AA Protein None 806 None Fasta, JSON
92207.m00089.kin_dom Protein Kinase Domain None 308 None Fasta, JSON

Protein domain

Protein domains of 92207.m00089.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_C2 92207.m00089.AA PI3K_C2 131-254 16 1.9e-14 54.28 Pfam 1-168 (168) Show / Hide
Range on Protein: 131-254
Range on HMM: 1-168/168
Sequence Identity: 16% (28 aa)

SARAYIIRAAIY--HGSNELGAPTMTKPSLGGT-----SVSWNEVLILT-TQIQLIPRSARVAITLYNYEKIGTKE---------GAVATINIPVFNF-D
.   .......|  || . |. |. ....  ..     ...||| ....  |.. .||.||  ||....     .|          ...  |.| |.. .
PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEK

GWVNSGVNFCSM-WNGKDTDPMLTT---------------------CQCEDEDATR---IL-FEIPQY
.  ..|    .| | .|...|| .|                      ..| ..  |   .. .  ...
CMLRCGMHKLHMTWPSKPPCPMFPTHTPWKVPRHWRDEMNRLEKLLKKHEWGQMQRNPRCDWLDFLTF

PI3K_C2 92207.m00089.AA PI3K_C2 97-209 20 3.8e-07 31.0 SMART 1-133 (133) Show / Hide
Range on Protein: 97-209
Range on HMM: 1-133/133
Sequence Identity: 20% (27 aa)

VKPCFAQIGGFPHL----LSKEYFSIIINGCFNIPKELSARAYIIRAAIYHG-SNELGAPTMTKP----SLGGTS-----VSWNEVLIL-TTQIQLIPRS
||.| .. . .|      ....|    |.. ..   | |   .......|||  . ...|  |..      ....     . ||| |..   |.. .||.
VKICSLWCCNRPFVFLPHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLPRM

ARVAITLYNYE--KIGTKEGA---VATINIPVF
|| .||.. .   ... ...    |.. |   |
ARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF

PI3Ka 92207.m00089.AA PI3Ka 294-460 34 1.1e-47 165.62 Pfam 21-211 (211) Show / Hide
Range on Protein: 294-460
Range on HMM: 21-211/211
Sequence Identity: 34% (65 aa)

DPLKKLSCEDKNLIYKHRHDLY-DMTSMLP------LVLS-SIDYTIPTQVNEVSILLQR--WDRLSPKEALTLLDSEFAD--YRVRTYAVEILES-FSD
||| .|. |.|.||.|.||...      ||        |. ..  . ..||...  |...  |. ..| .|| |||..|.|    || |||..||| .||
DPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSD

DEIMLYMLQLVQALKNE----MYDYSPLCRFLFRRGLNEPKFLGHKLFWQLMSEA------HISHI-RRRFSSFVVNFLYGSGIYREELIT
||. .|.|||||||| |     .. |.| |||..|..  .  .|| .|| . ||       |....   ||..    .... | ....|..
DELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK

PI3Ka 92207.m00089.AA PI3Ka 276-460 29 1.1e-43 152.33 SMART 1-232 (232) Show / Hide
Range on Protein: 276-460
Range on HMM: 1-232/232
Sequence Identity: 29% (68 aa)

RISTQQ--RISIENLKKRVF--DPLKKLSCEDKNLIYKHRHDLY-DMTSMLP-----LVLSSIDYTIPTQVNEVSILLQRW--DRLSPKEALTLLDSEFA
.       ....  . ....  .|...|. |.|.||.|.||..  .    ||      .|.... . ...|...  |...|  . ..| .|| |||..|.
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP

D---YRVRTYAVEILESFSDDEIMLYMLQLVQALKNE--------------------------MYDYSPLCRFLFRRGLNEPKFLGHKLFWQLMSEA---
|     || |||..||..||||. .| |||||||| |                           |  |||||||..| |  |  .|| ..|.| ||    
DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH

---HISHIRRRFSSFVVNFLYGS-GIYREELIT
   | .|. .|| .    ...|. | . ..|. 
CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK

PI3Kc 92207.m00089.AA PI3Kc 544-805 28 6.7e-80 272.66 SMART 1-336 (336) Show / Hide
Range on Protein: 544-805
Range on HMM: 1-336/336
Sequence Identity: 28% (95 aa)

RVLFKVGDDLRQDQLTLQVMSVMEHLWRQA----GMDFHMRCYGVLPTGFNQGFIEVVPNAITEQALQ--------------------------------
.|.||.|||||||....|. ..| ..|..     ..|.||| |...||| . |.||.|||. |   .|                                
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-----------------------QEKGTFAGVWNVSLFSDYLCKVNTTEQ-NQMLARENFMYSSAGYAVATCVLGIADRHPGNIMLQ-SDGHFLHIDFGH
                       .  .  ... ..  . |.. . ....  .   ||.|| .| ||| ..| .||| |||..||||   .|| .||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLGNFKTKLGYQ---RENAPYHFSPACVNVLG--DVNGEMFKKYRQLCGDALNVLRKNSNLLVTLLILMLGTGI-PELQQA-EDIRYMTDMLFLN-KTDS
..|....|.|..   || .|  . .  |.| |  ... ..|...|..|  |....||.|||...|. .|....| |...   .||.|  . ..|. ..| 
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

EAKIEFDR-----LTDLSIDSKRTKLNNLFHNIAVS
||   |..     |   |..|. |.....|||.|  
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

PI3_PI4_kinase 92207.m00089.AA PI3_PI4_kinase 542-756 23 6.3e-55 193.59 Pfam 1-300 (300) Show / Hide
Range on Protein: 542-756
Range on HMM: 1-300/300
Sequence Identity: 23% (70 aa)

PIRVLFKVGDDLR--QDQLTLQVM-----------------------SVMEHLWRQAGMDFH----MRCYGVLPTGFNQGFIEVVPNAITEQALQQEKGT
 ....||.|||||  ||....|                         ..|  .|.. |.|.     |. | ..||| . |.||.|||. | . .. ....
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

FAG-VWNV----------------------------------SLFSDYLCKVNTTE-QNQMLARENFMYSSAGYAVATCVLGIADRHPGNIML---QSDG
  .  ..                                     . ... | |...  .   ||.|| .| ||..|.. .||..|||..|||.    ..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HFLHIDFGHFLGNFKTKLGYQRENAPYHFSP------ACVNVLGD----VNGEMFKKYRQLCGDALNVLRKNSNLLVTLL-------ILMLGTGIPELQQ
|  ||||||.....|.| .  .|  |... .        |...|.     . ... ..|..| .|...||...||...||        .|. .|.|..  
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





Kinase 92207.m00089.AA FRAP 640-681 51 6e-08 25.44 In-house 137-179 (251) Show / Hide
Range on Protein: 640-681
Range on HMM: 137-179/251
Sequence Identity: 51% (22 aa)

RENFMYSSAGYAVATCVLGIADRHPGNIMLQ-SDGHFLHIDFG
| |.  | |   .|  .||. |||| |||||   |  .|||||
RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase 92207.m00089.AA ATR 620-746 18 2e-06 17.79 In-house 144-267 (267) Show / Hide
Range on Protein: 620-746
Range on HMM: 144-267/267
Sequence Identity: 18% (24 aa)

SLFSDYLCKVNTTEQNQMLARENFMYSSAGYAVATCVLGIADRHPGNIMLQS-DGHFLHIDFGHFLGNFKTKLGYQRENAPYHFSPACVNVLGDVNGEMF
..| |.  .     |.   .|||.. | | ...   ..|. |||  ||....  |   |.|.    .  ..      |  |.      |. .| .  .  
PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQF--EVPEIVPFRLTHNMVFGMGPMKTYGL

KKYRQLCGDALNVLRKNSNLLVTLLILM
  .|. | . . ..|.. . .. ..   
--FRRACEVIMMCMRDHRDDIMSVWDCF

Kinase 92207.m00089.AA PIKK 639-682 44 1.3e-05 16.84 In-house 185-229 (290) Show / Hide
Range on Protein: 639-682
Range on HMM: 185-229/290
Sequence Identity: 44% (20 aa)

ARENFMYSSAGYAVATCVLGIADRHPGNIMLQSD-GHFLHIDFGH
.|||.  | |   ..  .||. |||| |||.... |  .|||||.
RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC

Kinase 92207.m00089.AA PIKK 546-602 34 0.000998 9.88 In-house 34-94 (290) Show / Hide
Range on Protein: 546-602
Range on HMM: 34-94/290
Sequence Identity: 34% (21 aa)

LFKVGDDLRQDQLTLQVMSVMEHLWRQA----GMDFHMRCYGVLPTGFNQGFIEVVPNAIT
|.| ..|||||| ..|. ..|  . ..       ..|.| | | | . . | || |.|. |
LCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT