Gene 85241.m00259 (T.vaginalis)

85241.m00259

Species: T.vaginalis
Alias: TvagK0700, 85241.m00259
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
85241.m00259.AA Protein None 196 None Fasta, JSON
85241.m00259.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 85241.m00259.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85241.m00259.AA CAMKL 5-163 32 6.3e-50 157.43 In-house 60-242 (297) Show / Hide 
Range on Protein: 5-163
Range on HMM: 60-242/297
Sequence Identity: 32% (59 aa)

KREVESLVQFD---HPHIVKVYDVF-------SSETEMFIILEYCSGGS--LESIV--KSGKK--ITPKALFQYSKEISDAIYYIHSNGYEHCDIKPSNI
.||.. . ...   ||.|.| |.|.       .. .......||||||.  |   .  . ...  ....   .| . | .|..|.||.|  | |||| ||
RREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENI

LLDQFG--RIKLADFGLCCPCDD-----TTTKKQYCGSLSFMSPESLVG--KSCDPFKNDVWAFGVTLYYIIKRKLPFKGDNLP
|||. |   ||..|||..  ...       . |  |||...|.|| . |  |. | .| |.|. ||.|| ..  .|||..|...
LLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN
Kinase 85241.m00259.AA CAMK 5-172 23 3.2e-48 153.08 In-house 79-362 (425) Show / Hide 
Range on Protein: 5-172
Range on HMM: 79-362/425
Sequence Identity: 23% (66 aa)

KREVESLVQ-------FDHPHIVKVYDVFSS-------------------ETEMFIIL---EYCSGG----S-LESIVKSGK--------------KITP
.||.| . .        |||.|.| |.|. .                   ...|....   ||||||      .. ||. |.              ..| 
RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

KALFQYSKEISDAIYYIHSNGYEHCDIKPSNILLDQF-----------------GRIKLADFGLCCPCDD------------------------TTTKKQ
.   .| . | .|. |.||..  |.|.|| |||||.                  . ||..|||. . .|.                        .   | 
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT

YCGSLSFMS-PESLVG-------------KSCDPFKNDVWAFGVTLYYIIKRKLPFKGD-------------NLPDLLRDIDLG
.||....|. || | |             |  ...| |.|. || ||     ..|| ||             |...|.. |  |
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKG
Kinase 85241.m00259.AA Pkinase 2-166 28 4.5e-45 160.46 Pfam 43-224 (293) Show / Hide 
Range on Protein: 2-166
Range on HMM: 43-224/293
Sequence Identity: 28% (53 aa)

ISYKR--EVESLVQFDHPHIVKVYDVFSSETEMFIILEYCSGG----SLESIVK--SGKKI--TPKALFQYSKEISDAIYYIHSNGYEHCDIKPSNILLD
..  |  |.. .  ..||.||. ||.| ..... ...||| ||    .| ....  .....  ... .  | ..|  ...|.||.|  |.|.||.|||.|
QTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

QFGRI----KLADFGLCC---PCDDTTTKKQYCGSLSFMSPESLVGKSCDPFKNDVWAFGVTLYYIIKRKLPFKGD----NLPDLL
. | |    |..||||..      ..   . .||.. .|.|| . | . .. | |.|..|..||. . ...||.|.    |  | .
NNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQM
Kinase 85241.m00259.AA ULK 1-188 24 5.7e-42 144.31 In-house 54-297 (329) Show / Hide 
Range on Protein: 1-188
Range on HMM: 54-297/329
Sequence Identity: 24% (60 aa)

MISYKREVESLVQFD--------HPHIVKVYDVFSSETE--MFIILEYCSGGSLESIVK----------SGKKITPKALFQYSKEISDAIYYIHSNGYEH
. . |.|.. . . .        ||.||| ||.| . ..   .||.||| || ||.. |           .|... .   |. | |  .  ..|.... |
WQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIH

CDIKPSNILLDQF------------GRIKLADFGLCCPCD-D------TTTKK---QYCGSLSFMSPESLVGK--SCDPF-K-NDVWAFGVTLYYIIKRK
.||||.|||..              |..|.||||..  .| |      ..| .    .||.  .|.|. | |.   ...  .  |.| .|. .|...  |
RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK

LPFKGDNLPDLL-----RDIDLGYELPS---TTPFQIR---EKVT
 ||..    |.      . |......|    ..|.|..   ....
PPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ
Kinase 85241.m00259.AA MARK 5-165 33 1.3e-41 133.85 In-house 47-216 (262) Show / Hide 
Range on Protein: 5-165
Range on HMM: 47-216/262
Sequence Identity: 33% (58 aa)

KREVESLVQFDHPHIVKVYDVFS--SETE-MFIILEYCSGGSLESIVKSG--KKIT---PKALFQYSKEISDAIYYIHSNGYEHCDIKPSNILLDQFG--
.||.| . . |||.|.| ..|.    |.   ..|.||.|||.| . .|.    ...    ...|   . |  |..| ||..  |.|||| |||.|. |  
MREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIF---RQIVSAVNYCHSKNIVHRDIKPENILIDENGNH

RIKLADFGLCCPCDDTTTKKQYCGSLSFMSPESLVGKSCDPFKNDVWAFGVTLYYIIKRKLPFKGDN--LPDL
 ||..|||..  .   .  .  ||....|.|| . .|  | .| |.|. || ||...  ..||.||.  . .|
NIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKEL
Kinase 85241.m00259.AA ULK 1-165 26 2.3e-38 133.75 In-house 54-259 (324) Show / Hide 
Range on Protein: 1-165
Range on HMM: 54-259/324
Sequence Identity: 26% (55 aa)

MISYKREVESLVQFD---HPH--IVKVYDVFSSETE--MFIILEYCSGGSLESIVK---------SGKKITPKALFQYSKEISDAIYYIHSNGYEHCDIK
. . |.|.. . ...   ||.  ||| ||.| . ..   .||.||| || ||.. |          .|... .   |. | |  .  ..|.... |.|||
WQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIK

PSNILLDQF------------GRIKLADFGLCCPCDDTTTKKQYC----------GSLSFMSPESLVGK--SCDPF-K-NDVWAFGVTLYYIIKRKLPFK
|.|||.               |..|.||||..  .|. .  .| |          |.  .|.|. | |.   ...  .  |.| .|. .|...  | ||.
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFF

GDNLPDL
..   |.
SW-FNDQ
Kinase 85241.m00259.AA Ciliate-E2 15-195 24 1.5e-37 126.49 In-house 90-310 (365) Show / Hide 
Range on Protein: 15-195
Range on HMM: 90-310/365
Sequence Identity: 24% (62 aa)

DHPHIVKVYDVFS--SETEMFIILEYCSGGSLESIVK------------SGKKITPKALFQYSKEISD---------------AIYYIHSNG-YEHCDIK
.||.|.| |..|   ... .....|||.||.|... |              |..| |   ...|.| .               |. |.||..   | |||
NHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PSNILLDQFGRIKLADFGLCCPCDDTTTKKQY--------------------------------CGSLSFMSPESLVGKSCDP--------FKNDVWAFG
|.|||.     ||..||||.  .||   ....                                ||.. .|.|| | ||. |         .| |.|..|
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

VTLYYIIKRKLPFKGDNLPDLLRDIDLGYELPSTTPFQIREKVTKLFFESP
|.||. .  |.||                        |.  |  |. | .|
VILYEMLFGKPPF------------------------QQQIKQCKIDFPCP
Kinase 85241.m00259.AA Ciliate-E2c 5-158 38 6.6e-35 119.82 In-house 62-220 (310) Show / Hide 
Range on Protein: 5-158
Range on HMM: 62-220/310
Sequence Identity: 38% (62 aa)

KREVESLVQFDHPHIVKVYDVFSSETEMFIILEYCSGGSLESIVKSGK-KITPKALFQYSKEISDAIYYIHSN-GYEHCDIKPSNILLDQFGRIKLADFG
.||.... . .||||.| || .  .   ..|.|||.||.||. ... | |.. |    | . |. |  |.|.. .  | ||||.|||.   | ||.||||
IREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGTLEQYIYH-KPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHN-GMIKIADFG

LCCPCDDTTTK-KQ----YCGSLSFMSPESLVGKSCDPFKNDVWAFGVTLYYIIKRKLPFK
.   |.| . . .|    .||.  .|.|. | ||  .  |.|.|  |||||| . .|||..
FSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKSDIWSLGVTLYYMLCYKLPWE
Kinase 85241.m00259.AA MELK 5-176 33 8.4e-34 112.68 In-house 45-220 (254) Show / Hide 
Range on Protein: 5-176
Range on HMM: 45-220/254
Sequence Identity: 33% (59 aa)

KREVESLVQFDHPHIVKVYDVFSSETEMFIILEYCSGGSLESIVKSGKKITPKALFQYSKEISDAIYYIHSNGYEHCDIKPSNILLDQFGRIKLADFGLC
| |...| .. | || ..| .   |  .|...|||.|| .   . . ...  .   .. ..|  || |.|| || | |.|| |.|.|.  ..|| |||||
KTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLC

CPCDDTTTKK---QYCGSLSFMSPESLVGKSCDPFKNDVWAFGVTLYYIIKRKLPFKGDNLPDLLRDIDLG-YELP
        .      |||. .  || . ||.      |||. |. || ..   |||  ||.  . . |  | || |
AKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEP
Kinase 85241.m00259.AA Ciliate-E2-Unclassified 9-169 25 1.1e-33 114.28 In-house 73-298 (352) Show / Hide 
Range on Protein: 9-169
Range on HMM: 73-298/352
Sequence Identity: 25% (58 aa)

ESLVQFDHPHIVKVYDVFSSETEMFIILEYCSGGSLESIVKSGKK-----------------ITPKALF-----QYSKEISDAIYYIHSNG-YEHCDIKP
..|....||.||| ...| ..  ..|..||| ||.|. . |. ||                 .| ..       .| ..| ... |.|...   | ||||
QILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP

SNILLDQFG---RIKLADFGLCC---PCDDTTTKKQ-----------Y---CGSLSFM----SPESLVGKSCDP---FKNDVWAFGVTLYYIIKRKLPFK
.|||.|. |   .||..|||..     ... . ..|           .   ||....|    .|| | |.  |    .| |.|..|| ||...  ..||.
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY

GDNLPD----------------LLRDI
. |  .                |...|
DNNCEQHQQLITQWINNAYRKQLYQNI
Kinase 85241.m00259.AA TKL 5-168 20 1.6e-31 110.73 In-house 73-301 (364) Show / Hide 
Range on Protein: 5-168
Range on HMM: 73-301/364
Sequence Identity: 20% (48 aa)

KREVESLVQFDHPHIVKVYDVFSSETE-------------MFIILEYCSGGSLESIVKSGKKITPKALFQYSKEISDAIYYIHSNG--------YEHCDI
..|. .. ...||.||. . .  ...              ..|. |||.||||....       .  ... ...|. ...| ||..          |.|.
EEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL

KPSNILLDQFGR--------------IKLADFGLCCPCDDTT--------------------TKKQYCGSLSFMSPESLVGK---------------SCD
|..|||.|. ..              .|..||||.   . ..                    |.   ||.. .|.|| | |.               .  
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

PFKNDVWAFGVTLYYIIKRKLPFK-GDNLPDLLRD
  | ||..||. |. |. |..|..  .. | ...|
SEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD
Kinase 85241.m00259.AA S_TKc 1-192 24 3e-24 87.81 SMART 18-231 (231) Show / Hide 
Range on Protein: 1-192
Range on HMM: 18-231/231
Sequence Identity: 24% (59 aa)

MISYK---------------REVESLVQFDHPHIVKVYDVFSSETEMFIILEYCSG--GSLESIVKSGKK------ITPKALFQYSKEISDAIYYIHSNG
 .  |               ||.. | . .||.||| |||| . .......|||.|  |.| .. |. ..      ...     | ..| .|. |.||.|
CRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG

YEHCDIKPSNILLDQFGRIKLADFGLCCPCDDTTTKKQYCGSLSFMSPESLVGKSCDPFKNDVWAFGVTLYYIIKRKLPFKGDNLPDLLRDIDLGYELPS
  |.|.||.|||||.  .||..||||..        . .||.. .|.|| |   . ...| |.|..|..||  . .. ||   ..  ... |        
IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------

TTPFQ----------------IREKVT-------KLFF
. ..                 . |  .         .|
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85241.m00259.AA Pkinase_Tyr 6-104 28 4.8e-16 54.98 Pfam 52-158 (270) Show / Hide 
Range on Protein: 6-104
Range on HMM: 52-158/270
Sequence Identity: 28% (31 aa)

REVESLVQF-DHPHIVKVYDVFS--SET-EMFIILEYCSGGSLESIVKS----GKKITPKALFQYSKEISDAIYYIHSNGYEHCDIKPSNILLDQFGRIK
||.. . |. .||.||. | | .  .|  ...|..||. .|.| .  ..    ....|.| | |.. .|...  | .|... | |.   |.|..  . .|
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LADFGLC
 .||||.
ICDFGLA
Kinase 85241.m00259.AA TyrKc 2-187 18 1.7e-11 -36.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-187
Range on HMM: 1-280/280
Sequence Identity: 18% (51 aa)

ISYK----------------------------------REVESLVQF--DHPHIVKVYDVFSSE-------TEMFIILEYCSGGSLESIVKSGKK-ITPK
|. .                                  || . . ..  .||.||. | | ...         ..|..||...|.| .  .. .. ...|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

ALFQYSKEISDAIYYIHSNGYEHCDIKPSNILLDQFGRIKLADFGLCCPCDDT--------TTKKQY--CGS--LSF--MSPESLVGKSCDPFKNDVWAF
 | ...  |..   |.||... | |.   |.|..  ...| .||||.   .|         . .|.   .|   |    |.||..  . .  .| |||.|
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF

GVTLYYIIKR-KLPFKG-----DNLPDLLRDIDLGYELPSTTP----------------------F---------QIREKV
||... |  . . |  |      .  ....... || .|                          .         .|.|. 
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 85241.m00259.AA Pkinase_Tyr 139-148 60 0.211332 5.37 Pfam 196-205 (270) Show / Hide 
Range on Protein: 139-148
Range on HMM: 196-205/270
Sequence Identity: 60% (6 aa)

DVWAFGVTLY
|||.|||...
DVWSFGVLMW