Gene 86997.m00195 (T.vaginalis)

86997.m00195

Species: T.vaginalis
Alias: TvagK0057, 86997.m00195
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
86997.m00195.AA Protein None 320 None Fasta, JSON
86997.m00195.kin_dom Protein Kinase Domain None 210 None Fasta, JSON

Protein domain

Protein domains of 86997.m00195.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86997.m00195.AA CAMKL 5-211 37 3e-96 307.65 In-house 60-297 (297) Show / Hide 
Range on Protein: 5-211
Range on HMM: 60-297/297
Sequence Identity: 37% (91 aa)

QREIDTTSGLK---HKNIVNLHDFFWEDNN------FYLILDYCQNGE--LMDYIIKN----KKIAEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVL
.|||   . |.   |.||. |.. .  ...      .||.. ||..||  |.|||.|.    ... |. |  .| |.|||..|||| |..|||.||||.|
RREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL

FEKFP--LVKVSDFGLCGYMEE-----SKLMQTFCGSPCYSAPECLRQ--YAYDGQKSDIWSLGVNLYLMVTGMHPWNVTNI--------NVMLREILDC
. .     .|..|||.. ....      ... ||||||.| ||| .      |||.| ||||.|| || ||.|  |..  ..        . ..... . 
LDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-

TYT-IPKDVSAECRDLISKILVLEPEKRLTIDQIIKHPWL
.|  |...|| .|||||.|.|.  |||| ||.|| .|||.
YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 86997.m00195.AA CAMK 1-211 25 2.2e-92 297.95 In-house 75-425 (425) Show / Hide 
Range on Protein: 1-211
Range on HMM: 75-425/425
Sequence Identity: 25% (89 aa)

MKRFQREIDTTSG-------LKHKNIVNLHDFFWE-------------------DNNFYLIL---DYCQNGEL----MDYIIKN---------------K
.|...|||.  .        |.|.||..|....                     |...|...   .||..|||     |||...               .
RKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERG

KIAEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVLF-EKFP----------------LVKVSDFGLCGYMEESK------------------------
.. |  |. .| |..||..|||| ...||||||||.|. ....                 .|..|||.  ......                        
RFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ

LMQTFCGSPCYSA-PECLRQ-------------YAYDGQKSDIWSLGVNLYLMVTGMHPWNVT-------------NINVMLREILDCTYT-IPKD----
.|.||||.|.| | || |..               |.|.|.|.||.|| || |..|  |..               |.. ... |. . |. .|.     
KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPI

-------------------VSAECRDLISKILVLEPEKRLTIDQIIKHPWL
                   ||.||.|||.|.|. .||||.||.|. .|||.
SCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 86997.m00195.AA MARK 1-211 42 5.9e-86 280.96 In-house 43-262 (262) Show / Hide 
Range on Protein: 1-211
Range on HMM: 43-262/262
Sequence Identity: 42% (93 aa)

MKRFQREIDTTSGLKHKNIVNLHDFFW--EDNN-FYLILDYCQNGELMDYIIKN--KKIAEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVLFEKFP-
|| ..|||.  . |.|.||. |.. .   . .. .|||..|. .|||.|||..    .. |. |  || |.|||. |||| ...|||.||||.|  .   
MKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGN

-LVKVSDFGLCGYMEESKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNVTN--INVMLREILDCTYTIPKDVSAECRDLISKI
  .| .|||..   .. ..  ||||.| | ||| . .  |||.| ||||||| || ||.|  |.  ..  .. . ..|| . |.||  ||.|||.||...
HNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRL

LVLEPEKRLTIDQIIKHPWL
|.. ||.| ||..| ||||.
LTVNPEERPTIEEIMKHPWM
Kinase 86997.m00195.AA AMPK 1-211 39 3.3e-85 252.92 In-house 43-254 (254) Show / Hide 
Range on Protein: 1-211
Range on HMM: 43-254/254
Sequence Identity: 39% (83 aa)

MKRFQREIDTTSGLKHKNIVNLHDFF-WEDNNFYLILDYCQNGELMDYIIKNKKIAEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVLFEKFPLVKVS
..| ||||.    ..| .|. | .        ..... | ..||| |||.|.... |  |.  | |..|.. |||  ...||||||||.|. .   .|. 
VERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIV

DFGLCGYMEESKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNVTNINVMLREILDCTYTIPKDVSAECRDLISKILVLEPEKR
||||  .|.. ..  | |||||| |||      | | . |||| || || |. |  |    |. .  . |... |.|||..| |..|||...|   |.||
DFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKR

LTIDQIIKHPWL
.||..| .|||.
ITIHDIRNHPWF
Kinase 86997.m00195.AA QIK 1-211 35 1.1e-74 254.48 In-house 42-272 (272) Show / Hide 
Range on Protein: 1-211
Range on HMM: 42-272/272
Sequence Identity: 35% (81 aa)

MKRFQREIDTTSGLKHKNIVNLHDFFWEDNNFYLILDYCQNGELMDYIIKNKK--------------------IAEPTAALIFEQMVSAIAYCHSFGVAH
...  ||.     |.| .|. | .    |.  |.. .||.|||. ||..|. .                    .||. |. .| |..||..|||. ...|
LQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVH

RDLKPENVLFEKFPLVKVSDFGLCGYMEESKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNVTNINVMLREILDCTYTIPKDV
|||| ||.|. .   .|. |||.  . .. .|..|.|||| | ||| .    ||| |.||||.|| || .|.|  |    ... . . .|   . ||  .
RDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFM

SAECRDLISKILVLEPEKRLTIDQIIKHPWL
| .| .|| . ||..||.|.||.||..|.|.
SQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 86997.m00195.AA TSSK 6-211 37 1.3e-73 240.94 In-house 64-289 (289) Show / Hide 
Range on Protein: 6-211
Range on HMM: 64-289/289
Sequence Identity: 37% (84 aa)

REIDTTSG-LKHKNIVNLHDFFWEDN-NFYLILDYCQNGELMDYIIKN------KKIAEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVLFEKFPLVK
|||.   . |||.||.... .|   .   |... |...| | .|| ..      . . |. | . | |||||..|||| .|.||||| ||.|  |   .|
REIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIK

VSDFGLCGYMEESK------LMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNV--TNINVMLREIL--DCTYTI--PKDVSAECR
 .|||   |.....      | .|||||  |.||| ||   ||. ..|.||.|| || ||.|  | .   .||. ||...     ....   . .|.||.
LTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEILRGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECK

DLISKILVLEPEKRLTIDQIIKHPWL
|||...| ..| .|..|..|..|.|.
DLIRHMLQPHPCNRPHINEICHHCWM
Kinase 86997.m00195.AA Ciliate-E2 14-211 30 1.6e-71 243.92 In-house 89-365 (365) Show / Hide 
Range on Protein: 14-211
Range on HMM: 89-365/365
Sequence Identity: 30% (90 aa)

LKHKNIVNLHDFFW--EDNNFYLILDYCQNGELMDYIIKNKKIA-----------EPTAALIFEQMVS---------------AIAYCHSFG-VAHRDLK
|.|.||......|    |||.||...||| |.|.|||..|||             |  .. |..| ..               |. |.|| . . |||.|
LNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PENVLFEKFPLVKVSDFGL----------------CGYMEESK-----------------LMQTFCGSPCYSAPECLRQYAYDG--------QKSDIWSL
|||.||     .|..||||                |. . . |                 . .|.||.| | ||| |.   ||.         |.|||||
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GVNLYLMVTGMHPWNVTNINVMLREILDCTYTIP------------------KDVSAECRDLISK----ILVLEPEKRLT-IDQIIKHPWL
|| || |..| .|.        ...|..| . .|                  |..| || |||.|    .|. .||||.| ..||..|||.
GVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 86997.m00195.AA Pkinase 2-211 31 2.7e-70 244.66 Pfam 43-293 (293) Show / Hide 
Range on Protein: 2-211
Range on HMM: 43-293/293
Sequence Identity: 31% (79 aa)

KRFQR--EIDTTSGLKHKNIVNLHDFFWEDNNFYLILDYCQNG----ELMDYII--KNKKI--AEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVLFE
..  |  ||     |.|.||| |.|.| .... |....||..|    .|.|||   .....   | ..  .. |......|||| |. ||||||||.|. 
QTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

KFPLV----KVSDFGLCGY--MEESKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNVT------NINVMLREILDCTYTIPKD
. . .    |..||||.       .  |.||||.| | ||| .| . |.|.|.|.||.|. || |..|  |.         . ..|...|... .  . .
NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWP

VS---------------------AECRDLISKILVLEPEKRLTIDQIIKHPWL
 .                      ||.|.|...| . |.||.|..|| .|||.
WWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 86997.m00195.AA GIN4 6-211 39 6.1e-70 222.47 In-house 83-293 (293) Show / Hide 
Range on Protein: 6-211
Range on HMM: 83-293/293
Sequence Identity: 39% (83 aa)

REIDTTSGLKHKNIVNLHDFFWEDNNFYLILDYCQNGELMDYIIKNKKIAEPTAALIFEQMVSAIAYCHSFGVAHRDLKPENVLFEKFPL-VKVSDFGLC
|||     . | |.. |.| . ..|. ||.|.| . ||| .|...  .. |  |  .| |..  ..|||.|.. ||||||||.| ...   .|. |||. 
REIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMA

GYMEESKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNVT--NINVMLREILDCTYTIPKD--VSAECRDLISKILVLEPEKRL
    ..||..| |||| | |||      |.|  ||.|| || |. ..||  |..    ||  .|  .    | .| |  .| | .|||.||||..||||.
ALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRI

TIDQIIKHPWL
.. .|.||| .
KTRDILKHPLI
Kinase 86997.m00195.AA ULK 1-211 28 8.9e-65 221.52 In-house 54-324 (324) Show / Hide 
Range on Protein: 1-211
Range on HMM: 54-324/324
Sequence Identity: 28% (77 aa)

MKRFQREIDTTSGLK---HKN--IVNLHDFFWED--NNFYLILDYCQNGELMDYIIKNKK---------IAEPTAALIFEQMVSAIAYCHSFGVAHRDLK
.. ...|| .   ||   |.|  || |.|.|...  ||.|.|..||. | | .|| ||||         . |. |  .| | ...  . |. .. |||.|
WQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIK

PENVLFEKF------------PLVKVSDFGLCGYMEES----KLMQTFC------GSPCYSAPECLR----QYAYDGQKSDIWSLGVNLYLMVTGMHP--
|.| |  .             . .|..|||..   ..      ..||..      |.| | ||. |     |  |.  |.||||||. .| |..|  |  
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFF

-WNVTNIN----VMLR-----EILDCTYTIPKD-------VSAECRDLISKILVLEPEKRLTIDQIIKHPWL
 |  .. .     ...     .|. ..  |...       .| ||.|||.. |. ....| ....|..|||.
SW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 86997.m00195.AA ULK 1-211 27 1.9e-64 220.44 In-house 54-329 (329) Show / Hide 
Range on Protein: 1-211
Range on HMM: 54-329/329
Sequence Identity: 27% (76 aa)

MKRFQREIDTTSGLK----HKN----IVNLHDFFWED--NNFYLILDYCQNGELMDYIIKNKK----------IAEPTAALIFEQMVSAIAYCHSFGVAH
.. ...||..   ||    |||    || |.|.|...  ||.|.|..||. | |..|| ||||          . |. |  .| | ...  . |. .. |
WQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIH

RDLKPENVLFEKF------------PLVKVSDFGLCGYMEES----KLMQTFC------GSPCYSAPECLR----QYAYDGQKSDIWSLGVNLYLMVTGM
||.||.|.|  .             . .|..|||..  ....    ..|.|.       |.| | ||. |     |  |.  |.||||||. .| |..| 
RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK

HP---WNVTNINVMLR-EILDCTYTIP-------KD---------VSAECRDLISKILVLEPEKRLTIDQIIKHPWL
 |   |  .  . .   . .. ....|        .         .| ||.|||.. |. ....| .......|||.
PPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 86997.m00195.AA S_TKc 1-211 30 6.2e-64 219.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-211
Range on HMM: 1-231/231
Sequence Identity: 30% (79 aa)

M--------------------------------KRFQREIDTTSGLKHKNIVNLHDFFWEDNNFYLILDYCQN--GELMDYIIKNKK------IAEPTAA
                                 ....|||.  .  .|.|||.|.|.| . ...|....|| .  |.|.||| |...      . | .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

LIFEQMVSAIAYCHSFGVAHRDLKPENVLFEKFPLVKVSDFGLCGYMEESKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGVNLYLMVTGMHPWNVT
 .. |...|..|||| |. ||||||||.|. .   .|..||||.  .       ||||.| | ||| |    |.. |.|.||.|. || |..|  |.   
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

NINVMLREILDCTYTIPKDVSAECRDLISKILVLEPEKRLTIDQIIK-------HPWL
....|.. |.          | |..|.|.|.|. .||||.|. .. .       |||.
QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86997.m00195.AA TyrKc 1-211 20 3.1e-11 -41.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-211
Range on HMM: 1-280/280
Sequence Identity: 20% (57 aa)

M---------------------------------KRFQREIDTTSGL--KHKNIVNLHDFFWED-------NNFYLILDYCQNGELMDYIIKNKK-IAEP
                                  . | ||.   . |  .|.|||.|.    ..          .... |. .| | ||. |... .  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

TAALIFEQMVSAIAYCHSFGVAHRDLKPENVLFEKFPLVKVSDFGLCGYMEES------KLMQTF----CG---SPC-YSAPECLRQYAYDGQKSDIWSL
.   .  |  .  .| || .. ||||   |.|  .   ||.|||||. . ..       | . .     .|    |    ||||.. . .   |||.|| 
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF

GVNLYLMVT-GMHPWNV-----TNINVMLREILDC-TYTIPKD--------VSAECRDLISKILVLEPEKRLTIDQIIKHPWL
|| .. . | |. |.        .   ... . .     .|..         ..|  .....    .||.| |  .|  |  .
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 86997.m00195.AA Pkinase_Tyr 4-68 26 0.018281 8.97 Pfam 50-115 (270) Show / Hide 
Range on Protein: 4-68
Range on HMM: 50-115/270
Sequence Identity: 26% (18 aa)

FQREIDTTSGL-KHKNIVNLHDFFW-EDNN--FYLILDYCQNGELMDYIIKNKKIAEPTAALIFEQMVS
| ||. . . | .|.|||.|.     ..     |... |...| | ||  |..   |.  .|  .....
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQ
Kinase 86997.m00195.AA Pkinase_Tyr 87-145 31 0.043057 7.71 Pfam 141-202 (270) Show / Hide 
Range on Protein: 87-145
Range on HMM: 141-202/270
Sequence Identity: 31% (20 aa)

NVLFEKFPLVKVSDFGLCGYM----EE-SKLMQTFCGSPCYSAPECLRQYAYDGQKSDIWSLGV
|.| ..   ||..||||. ..    .   |   .        ||||.. . .   |||.|| ||
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFT-TKSDVWSFGV