Gene 92815.m00005 (T.vaginalis)
92815.m00005
Species: T.vaginalis
Alias: 92815.m00005, TvagK0976
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 92815.m00005.AA | Protein | None | 521 | None | Fasta, JSON |
| 92815.m00005.kin_dom | Protein Kinase Domain | None | 225 | None | Fasta, JSON |
Protein domains of 92815.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 92815.m00005.AA | TK | 92-267 | 14 | 6.1e-29 | 93.53 | In-house | 121-486 (486) | Show / Hide |
Range on Protein: 92-267
Range on HMM: 121-486/486
Sequence Identity: 14% (52 aa)
FN-----NPIIIASNYIPNGN----LYEAIKSGR------------------------------------------------------------------
|. |..| | |.|. | . .. |
FEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQM
-----------LNPTDKTKIAMGIAYALRRLHKM------HIVHGDLKSRNIMLGDDMR-----------PLVSDFGYGAIA---LALQVP---IQYRIN
|.. .. ... || ... ||.. ..||.|| ||...|.... ..||| || .. || .
AWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKS
DPY----------------------------WCAPEVLTGAV---------PTSASDVYSFGTLISELYN--EQVPAQG------------AAVLARTHQ
... |.|||.|.. | |..|||.||| |. |.. .. .. | . |. . .
SYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRR
E--------------FIPS---SAP--------------KILRALVQCCTMENPARRPDFRRIYRLF
. . . .| ... | |.| ..|..||.|. ... .
GGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | 92815.m00005.AA | TKL | 94-267 | 18 | 4.4e-28 | 98.23 | In-house | 105-364 (364) | Show / Hide |
Range on Protein: 94-267
Range on HMM: 105-364/364
Sequence Identity: 18% (50 aa)
NP------IIIASNYIPNGNLYEAIKSGRLNPTDKTKIAMGIAYALRRLHKMH--------IVHGDLKSRNIMLGDDMR--------------PLVSDFG
.| . | |.|.|.|.. . . . ..|..|| .. || |. |.| ||||.||.. .... . ..|||
HPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFG
----------YGAIALA--------LQVPIQYRIN-DPYWCAPEVLTGA----------------VPTSASDVYSFGTLISELYNEQVPAQGAA------
... . .. ... |.|.||||| |. . ..|||||| .. |.. ..| ..
LSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIF
--------VLARTHQE--FIP------------SSAPKILRALVQCCTMENPARRPDFRRIYRLF
... ... || ...|. .. | |.| ..| || | .| .
QDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | 92815.m00005.AA | TKL-Unique | 97-267 | 25 | 2.3e-15 | 50.79 | In-house | 76-290 (290) | Show / Hide |
Range on Protein: 97-267
Range on HMM: 76-290/290
Sequence Identity: 25% (55 aa)
IIASNYIPNGNLYEAIK-----------SGRLNPTDKTKIAMGIAYALRRLHKMH--IVHGDLKSRNIMLGDD-----MRPLVSDFGYGAIAL-ALQVPI
.| . |.| |.||. . . ||. . |.| || .. .|| | |.||||.|. . . .. ..||| .. .. ..
CIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN
Q--------YRINDPYWCAPEVLTG--AVPTSASDVYSFGTLISELYNEQV------PAQGAAVL--A-------RTHQEFIPSSAPKILRALVQCCTME
|. . | |||||.. . . |||||||. |... .. | || . . . .. ||.. ||..| | | |
NEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHH
NPARRPDFRRIYRLF
.| || | |.
DPSQRPSFDEIIHRL
|
|||||||||
| Kinase | 92815.m00005.AA | TK-Unique | 125-210 | 32 | 6.4e-15 | 48.0 | In-house | 136-229 (294) | Show / Hide |
Range on Protein: 125-210 Range on HMM: 136-229/294 Sequence Identity: 32% (32 aa) IAMGIAYALRRLHK--MHIVHGDLKSRNIMLGDDMRPLVSDFGYGA--------IALALQVPIQYRINDPYWCAPEVLT--GAVP-TSASDVYSFGTLI .| .|| .. |.. ..|||.|| .||..|..| . ..||| . | .|..| |.|||.| . . |. |||.||| |. FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR-----WMAPESLKCYHGMYHTTKSDVWSFGVLM |
|||||||||
| Kinase | 92815.m00005.AA | UTK | 117-214 | 27 | 6.7e-15 | 47.42 | In-house | 115-234 (296) | Show / Hide |
Range on Protein: 117-214 Range on HMM: 115-234/296 Sequence Identity: 27% (33 aa) LNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDD-------MRPLVSDFGYGAIALALQVP----------IQYRINDP------YWCAPEVLT |. ..... |. || .. || ...||.|| ||. .... | ..||| |. .. .|. .| .. |.|||.|| LTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGG--MSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALT GA-VPTSASDVYSFGTLISELY . .|..|||.||| . |.. HHTRFTTKSDVWSFGVVCWEIW |
|||||||||
| Kinase | 92815.m00005.AA | RTKE | 185-267 | 25 | 9.5e-15 | 46.7 | In-house | 192-293 (293) | Show / Hide |
Range on Protein: 185-267 Range on HMM: 192-293/293 Sequence Identity: 25% (26 aa) YWCAPEVLTGAVPTSASDVYSFGTLISELY-NEQV-----PAQGAAVLARTHQE-------------FIPSSAPKILRALVQCCTMENPARRPDFRRIYR .| ||||. .....|||...| | |.. |.| . | . ...| |...| ...| | |. ||..||.|. .|. RWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQ LF MW |
|||||||||
| TyrKc | 92815.m00005.AA | TyrKc | 25-267 | 19 | 6.3e-14 | 2.44 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-267
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)
TIPMQKLETGDYGYSNISKYSITNRNIVIKQIY-YADSDQEKLNKLFSQYILLMRA--TNRYLNPPIGFIFN--------NPIIIASNYIPNGNLYEAIK
.|| | .| ... .. .| . .| . . . .... . . .| . |. | | |.|.| . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR
SGR--LNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFGYGAIALALQVPIQ---------YRI----NDP-----YWCAPEVLT
. | |.. |. ... || . ||.....| || ||...|.. . .|||| |. . || . |.|||..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN
GAVPTSASDVYSFG-------TLISELYNE-----QVPAQGAAVLARTHQEFIPSS--------APKILRALVQCCTMENPARRPDFRRIYRLF
. |..|||.||| |. . | . ... . . . . .| . .|. . . ..| .|.|. || |. |...|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
|||||||||
| S_TKc | 92815.m00005.AA | S_TKc | 25-267 | 17 | 8.9e-14 | 25.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-267 Range on HMM: 1-231/231 Sequence Identity: 17% (46 aa) TIPMQKLETGDYGYSNISKYSITNRNIVIKQIYYADSDQEKLNKLFSQYILLMRATNRYLNPPIGFIFN-NPIIIASNYIPN--GNLYEAIKSGR----- ..|. | .| . |.| ||.| . . . | ... . . .| . . . |... |.|.. ||. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFGYGAIALALQVPIQYRINDPYWCAPEVLTGAVPTS-ASDVYSFGTLISEL ... . ... |. || .|...|.| ||| ||.| . . ..||| .. . |...||||| . ..|..|.| .. |. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM YNEQVPAQGAAVLARTHQEFIPSSAPKILRALVQCCTMENPARRPDFRRIYR---------LF . . | . .... . .. .. ... | .|..|| . . | LCGYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 92815.m00005.AA | Pkinase | 102-267 | 17 | 1.3e-11 | 42.16 | Pfam | 81-293 (293) | Show / Hide |
Range on Protein: 102-267 Range on HMM: 81-293/293 Sequence Identity: 17% (38 aa) YIPNG----NLYEAIK---SGRL--NPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRP----LVSDFGYGAIA-LALQVPIQYRINDPYWC | ..| |.. |. .|.. . . ... |. .| .|.| |.| |||. ||.. ... . ..||| . . . .. . . |... YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM APEVLT-GAVPTSASDVYSFGTLISELYNEQVPAQGA-------------AVLARTHQEFIPSSAP-------------------KILRALVQCCTMENP ||||. | ....|..|.| .. |... . | .|. .. . . .| . . . .. .. .| .| APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP ARRPDFRRIYRL--F ..|| .. | | KKRPTAEQILQHPWF |
|||||||||
| Kinase | 92815.m00005.AA | RAF | 125-219 | 30 | 2.2e-11 | 32.84 | In-house | 108-220 (282) | Show / Hide |
Range on Protein: 125-219 Range on HMM: 108-220/282 Sequence Identity: 30% (34 aa) IAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFGYGAIALALQVPIQYRINDP----YWCAPEVLT-------------GAVP-TSASDVYSF |. .. .. ||. |.| ||||.||.| .||. . ||| . . . .. | | |||| | . |||||| ISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSF GTLISELYNEQVP |. . || .. | GIVMYELMTRHMP |
|||||||||
| Kinase | 92815.m00005.AA | Fer | 186-268 | 20 | 1.9e-10 | 31.94 | In-house | 184-283 (283) | Show / Hide |
Range on Protein: 186-268 Range on HMM: 184-283/283 Sequence Identity: 20% (20 aa) WCAPEVLTGAVPTSASDVYSFGTLISELYN-------E--------QVPAQGAAVLAR-THQEFIPSSAPKILRALVQ-CCTMENPARRPDFRRIYRLFK | |||... . ....||.||| .. | .. . .|. | .. .. . ..|...|. .. .. .| ..| || . |.. .| WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
|||||||||
| Kinase | 92815.m00005.AA | MLK | 186-267 | 27 | 2.3e-10 | 32.3 | In-house | 199-291 (291) | Show / Hide |
Range on Protein: 186-267 Range on HMM: 199-291/291 Sequence Identity: 27% (26 aa) WCAPEVL---TGAVPTSASDVYSFGTLISEL------YN-EQVPAQGAAVLARTH-QEFIPSSAPKILRALVQCCTMENPARRPDFRRIYRLF | ||||. . . ..||.|.| .. |. | .. |.. |. | .. |||..|... | ..| ..|..||.|| | . WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | 92815.m00005.AA | NZAK | 96-165 | 31 | 4.1e-09 | 26.21 | In-house | 77-150 (329) | Show / Hide |
Range on Protein: 96-165 Range on HMM: 77-150/329 Sequence Identity: 31% (23 aa) IIIASNYIPNGNLYEAI----KSGRLNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFG . | . .. ||| . . | .| .. |. || . ||| ||.| |.|| |..| . ||| HCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDFG |
|||||||||
| Kinase | 92815.m00005.AA | NZAK | 188-267 | 23 | 7.4e-08 | 21.94 | In-house | 240-329 (329) | Show / Hide |
Range on Protein: 188-267 Range on HMM: 240-329/329 Sequence Identity: 23% (21 aa) APEVLTGAVPTSASDVYSFGTLISEL--YNEQ----VPAQGAAVLARTHQEF---IPSSAPKILRALVQCCTMENPARR-PDFRRIYRLF |||.. . . |||.||| .. .. || . | |.. . .. || | ... ... | .| .| || . . APENKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL |
|||||||||
| Kinase | 92815.m00005.AA | MLK | 102-165 | 23 | 1e-06 | 18.91 | In-house | 91-178 (291) | Show / Hide |
Range on Protein: 102-165 Range on HMM: 91-178/291 Sequence Identity: 23% (21 aa) YIPNGNLYEAIKSGR---------------LNPTDKTKIAMGIAYALRRLHKMH---IVHGDLKSRNIMLGD------DMRPLVSDFG |...| ||. ....| . . ..|. .| .. ||.| |.| ||||.||.. . .. ..||| YCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG |
|||||||||
| Kinase | 92815.m00005.AA | Pkinase_Tyr | 102-165 | 24 | 3e-06 | 21.88 | Pfam | 88-156 (270) | Show / Hide |
Range on Protein: 102-165 Range on HMM: 88-156/270 Sequence Identity: 24% (17 aa) YIPNGNLYEAIKSG-----RLNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFG | |.|.|.. .. .|.. |. .... || .. |. ....| || ||....... ..||| YMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG |
|||||||||
| Kinase | 92815.m00005.AA | Pkinase_Tyr | 186-214 | 44 | 1.4e-05 | 19.48 | Pfam | 180-208 (270) | Show / Hide |
Range on Protein: 186-214 Range on HMM: 180-208/270 Sequence Identity: 44% (13 aa) WCAPEVLTGAVPTSASDVYSFGTLISELY |.|||.. . |..|||.||| |. |.. WMAPECINYGKFTTKSDVWSFGVLMWEIF |
|||||||||
| Kinase | 92815.m00005.AA | Fer | 136-165 | 33 | 0.000738 | 9.15 | In-house | 127-159 (283) | Show / Hide |
Range on Protein: 136-165 Range on HMM: 127-159/283 Sequence Identity: 33% (11 aa) LHKMHIVHGDLKSRNIMLGDDMRPL---VSDFG ||.....| |. .||. ...| . .|||| LHSKNCIHRDIAARNCLYHKDKVKKKCKISDFG |
|||||||||
| Kinase | 92815.m00005.AA | UTK | 223-267 | 21 | 0.004026 | 6.53 | In-house | 251-296 (296) | Show / Hide |
Range on Protein: 223-267 Range on HMM: 251-296/296 Sequence Identity: 21% (10 aa) AAVLART-HQEFIPSSAPKILRALVQCCTMENPARRPDFRRIYRLF ..|... .. . | . | . |.. | . .|..||||.... . HQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | 92815.m00005.AA | RAF | 234-269 | 22 | 0.005313 | 5.23 | In-house | 247-282 (282) | Show / Hide |
Range on Protein: 234-269 Range on HMM: 247-282/282 Sequence Identity: 22% (8 aa) IPSSAPKILRALVQCCTMENPARRPDFRRIYRLFKN . . .|| .. |.. | . .. || |. | . VRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV |
|||||||||
| Kinase | 92815.m00005.AA | Pkinase_Tyr | 251-267 | 29 | 0.045464 | 7.63 | Pfam | 254-270 (270) | Show / Hide |
Range on Protein: 251-267 Range on HMM: 254-270/270 Sequence Identity: 29% (5 aa) MENPARRPDFRRIYRLF ...|..|| |. |.. . HYDPEDRPTFSEIHEQL |
|||||||||